Product Name

  • Name

    L-Acetylcarnitine

  • EINECS
  • CAS No. 3040-38-8
  • Article Data7
  • CAS DataBase
  • Density g/cm3
  • Solubility
  • Melting Point
  • Formula C9H17 N O4
  • Boiling Point °Cat760mmHg
  • Molecular Weight 203.238
  • Flash Point °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 3040-38-8 (L-Acetylcarnitine)
  • Hazard Symbols
  • Synonyms 1-Propanaminium,2-(acetyloxy)-3-carboxy-N,N,N-trimethyl-, inner salt, (R)-;Ammonium,(3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, acetate, L-(8CI);(-)-Acetylcarnitine;(R)-Acetylcarnitine;ALCAR;Acetyl-L-(-)-carnitine;Acetyl-L-carnitine;Acetylcarnitine;L-Acetylcarnitine;L-Carnitine acetylester;L-O-Acetylcarnitine;Levocarnitine acetyl;Nicetile;O-Acetyl-L-carnitine;O-Acetylcarnitine;74832-89-6;
  • PSA 66.43000
  • LogP -1.23570

Synthetic route

acetic anhydride
108-24-7

acetic anhydride

L-carnitine
541-15-1

L-carnitine

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
With acetic acid at 80℃; for 12h; Temperature;88.9%
L-carnitine
541-15-1

L-carnitine

acetyl chloride
75-36-5

acetyl chloride

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 5℃; for 12h; Concentration;71.4%
L-carnitine chloride
6645-46-1

L-carnitine chloride

acetyl chloride
75-36-5

acetyl chloride

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 5℃; for 12h; Concentration;68.3%
O-acetyl-L-carnitine hydrochloride
5080-50-2

O-acetyl-L-carnitine hydrochloride

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
With ethanol; triethylamine In dichloromethane at 20 - 25℃; for 6h;66.89%
Multi-step reaction with 3 steps
1: oxalyl dichloride / 2 h / 30 °C / Inert atmosphere
2: tetrahydrofuran / 3 h / 30 °C
3: D-glucose / pH 7.2 / Alkaline conditions
View Scheme
sodium acetate
127-09-3

sodium acetate

Trimethyl-((S)-4-oxo-oxetan-2-ylmethyl)-ammonium; chloride

Trimethyl-((S)-4-oxo-oxetan-2-ylmethyl)-ammonium; chloride

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
In dimethyl sulfoxide for 24h; Yield given;
L-carnitine chloride
6645-46-1

L-carnitine chloride

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) HCl, 2.) Amberlite IRA-402 (ClO4- form)
2: pyridine / 1.75 h
3: 99 percent / H2 / 10percent Pd/C / 4 h / 2327.2 Torr
4: NaHCO3 / dimethylsulfoxide / 6 h / Ambient temperature
5: dimethylsulfoxide / 24 h
View Scheme
(S)-(+)-3-hydroxy-4-(trimethylammonio)-butanoic acid chloride
10017-44-4

(S)-(+)-3-hydroxy-4-(trimethylammonio)-butanoic acid chloride

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 37 percent / SO2Cl2 / acetonitrile / 18 h
2: NaHCO3 / dimethylsulfoxide / 24 h
3: dimethylsulfoxide / 24 h
View Scheme
(R)-carnitine mesylate mesylate

(R)-carnitine mesylate mesylate

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaHCO3 / dimethylsulfoxide / 6 h / Ambient temperature
2: dimethylsulfoxide / 24 h
View Scheme
((R)-3-Carboxy-2-chloro-propyl)-trimethyl-ammonium; chloride

((R)-3-Carboxy-2-chloro-propyl)-trimethyl-ammonium; chloride

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NaHCO3 / dimethylsulfoxide / 24 h
2: dimethylsulfoxide / 24 h
View Scheme
((R)-3-Benzyloxycarbonyl-2-hydroxy-propyl)-trimethyl-ammonium; perchlorate

