Methyl pyruvate supplier | CasNO.600-22-6

Name
Methyl pyruvate
EINECS 209-987-4
CAS No. 600-22-6
Article Data72
CAS DataBase
Density 1.072 g/cm³
Solubility Soluble in chloroform, methanol, ether, alcohol. Slightly soluble in water.
Melting Point -22 °C
Formula C₄H₆O₃
Boiling Point 135.5 °C at 760 mmHg
Molecular Weight 102.09
Flash Point 39.4 °C
Transport Information UN 3272 3/PG 3
Appearance Clear colourless to yellow liquid
Safety 16
Risk Codes 10
Molecular Structure
Hazard Symbols R10:;
Synonyms Pyruvicacid, methyl ester (6CI,7CI,8CI);2-Oxo-propionic acid methyl ester;2-Oxopropanoic acid methyl ester;Methyl 2-oxopropanoate;Methyl2-oxopropionate;Methyl acetoformate;Methyl pyroracemate;Methyl pyruvate;Methylglyoxylic acid methyl ester;NSC 65430;Pyroracemic acid methyl ester;
PSA 43.37000
LogP -0.25160

Synthetic route

: 547-64-8
methyl lactate

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With hydrogenchloride; zinc(II) nitrate; hydroxylamine hydrochloride; oxygen; copper(II) nitrate; sodium hydroxide at 100℃; under 75.0075 Torr; for 8h; Molecular sieve; Autoclave; Green chemistry;	98.9%
With p-methoxybenzenetellurinic acid anhydride In neat (no solvent) at 130℃; for 1h;	90%
With hydrogenchloride; sodium hypobromide In dichloromethane; water at 25℃; for 5h;	90%

: 67-56-1
methanol

: 127-17-3
2-oxo-propionic acid

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With toluene-4-sulfonic acid at 83℃; Temperature;	76.38%
With ethanesulfonic acid; 1,2-dichloro-ethane

: 80-62-6
methacrylic acid methyl ester

A: 50-00-0
formaldehyd

B: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With dihydrogen peroxide; acetic acid at 24.84℃; under 760.051 Torr; Kinetics; Mechanism; UV-irradiation;	A n/a B 76%
With ozone at 20.84℃; under 760 Torr; Kinetics; Darkness;	A 55% B 69%

: 480-96-6
benzofurazan oxide

: 2605-68-7
methyl 2-(triphenylphosphoranylidene)propionate

A: 273-09-6
benzofurazan

B: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
In benzene for 6h; Heating;	A 45% B n/a

...Expand

: 80-62-6
methacrylic acid methyl ester

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With dihydrogen peroxide; triethylamine; chromium(VI) oxide In acetonitrile at 40℃; for 20h; Product distribution; variation of catalyst, reagent, temperature, time;	41%
With dihydrogen peroxide; triethylamine; chromium(VI) oxide In acetonitrile at 40℃; for 20h;	41%
Stage #1: methacrylic acid methyl ester With cis-[Ru(2,9-Me2phen)2(OH2)2](PF6)2 In acetonitrile at 55℃; for 0.5h; Stage #2: With dihydrogen peroxide In acetonitrile for 8h;

: 67-56-1
methanol

: 78-98-8
2-oxopropanal

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With carbon dioxide; 1,3-bis[2,6-di(propan-2-yl)phenyl]-2-methoxyimidazolidine In tetrahydrofuran at 20℃; for 8h; Inert atmosphere; Sealed tube;	10%

: 67-56-1
methanol

: 107-02-8
acrolein

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With selenium(IV) oxide

: 35356-70-8
Methyl 2-acetamidoacrylate

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With hydrogen bromide In chloroform

: 91765-79-6
1,4-Bis-methoxycarbonyl-1,2,3,4-tetramethyl-butadien-1,3

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
(i) O3, MeOH, (ii) H2, Pd-C; Multistep reaction;

: 62163-16-0
silver pyruvate

: 74-88-4
methyl iodide

: 600-22-6
pyruvic acid methyl ester

: 67-56-1
methanol

: 1809-02-5
2-chloro-3-methylbutadiene

A: 600-22-6
pyruvic acid methyl ester

B: 109-87-5
Dimethoxymethane

C: 79-20-9
acetic acid methyl ester

D: 10076-48-9
methyl 2,2-dimethoxypropionate

E: 80-62-6
methacrylic acid methyl ester

F: 108365-85-1
2-Chlor-3,3-dimethoxy-1-buten

Conditions

Conditions	Yield
With ozone at -78℃; Product distribution; mono- and diozonolysies; with and without work up with DMS;	A n/a B n/a C 35 % Spectr. D 47 % Spectr. E 7 % Spectr. F 93 % Spectr.

