Methanesulfonamide supplier

Name
Methanesulfonamide
EINECS 221-553-6
CAS No. 3144-09-0
Article Data79
CAS DataBase
Density 1.363 g/cm³
Solubility
Melting Point 85-89 °C(lit.)
Formula CH₅NO₂S
Boiling Point 208.2 °C at 760 mmHg
Molecular Weight 95.1222
Flash Point 79.7 °C
Transport Information
Appearance white to yellow crystals, powder or flakes
Safety 26-36-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Mesylamide;Methanesulfonic amide;Methanesulphonamide;NSC 191039;NSC271;
PSA 68.54000
LogP 0.68580

Synthetic route

: 80284-02-2
N-nitromethanesulfonimide

A: 3144-09-0
methanesulfonamide

B: CH3N2O4S(1-)*H4N(1+)

Conditions

Conditions	Yield
With ammonia In dichloromethane for 0.0833333h;	A n/a B 100%

: 1578267-78-3
N-(3-methylbut-2-en-1-yl)methanesulfonamide

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With silver hexafluoroantimonate In 1,2-dichloro-ethane at 140℃; for 0.0333333h; Inert atmosphere; Microwave irradiation;	100%

: 124-63-0
methanesulfonyl chloride

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane; ethyl acetate	99%
With triethylamine In dichloromethane	98%
	97%

: N,N-bis(3-methylbut-2-en-1-yl)methanesulfonamide

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With silver hexafluoroantimonate In 1,2-dichloro-ethane at 140℃; for 0.0333333h; Microwave irradiation; Inert atmosphere;	98%

HCl(aq): HCl(aq)

: 124-63-0
methanesulfonyl chloride

: 4-(4-bromophenyl)-4-hydroxy-piperidine

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane; water	95.6%
With triethylamine In dichloromethane; water	95.6%
With triethylamine In dichloromethane; water

...Expand

: 624-90-8, 1516-70-7
Methanesulfonyl azide

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With benzyltriethylammonium tetrathiomolybdate In water; acetonitrile at 25℃; for 0.1h;	95%
With zinc In methanol at 20℃; for 2h;	92%
With iron In water at 20℃; for 2h; Inert atmosphere;	87%

: N,N-bis[(E)-3,7-dimethylocta-2,6-dien-1-yl]methanesulfonamide

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With silver hexafluoroantimonate In 1,2-dichloro-ethane at 140℃; for 0.0333333h; Microwave irradiation; Inert atmosphere;	81%

: 31562-43-3
tert-butylsulfinyl chloride

: 50695-55-1
N-hydroxylmethanesulfonamide

A: 3144-09-0
methanesulfonamide

B: 31562-41-1
di-tert-butyl thiosulfonate

C: 75975-45-0
trifluoromethane sulfonic anhydride

D: 75975-41-6
C5H13NO4S2

Conditions

Conditions	Yield
With pyridine In acetone at 20℃; for 2h; Mechanism; Product distribution; other N-hydroxy sulfonamides;	A 80% B 13% C 22% D 15%

...Expand

: N-[(E)-morpholin-4-ylmethylidene]methanesulfonamide

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 20℃; for 2h;	80%

: 362665-07-4
N-methanesulfonyl-3-phenylpropylamine

A: 104-53-0
3-phenyl-propionaldehyde

B: 3144-09-0
methanesulfonamide

C: 213264-51-8
3-(4-iodophenyl)propionaldehyde

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; iodine In 1,2-dichloro-ethane at 30 - 40℃; for 3h; ultrasonic irradiation;	A 24% B 66% C 39%

...Expand

: 110955-56-1
N-Isopropylidene-methanesulfonamide

A: 3144-09-0
methanesulfonamide

B: 67-64-1
acetone

Conditions

Conditions	Yield
With water for 1h; Heating;	A 56% B n/a

: 303165-07-3
4-{2-[3,4-bis(difluoromethoxy)phenyl]-2-[6-(4-aminophenoxy)-pyridin-3-yl]ethyl}pyridine

