Product Name

  • Name

    L-Valine methyl ester hydrochloride

  • EINECS 228-620-9
  • CAS No. 6306-52-1
  • Article Data143
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point 171-173 °C(lit.)
  • Formula C6H14ClNO2
  • Boiling Point 145.7 °C at 760 mmHg
  • Molecular Weight 167.636
  • Flash Point 20.7 °C
  • Transport Information
  • Appearance Crystalline
  • Safety 22-24/25-36-26
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 6306-52-1 (L-Valine methyl ester hydrochloride)
  • Hazard Symbols IrritantXi
  • Synonyms H-Val-OMe·HCl;
  • PSA 52.32000
  • LogP 1.64500

Synthetic route

methanol
67-56-1

methanol

L-valine
72-18-4

L-valine

L-valine methylester hydrochloride
6306-52-1

L-valine methylester hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃;100%
With thionyl chloride at 20℃; Cooling with ice; Inert atmosphere;100%
Stage #1: L-valine With thionyl chloride at 0℃; for 4.16667h; Reflux;
Stage #2: methanol		100%
methanol
67-56-1

methanol

t-Boc-L-valine
13734-41-3

t-Boc-L-valine

L-valine methylester hydrochloride
6306-52-1

L-valine methylester hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃;100%
With thionyl chloride at 20℃; Cooling;
methanol
67-56-1

methanol

L-valine hydrochloride
17498-50-9, 25616-14-2, 31320-20-4

L-valine hydrochloride

L-valine methylester hydrochloride
6306-52-1

L-valine methylester hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0℃;97%
With thionyl chloride at -10 - 20℃; for 16h;
With thionyl chloride at 20℃; for 12h; Inert atmosphere;
(3S,6R)-[6-2H]-3-isopropyl-6-benzyl-2,5-dimethoxy-3,6-dihydropyrazine
901355-36-0

(3S,6R)-[6-2H]-3-isopropyl-6-benzyl-2,5-dimethoxy-3,6-dihydropyrazine

A

(R)-[α-2H]-phenylalanine methyl ester hydrochloride

(R)-[α-2H]-phenylalanine methyl ester hydrochloride

B

L-valine methylester hydrochloride
6306-52-1

L-valine methylester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In acetonitrile for 0.5h;A 88%
B n/a

L-Valine methyl ester hydrochloride Chemical Properties

The Molecular Structure of L-Valine methyl ester hydrochloride (CAS NO.6306-52-1):

Empirical Formula: C6H14ClNO2
Molecular Weight: 167.6339
Nominal Mass: 167 Da
Average Mass: 167.6339 Da
Monoisotopic Mass: 167.071306 Da 
Flash Point: 20.7 °C 
Melting Point: 171-173 °C 
Enthalpy of Vaporization: 38.27 kJ/mol
Boiling Point: 145.7 °C at 760 mmHg
Vapour Pressure: 4.8 mmHg at 25°C 
Appearance: Crystalline
Stability: Stable. Incompatible with strong oxidizing agents.
IUPAC Name: methyl 2-amino-3-methylbutanoate hydrochloride   
Synonyms: (S)-2-amino-3-methyl-butyric acid methyl esterhydrochloride ; Valine methyl ester hydrochloride ; Valine-ome hcl ; H-l-val-ome hcl ; H-val-ome hcl ;
H-val-ome hydrochloride ; L-2-aminoisovaleric acid methyl ester hydrochloride ; L-methyl valinate hydrochloride   
Product Categories: Chemical intermediate for Valsartan;Starting Raw Materials & Intermediates;INTERMEDIATESOF;(intermediate of valsartan);Amino Acids;Valine [Val, V];Amino Acids and Derivatives;Amino Acid Methyl Esters;Amino Acids (C-Protected);Biochemistry;Amino hydrochloride;Amino Acid Derivatives;Peptide Synthesis;Valine

L-Valine methyl ester hydrochloride Uses

 L-Valine Methyl ester Hydrochloride (CAS NO.6306-52-1)  is used as an unnatural amino acid for peptidomimetics and biological research.

L-Valine methyl ester hydrochloride Toxicity Data With Reference

SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and toxicological properties of L-Valine methyl ester hydrochloride (CAS NO.6306-52-1) have not been thoroughly investigated.

L-Valine methyl ester hydrochloride Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25-36-26 
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36: Wear suitable protective clothing
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29224995

L-Valine methyl ester hydrochloride Standards and Recommendations

APPEARANCE of L-Valine Methyl ester Hydrochloride (CAS NO.6306-52-1) : White to off-white crystalline powder
IDENTIFICATION: pass IR Spectrum
ASSAY: 98.5% min
OPTICAL ROTATION [a]20: +22° ~ +24° (C=2 in MeOH)
ISOMER IMPURITY: 0.5% max
RELATED SUBSTANCE: pass
LOSS ON DRYING: 0.5% max

L-Valine methyl ester hydrochloride Specification

Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,NITROGEN oxides, HYDROGEN chloride gas.

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