L(+)-Citrulline supplier | CasNO.372-75-8

Name
L(+)-Citrulline
EINECS 206-759-6
CAS No. 372-75-8
Article Data48
CAS DataBase
Density 1.289 g/cm³
Solubility 200 g/L (20 °C) in water
Melting Point 214 °C
Formula C₆H₁₃N₃O₃
Boiling Point 386.7 °C at 760 mmHg
Molecular Weight 175.188
Flash Point 187.7 °C
Transport Information
Appearance white powder
Safety 24/25-36-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms L-Citrullin;L-Cit-OH;L-Citrulline;N5-(Aminocarbonyl)ornithine;L-Citrulline (Fermentation);H-Cit-OH;.delta.-Ureidonorvaline;2-Amino-5-uredovaleric acid;Ngamma-carbamylornithine;delta-Ureidonorvaline;N~5~-(aminocarbonyl)ornithine;2-amino-5-(carbamoylamino)pentanoic acid;L-Citrulline;(2S)-2-amino-5-(carbamoylamino)pentanoic acid;Ornithine, N5-carbamoyl-, L- (8CI);L-Ornithine, N5-(aminocarbonyl)-;Ornithine, N5-(aminocarbonyl)-;Citrulline, L-;Ornithine, N5-carbamoyl-, L-;Citrulline;L-Ornithine,N5-(aminocarbonyl)-;.alpha.-Amino-.delta.-ureidovaleric acid;N5-(Aminocarbonyl)-L-ornithine;alpha-Amino-delta-ureidovaleric acid;N(.delta.)-Carbamylornithine;
PSA 118.44000
LogP 0.63830

Synthetic route

: 74-79-3
L-arginine

: 372-75-8
Citrulline

Conditions

Conditions	Yield
for 46 - 120h; Product distribution / selectivity; Enzymatic reaction;	91%
With dihydrogen peroxide; K[Ru(Hedta)Cl]*2H2O	71%
durch Einwirkung von Faeulnisbakterien;

: 70-26-8
L-ornithine

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With carbamoyl phosphate

: 1188-38-1
L-carglumic acid

: 372-75-8
Citrulline

Conditions

Conditions	Yield
Biosynthese;

: 1119-34-2
L-arginine hydrochloride

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With dipotassium hydrogenphosphate; phosphoric acid; water at 25 - 37℃; Thermodynamic data; ΔH; aginine deiminase (EC 3.5.3.6) from Pseudomonas putida; var. pH and ionic strength;

L-ornithine-monohydrochloride: L-ornithine-monohydrochloride

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With copper (II) carbonate hydroxide; water at 100℃; Durch Erhitzen des erhaeltlichen Komplexsalzes mit Harnstoff in wss. Loesung auf 100grad und Zerlegung des gebildeten Kupfer(II)-Komplexsalzes des L-Citrullins mit H2S in Wasser;

: 139461-37-3
Nω-allyl-L-arginine

A: 372-75-8
Citrulline

B: 107-02-8
acrolein

Conditions

Conditions	Yield
With NADPH; calcium chloride; calmodulin; neuronal nitric oxide synthase at 20℃; pH=7.5; Enzyme kinetics; Oxidation; Enzymatic reaction;

: Nω-allyl-Nω-hydroxy-L-arginine

A: 372-75-8
Citrulline

B: 107-02-8
acrolein

Conditions

Conditions	Yield
With NADPH; calcium chloride; calmodulin; neuronal nitric oxide synthase at 20℃; pH=7.5; Enzyme kinetics; Oxidation; Enzymatic reaction;

: 53054-07-2
L-NOHA

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With mammalian nitric oxide synthase; oxygen Enzyme kinetics;

: Nω-tert-butoxy-L-arginine

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With mammalian nitric oxide synthase; NADPH; diothiothreitol; tetrahydrobiopterin In various solvent(s) at 30℃; for 0.0333333h; Enzyme kinetics;

: Nω-O-(3-methyl-2-butenyl)hydroxy-L-arginine

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With mammalian nitric oxide synthase; NADPH; diothiothreitol; tetrahydrobiopterin In various solvent(s) at 30℃; for 0.0333333h; Enzyme kinetics;

: N-hydroxy-L-arginine

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With dihydrogen peroxide; Cl8TPPFe(III)Cl In various solvent(s) at 20℃;

