Product Name

  • Name

    102767-28-2

  • EINECS 200-659-6
  • CAS No. 102767-28-2
  • Article Data54
  • CAS DataBase
  • Density 1.168 g/cm3
  • Solubility
  • Melting Point 118-119 °C
  • Formula C8H14N2O2
  • Boiling Point 395.9 °C at 760 mmHg
  • Molecular Weight 170.211
  • Flash Point 193.2 °C
  • Transport Information
  • Appearance White crystalline powder
  • Safety 26
  • Risk Codes 22-36
  • Molecular Structure Molecular Structure of 102767-28-2 (102767-28-2)
  • Hazard Symbols HarmfulXn
  • Synonyms 2-(2-oxopyrrolidin-1-yl)butanamide;Keppra (TN);1-Pyrrolidineacetamide,R-ethyl-2-oxo-,(RS)-;Levetiracetamum [INN-Latin];(S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetamide;(2R)-2-(2-oxopyrrolidin-1-yl)butanamide;(2S)-2-(2-oxopyrrolidin-1-yl)butanamide;UCB-L 059;Levetiracetam [INN];Keppra;1-Pyrrolidineacetamide, alpha-ethyl-2-oxo-, (S)-;Levetiracetam butanamide;
  • PSA 63.40000
  • LogP 0.51090

Synthetic route

1-((S)-1-carbamoylpropyl)-2-oxopyrrolidine-3-carboxylic acid methyl ester
941289-97-0

1-((S)-1-carbamoylpropyl)-2-oxopyrrolidine-3-carboxylic acid methyl ester

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With water; sodium chloride In N,N-dimethyl-formamide at 130 - 140℃; for 18h; Product distribution / selectivity;100%
In 4-methyl-2-pentanone at 115 - 120℃; for 12h; Product distribution / selectivity;52%
dehydro levetiracetam

dehydro levetiracetam

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With C68H72Cl2Co2P4; hydrogen In methanol at 50℃; Reagent/catalyst; enantioselective reaction;99.9%
(2S)-2-(3,4-dichloro-2,5-dihydro-2-oxo-1H-pyrrol-1-yl)butanamide

(2S)-2-(3,4-dichloro-2,5-dihydro-2-oxo-1H-pyrrol-1-yl)butanamide

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With hydrogen; triethylamine; palladium on activated charcoal In ethanol under 2587.71 Torr; for 2h;91%
(S)-2-amino-butanamide hydrochloride
53726-14-0

(S)-2-amino-butanamide hydrochloride

4-Chlorobutanoyl chloride
4635-59-0

4-Chlorobutanoyl chloride

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Stage #1: (S)-2-amino-butanamide hydrochloride With tetrabutylammomium bromide; sodium sulfate In dichloromethane at 0℃; for 0.5h;
Stage #2: 4-Chlorobutanoyl chloride With potassium hydroxide In dichloromethane at 0℃; for 7h;		89%
Stage #1: (S)-2-amino-butanamide hydrochloride; 4-Chlorobutanoyl chloride With potassium hydroxide; sodium sulfate In acetonitrile at 3 - 5℃; for 5h;
Stage #2: With hydrogenchloride pH=6; Product distribution / selectivity;		84%
With potassium hydroxide; tetrabutylammomium bromide; sodium sulfate; molecular sieve In dichloromethane; ethyl acetate; toluene74.1%
(S)-2-amino-butanamide
7324-11-0, 53726-14-0, 104652-77-9, 143164-46-9

(S)-2-amino-butanamide

4-Chlorobutanoyl chloride
4635-59-0

4-Chlorobutanoyl chloride

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Stage #1: (S)-2-amino-butanamide With tetrabutylammomium bromide; potassium hydroxide In dichloromethane at -15 - -5℃; for 2.25h;
Stage #2: 4-Chlorobutanoyl chloride In dichloromethane at -10 - -8℃;		85%
butyl 4-chlorobutyrate
3153-33-1

butyl 4-chlorobutyrate

(S)-2-amino-butanamide hydrochloride
53726-14-0

(S)-2-amino-butanamide hydrochloride

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With triethylamine; sodium iodide In isopropyl alcohol at 90℃; for 36h; Inert atmosphere;85%
(S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt
102916-46-1

