Product Name

  • Name

    Isopropenyl chloroformate

  • EINECS 261-018-4
  • CAS No. 57933-83-2
  • Density 1.103 g/cm3
  • Solubility reacts
  • Melting Point
  • Formula C4H5ClO2
  • Boiling Point 100 °C at 760 mmHg
  • Molecular Weight 120.535
  • Flash Point 16.1 °C
  • Transport Information UN 3390
  • Appearance Colorless clear liquid
  • Safety 16-26-27-36/37/39-45-8-28
  • Risk Codes 11-23/24/25-34-36/37-29-26-21/22
  • Molecular Structure Molecular Structure of 57933-83-2 (Isopropenyl chloroformate)
  • Hazard Symbols FlammableF； ToxicT； VeryT+
  • Synonyms Isopropenylchloroformate;
  • PSA 26.30000
  • LogP 1.89540

Synthetic route

phosgene
75-44-5

phosgene

acetone
67-64-1

acetone

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

Conditions
ConditionsYield
at 20℃;
phosgene
75-44-5

phosgene

bis(acetonyl)mercury
6704-33-2

bis(acetonyl)mercury

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

Conditions
ConditionsYield
In dichloromethane
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

2-(3,4-dimethoxyphenyl)-2-cyclohexen-1-ol
189363-85-7

2-(3,4-dimethoxyphenyl)-2-cyclohexen-1-ol

2-(3,4-dimethoxyphenyl)-3-[(isopropenyloxycarbonyl)oxy]-1-cyclohexene

2-(3,4-dimethoxyphenyl)-3-[(isopropenyloxycarbonyl)oxy]-1-cyclohexene

Conditions
ConditionsYield
With pyridine In dichloromethane at 0℃;100%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

2-(3,4-methylenedioxyphenyl)-2-cyclohexen-1-ol
215609-91-9

2-(3,4-methylenedioxyphenyl)-2-cyclohexen-1-ol

2-(3,4-methylenedioxyphenyl)-3-[(isopropenyloxycarbonyl)oxy]-1-cyclohexene
335371-06-7

2-(3,4-methylenedioxyphenyl)-3-[(isopropenyloxycarbonyl)oxy]-1-cyclohexene

Conditions
ConditionsYield
With pyridine In dichloromethane at 0℃;100%
ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate
897372-42-8

ethyl 2-(3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)phenyl)acetate

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

C21H27N3O4
897373-29-4

C21H27N3O4

Conditions
ConditionsYield
With sodium hydroxide In water; ethyl acetate at 20℃; for 1h;100%
(1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine
939398-43-3

(1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

(R)-prop-1-en-2-yl 1-(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)-1-(4-fluorophenyl)-2-phenylethylcarbamate

(R)-prop-1-en-2-yl 1-(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)-1-(4-fluorophenyl)-2-phenylethylcarbamate

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; water at 20℃;100%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

3-(5-amino-4-fluoro-2-methylphenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one
1012878-89-5

3-(5-amino-4-fluoro-2-methylphenyl)-1-ethyl-7-(methylamino)-1,6-naphthyridin-2(1H)-one

prop-1-en-2-yl (5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate
1442470-95-2

prop-1-en-2-yl (5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 6h;100%
With sodium hydrogencarbonate In ethyl acetate at 20℃;100%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

2-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
1012880-11-3

2-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

prop-1-en-2-yl 2-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate
1454682-73-5

prop-1-en-2-yl 2-fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 6h;100%
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 6h;
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 6h; Schotten-Baumann Reaction;
tert-butyl 5-(5-amino-3-isopropyl-pyrazol-1-yl)-indazole-1-carboxylate
1020173-63-0

tert-butyl 5-(5-amino-3-isopropyl-pyrazol-1-yl)-indazole-1-carboxylate

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

tert-butyl 5-(3-isopropyl-5-((prop-1-en-2-yloxy)carbonylamino)-1H-pyrazol-1-yl)-1H-indazole-1-carboxylate
1020173-64-1

tert-butyl 5-(3-isopropyl-5-((prop-1-en-2-yloxy)carbonylamino)-1H-pyrazol-1-yl)-1H-indazole-1-carboxylate

Conditions
ConditionsYield
With sodium hydroxide In ethyl acetate at 0 - 20℃;99%
With sodium hydroxide In water; ethyl acetate at 0 - 20℃;99%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl-1,6-naphthyridin-7-amine
1455036-08-4