...Expand

: 67-56-1
methanol

: 108365-81-7
(2-Chlor-1-methoxy-1-methyl-2-propenyl)hydroperoxide

A: 600-22-6
pyruvic acid methyl ester

B: 109-87-5
Dimethoxymethane

C: 79-20-9
acetic acid methyl ester

D: 10027-72-2
methoxymethyl hydroperoxide

E: 64-19-7
acetic acid

F: 108365-82-8
methyl α-hydroperoxy-α-methoxypropionate

Conditions

Conditions	Yield
With ozone In 1,1,2,2-tetrachloroethylene at -50℃; Product distribution; ozonolysis;

...Expand

: 5445-17-0
Methyl 2-bromopropionate

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With 4-(dimethylamino)pyridine N-oxide In acetonitrile for 0.333333h; Heating;	90 % Chromat.

: 56410-68-5
3-chloro-DL-alanine methyl ester

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With H2O In water at 25℃; Rate constant; Thermodynamic data; Kinetics; E(act.), ΔH(act.), ΔS(act.); with or without pyridoxal methochloride;

: 7001-18-5
methyl 2-methoxyacrylate

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With perchloric acid at 25℃; Rate constant;

: 96204-70-5
C10H14O10

A: 600-22-6
pyruvic acid methyl ester

B: 547-64-8
methyl lactate

C: 124-38-9
carbon dioxide

Conditions

Conditions	Yield
In benzene at 55℃; Rate constant; Product distribution; oth. temperature. oth. solvent;

...Expand

: 105949-86-8
3-carbomethoxy-3-methyl-1,2,4-trioxolane

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With dimethylsulfide In chloroform-d1 Yield given;

: 431-03-8
dimethylglyoxal

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With (η5-C5H4SiMe3)2NbH(O)C=CPh2 at 25℃;

: 67-56-1
methanol

: 80-62-6
methacrylic acid methyl ester

A: 600-22-6
pyruvic acid methyl ester

B: 4461-52-3
methoxymethanol

C: 10027-72-2
methoxymethyl hydroperoxide

D: 105949-86-8
3-carbomethoxy-3-methyl-1,2,4-trioxolane

E: 108365-82-8
methyl α-hydroperoxy-α-methoxypropionate

Conditions

Conditions	Yield
With ozone at -78℃; Product distribution; ozonolysis;

...Expand

: 328-42-7
Oxalacetic acid

: 74-88-4
methyl iodide

A: 600-22-6
pyruvic acid methyl ester

B: 63921-06-2
3-methyl-2-oxo-butane-1,4-dioic acid dimethyl ester

Conditions

Conditions	Yield
Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 67-56-1
methanol

: 127-17-3
2-oxo-propionic acid

A: 600-22-6
pyruvic acid methyl ester

B: 10076-48-9
methyl 2,2-dimethoxypropionate

Conditions

Conditions	Yield
With chloro-trimethyl-silane; 2,2-dimethoxy-propane for 24h; Ambient temperature;	A 71 % Chromat. B 29 % Chromat.

...Expand

: 547-63-7
Methyl isobutyrate

A: 600-22-6
pyruvic acid methyl ester

B: 67-64-1
acetone

Conditions

Conditions	Yield
With hydroxide at 23.85℃; under 760 Torr; Kinetics; Oxidation;

: 74-88-4
methyl iodide

silver salt of/the/ pyruvic acid: silver salt of/the/ pyruvic acid

: 600-22-6
pyruvic acid methyl ester

: 53358-15-9
cis-form of γ-methyl-glutaconic acid dimethyl ester

: 10028-15-6
ozone

: 600-22-6
pyruvic acid methyl ester

: 547-64-8
methyl lactate

air: air

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
in der Waerme am Licht;