: 124-63-0
methanesulfonyl chloride

A: 4-{2-[3,4-Bis(difluoromethoxy)phenyl]-2-{6-[4-(methylsulfonylamino)phenoxy]-pyridin-3-yl}ethyl}pyridine

B: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With potassium carbonate; triethylamine In tetrahydrofuran; methanol; dichloromethane	A 51% B n/a

...Expand

: 20277-69-4
sodium methansulfinate

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
Stage #1: sodium methansulfinate With iodine at 20℃; for 0.333333h; Green chemistry; Stage #2: With ammonium hydroxide; water at 20℃; for 3h; Green chemistry;	23%

: 170569-88-7
mavacoxib

: 74-88-4
methyl iodide

A: 3144-09-0
methanesulfonamide

B: 4-[5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-N-methylbenzenesulfonamide

Conditions

Conditions	Yield
In dimethyl sulfoxide	A n/a B 21%

...Expand

: 292638-84-7
styrene

: [N-(methylsulfonyl)imino]phenyliodinane

A: 3144-09-0
methanesulfonamide

B: 102535-89-7
(N-methanesulfonyl)-2-phenylaziridine

Conditions

Conditions	Yield
With copper acetylacetonate In acetonitrile Ambient temperature;	A n/a B 7%

...Expand

: 56-23-5
tetrachloromethane

: N,N-bis-methanesulfonyl-alanine

: 3144-09-0
methanesulfonamide

: 859980-70-4
N,N-bis-methanesulfonyl-glycine

: 623-11-0
1-methyl-4-nitrosobenzene

A: 79-14-1
glycolic Acid

B: 3144-09-0
methanesulfonamide

C: 35688-18-7
2-(methylsulfonylamino)acetic acid

...Expand

: 999-96-2
N-(trimethylsilyl)methanesulfonamide

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With water

: 67-71-0
dimethylsulfone

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 594-43-4
ethyl methyl sulfone

A: 3144-09-0
methanesulfonamide

B: 1520-70-3
Ethanesulfonamide

Conditions

Conditions	Yield
Yield given. Multistep reaction. Yields of byproduct given;

: 78488-82-1
C9H9ClF2N2O3S2

A: 3144-09-0
methanesulfonamide

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With acidic media Product distribution; heating;

: 78488-80-9
C9H9Cl2FN2O3S2

A: 3144-09-0
methanesulfonamide

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With acidic media Product distribution; heating;

: 75142-05-1
Trimesylhydroxylamine

A: 3144-09-0
methanesulfonamide

B: 5347-82-0
dimesylamine

C: 2386-57-4
methanesulfonic acid sodium salt

D: 41921-91-9
N-methylsulfamic acid monosodium salt

Conditions

Conditions	Yield
With sodium hydroxide In water Mechanism; Product distribution; Heating; hydrolysis with basic, neutral and acidic aqu. solutions (other products);	A 6 % Spectr. B 20 % Spectr. C 70 % Spectr. D 4 % Spectr.

...Expand

: N-chlorosulphonyl-methanesulphonamide

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With water In methanol Mechanism;

: 41138-92-5
methanesulfonyl bromide

: 3144-09-0
methanesulfonamide

Conditions

Conditions	Yield
With ammonia; triethylamine In acetonitrile at 0 - 20℃; Yield given;

: 3611-92-5
methanesulfonyl isocyanate

: 64-17-5
ethanol

A: 3144-09-0
methanesulfonamide

B: 124-38-9
carbon dioxide

...Expand

: 3611-92-5
methanesulfonyl isocyanate

: 7732-18-5
water

A: 3144-09-0
methanesulfonamide

B: 124-38-9
carbon dioxide

...Expand

: 3611-92-5
methanesulfonyl isocyanate

A: 3144-09-0
methanesulfonamide

B: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
With water

: 3144-09-0
methanesulfonamide

: 24424-99-5
di-tert-butyl dicarbonate

: 147751-16-4
tert-butyl (methylsulfonyl)carbamate

Conditions

Conditions	Yield
With trimethylamine In dichloromethane at 0 - 20℃; for 16h;	100%
With triethylamine; dmap In dichloromethane for 2h; Ambient temperature;	88%
With triethylamine; dmap In dichloromethane at 25℃; for 2h;	83%