3-(3-amino-4-fluorophenyl)-N-(4-methoxybenzyl)-N,2-dimethyl-1,6-naphthyridin-7-amine

prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl-1,6-naphthyridin-3-yl)phenyl)carbamate
1455036-62-0

prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl-1,6-naphthyridin-3-yl)phenyl)carbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 2h; Schotten-Baumann Reaction;99%
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 2h;99%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

C12H13Cl2NO
1263184-89-9

C12H13Cl2NO

C16H17Cl2NO3

C16H17Cl2NO3

Conditions
ConditionsYield
With triethylamine In toluene at 25℃; for 2.66667h;99%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

6-(5-amino-4-fluoro-2-methylphenyl)-N-(4-methoxybenzyl)-N-methylpyrido[2,3-d]pyrimidin-2-amine

6-(5-amino-4-fluoro-2-methylphenyl)-N-(4-methoxybenzyl)-N-methylpyrido[2,3-d]pyrimidin-2-amine

C27H26FN5O3

C27H26FN5O3

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 2h;99%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

3-(5-amino-4-fluoro-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl-1,6-naphthyridin-7-amine
1455036-17-5

3-(5-amino-4-fluoro-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl-1,6-naphthyridin-7-amine

prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl-1,6-naphthyridin-3-yl)-4-methylphenyl)carbamate
1455036-70-0

prop-1-en-2-yl (2-fluoro-5-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl-1,6-naphthyridin-3-yl)-4-methylphenyl)carbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 4h;99%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

N-hydroxy-5-norbornene-2,3-dicarboximide
21715-90-2

N-hydroxy-5-norbornene-2,3-dicarboximide

Carbonic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester isopropenyl ester
137283-63-7

Carbonic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl ester isopropenyl ester

Conditions
ConditionsYield
With triethylamine In acetone; acetonitrile at 0℃;98%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

7-((4-methoxybenzyl)(methyl)amino)-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one
1442470-43-0

7-((4-methoxybenzyl)(methyl)amino)-3-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

prop-1-en-2-yl (4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)carbamate
1442470-93-0

prop-1-en-2-yl (4-chloro-5-(1-ethyl-7-((4-methoxybenzyl)(methyl)amino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)carbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 3h;98%
In ethyl acetate at 20℃; for 3h;98%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

5-[(2R,3R)-3-amino-2-methylpiperidin-1-yl]-3-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazine-2-carboxamide

5-[(2R,3R)-3-amino-2-methylpiperidin-1-yl]-3-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazine-2-carboxamide

prop-1-en-2-yl N-[(2R,3R)-1-{5-carbamoyl-6-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazin-2-yl}-2-methylpiperidin-3-yl]carbamate

prop-1-en-2-yl N-[(2R,3R)-1-{5-carbamoyl-6-[(1-methyl-1H-pyrazol-4-yl)amino]pyrazin-2-yl}-2-methylpiperidin-3-yl]carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;98%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

(2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine
1619983-12-8

(2R,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-amine

prop-1-en-2-yl N-[(2R,3S,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]carbamate
1619984-40-5

prop-1-en-2-yl N-[(2R,3S,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]carbamate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 23h; Inert atmosphere;97%
4-trifluoromethylphenylamine
455-14-1

4-trifluoromethylphenylamine

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

prop-1-en-2-yl (4-(trifluoromethyl)phenyl)carbamate
1622427-09-1

prop-1-en-2-yl (4-(trifluoromethyl)phenyl)carbamate

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at -78 - 20℃; for 3h; Inert atmosphere;97%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

Isopropenyl Succinimido Carbonate
96935-01-2

Isopropenyl Succinimido Carbonate

Conditions
ConditionsYield
With triethylamine In acetone; acetonitrile at 0℃; for 4h;96%
(1S,4aS,5S,8aR)-2, 8a-dihydroxy-3,8-dimethyl-5-(1-methylethyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate
745065-96-7

(1S,4aS,5S,8aR)-2, 8a-dihydroxy-3,8-dimethyl-5-(1-methylethyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

(1S,2R,4aS,5S,8R,8aR)-8a-hydroxy-3,8-dimethyl-2-({[(1-methylethenyl) oxy] carbonyl} oxy)-5-(1-methylethyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate
745063-60-9

