Product Name

  • Name

    L-Valine benzyl ester hydrochloride

  • EINECS
  • CAS No. 2462-34-2
  • Article Data11
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point 138 °C
  • Formula C12H18ClNO2
  • Boiling Point 285.5 °C at 760 mmHg
  • Molecular Weight 243.733
  • Flash Point 143.7 °C
  • Transport Information
  • Appearance crystalline
  • Safety 24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 2462-34-2 (L-Valine benzyl ester hydrochloride)
  • Hazard Symbols
  • Synonyms L-Valine,phenylmethyl ester, hydrochloride (9CI);Valine, benzyl ester, hydrochloride(6CI,7CI);Valine, benzyl ester, hydrochloride, L- (8CI);(S)-Benzyl2-amino-3-methylbutanoate hydrochloride;Benzyl L-valinate hydrochloride;
  • PSA 52.32000
  • LogP 3.21540

Synthetic route

((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester
66447-55-0

((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 20℃; Inert atmosphere;100%
Stage #1: ((S)-1-benzylcarbamoyl-2-methyl-propyl)-carbamic acid tert-butyl ester With trifluoroacetic acid at 20℃; for 1h;
Stage #2: With hydrogenchloride In 1,4-dioxane; water
85%
With hydrogenchloride In tetrahydrofuran; 1,4-dioxane at 0℃; for 12h; Inert atmosphere;
With hydrogenchloride In ethyl acetate at 20℃; for 5h;
L-valine
72-18-4

L-valine

benzyl alcohol
100-51-6

benzyl alcohol

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Stage #1: L-valine With hydrogenchloride; iron(III) chloride In 1,2-dichloro-ethane at 20℃; for 0.5h;
Stage #2: benzyl alcohol In dichloromethane for 3h; Concentration; Reflux;
98%
With thionyl chloride at 5℃; for 5.33333h; Heating;70%
Stage #1: L-valine; benzyl alcohol at 20 - 90℃;
Stage #2: With sodium carbonate In water pH=10;
Stage #3: With hydrogenchloride In diethyl ether
With thionyl chloride at 20℃; Cooling with ice; Inert atmosphere;
t-Boc-L-valine
13734-41-3

t-Boc-L-valine

polymer supported Naphthyl Rinkamino Gly peptide

polymer supported Naphthyl Rinkamino Gly peptide

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 85 percent / Et3N / dimethylformamide / 0 - 20 °C
2.1: TFA / 1 h / 20 °C
2.2: 85 percent / HCl / dioxane; H2O
View Scheme
L-valine
72-18-4

L-valine

Asp(Bzl)

Asp(Bzl)

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 100 percent / Et3N / dioxane; H2O
2.1: 85 percent / Et3N / dimethylformamide / 0 - 20 °C
3.1: TFA / 1 h / 20 °C
3.2: 85 percent / HCl / dioxane; H2O
View Scheme
L-valine
72-18-4

L-valine

benzyl chloride
100-44-7

benzyl chloride

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
at 90℃; for 5h; Ionic liquid; Inert atmosphere;
t-Boc-L-valine
13734-41-3

t-Boc-L-valine

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere
2.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 12 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 16 h / 0 - 20 °C
2: hydrogenchloride / ethyl acetate / 5 h / 20 °C
View Scheme
benzyl bromide
100-39-0

benzyl bromide

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
1.2: 12 h / Inert atmosphere
2.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 12 h / 0 °C / Inert atmosphere
View Scheme
(S)-N(1)-(p-methoxybenzyl)-6-isopropylpiperazine-2,5-dione
437768-95-1

(S)-N(1)-(p-methoxybenzyl)-6-isopropylpiperazine-2,5-dione

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 48 h / 0 - 20 °C / Inert atmosphere
2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 18 h / 20 °C
3.1: dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
4.2: 18 h / -78 - 20 °C / Inert atmosphere
5.1: hydrogenchloride / acetonitrile; water / 18 h / 20 °C
View Scheme
C22H26N2O3

C22H26N2O3

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ammonium cerium (IV) nitrate / acetonitrile; water / 18 h / 20 °C
2.1: dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
3.2: 18 h / -78 - 20 °C / Inert atmosphere
4.1: hydrogenchloride / acetonitrile; water / 18 h / 20 °C
View Scheme
C14H18N2O2

C14H18N2O2

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
2.2: 18 h / -78 - 20 °C / Inert atmosphere
3.1: hydrogenchloride / acetonitrile; water / 18 h / 20 °C
View Scheme
(S)-2-isopropyl-3-benzyloxy-6-ethoxy-2,5-dihydropyrazine