(S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Stage #1: (S)-α-ethyl-2-oxo-1-pyrrolidineacetic acid (R)-α-methylbenzylamine salt With sodium hydroxide In water for 0.5h;
Stage #2: With chloroformic acid ethyl ester In dichloromethane at -10℃; for 2h;
Stage #3: With ammonia In dichloromethane at -15 - -10℃; for 2h; Solvent; Reagent/catalyst;		85%
Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / 0.5 h / 0 - 10 °C
1.2: pH 4 - 5
2.1: toluene-4-sulfonic acid / 7 h / 60 °C
3.1: ammonia / 24 h / 0 - 10 °C
View Scheme
4-chloro-butyric acid ethyl ester
3153-36-4

4-chloro-butyric acid ethyl ester

(S)-2-amino-butanamide hydrochloride
53726-14-0

(S)-2-amino-butanamide hydrochloride

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With sodium carbonate; sodium iodide In dimethyl sulfoxide at 90℃; for 24h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;84%
isopropyl 4-chlorobutanoate
3153-34-2

isopropyl 4-chlorobutanoate

(S)-2-amino-butanamide hydrochloride
53726-14-0

(S)-2-amino-butanamide hydrochloride

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With sodium carbonate; sodium iodide In N,N-dimethyl-formamide at 110℃; for 12h; Inert atmosphere;83%
(S)-N-[1(aminocarbonyl)propyl]-4-bromobutyramide

(S)-N-[1(aminocarbonyl)propyl]-4-bromobutyramide

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;82%
(2S,3R)-3-methylsulfonyloxy-2-(2-oxopyrrolidin-1-yl)butanamide

(2S,3R)-3-methylsulfonyloxy-2-(2-oxopyrrolidin-1-yl)butanamide

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With sodium tetrahydroborate; ethanol for 3h; Reflux;81%
C8H15ClN2O2*ClH

C8H15ClN2O2*ClH

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With potassium hydroxide In dichloromethane at -5 - 0℃; for 3h; Large scale;80.6%
allyl 4-chlorobutyrate
4897-91-0

allyl 4-chlorobutyrate

(S)-2-amino-butanamide hydrochloride
53726-14-0

(S)-2-amino-butanamide hydrochloride

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 50℃; for 36h; Inert atmosphere;80%
methyl 4-chlorobutyrate
3153-37-5

methyl 4-chlorobutyrate

(S)-2-amino-butanamide hydrochloride
53726-14-0

(S)-2-amino-butanamide hydrochloride

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In dimethyl sulfoxide at 100℃; for 24h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;80%
(S)-2-(4-chlorobutyramido)butanamide
102767-31-7

(S)-2-(4-chlorobutyramido)butanamide

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0 - 5℃; Reagent/catalyst;78.9%
With potassium hydroxide at 20 - 25℃; for 2.5h;76.4%
With potassium hydroxide; potassium iodide In tert-butyl methyl ether at 20℃; for 4h; Product distribution / selectivity;
With potassium hydroxide In tert-butyl methyl ether at 20℃; for 4h; Product distribution / selectivity;
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid
102849-49-0

(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Stage #1: (2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid With thionyl chloride In methanol at 45℃;
Stage #2: With ammonia In methanol at 20℃; under 2250.23 Torr; Product distribution / selectivity;		78.4%
Stage #1: (2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: With ammonium hydroxide In tetrahydrofuran for 16h;		75%
Stage #1: (2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid With ammonium hydroxide; triethylamine; isobutyl chloroformate In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: With ammonium hydroxide In tetrahydrofuran at 20℃; for 11h;		72%
(S)-methyl 2-(2-oxopyrrolidin-1-yl)-2-butanoate
358629-51-3

(S)-methyl 2-(2-oxopyrrolidin-1-yl)-2-butanoate

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With ammonia In methanol at 20℃; under 2250.23 Torr; Product distribution / selectivity; Autoclave;78.4%
With ammonia; water at 0 - 20℃; for 14h; Product distribution / selectivity;62.2%
(2S,3R)-3-(4-tolyl)sulfonyloxy-2-(2-oxopyrrolidin-1-yl)butanamide