(1S,2R,4aS,5S,8R,8aR)-8a-hydroxy-3,8-dimethyl-2-({[(1-methylethenyl) oxy] carbonyl} oxy)-5-(1-methylethyl)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl (2S,3aR,9bR)-6-chloro-9b-hydroxy-5-methyl-1,2,3,3a,5,9b-hexahydropyrrolo[2,3-c][2,1]benzoxazine-2-carboxylate

Conditions
ConditionsYield
With dmap In dichloromethane at 0 - 20℃; for 2.5h;96%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

7-amino-3-(5-amino-4-fluoro-2-methylphenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one
1012878-90-8

7-amino-3-(5-amino-4-fluoro-2-methylphenyl)-1-ethyl-1,6-naphthyridin-2(1H)-one

prop-1-en-2-yl (5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate
1442474-13-6

prop-1-en-2-yl (5-(7-amino-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoro-4-methylphenyl)carbamate

Conditions
ConditionsYield
In pyridine at 0℃; for 0.5h;96%
With pyridine at 0℃; for 0.5h;96%
N-hydroxyphthalimide
524-38-9

N-hydroxyphthalimide

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

Carbonic acid 1,3-dioxo-1,3-dihydro-isoindol-2-yl ester isopropenyl ester
137283-62-6

Carbonic acid 1,3-dioxo-1,3-dihydro-isoindol-2-yl ester isopropenyl ester

Conditions
ConditionsYield
With triethylamine In acetone; acetonitrile at 0℃;95%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

3-(5-amino-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl-1,6-naphthyridin-7-amine
1455036-18-6

3-(5-amino-2-methylphenyl)-N-(4-methoxybenzyl)-N,2-dimethyl-1,6-naphthyridin-7-amine

prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl-1,6-naphthyridin-3-yl)-4-methylphenyl)carbamate
1455036-73-3

prop-1-en-2-yl (3-(7-((4-methoxybenzyl)(methyl)amino)-2-methyl-1,6-naphthyridin-3-yl)-4-methylphenyl)carbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; ethyl acetate at 20℃; for 1h;95%
4-nitro-phenol
100-02-7

4-nitro-phenol

Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

4-nitrophenyl prop-1-en-2-yl carbonate
96916-42-6

4-nitrophenyl prop-1-en-2-yl carbonate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 1.5h;94%
With pyridine; sodium hydroxide In chloroform84%
With pyridine; sodium hydroxide In hydrogenchloride; chloroform
With pyridine In chloroform at 20℃; Cooling with ice;
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

3-(5-amino-2-chloro-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one
1012878-91-9

3-(5-amino-2-chloro-4-fluorophenyl)-7-chloro-1-ethyl-1,6-naphthyridin-2(1H)-one

prop-1-en-2-yl (4-chloro-5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)carbamate
1442474-41-0

prop-1-en-2-yl (4-chloro-5-(7-chloro-1-ethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)carbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 2h;94%
With sodium hydrogencarbonate In ethyl acetate at 20℃; for 2h;94%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

N-((5-((2-aminopyridin-4-yl)oxy)-6-methylpyridin-2-yl)carbamoyl)pivalamide

N-((5-((2-aminopyridin-4-yl)oxy)-6-methylpyridin-2-yl)carbamoyl)pivalamide

prop-1-en-2-yl (4-((2-methyl-6-(3-pivaloylureido)pyridin-3-yl)oxy)pyridin-2-yl)carbamate

prop-1-en-2-yl (4-((2-methyl-6-(3-pivaloylureido)pyridin-3-yl)oxy)pyridin-2-yl)carbamate

Conditions
ConditionsYield
With pyridine In pyridine at 20℃;94%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
43200-81-3

6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one

6-(5-chloropyridin-2-yl)-7-oxo-5-(2-propenyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine
862210-86-4

6-(5-chloropyridin-2-yl)-7-oxo-5-(2-propenyloxycarbonyloxy)-5,6-dihydropyrrolo[3,4b]pyrazine

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 6h;93%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

(Z)-3-{3,4,5-trimethoxy-2-[2-(trifluoroacetylamino)ethyl]-phenyl}prop-2-enol
1332523-83-7