(S)-2-isopropyl-3-benzyloxy-6-ethoxy-2,5-dihydropyrazine

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
1.2: 18 h / -78 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / acetonitrile; water / 18 h / 20 °C
View Scheme
(2S,5R)-2-isopropyl-3-benzyloxy-5-ethyl-6-ethoxy-2,5-dihydropyrazine

(2S,5R)-2-isopropyl-3-benzyloxy-5-ethyl-6-ethoxy-2,5-dihydropyrazine

A

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

B

ethyl (2R)-2-aminobutanoate hydrochloride
127641-80-9

ethyl (2R)-2-aminobutanoate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water; acetonitrile at 20℃; for 18h;
O-benzyl 2,2,2-trichloroacetimidate
81927-55-1

O-benzyl 2,2,2-trichloroacetimidate

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: boron trifluoride diethyl etherate / dichloromethane / 48 h / 0 - 20 °C / Inert atmosphere
2.1: ammonium cerium (IV) nitrate / acetonitrile; water / 18 h / 20 °C
3.1: dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere
4.2: 18 h / -78 - 20 °C / Inert atmosphere
5.1: hydrogenchloride / acetonitrile; water / 18 h / 20 °C
View Scheme
benzyl alcohol
100-51-6

benzyl alcohol

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 16 h / 0 - 20 °C
2: hydrogenchloride / ethyl acetate / 5 h / 20 °C
View Scheme
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

C20H23NO3
1076214-41-9

C20H23NO3

Conditions
ConditionsYield
With sodium carbonate In methanol at 20℃; for 18h;100%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(S)-3-methyl-2-(2-trifluoromethyl-acryloylamino)-butyric acid benzyl ester
587885-44-7

(S)-3-methyl-2-(2-trifluoromethyl-acryloylamino)-butyric acid benzyl ester

(S)-2-{2-[((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-methyl]-3,3,3-trifluoro-propionylamino}-3-methyl-butyric acid benzyl ester

(S)-2-{2-[((S)-1-Benzyloxycarbonyl-2-methyl-propylamino)-methyl]-3,3,3-trifluoro-propionylamino}-3-methyl-butyric acid benzyl ester

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 20℃; for 2h; aza-Michael addition;98%
(R)-N-Boc-3,5-dibenzoxyphenylglycine
1149740-71-5

(R)-N-Boc-3,5-dibenzoxyphenylglycine

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

C39H44N2O7
1149740-78-2

C39H44N2O7

Conditions
ConditionsYield
With sodium hydrogencarbonate; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one In tetrahydrofuran at 0 - 20℃; Inert atmosphere;98%
With sodium hydrogencarbonate; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one In N,N-dimethyl-formamide at 0 - 20℃; for 25h;
Fmoc-Pro-OH
71989-31-6

Fmoc-Pro-OH

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(9H-fluoren-9-yl)methyl-(S)-2-(((S)-1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)carbamoyl) pyrrolidine-1-carboxylate

(9H-fluoren-9-yl)methyl-(S)-2-(((S)-1-(benzyloxy)-3-methyl-1-oxobutan-2-yl)carbamoyl) pyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: L-valine benzyl ester hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Inert atmosphere;
Stage #2: Fmoc-Pro-OH With benzotriazol-1-ol In dichloromethane at 0℃; for 0.25h; Inert atmosphere;
Stage #3: With dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;
98%
Stage #1: Fmoc-Pro-OH; L-valine benzyl ester hydrochloride With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.25h; Inert atmosphere;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere;
98%
N-tert-butoxycarbonyl-L-methionine
2488-15-5

N-tert-butoxycarbonyl-L-methionine

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Boc-Met-Val-OBn

Boc-Met-Val-OBn

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 2h;97%
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-valinate
136282-23-0

benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-valinate

Conditions
ConditionsYield
With C14H16B2O6 In toluene at 80℃; for 48h; Molecular sieve;97%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

2-tert-butoxycarbonylamino-succinic acid 1-benzotriazol-1-yl ester 4-cyclohexyl ester

2-tert-butoxycarbonylamino-succinic acid 1-benzotriazol-1-yl ester 4-cyclohexyl ester

Boc-Asp(OcHex)-Val-OBzl
152020-28-5

Boc-Asp(OcHex)-Val-OBzl

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at 20℃; for 24h; Substitution;96%
BOC-L-aspartic acid 4-benzyl ester
7536-58-5

BOC-L-aspartic acid 4-benzyl ester

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Boc-Asp(OBzl)-Val-OBzl
110863-06-4