(2S,3R)-3-(4-tolyl)sulfonyloxy-2-(2-oxopyrrolidin-1-yl)butanamide

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With methanol; potassium borohydride In dichloromethane for 8h; Reflux;78%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid
102849-49-0

(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With ammonia; triethylamine In molecular sieve; dichloromethane; ethyl acetate; toluene72.3%
(S)-(+)-amino butynamide tartarate

(S)-(+)-amino butynamide tartarate

4-Chlorobutanoyl chloride
4635-59-0

4-Chlorobutanoyl chloride

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Stage #1: (S)-(+)-amino butynamide tartarate With potassium carbonate; sodium sulfate In acetonitrile at 0 - 5℃;
Stage #2: 4-Chlorobutanoyl chloride In acetonitrile at 0 - 25℃; for 5h;
Stage #3: With sodium hydroxide In acetonitrile at 0 - 5℃; for 10h;		67%
(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid
102849-49-0

(2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid

A

levetiracetam

levetiracetam

B

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Stage #1: (2S)-2-(2-oxopyrrolidin-1-yl)butanoic acid With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: With ammonium hydroxide In tetrahydrofuran; water at 20℃; for 16h;		A n/a
B 65%
(R)-2-pyrrolidone-N-butyric acid
103833-72-3

(R)-2-pyrrolidone-N-butyric acid

A

levetiracetam

levetiracetam

B

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Stage #1: (R)-2-pyrrolidone-N-butyric acid With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: With ammonium hydroxide In tetrahydrofuran; water at 20℃; for 16h;		A 63%
B n/a
2-(2-oxo-1-pyrrolidinyl)butanenitrile

2-(2-oxo-1-pyrrolidinyl)butanenitrile

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With sulfuric acid; water In dichloromethane at 100℃; for 0.166667h; Reagent/catalyst; Temperature;50%
(S)-(-)-α-ethyl-2-oxo-1-pyrrolidineacetamide

(S)-(-)-α-ethyl-2-oxo-1-pyrrolidineacetamide

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
With sodium periodate; (x)H2O*O4Ru In ethyl acetate at 20℃; for 0.5h; Solvent; Electrochemical reaction;49%
2,5-dihydro-2,5-dimethoxyfuran
332-77-4

2,5-dihydro-2,5-dimethoxyfuran

(S)-2-amino-butanamide
7324-11-0, 53726-14-0, 104652-77-9, 143164-46-9

(S)-2-amino-butanamide

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Stage #1: 2,5-dihydro-2,5-dimethoxyfuran; (S)-2-amino-butanamide With hydrogenchloride In water at 20℃; for 1.5h;
Stage #2: With sodium carbonate In water pH=8 - 9;
Stage #3: With hydrogen; 5%-palladium/activated carbon In ethanol; water for 0.583333h;		13%
1-((S)-1-hydroxybutane-2-yl)pyrrolidin-2-one
909566-58-1

1-((S)-1-hydroxybutane-2-yl)pyrrolidin-2-one

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 90 percent / 2,2,6,6-tetramethyl-1-piperidinyloxy; sodium hypochlorite; sodium chlorite / acetonitrile; aq. phosphate buffer / 6 h / 25 °C / pH 6.8
2.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C
2.2: 75 percent / ammonium hydroxide / tetrahydrofuran / 16 h
View Scheme
Multi-step reaction with 3 steps
1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite; sodium hypochlorite / acetonitrile; aq. phosphate buffer / 7 h / 35 °C / pH 6.7
1.2: 0.75 h / 20 °C / pH 8
1.3: pH 3 - 4
2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
3.1: ammonium hydroxide / tetrahydrofuran; water / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite; sodium hypochlorite / acetonitrile; aq. phosphate buffer / 7 h / 35 °C / pH 6.7
1.2: 0.75 h / 20 °C / pH 8
1.3: pH 3 - 4
2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
3.1: ammonium hydroxide / tetrahydrofuran; water / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide; tetrabutylammomium bromide; potassium permanganate / water; dichloromethane / 12.5 h / 20 °C
2: triethylamine; chloroformic acid ethyl ester; ammonium hydroxide / water; tetrahydrofuran / 12.5 h / 0 - 20 °C
View Scheme
(S)-1-(1-(benzyloxy)butan-2-yl)pyrrolidin-2-one
912643-33-5