: 3144-09-0
methanesulfonamide

: 5275-46-7
2-nitro-2-nitrosopropane

: C4H9N3O5S

Conditions

Conditions	Yield
With phenformin In dichloromethane at 20℃;	100%

: 3144-09-0
methanesulfonamide

: 139308-14-8
2,2-dimethyl-5-nitro-5-nitroso-1,3-dioxane

: C7H13N3O7S

Conditions

Conditions	Yield
With phenformin In dichloromethane at 20℃;	100%

: 3144-09-0
methanesulfonamide

: 334-99-6
trifluoronitrosomethane

: trifluoromethylazosulfonylmethane

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 12h;	100%

: 3144-09-0
methanesulfonamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 78523-02-1
N-[1-Dimethylamino-meth-(E)-ylidene]-methanesulfonamide

Conditions

Conditions	Yield
In dichloromethane for 0.5h; Heating;	100%

: 3144-09-0
methanesulfonamide

: 106-38-7
para-bromotoluene

: 4284-47-3
N-(4-methylphenyl)methanesulfonamide

Conditions

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tert-butyl XPhos In tert-Amyl alcohol at 80℃; Kinetics; Inert atmosphere;	100%
With bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; tert-butyl XPhos In 2-methyltetrahydrofuran at 80℃; for 6h; Inert atmosphere;	93%
With potassium phosphate; copper(l) iodide; dimethylaminoacetic acid In N,N-dimethyl-formamide for 48h; Heating;	89%

: C38H44FNO6

: 3144-09-0
methanesulfonamide

: C39H47FN2O7S

Conditions

Conditions	Yield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃;	100%

: 3144-09-0
methanesulfonamide

: 1064681-32-8
1-(3-Iodophenyl)-2-methoxy-6-(3-methoxyphenyl)naphthalene

: 13939-06-5, 199620-15-0
molybdenum hexacarbonyl

: 1064681-28-2
3-(2-Methoxy-6-(3-methoxyphenyl)naphthalene-1-yl)-N-(methylsulfonyl)-benzamide

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium diacetate In 1,4-dioxane at 110℃; for 0.25h; microwave irradiation;	100%

...Expand

: 3144-09-0
methanesulfonamide

: 1354960-59-0
4-Methylphenyl 5-chloro-4-(3,4-dichlorophenoxy)-2-fluorobenzoate

: 1354955-37-5
5-Chloro-4-(3,4-dichlorophenoxy)-2-fluoro-N-(methylsulfonyl)benzamide

Conditions

Conditions	Yield
Stage #1: methanesulfonamide With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.516667h; Stage #2: 4-Methylphenyl 5-chloro-4-(3,4-dichlorophenoxy)-2-fluorobenzoate In tetrahydrofuran; mineral oil at 70℃;	100%

: 497225-66-8
2-n-butyl-5-bromo-benzofuran

: 3144-09-0
methanesulfonamide

: 437652-07-8
N-(2-butyl-2,3-dihydro-5-benzofuranyl)methanesulfonamide

Conditions

Conditions	Yield
With bis(dibenzylideneacetone)-palladium(0); tert-butyl XPhos In 1,4-dioxane at 100℃; for 24h; Reagent/catalyst; Solvent; Inert atmosphere;	100%

: 3144-09-0
methanesulfonamide

: 1445862-88-3
4-(4-chlorophenoxy)-2-fluoro-5-iodobenzoic acid

: 1445862-89-4
4-(4-chlorophenoxy)-2-fluoro-5-iodo-N-(methylsulfonyl)benzamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;	100%

: 3144-09-0
methanesulfonamide

: 4-bromo-3-(difluoromethoxy)benzoic acid

: 4-bromo-3-(difluoromethoxy)-N-(methylsulfonyl)benzamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	100%

: 3144-09-0
methanesulfonamide

: 6-bromo-3-(chloromethyl)benzofuran

: N-((6-bromobenzofuran-3-yl)methyl)methanesulfonamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide at 80℃; for 11h;	100%