Boc-Asp(OBzl)-Val-OBzl

Conditions
ConditionsYield
Stage #1: BOC-L-aspartic acid 4-benzyl ester With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran for 0.333333h; Cooling with ice;
Stage #2: L-valine benzyl ester hydrochloride With 4-methyl-morpholine In tetrahydrofuran at 20℃; for 24h;
96%
Stage #1: BOC-L-aspartic acid 4-benzyl ester With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: L-valine benzyl ester hydrochloride With 4-methyl-morpholine In tetrahydrofuran at 20℃; for 8h; pH=8.5; Further stages.;
95%
(S)-2-Hydroxy-3-methylbutanoic acid
17407-55-5

(S)-2-Hydroxy-3-methylbutanoic acid

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

L-O-valine-L-valine benzyl ester

L-O-valine-L-valine benzyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃;95%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃;92%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃;92%
With potassium carbonate; dicyclohexyl-carbodiimide 1.) water, 2.) CH2Cl2, 15 deg C, 5 h; Yield given. Multistep reaction;
t-Boc-L-valine
13734-41-3

t-Boc-L-valine

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate
77443-49-3

(S)-benzyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)-3-methylbutanoate

Conditions
ConditionsYield
With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; Acylation;95%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

carbonochloridic acid, chloromethyl ester
22128-62-7

carbonochloridic acid, chloromethyl ester

(S)-2-chloromethoxycarbonylamino-3-methyl-butyric acid benzyl ester

(S)-2-chloromethoxycarbonylamino-3-methyl-butyric acid benzyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;95%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester phosphite

N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester phosphite

Conditions
ConditionsYield
Stage #1: L-valine benzyl ester hydrochloride With sodium hydroxide In water; ethyl acetate for 0.333333h; pH=10 - 12;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In ethyl acetate at 55 - 60℃;
Stage #3: With phosphonic Acid In ethyl acetate for 1h;
95%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
124750-51-2

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

N-[(2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester phosphorous acid salt

N-[(2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl)methyl]-(L)-valine benzyl ester phosphorous acid salt

Conditions
ConditionsYield
Stage #1: L-valine benzyl ester hydrochloride With sodium hydroxide In water pH=10 - 12;
Stage #2: N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole In ethyl acetate at 55 - 60℃;
Stage #3: With phosphorous acid In ethyl acetate for 1h;
95%
5-Chlorovaleroyl chloride
1575-61-7

5-Chlorovaleroyl chloride

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(S)-benzyl 2-(5-chloropentanamido)-3-methylbutanoate

(S)-benzyl 2-(5-chloropentanamido)-3-methylbutanoate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water at 0 - 20℃;95%
With sodium hydrogencarbonate In dichloromethane; water95%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
66863-43-2

(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid

N-[(3S)-N-Boc-1,2,3,4-tetrahydro-β-carboline-3-carboxyl]-L-valine benzyl ester
945650-42-0

N-[(3S)-N-Boc-1,2,3,4-tetrahydro-β-carboline-3-carboxyl]-L-valine benzyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 18h;94%
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 18h; pH=8 - 9;94%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

benzyl (fluorosulfuryl)-L-valinate

benzyl (fluorosulfuryl)-L-valinate

Conditions
ConditionsYield
Stage #1: L-valine benzyl ester hydrochloride With sodium carbonate In acetonitrile at 20℃; for 16h;
Stage #2: With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate at 20℃; for 1h;
94%
(C5H9O2)(NHCHCO)2(C4H9)(C3H7)(NHC4H4NO3)
663621-54-3

(C5H9O2)(NHCHCO)2(C4H9)(C3H7)(NHC4H4NO3)

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(C5H9O2)(NHCH(C4H9)CO)(NHCH(C3H7))(NHCONHCH(C3H7)COOC7H7)

(C5H9O2)(NHCH(C4H9)CO)(NHCH(C3H7))(NHCONHCH(C3H7)COOC7H7)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile93%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

benzyl N-triflyl-L-valinate

benzyl N-triflyl-L-valinate

Conditions
ConditionsYield
Stage #1: L-valine benzyl ester hydrochloride With triethylamine In dichloromethane at -78℃; for 0.0833333h; Schlenk technique;
Stage #2: trifluoromethylsulfonic anhydride In dichloromethane at -78℃; Schlenk technique;
93%
2-(3-(trifluoromethoxy)phenyl)acetic acid
203302-97-0

2-(3-(trifluoromethoxy)phenyl)acetic acid

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(S)-3-methyl-2-[2-(3-trifluoromethoxyphenyl)acetylamino]butyric acid benzyl ester

(S)-3-methyl-2-[2-(3-trifluoromethoxyphenyl)acetylamino]butyric acid benzyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide Cooling with ice;92.5%
formic acid cyanomethyl ester
150760-95-5

formic acid cyanomethyl ester

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

N-Formyl-L-valine benzyl ester
71738-67-5

N-Formyl-L-valine benzyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane for 12h; Ambient temperature;92%
L-N-Boc-Ala
15761-38-3