: 547-64-8
methyl lactate

oxygen: oxygen

vanadium pentoxide: vanadium pentoxide

: 600-22-6
pyruvic acid methyl ester

...Expand

: 554-12-1
propanoic acid methyl ester

A: 600-22-6
pyruvic acid methyl ester

B: 922-68-9
Methyl glyoxylate

C: 10500-31-9
Propionic formic anhydride

D: 802294-64-0
propionic acid

Conditions

Conditions	Yield
With air; Propanil at 22.85℃; under 740 Torr; Kinetics; Oxidation;	A 0.289 mol B 0.111 mol C 0.099 mol D 0.139 mol

...Expand

: 5634-53-7
methyl pyruvate oxime

: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With hydroxylamine In 1,4-dioxane; water at 30℃; pH=6.75; Equilibrium constant;

: 80-62-6
methacrylic acid methyl ester

A: 58653-97-7
methyl 2-methyl-2-oxiranecarboxylate

B: 600-22-6
pyruvic acid methyl ester

Conditions

Conditions	Yield
With Nitrogen dioxide; ozone at 250℃; for 4.44444E-06h; gas phase;	A 88 % Spectr. B n/a

: 600-22-6
pyruvic acid methyl ester

: 547-64-8
methyl lactate

Conditions

Conditions	Yield
With magnesium(II) perchlorate; polymer-bound NADH (2a) In acetonitrile; benzene at 80℃; for 120h; Further byproducts given;	100%
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium hydrogencarbonate In methanol at 25℃; under 7500.75 Torr; for 12h; Glovebox; Autoclave; chemoselective reaction;	98%
With hydrogen; Et4N	91%

: 600-22-6
pyruvic acid methyl ester

: 63584-41-8
1-ethylthio-1-(trimethylsiloxy)ethene

: 127658-10-0
(S)-ethyl 3-hydroxy-3-methoxycarbonylbutanethioate

Conditions

Conditions	Yield
With hydrogenchloride; (S,S)-Cu(II) complex from bis(oxazolinyl) ligand and Cu(OTf)2 In tetrahydrofuran at -78℃;	100%

: 600-22-6
pyruvic acid methyl ester

: 17392-83-5
(R)-Methyl lactate

Conditions

Conditions	Yield
With hydrogen; Cinchonidin; polyvinylpyrrolidone-stabilized platinum clusters In acetic acid at 25℃; under 30002.4 Torr; for 0.5h;	100%
With hydrogen; butan-1-ol; PVP-Pt; Cinchonidin In acetic acid at 24.85℃; under 30002.4 Torr; for 0.5h;
Stage #1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-N-diphenylphosphino-N-methyl-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine In tetrahydrofuran at 25℃; for 0.25h; Stage #2: pyruvic acid methyl ester With hydrogen In tetrahydrofuran under 1277.21 - 1794.37 Torr; for 6h; Product distribution / selectivity;	n/a

: 600-22-6
pyruvic acid methyl ester

: 507989-55-1
4,4-bis(benzyloxycarbonyl)-1,7-dimethylhepta-1,6-diyne

: C29H30O7

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In dichloromethane at 20℃; for 0.166667h;	100%

: 600-22-6
pyruvic acid methyl ester

: (2-chloro-5-methyl-phenyl)-hydrazine

: 187607-97-2
methyl pyruvate 2-chloro-5-methylphenylhydrazone

Conditions

Conditions	Yield
In benzene	100%

: 600-22-6
pyruvic acid methyl ester

: 27871-49-4
(S)-Methyl lactate

Conditions

Conditions	Yield
With hydrogen; Cinchonin In acetic acid at 25℃; under 7500.75 Torr; for 12h; enantioselective reaction;	99.8%

: 600-22-6
pyruvic acid methyl ester

: 41978-94-3
2-methoxy-4-nitrophenylhydrazine

: (E)-2-[(2-methoxy-4-nitrophenyl)hydrazono]propionic acid methyl ester

Conditions

Conditions	Yield
With sodium acetate In methanol at 20℃; for 18h;	99%

: 603-76-9
1-methylindole

: 600-22-6
pyruvic acid methyl ester

: methyl 2,2-bis(1-methyl-1H-indol-3-yl)propanoate

Conditions

Conditions	Yield
With (S)-[1,1']-binaphthalenyl-2,2'-diol; titanium(IV) isopropylate In diethyl ether; toluene at -20℃; for 60h; Friedel-Crafts reaction;	99%