((R)-3-Benzyloxycarbonyl-2-hydroxy-propyl)-trimethyl-ammonium; perchlorate

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: pyridine / 1.75 h
2: 99 percent / H2 / 10percent Pd/C / 4 h / 2327.2 Torr
3: NaHCO3 / dimethylsulfoxide / 6 h / Ambient temperature
4: dimethylsulfoxide / 24 h
View Scheme
((R)-3-Benzyloxycarbonyl-2-methanesulfonyloxy-propyl)-trimethyl-ammonium; perchlorate

((R)-3-Benzyloxycarbonyl-2-methanesulfonyloxy-propyl)-trimethyl-ammonium; perchlorate

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / H2 / 10percent Pd/C / 4 h / 2327.2 Torr
2: NaHCO3 / dimethylsulfoxide / 6 h / Ambient temperature
3: dimethylsulfoxide / 24 h
View Scheme
(2R)-2-(acetyloxy)-4-({[(2Z,3E)-2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,2-dihydro-3H-indol-3-ylidene]amino}oxy)-N,N,N-trimethyl-4-oxobutan-1-aminium chloride
1415677-96-1

(2R)-2-(acetyloxy)-4-({[(2Z,3E)-2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-1,2-dihydro-3H-indol-3-ylidene]amino}oxy)-N,N,N-trimethyl-4-oxobutan-1-aminium chloride

A

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

B

indirubin-3'-monoxime
667463-82-3

indirubin-3'-monoxime

Conditions
ConditionsYield
With D-glucose pH=7.2; Kinetics; Alkaline conditions;
Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

[3H]-Phytic acid

[3H]-Phytic acid

acetyl L-carnitine phytate

acetyl L-carnitine phytate

Conditions
ConditionsYield
In water at 20℃; pH=~ 4;100%
Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

myo-inositol 1,2,3,4,5,6-hexakisphosphate

myo-inositol 1,2,3,4,5,6-hexakisphosphate

acetyl L-carnitine phytate

acetyl L-carnitine phytate

Conditions
ConditionsYield
In water at 20℃; for 0.583333h;100%
Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

C9H18NO4(1+)*AsH2O4(1-)

C9H18NO4(1+)*AsH2O4(1-)

Conditions
ConditionsYield
With orthoarsenic acid In ethanol for 1h;97.1%
Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

citric acid monohydrate
5949-29-1

citric acid monohydrate

acetyl L-carnitine calcium citrate

acetyl L-carnitine calcium citrate

Conditions
ConditionsYield
Stage #1: citric acid monohydrate With calcium carbonate In water at 20℃;
Stage #2: Acetyl-L-carnitine In water at 70 - 80℃; for 4h;		95.8%
malic acid
617-48-1

malic acid

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

acetyl-L-carnitine malate
1351564-17-4

acetyl-L-carnitine malate

Conditions
ConditionsYield
In ethanol at 0℃; for 2h; Product distribution / selectivity;95.51%
Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

citric acid
77-92-9

citric acid

acetyl-L-carnitine magnesium citrate

acetyl-L-carnitine magnesium citrate

Conditions
ConditionsYield
With magnesium hydroxide In water for 0.5h; Stirring;95%
Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

acetyl-L-carnitine nitrate

acetyl-L-carnitine nitrate

Conditions
ConditionsYield
With nitric acid; acetic acid at 60 - 80℃; for 5h; Temperature;92.1%
Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

2-buten-4-olide
497-23-4

2-buten-4-olide

Conditions
ConditionsYield
In acetonitrile for 24h; Heating;77%
methanol
67-56-1

methanol

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

acetyl-L-carnitine methyl ester hydrochloride

acetyl-L-carnitine methyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 80℃; for 0.25h;
Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

(3R)-β-acetoxy-γ-butyrolactone

(3R)-β-acetoxy-γ-butyrolactone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 120℃; for 0.5h;
Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

A

2-buten-4-olide
497-23-4

2-buten-4-olide

B

(3R)-β-acetoxy-γ-butyrolactone

(3R)-β-acetoxy-γ-butyrolactone

Conditions
ConditionsYield
In acetonitrile for 4h; Heating; Title compound not separated from byproducts;
3-(4-(piperazin-1-yl)-3-fluorophenyl)-5(R)-(isoxazol-3-yloxymethyl)-oxazolidin-2-one dihydrochloride