L-N-Boc-Ala

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

Boc-L-Ala-L-Val-OBzl
116798-35-7

Boc-L-Ala-L-Val-OBzl

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃;92%
2,3-dihydro-1,4-benzodioxin-6-carboxylic acid
4442-54-0

2,3-dihydro-1,4-benzodioxin-6-carboxylic acid

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(S)-benzyl 2-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-3-methylbutanoate
1391931-81-9

(S)-benzyl 2-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-3-methylbutanoate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 25℃; for 18h; Inert atmosphere;92%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(E)-3-(4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one
243121-09-7

(E)-3-(4,4,4-trifluorobut-2-enoyl)oxazolidin-2-one

(S)-3-Methyl-2-[3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-trifluoromethyl-propylamino]-butyric acid benzyl ester

(S)-3-Methyl-2-[3-oxo-3-(2-oxo-oxazolidin-3-yl)-1-trifluoromethyl-propylamino]-butyric acid benzyl ester

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine In dichloromethane at 20℃; for 68h; Addition;90%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

L-valine benzyl ester
21760-98-5

L-valine benzyl ester

Conditions
ConditionsYield
With triethylamine In chloroform at 0 - 5℃; for 0.166667h;90%
With sodium hydrogencarbonate In water pH=8 - 9;
With sodium carbonate In water
C24H22ClN2OP

C24H22ClN2OP

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

C36H38N3O3P

C36H38N3O3P

Conditions
ConditionsYield
With triethylamine In dichloromethane at 90℃; for 12h; Molecular sieve; Sealed tube; Green chemistry;90%
N-(9-fluorenylmethyloxycarbonyl)-S-(4-O-acetyl-2,3,6-trideoxy-α-L-erythrohex-2-enopyranosyl)-L-cysteine

N-(9-fluorenylmethyloxycarbonyl)-S-(4-O-acetyl-2,3,6-trideoxy-α-L-erythrohex-2-enopyranosyl)-L-cysteine

L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

N-(9-fluorenylmethyloxycarbonyl)-S-(4-O-acetyl-2,3,6-trideoxy-α-L-erythro-hex-2-enopyranosyl)-L-cysteinyl-L-valine benzyl ester

N-(9-fluorenylmethyloxycarbonyl)-S-(4-O-acetyl-2,3,6-trideoxy-α-L-erythro-hex-2-enopyranosyl)-L-cysteinyl-L-valine benzyl ester

Conditions
ConditionsYield
With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine In dichloromethane at 20℃; for 24h;90%
L-valine benzyl ester hydrochloride
2462-34-2

L-valine benzyl ester hydrochloride

(2-trifluoromethyl-acryloylamino)-acetic acid benzyl ester
587885-53-8

(2-trifluoromethyl-acryloylamino)-acetic acid benzyl ester

(S)-2-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3,3,3-trifluoro-propylamino]-3-methyl-butyric acid benzyl ester

(S)-2-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3,3,3-trifluoro-propylamino]-3-methyl-butyric acid benzyl ester

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In tetrachloromethane at 20℃; for 2h; aza-Michael addition;89%

L-Valine benzyl ester hydrochloride Chemical Properties

Molecular structure of L-Valine benzyl ester hydrochloride (CAS NO.2462-34-2) is:

Product Name: L-Valine benzyl ester hydrochloride
CAS Registry Number: 2462-34-2
IUPAC Name:benzyl 2-amino-3-methylbutanoate hydrochloride
Molecular Weight: 243.72982 [g/mol]
Molecular Formula: C12H18ClNO2
H-Bond Donor: 2
H-Bond Acceptor: 3
Melting Point: 138 °C
Refractive index: -10 ° (C=2, H2O)
Storage temp.: -20°C 
Flash Point: 143.7 °C
Enthalpy of Vaporization: 52.45 kJ/mol
Boiling Point: 285.5 °C at 760 mmHg
Vapour Pressure: 0.0028 mmHg at 25°C

L-Valine benzyl ester hydrochloride Safety Profile

WGK Germany: 3

L-Valine benzyl ester hydrochloride Specification

 L-Valine benzyl ester hydrochloride , its cas register number is 2462-34-2. It also can be called L-Valine,phenylmethyl ester, hydrochloride (9CI) ; Valine, benzyl ester, hydrochloride(6CI,7CI) ; Valine, benzyl ester, hydrochloride, L- (8CI) ; (S)-Benzyl2-amino-3-methylbutanoate hydrochloride .It is a crystalline.

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