: Nω-hydroxy-L-arginine

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With full-length inducible nitric oxide synthase; (6R)-5,6,7,8-tetrahydro-L-biopterin; oxygen at 37℃; pH=7.4; Kinetics; aq. buffer;
With 1,4-dithio-D,L-threitol; neuronal NO synthase; NADPH; FAD; 4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid; (6-R,S)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride; Flavin mononucleotide; superoxide dismutase; catalase; calmodulin at 25℃; Enzymatic reaction;
With recombinant murine inducible nitric oxide synthase-oxy substituted with mesohaem; (1'R,2'S,6R)-2-amino-6-(1',2'-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one-dihydrochloride In aq. phosphate buffer Kinetics; Reagent/catalyst;

: L-N-gamma-Aminoarginine

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With α-ketoglutaric acid; recombinant Giardia lamblia arginine deiminase; water; NADH at 25℃; Kinetics; Reagent/catalyst; Time; pH-value; aq. buffer;

: 3184-13-2
L-ornithine hydrochloride

: 57-13-6
urea

: 372-75-8
Citrulline

Conditions

Conditions	Yield
Stage #1: L-ornithine hydrochloride With sodium hydrogencarbonate In water at 20℃; Stage #2: With copper(ll) sulfate pentahydrate In water at 100℃; Stage #3: urea Further stages;

: Nω-hydroxy-L-arginine

A: 372-75-8
Citrulline

B: 10102-43-9
nitrogen(II) oxide

Conditions

Conditions	Yield
With nitric oxide synthase; NADH at 25℃; Catalytic behavior; Kinetics; Enzymatic reaction;

: 74-79-3
L-arginine

A: 372-75-8
Citrulline

B: 10102-43-9
nitrogen(II) oxide

Conditions

Conditions	Yield
With inducible NO synthase at 20℃; Enzymatic reaction;
With dihydrogen peroxide; C48H28ClFeN4O8 In aq. phosphate buffer for 0.416667h; pH=7.4; Kinetics; Green chemistry;

: L-citrulline copper complex

: 372-75-8
Citrulline

Conditions

Conditions	Yield
With sodium sulfide In water Reagent/catalyst; Large scale;

L(+)-Citrulline Specification

1. Introduction of L(+)-Citrulline

L(+)-Citrulline (372-75-8), with its IUPAC name of (2S)-2-amino-5-(carbamoylamino)pentanoic acid, is one kind of white powder. The product's categories are Citruline [Cit]; Amino Acids; Unusual Amino Acids; Biochemistry; non-Proteinorganic Amino Acids; Nutritional Supplements; L-Amino Acids; Amino Acids. Besides, it should be sealed in a cool and dry place at 0-5 °C.

2. Properties of L(+)-Citrulline

The other characteristics of L(+)-Citrulline can be summarized as: (1)EINECS: 206-759-6; (2)ACD/LogP: -1.53; (3)# of Rule of 5 Violations: 1; (4)ACD/LogD (pH 5.5): -4.03; (5)ACD/LogD (pH 7.4): -4.03; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 1; (10)#H bond acceptors: 6; (11)#H bond donors: 6; (12)#Freely Rotating Bonds: 6; (13)Index of Refraction: 1.531; (14)Molar Refractivity: 42.06 cm³; (15)Molar Volume: 135.8 cm³; (16)Surface Tension: 61.9 dyne/cm; (17)Density: 1.289 g/cm³; (18)Flash Point: 187.7 °C; (19)Melting Point: 214-216 °C; (20)alpha: 25.5 °(c=8, 6N HCl); (21)Water solubility: 200 g/L (20 °C); (22)Enthalpy of Vaporization: 69.78 kJ/mol; (23)Boiling Point: 386.7 °C at 760 mmHg; (24)Vapour Pressure: 4.7E-07 mmHg at 25 °C.

3. Structure Descriptors of L(+)-Citrulline

You could convert the following datas into the molecular structure:
(1)SMILES: O=C(O)[C@@H](N)CCCNC(=O)N
(2)InChI: InChI=1/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1
(3)InChIKey: RHGKLRLOHDJJDR-BYPYZUCNBX

4. Uses of L-Citrulline

L-Citrulline is amino acids drug used for the treatment of hyperammonemia. Moreover, it can react with trifluoroacetic acid anhydride to get 2-oxo-3-(2,2,2-trifluoro-acetylamino)-piperidine-1-carboxylic acid amide and 1-[3-(5-oxo-2-trifluoromethyl-2,5-dihydro-oxazol-4-yl)-propyl]-3-trifluoroacetyl-urea.

This reaction will occur by heating for 24 hours. The yield is 48 %.

5. Safety information of L(+)-Citrulline

Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-36-26
WGK Germany 3
HS Code 29241900

When you are using this chemical, please be cautious about it as the following: it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing to avoid contact with skin and eyes.

Product Name

L(+)-Citrulline

Synthetic route

L(+)-Citrulline Specification

Related Products

Hot Products