3-(4-(piperazin-1-yl)-3-fluorophenyl)-5(R)-(isoxazol-3-yloxymethyl)-oxazolidin-2-one dihydrochloride

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

3-(4-(4-((3R)-3-Acetoxy-4-trimethylammoniobutanoyl)piperazin-1-yl)-3-fluorophenyl)-5(R)-(isoxazol-3-yloxymethyl)oxazolidin-2-one chloride

3-(4-(4-((3R)-3-Acetoxy-4-trimethylammoniobutanoyl)piperazin-1-yl)-3-fluorophenyl)-5(R)-(isoxazol-3-yloxymethyl)oxazolidin-2-one chloride

Conditions
ConditionsYield
With triethylamine In thionyl chloride; dichloromethane; water; acetonitrile
meso-galactaric acid
526-99-8, 1213827-87-2

meso-galactaric acid

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

acetyl-L-carnitine mucate
352431-80-2, 514190-30-8

acetyl-L-carnitine mucate

Conditions
ConditionsYield
In water; acetone for 1h;
rociletinib

rociletinib

Acetyl-L-carnitine
3040-38-8

Acetyl-L-carnitine

acetylcoenzyme A
72-89-9

acetylcoenzyme A

C24H26F3N7O2

C24H26F3N7O2

Conditions
ConditionsYield
With human liver cytosol; ethylenediaminetetraacetic acid; 1,4-dithio-D,L-threitol; acetylcarnitine acetyltransferase In aq. phosphate buffer; dimethyl sulfoxide at 37℃; for 1h; pH=7.5; Kinetics; Enzymatic reaction;
...Expand

L-Acetylcarnitine Chemical Properties

Molecule structure of L-Acetylcarnitine (CAS NO.3040-38-8):

IUPAC Name: (3S)-3-Acetyloxy-4-(trimethylazaniumyl)butanoate 
Molecular Weight: 203.23558 [g/mol]
Molecular Formula: C9H17NO4
XLogP3-AA: 0.4
H-Bond Acceptor: 4
Rotatable Bond Count: 5
Exact Mass: 203.115758
MonoIsotopic Mass: 203.115758
Topological Polar Surface Area: 66.4
Heavy Atom Count: 14
Complexity: 214
Canonical SMILES: CC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
Isomeric SMILES: CC(=O)O[C@@H](CC(=O)[O-])C[N+](C)(C)C
InChI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m0/s1
InChIKey of L-Acetylcarnitine (CAS NO.3040-38-8): RDHQFKQIGNGIED-QMMMGPOBSA-N

L-Acetylcarnitine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 795mg/kg (795mg/kg)   British UK Patent Application. Vol. #2008578,
mouse LD50 subcutaneous 8400mg/kg (8400mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS		 Acta Biologica et Medica Germanica. Vol. 35, Pg. 645, 1976.
rat LD50 intravenous 1265mg/kg (1265mg/kg)   British UK Patent Application. Vol. #2008578,

L-Acetylcarnitine Specification

 L-Acetylcarnitine (CAS NO.3040-38-8) is also named as Acetylcarnitine ; Acetyl-L-carnitine ; Acetylcarnitine ; (-)-Acetylcarnitine ; (R)-Acetylcarnitine ; ALCAR ; Acetyl-L-(-)-carnitine ; Acetyl-L-carnitine ; HSDB 7587 ; L-Acetylcarnitine ; L-Carnitine acetyl ester ; L-O-Acetylcarnitine ; Levocarnitine acetyl ; Nicetile ; O-Acetyl-L-carnitine ; O-Acetylcarnitine ; R-Acetylcarnitine; 1-Propanaminium, 2-(acetyloxy)-3-carboxy-N,N,N-trimethyl-, hydroxide, inner salt, (R)- (9CI) ; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, acetate, L- .

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