: 3144-09-0
methanesulfonamide

: 461009-54-1
(S)-3-(((benzyloxy)carbonyl)amino)-4-((tert-butyldiphenylsilyl)oxy)butanoic acid

: benzyl (S)-(1-((tert-butyldiphenylsilyl)oxy)-4-(methylsulfonamido)-4-oxobutan-2-yl)carbamate

Conditions

Conditions	Yield
Stage #1: (S)-3-(((benzyloxy)carbonyl)amino)-4-((tert-butyldiphenylsilyl)oxy)butanoic acid With 1,1'-carbonyldiimidazole at 20℃; for 3h; Inert atmosphere; Stage #2: methanesulfonamide With 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; Inert atmosphere;	100%

: 108-86-1
bromobenzene

: 3144-09-0
methanesulfonamide

: 1197-22-4
N-phenylmethanesulfonamide

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; dimethylaminoacetic acid In N,N-dimethyl-formamide for 48h; Heating;	99%
With potassium phosphate; copper(l) iodide In N,N-dimethyl-formamide at 130℃; for 18h; Sealed tube;	75%
With copper(l) iodide; potassium carbonate In various solvent(s) at 195℃; for 2h; microwave irradiation;	67%
With copper(I) oxide; caesium carbonate In water at 130℃; for 24h; Sealed tube;	36%

: 591-50-4
iodobenzene

: 3144-09-0
methanesulfonamide

: 1197-22-4
N-phenylmethanesulfonamide

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; sarcosine In N,N-dimethyl-formamide at 100℃; for 24h;	99%
With copper(I) oxide; caesium carbonate In water at 130℃; for 24h; Catalytic behavior; Reagent/catalyst; Solvent; Sealed tube;	90%
With copper(I) oxide; caesium carbonate In water at 130℃; for 24h; Sealed tube;	90%

: 3144-09-0
methanesulfonamide

: 618-91-7
methyl 3-iodo-benzoate

: 32087-05-1
3-methanesulfonylaminobenzoic acid methyl ester

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; sarcosine In N,N-dimethyl-formamide at 100℃; for 24h;	99%

: 3144-09-0
methanesulfonamide

: 177896-09-2
tert-butyl benzylidenecarbamate

: tert-butyl N-[(4-methylsulfonamido)(phenyl)methyl]carbamate

Conditions

Conditions	Yield
With bis(trifluoromethanesulfonyl)amide In diethyl ether at 20℃; for 0.333333h;	99%

: 3144-09-0
methanesulfonamide

: 26825-94-5
10-bromodecanoic acid methyl ester

: 1161364-44-8
methyl 10-(methylsulfonamido)decanoate

Conditions

Conditions	Yield
Stage #1: methanesulfonamide With sodium hydride In N,N-dimethyl-formamide at 100℃; for 2h; Stage #2: 10-bromodecanoic acid methyl ester In N,N-dimethyl-formamide at 100℃;	99%

: 3144-09-0
methanesulfonamide

: 62668-02-4
(E)-1,3-diphenyl-2-propen-1-ol

: 1262765-49-0
N-[(2E)-1,3-diphenyl-2-propen-1-yl]methanesulfonamide

Conditions

Conditions	Yield
With 3-tetradecyl-1-(4-sulfobutyl)imidazolium trifluoromethanesulfonate In 1,4-dioxane at 80℃; for 2h;	99%
With [BsTdmim]OTf In 1,4-dioxane at 80℃; for 2h;	99%
With iron(III) chloride hexahydrate In 1,4-dioxane at 25℃; for 24h;	89%

: (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II)

: 3144-09-0
methanesulfonamide

: (η6-cymene)Ru(TsN(CHPh)2NH2)(NHSO2Me)