(S)-1-(1-(benzyloxy)butan-2-yl)pyrrolidin-2-one

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 97 percent / hydrogen / Pd/C / methanol / 6 h / 760 Torr
2.1: 90 percent / 2,2,6,6-tetramethyl-1-piperidinyloxy; sodium hypochlorite; sodium chlorite / acetonitrile; aq. phosphate buffer / 6 h / 25 °C / pH 6.8
3.1: ethyl chloroformate; triethylamine / tetrahydrofuran / 0.5 h / 0 °C
3.2: 75 percent / ammonium hydroxide / tetrahydrofuran / 16 h
View Scheme
Multi-step reaction with 4 steps
1.1: palladium(II) hydroxide; hydrogen / methanol / 24 h / 20 °C / 3102.97 Torr
2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite; sodium hypochlorite / acetonitrile; aq. phosphate buffer / 7 h / 35 °C / pH 6.7
2.2: 0.75 h / 20 °C / pH 8
2.3: pH 3 - 4
3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
4.1: ammonium hydroxide / tetrahydrofuran; water / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: palladium(II) hydroxide; hydrogen / methanol / 24 h / 20 °C / 3102.97 Torr
2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite; sodium hypochlorite / acetonitrile; aq. phosphate buffer / 7 h / 35 °C / pH 6.7
2.2: 0.75 h / 20 °C / pH 8
2.3: pH 3 - 4
3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
4.1: ammonium hydroxide / tetrahydrofuran; water / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
(αS,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 2-(2-oxopyrrolidin-1-yl)butyrate
873786-87-9

(αS,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 2-(2-oxopyrrolidin-1-yl)butyrate

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 140 mg / LiOH*H2O; H2O2 / tetrahydrofuran / 7 h / 0 °C
2.1: (C2H5)3N; ethyl chloroformate / tetrahydrofuran / 0.5 h / 0 °C
2.2: 65 percent / ammonium hydroxide / tetrahydrofuran; H2O / 16 h / 20 °C
View Scheme
(αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 2-(2-oxopyrrolidin-1-yl)butyrate
873786-88-0

(αR,3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 2-(2-oxopyrrolidin-1-yl)butyrate

levetiracetam
102767-28-2

levetiracetam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 141 mg / LiOH*H2O; H2O2 / tetrahydrofuran / 7 h / 0 °C
2.1: (C2H5)3N; ethyl chloroformate / tetrahydrofuran / 0.5 h / 0 °C
2.2: ammonium hydroxide / tetrahydrofuran; H2O / 16 h / 20 °C
View Scheme
levetiracetam
102767-28-2

levetiracetam

(2S)-2-(2-oxo-1-pyrrolidinyl)butanenitrile
664304-29-4

(2S)-2-(2-oxo-1-pyrrolidinyl)butanenitrile

Conditions
ConditionsYield
With pyridine; p-toluenesulfonyl chloride In dichloromethane at 20℃; for 20h;93%
oxalyl dichloride
79-37-8

oxalyl dichloride

(Z)-4-hydroxybut-2-enyl 1-(nitrooxy)ethyl carbonate
1345092-28-5

(Z)-4-hydroxybut-2-enyl 1-(nitrooxy)ethyl carbonate

levetiracetam
102767-28-2

levetiracetam

(Z)-4-((1-(nitrooxy)ethoxy)carbonyloxy)but-2-enyl (S)-2-(2-oxopyrrolidin-1-yl)butanoylcarbamate
1345092-06-9

(Z)-4-((1-(nitrooxy)ethoxy)carbonyloxy)but-2-enyl (S)-2-(2-oxopyrrolidin-1-yl)butanoylcarbamate