(Z)-3-{3,4,5-trimethoxy-2-[2-(trifluoroacetylamino)ethyl]-phenyl}prop-2-enol

1-methylethenyl (Z)-3-{3,4,5-trimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate
1332523-88-2

1-methylethenyl (Z)-3-{3,4,5-trimethoxy-2-[2-(trifluoroacetylamino)ethyl]phenyl}prop-2-enyl carbonate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0℃; for 3h; Inert atmosphere;91%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

diethylamine
109-89-7

diethylamine

prop-1-en-2-yl diethylcarbamate
130032-69-8

prop-1-en-2-yl diethylcarbamate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;91%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

sodium 2,4,6-trichlorophenolate
3784-03-0

sodium 2,4,6-trichlorophenolate

Carbonic acid isopropenyl ester 2,4,6-trichloro-phenyl ester
96916-44-8

Carbonic acid isopropenyl ester 2,4,6-trichloro-phenyl ester

Conditions
ConditionsYield
In acetonitrile Ambient temperature;90%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

sodium salt of N-hydroxysuccinimide
72719-82-5

sodium salt of N-hydroxysuccinimide

Isopropenyl Succinimido Carbonate
96935-01-2

Isopropenyl Succinimido Carbonate

Conditions
ConditionsYield
In acetonitrile Ambient temperature;90%
Isopropenyl chloroformate
57933-83-2

Isopropenyl chloroformate

tert-butyl (3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)carbamate
1442474-50-1

tert-butyl (3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)carbamate

prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)carbamate
1442474-52-3

prop-1-en-2-yl (3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)carbamate

Conditions
ConditionsYield
Stage #1: tert-butyl (3-(4-fluoro-2-methyl-5-(3-phenylureido)phenyl)-1-isopropyl-2-oxo-1,2-dihydro-1,6-naphthyridin-7-yl)carbamate With hydrogenchloride In 1,4-dioxane; methanol at 20℃; for 16h;
Stage #2: Isopropenyl chloroformate With pyridine at 20℃; for 1h;		90%
With hydrogenchloride In 1,4-dioxane; methanol at 20℃; for 16h;175 mg

Isopropenyl chloroformate Specification

The Isopropenyl chloroformate, with CAS registry number 57933-83-2, has the systematic name of (1)Acid Halides; (2)Carbonyl Compounds; (3)Organic Building Blocks. Its systematic name and its IUPAC name are the same, which is prop-1-en-2-yl carbonochloridate. This chemical should be stored at the temperature of 2-8°C.

Physical properties of Isopropenyl chloroformate: (1)ACD/LogP: 2.06; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.06; (4)ACD/LogD (pH 7.4): 2.06; (5)ACD/BCF (pH 5.5): 21.66; (6)ACD/BCF (pH 7.4): 21.66; (7)ACD/KOC (pH 5.5): 314.59; (8)ACD/KOC (pH 7.4): 314.59; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 26.3 Å2; (13)Index of Refraction: 1.426; (14)Molar Refractivity: 26.77 cm3; (15)Molar Volume: 104.3 cm3; (16)Polarizability: 10.61×10-24cm3; (17)Surface Tension: 27.8 dyne/cm; (18)Enthalpy of Vaporization: 33.93 kJ/mol; (19)Vapour Pressure: 37.4 mmHg at 25°C.

Uses of Isopropenyl chloroformate: it can be used to phenyl-carbamic acid isopropenyl ester. This reaction will need reagent sodium hydroxide and solvents H2O, ethyl acetate. The reaction time is 45 min with reaction temperature of 10 - 20 ℃. The yield is about 38%.

When you are using this chemical, please be cautious about it as the following:
The Isopropenyl chloroformate is highly flammable, and it may cause burns, so keep it away from sources of ignition. This chemical is very toxic and harmful by inhalation, in contact with skin and if swallowed. When it contact with water, it liberates toxic gas, so keep its container dry. This chemical irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) After using it, take off immediately all contaminated clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: ClC(=O)O/C(=C)C
(2)InChI: InChI=1/C4H5ClO2/c1-3(2)7-4(5)6/h1H2,2H3
(3)InChIKey: AMMGCGVWJMRTQI-UHFFFAOYAT
(4)Std. InChI: InChI=1S/C4H5ClO2/c1-3(2)7-4(5)6/h1H2,2H3
(5)Std. InChIKey: AMMGCGVWJMRTQI-UHFFFAOYSA-N

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