: 600-22-6
pyruvic acid methyl ester

: 519168-62-8
2-(1-allyl-2-oxoindolin-3-ylidene)malononitrile

: 1370462-66-0
(R)-methyl 1-allyl-2'-amino-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-6'-carboxylate

Conditions

Conditions	Yield
With 1-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)-3-((1R)-(6-methoxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)-methyl)thiourea In diethyl ether at 20℃; for 0.5h; asymmetric Michael cyclization; Molecular sieve; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 600-22-6
pyruvic acid methyl ester

: 1370462-98-8
2-(2-oxo-1-phenylindolin-3-ylidene)malononitrile

: 1370462-64-8
(R)-methyl 2'-amino-3'-cyano-2-oxo-1-phenylspiro[indoline-3,4'-pyran]-6'-carboxylate

Conditions

Conditions	Yield
With 1-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)-3-((1R)-(6-methoxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)-methyl)thiourea In diethyl ether at 20℃; for 3h; asymmetric Michael cyclization; Molecular sieve; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 600-22-6
pyruvic acid methyl ester

: 6623-89-8
2-oxo-2,3-dihydroindolylidenemalononitrile

: 1370462-61-5
(R)-methyl 2'-amino-3'-cyano-2-oxospiro[indoline-3,4'-pyran]-6'-carboxylate

Conditions

Conditions	Yield
With 1-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)-3-((1R)-(6-methoxyquinolin-4-yl)(8-vinylquinuclidin-2-yl)-methyl)thiourea In diethyl ether at 20℃; for 12h; asymmetric Michael cyclization; Molecular sieve; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	99%

: 7521-41-7
2-Aminonicotinaldehyde

: 600-22-6
pyruvic acid methyl ester

: 215523-34-5
1,8-naphthyridine-2-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 20℃; for 16h; Cooling;	99%
With water; sodium hydroxide In ethanol at 0 - 20℃; for 18h;

: 600-22-6
pyruvic acid methyl ester

: 145259-91-2
Benzoic acid (2S,3R,4R,4aS,10aR)-3-acetylamino-2-benzyloxy-6,6,8,8-tetraisopropyl-hexahydro-1,5,7,9-tetraoxa-6,8-disila-benzocycloocten-4-yl ester

: 143836-21-9
Benzyl 2-acetamido-3-O-benzoyl-2-deoxy-4,6-O-<1-(methoxycarbonyl)ethylidene>-α-D-glucopyranoside

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane for 15h; Ambient temperature;	98%

: 600-22-6
pyruvic acid methyl ester

: 62-53-3
aniline

: 26458-36-6
methyl 2-methyl-5-oxo-1-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2-carboxylate

Conditions

Conditions	Yield
In dichloromethane at 20 - 25℃; for 1h; Irradiation;	98%

: 600-22-6
pyruvic acid methyl ester

: 55991-65-6
[1-(4-methoxyphenyl)vinyloxy]trimethylsilane

: 1010691-58-3
(R)-methyl 2-hydroxy-2-methyl-4-oxo-4-(4-methoxy-phenyl)butanoate

Conditions

Conditions	Yield
With (S)-N-[2-[(4S,5R)-4-methyl-5-phenyl-4,5-dihydro-2-oxazolyl]phenyl]-S-methyl-S-phenylsulfoximine; copper(II) bis(trifluoromethanesulfonate) In 2,2,2-trifluoroethanol; toluene at -20℃; for 16h; Mukaiyama reaction; optical yield given as %ee; enantioselective reaction;	98%

: 600-22-6
pyruvic acid methyl ester

: 106-49-0
p-toluidine

: 1333149-53-3
dimethyl 2,6‐dimethyl‐1,2‐dihydroquinoline‐2,4‐dicarboxylate

Conditions

Conditions	Yield
With TiO2 nanoparticles In neat (no solvent) at 80℃; for 1h; Green chemistry;	98%
With iodine In acetonitrile at 50℃; for 12h;	94%
With N-chloro-succinimide; O,O-bis(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl) hydrazine-1,2-bis(carbothioate) In acetonitrile at 60℃; Green chemistry;	92%
With lithium carbonate; magnesium bromide In neat (no solvent) at 60℃; for 1h; regioselective reaction;	78%