Conditions

Conditions	Yield
In dichloromethane 23°C, 0.5-1 min;	99%

: 3144-09-0
methanesulfonamide

: 824-94-2
p-methoxybenzyl chloride

: N,N-bis(4-methoxybenzyl)methanesulfonamide

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In butanone at 75℃;	99%
With potassium carbonate; potassium iodide In butanone at 81℃; for 18h; Concentration; Temperature;	81%
Stage #1: methanesulfonamide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 5h; Stage #2: p-methoxybenzyl chloride In N,N-dimethyl-formamide at 20℃; for 19h;	17.1 g
With potassium carbonate; potassium iodide In butanone at 75℃;

: 188813-02-7
3-bromo-5-fluorobenzaldehyde

: 3144-09-0
methanesulfonamide

: 1467083-70-0
N-(3-bromo-5-fluorobenzyl) methanesulfonamide

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; triethylamine In 1,2-dichloro-ethane at 20℃;	99%
With sodium tris(acetoxy)borohydride; triethylamine In 1,2-dichloro-ethane at 20℃;	93.9%

: 3144-09-0
methanesulfonamide

: 207743-78-0
tert-butyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylate

: 1452776-84-9
tert-butyl 2-(3-(methylsulfonyl)thioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

Conditions

Conditions	Yield
Stage #1: methanesulfonamide With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.25h; Stage #2: tert-butyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]-thiophene-3-carboxylate In N,N-dimethyl-formamide; mineral oil at 60℃; for 1h;	99%

: 3144-09-0
methanesulfonamide

: 1173900-33-8
AZD 6482

: 1622905-82-1
C23H27N5O5S

Conditions

Conditions	Yield
With dmap for 72h;	99%

: 3144-09-0
methanesulfonamide

: 415965-24-1
4-bromo-2-fluoro-5-methylbenzoic acid

: 4-bromo-2-fluoro-5-methyl-N-(methylsulfonyl)benzamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	99%

: 3144-09-0
methanesulfonamide

: 2-(5-((S)-1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazole-4-carboxamido)-2-(2,4-difluorophenyl)acetic acid

: tert-butyl ((1S)-1-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-4-((1-(2,4-difluorophenyl)-2-(methylsulfonamido)-2-oxoethyl)carbamoyl)oxazol-5-yl)ethyl)carbamate

Conditions

Conditions	Yield
Stage #1: 2-(5-((S)-1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazole-4-carboxamido)-2-(2,4-difluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 60℃; for 0.5h; Stage #2: methanesulfonamide With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 60℃; for 10h;	99%

Methanesulfonamide Chemical Properties

Molecular Formula: CH₅NO₂S

Formula Weight: 95.12
Synonyms: Methylsulfonamid; Methanesulfonic amide; Methanesulfonyl amide; METHYLSULFAMIDE
Melting Point: 85-89 ^°C(lit.)
Flash Point: 79.7 ^°C
Boiling Point: 208.2 ^°C at 760 mmHg
Density of Methanesulfonamide (3144-09-0): 1.363 g/cm³
Vapour Pressure: 0.216 mmHg at 25^°C
Index of Refraction: 1.46
Appearence: Methanesulfonamide (3144-09-0) is an off-white flake

Methanesulfonamide Uses

Methanesulfonamide (3144-09-0) can react with thionyl chloride, cyanates, carbon disulfide and ketones and aldehydes to prepare herbicides, pharmaceuticals, insecticides, brightening agent and other target molecules.

Methanesulfonamide Safety Profile

Safety: WARNING: Irritates lungs, eyes, skin
Hazard Codes : Xi: Irritant
Risk Statements : 36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements : 26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
24/25: Avoid contact with skin and eyes
WGK Germany : 3
Hazard Note : Irritant
TSCA : T
HS Code : 29350090

Methanesulfonamide Standards and Recommendations

PURITY: 98.0% min
WATER: 0.5% max
LOSS ON DRYING: 2.0% max
HEAVY METALS: 20ppm max

Methanesulfonamide Specification

Storage: Keep container tightly closed. Store in cool, well ventilated area.

Product Name

Methanesulfonamide

Synthetic route

Methanesulfonamide Chemical Properties

Methanesulfonamide Uses

Methanesulfonamide Safety Profile

Methanesulfonamide Standards and Recommendations

Methanesulfonamide Specification

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