Conditions
ConditionsYield
Stage #1: oxalyl dichloride; levetiracetam In 1,1-dichloroethane; dichloromethane for 8h; Reflux;
Stage #2: (Z)-4-hydroxybut-2-enyl 1-(nitrooxy)ethyl carbonate In 1,1-dichloroethane; dichloromethane at 20℃; for 12h;		30.6%
...Expand
Hexanoyl chloride
142-61-0

Hexanoyl chloride

levetiracetam
102767-28-2

levetiracetam

(S)-N-(2-(2-oxopyrrolidin-1-yl)butanoyl)hexanamide

(S)-N-(2-(2-oxopyrrolidin-1-yl)butanoyl)hexanamide

Conditions
ConditionsYield
Stage #1: levetiracetam With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.5h;
Stage #2: Hexanoyl chloride In tetrahydrofuran; mineral oil at 0 - 20℃; for 16h;		21%

Levetiracetam Specification

1. Introduction of Levetiracetam
Levetiracetam is a white crystalline solid. The IUPAC Name of this chemical is (2R)-2-(2-oxopyrrolidin-1-yl)butanamide. Besides, it belongs to Anticonvulsant;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Compounds. In addition, the Classification Code of this chemical is Antiepileptic; Drug / Therapeutic Agent. It is very soluble in water and  freely soluble in chloroform (65.3 g/100 mL) and in methanol (53.6 g/100 mL), soluble in ethanol (16.5 g/100 mL), sparingly soluble in acetonitrile (5.7 g/100 mL) and practically insoluble in n-hexane. (Solubility limits are expressed as g/100 mL solvent.)

2. Properties of Levetiracetam
Physical properties about Levetiracetam are:
(1)XLogP3-AA: -0.3; (2)H-Bond Donor: 1; (3)H-Bond Acceptor: 2; (4)Melting Point: 118-119 °C; (5)Surface Tension: 48.8 dyne/cm; (6)Density: 1.168 g/cm3; (7)Flash Point: 193.2 °C; (8)Enthalpy of Vaporization: 64.61 kJ/mol; (9)Boiling Point: 395.9 °C at 760 mmHg; (10)Vapour Pressure: 1.78E-06 mmHg at 25 °C.

3. Structure Descriptors of Levetiracetam
(1)InChI: InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1
(2)InChIKey: HPHUVLMMVZITSG-LURJTMIESA-N
(3)Canonical SMILES : CCC(C(=O)N)N1CCCC1=O
(4)Isomeric SMILES: CC[C@@H](C(=O)N)N1CCCC1=O
(5)Smiles: N1([C@H](C(=O)N)CC)C(=O)CCC1

4. Toxicity of Levetiracetam

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 1081mg/kg (1081mg/kg)   United States Patent Document. Vol. #4696943,
rat LD50 intravenous 1038mg/kg (1038mg/kg)   United States Patent Document. Vol. #4696943,

5. Safety information of Levetiracetam
Hazard Codes: HarmfulXn
Risk Statements: 22-36 
R22:Harmful if swallowed. 
R36:Irritating to eyes.
Safety Statements: 26 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RTECS: UX9656166

6. Uses of Levetiracetam
Levetiracetam (CAS NO.102767-28-2) is also sometimes used to treat neuropathic pain.It has recently been approved in the United Kingdom as a monotherapy treatment for epilepsy. It is also used in veterinary medicine for similar purposes.

7. Production of Levetiracetam
(1)H-MET-NH2 can be used to manufacture Levetiracetam. The detail is as follows:

Production of Levetiracetam

(2)A reaction flask was added 500ml of methanol and deionized water 33ml, cooled to 0 ° C. Then add with stirring 50.0g (0.27mol), pass ammonia and dissolve to saturation, and seale reaction flask 0 to 5 º C reaction was stirred 96h TLC tracking,eluent, ethyl acetate / acetone (3:1) product Rf = 0.28, raw material Rf = 0.6]. feedstock point disappears, and the end of the reaction. Finanly, it was distilled under reduced pressure to obtain a yellow solid levetiracetam crude product 41.5g and the yield is 90.2%.

Production of Levetiracetam

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