: 600-22-6
pyruvic acid methyl ester

: 149-73-5
trimethyl orthoformate

: 10076-48-9
methyl 2,2-dimethoxypropionate

Conditions

Conditions	Yield
With sulfuric acid In methanol for 5h; Heating;	97%
With sulfuric acid In methanol for 4h; Reflux;	77%

: 600-22-6
pyruvic acid methyl ester

: 106-49-0
p-toluidine

: 26458-39-9
2-methyl-4-(4-methyl-anilino)-5-oxo-1-p-tolyl-2,5-dihydro-pyrrole-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
In dichloromethane at 20 - 25℃; for 1h; Irradiation;	97%

: 600-22-6
pyruvic acid methyl ester

: 106-47-8
4-chloro-aniline

: 141214-22-4
methyl 3-(4-chloroanilino)-1-(4-chlorophenyl)-5-methyl-2-oxo-3-pyrroline-5-carboxylate

Conditions

Conditions	Yield
In dichloromethane at 20 - 25℃; for 1h; Irradiation;	97%

: 600-22-6
pyruvic acid methyl ester

: 188120-44-7
(4aR,5R,6S)-6-tert-butyldimethylsilyloxy-4,4a,5,6,7,8-hexahydro-4a,5-dimethyl-2(3H)-naphthalenone

: 7646-85-7
zinc(II) chloride

: 4039-32-1
lithium hexamethyldisilazane

: 194789-70-3
(4R,6R,7R,8S)-8-t-Butyldimethylsilyloxy-4-(1'-hydroxy-1'-methoxycarbonyl)ethyl-6,7-dimethylbicyclo[4,4,0]deca-1-en-3-one

Conditions

Conditions	Yield
In tetrahydrofuran; hexane	97%

...Expand

: 600-22-6
pyruvic acid methyl ester

: 61550-02-5
(furan-2-yloxy)-trimethylsilane

: (1'R,4S)-4-(1'-hydroxy-1'-methoxycarbonylethyl)-5-oxacyclopent-2-enone

Conditions

Conditions	Yield
With 2,2,2-trifluoroethanol; (R)-N-[2-(2,4,6-trimethylbenzyl)aminophenyl]-S-(4-biphenyl)-S-methylsulfoximine; copper(II) bis(trifluoromethanesulfonate) In diethyl ether at 20℃; Vinylogous Mukaiyama-type aldol reaction; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	97%

: 600-22-6
pyruvic acid methyl ester

: 62-53-3
aniline

: 120453-92-1
dimethyl 2‐methyl‐1,2‐dihydroquinoline‐2,4‐dicarboxylate

Conditions

Conditions	Yield
With iodine In acetonitrile at 50℃; for 13h;	97%
With TiO2 nanoparticles In neat (no solvent) at 80℃; for 1.5h; Green chemistry;	97%
With nitric acid In water; acetonitrile at 80℃; Inert atmosphere;	95%

: 600-22-6
pyruvic acid methyl ester

: 873-74-5
4-Aminobenzonitrile

: 1403657-23-7
dimethyl 6-cyano-2-methyl-1,2-dihydroquinoline-2,4-dicarboxylate

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In acetonitrile at 100℃; under 7500.75 Torr; for 10h; Temperature; Time; Microwave irradiation;	97%
With lithium carbonate; magnesium bromide In neat (no solvent) at 90℃; for 5h; regioselective reaction;	94%

: 600-22-6
pyruvic acid methyl ester

: (2E, 2'E)-dimethyl 2,2'-(hydrazine-1,2-diylidene)dipropanoate

Conditions

Conditions	Yield
With carbazic acid In neat (no solvent) at 70℃; for 0.5h; Green chemistry;	97%

: 600-22-6
pyruvic acid methyl ester

: C15H30O2Si

: C19H36O5Si

Conditions

Conditions	Yield
Stage #1: C15H30O2Si With lithium hexamethyldisilazane In tetrahydrofuran at -78 - -45℃; for 2h; Inert atmosphere; Stage #2: pyruvic acid methyl ester In tetrahydrofuran at -45℃; for 1h; Inert atmosphere;	97%

: 600-22-6
pyruvic acid methyl ester

: 106046-48-4
methyl 2-methyl-2-(dimethylphenylsilyl)-3-butenoate

: dimethyl 5-hydroxy-2,5-dimethyl-2-hexedioate

Conditions

Conditions	Yield
With titanium tetrachloride In dichloromethane for 3h; from -78 deg C to RT;	96%

: 600-22-6
pyruvic acid methyl ester

: 121-45-9
phosphorous acid trimethyl ester

: methyl-2-dimethoxyphosphoryl-2-dichlorophosphinoxypropanoate

Conditions

Conditions	Yield
With phosphorus trichloride at 20℃; for 1h;	96%

: 600-22-6
pyruvic acid methyl ester

: 76943-94-7
(Z)-1-(tert-butylthio)-1-trimethylsilyloxyprop-1-ene

: (2S,3S)-tert-butyl 3-hydroxy-3-methoxycarbonyl-2-methylbutanethioate

Conditions

Conditions	Yield
With hydrogenchloride; (S,S)-Cu(II) complex from bis(oxazolinyl) ligand and Cu(OTf)2 In dichloromethane at -78℃;	96%

: 600-22-6
pyruvic acid methyl ester

: 31469-15-5
1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

: dimethyl 3-hydroxy-2,2,3-trimethylbutanedioate

Conditions

Conditions	Yield
[bis(diphenylphosphino)methane]bis(propenyl)Ru(II) In tetrahydrofuran at 65℃; for 20h; Condensation; aldol addition;	96%
Stage #1: pyruvic acid methyl ester; 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene With pentafluorophenylammonium trifluoromethanesulfonimide In toluene at -50 - -45℃; for 1h; Mukaiyama reaction; Inert atmosphere; Stage #2: With hydrogenchloride In methanol; water at 20 - 25℃; for 1h; Mukaiyama reaction; Inert atmosphere;	68%

Methyl pyruvate Specification

The Propanoic acid, 2-oxo-,methyl ester, with the CAS registry number 600-22-6, is also known as 2-Oxopropanoic acid methyl ester. It belongs to the product category of Pyruvic Acid Series. Its EINECS number is 209-987-4. This chemical's molecular formula is C₄H₆O₃ and molecular weight is 102.09. What's more, its systematic name is methyl 2-oxopropanoate. It can be used in organic synthesis. It should be sealed and stored in a cool and dry place.

Physical properties of Propanoic acid, 2-oxo-,methyl ester are: (1)ACD/LogP: -0.48; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.48; (4)ACD/LogD (pH 7.4): -0.48; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 13.01; (8)ACD/KOC (pH 7.4): 13.01; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 43.37 Å²; (13)Index of Refraction: 1.386; (14)Molar Refractivity: 22.38 cm³; (15)Molar Volume: 95.1 cm³; (16)Polarizability: 8.87×10^-24cm³; (17)Surface Tension: 29.1 dyne/cm; (18)Density: 1.072 g/cm³; (19)Flash Point: 39.4 °C; (20)Enthalpy of Vaporization: 37.29 kJ/mol; (21)Boiling Point: 135.5 °C at 760 mmHg; (22)Vapour Pressure: 7.7 mmHg at 25°C.

Preparation: this chemical can be prepared by lactic acid methyl ester at the temperature of 25 °C. This reaction will need reagents NaOBr, HCl and solvents CH₂Cl₂, H₂O with the reaction time of 5 hours. The yield is about 90%.

Propanoic acid, 2-oxo-,methyl ester can be prepared by lactic acid methyl ester at the temperature of 25 °C

Uses of Propanoic acid, 2-oxo-,methyl ester: it can be used to produce 2-piperidin-1-yl-acrylic acid methyl ester. It will need reagent AsCl₃ and solvent diethyl ether with the reaction time of 10 min. The yield is about 73%.

Propanoic acid, 2-oxo-,methyl ester can be used to produce 2-piperidin-1-yl-acrylic acid methyl ester

When you are using this chemical, please be cautious about it as the following:
It is flammable, so you should keep it away from sources of ignition - No smoking. You must not breathe vapour. When using it, you need avoid contact with skin and eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(C(=O)OC)C
(2)Std. InChI: InChI=1S/C4H6O3/c1-3(5)4(6)7-2/h1-2H3
(3)Std. InChIKey: CWKLZLBVOJRSOM-UHFFFAOYSA-N

Product Name

Methyl pyruvate

Synthetic route

Methyl pyruvate Specification

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