N-(tert-Butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine supplier

Name
BOC-HIS(DNP)-OH
EINECS 246-569-0
CAS No. 25024-53-7
Article Data2
CAS DataBase
Density 1.49 g/cm³
Solubility Slightly soluble in water.
Melting Point 98-100 °C (dec.)
Formula C₁₇H₁₉N₅O₈
Boiling Point 663.2 °C at 760 mmHg
Molecular Weight 421.367
Flash Point 354.9 °C
Transport Information
Appearance
Safety 22-24/25
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Histidine,N-carboxy-1-(2,4-dinitrophenyl)-, N-tert-butyl ester, L- (8CI);Boc-His(Dnp)-OH;
PSA 185.09000
LogP 3.64640

Synthetic route

: 61434-84-2
(4R)-thiazolidine-4-carboxamide

: 25024-53-7
Boc-His(Dnp)-OH

: 77897-75-7
Boc-His(DNP)-Tzl-NH2

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 4h;	96%

: 141076-78-0
3-hydroxy-1,2,3-benzotriazin-4(3H)-one ethylammonium salt

: 25024-53-7
Boc-His(Dnp)-OH

: 141076-75-7
Boc-His(τ-Dnp)-NH-Et

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide 1) 0 deg C, 1 h, 2) RT, 2 h;	93%

: 25024-53-7
Boc-His(Dnp)-OH

: 141076-73-5
Boc-His(τ-Dnp)-NH2

Conditions

Conditions	Yield
With 3-hydroxy-1,2,3-benzotriazin-4(3H)-one ammonium salt; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide 1) 0 deg C, 1 h, 2) RT, 2 h;	93%

: 25024-53-7
Boc-His(Dnp)-OH

: L-leucyl-O-benzyl-L-tyrosine benzyl ester hydrochloride

: 226545-68-2
Nα-tert-butoxycarbonyl-Nim-2,4-dinitrophenyl-L-histidyl-L-leucyl-O-benzyl-L-tyrosine benzyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropylamine; isopropyl alcohol In N,N-dimethyl-formamide Ambient temperature;	90%

: 141076-77-9
3-hydroxy-1,2,3-benzotriazin-4(3H)-one methylammonium salt

: 25024-53-7
Boc-His(Dnp)-OH

: 141076-74-6
Boc-His(τ-Dnp)-NH-Me

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide 1) 0 deg C, 1 h, 2) RT, 2 h;	89%

: 5680-79-5
glycine ethyl ester hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: Boc-His(DNP)-Gly-OMe

Conditions

Conditions	Yield
Stage #1: Boc-His(Dnp)-OH With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In dichloromethane for 0.5h; Cooling with ice; Stage #2: glycine ethyl ester hydrochloride With triethylamine In dichloromethane at 20℃; Cooling with ice;	85.4%

: 143122-17-2
(2S,3S)-2-Amino-1-cyclohexyl-5-(pyridin-2-ylsulfanyl)-pentan-3-ol; hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: 139470-37-4
{(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(pyridin-2-ylsulfanyl)-butylcarbamoyl]-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 14h; Ambient temperature;	79%

: 13325-10-5
4-Aminobutanol

: 25024-53-7
Boc-His(Dnp)-OH

: 291779-95-8
4-[Nα-tert-butyloxycarbonyl-NIm(1)-(2,4-dinitrophenyl)-L-histidyl]aminobutan-1-ol

Conditions

Conditions	Yield
With 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.666667h; Substitution;	78%

: 95-95-4
2,4,5-trichlorophenol

: 25024-53-7
Boc-His(Dnp)-OH

: 95485-18-0
Nα-(tert-butyloxycarbonyl)-Nim-(2,4-dinitrophenyl)-L-histidine 2,4,5-trichlorophenyl ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In ethyl acetate at -5℃;	77%

: 150577-70-1
(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexane

: 25024-53-7
Boc-His(Dnp)-OH

: 129765-76-0
N-im-(2,4-dinitrophenyl)-L-histidyl>-(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexan-2-amine

Conditions

Conditions	Yield
With N-ethylmorpholine;; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide for 24h; Ambient temperature;	65.3%

: 62-31-7
dopamine hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: 406728-65-2
N-[Nα-tert-butoxycarbonyl-Nτ-(2,4-dinitrophenyl)-L-histidinyl]dopamine

Conditions

Conditions	Yield
With acetic acid In methanol; dichloromethane; ethyl acetate	56%

: 131372-76-4
-(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: 125399-59-9, 131434-99-6
((1S,2S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionylamino}-3-cyclohexyl-1-hydroxy-propyl)-phosphonic acid dimethyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide	55%

: 16290-26-9
3,4-dihydroxybenzylamine hydrobromide

: 25024-53-7
Boc-His(Dnp)-OH

: 406727-68-2
N-[Nα-tert-Butoxycarbonyl-Nτ-(2,4-dinitrophenyl)-L-histidinyl]-3,4-dihydroxybenzylamine

Conditions

Conditions	Yield
With acetic acid In methanol; dichloromethane; ethyl acetate	40%

: 883566-52-7
2-(4-(triphenylmethylthio)phenyl)acetic acid

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 13734-41-3
t-Boc-L-valine

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 15761-38-3
L-N-Boc-Ala

: 2488-15-5
N-tert-butoxycarbonyl-L-methionine

: 7536-58-5
BOC-L-aspartic acid 4-benzyl ester

: 15260-10-3
N-Boc-O-benzyl-L-threonine

: 2419-94-5
Boc-Glu

: 54613-99-9
Boc-(S)-Lys(2-Cl-Z)-OH

: 47689-67-8
(S)-3-[4-(2-Bromo-benzyloxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionic acid

: 55260-24-7
Nα-t-butoxycarbonyl-Nδ-xanthydryl-L-glutamine

: 25024-53-7
Boc-His(Dnp)-OH

: C130H200N32O39S2

Conditions

Conditions	Yield
Stage #1: 2-(4-(triphenylmethylthio)phenyl)acetic acid With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 1h; Stage #2: With triethylsilane; trifluoroacetic acid In dichloromethane; water Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-leucine; L-N-Boc-Ala; N-tert-butoxycarbonyl-L-methionine; BOC-L-aspartic acid 4-benzyl ester; N-Boc-O-benzyl-L-threonine; Boc-Glu; Boc-(S)-Lys(2-Cl-Z)-OH; (S)-3-[4-(2-Bromo-benzyloxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionic acid; Nα-t-butoxycarbonyl-Nδ-xanthydryl-L-glutamine; Boc-His(Dnp)-OH Further stages;	14%

Yield

Stage #1: 2-(4-(triphenylmethylthio)phenyl)acetic acid With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 1h;
Stage #2: With triethylsilane; trifluoroacetic acid In dichloromethane; water
Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-leucine; L-N-Boc-Ala; N-tert-butoxycarbonyl-L-methionine; BOC-L-aspartic acid 4-benzyl ester; N-Boc-O-benzyl-L-threonine; Boc-Glu; Boc-(S)-Lys(2-Cl-Z)-OH; (S)-3-[4-(2-Bromo-benzyloxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionic acid; Nα-t-butoxycarbonyl-Nδ-xanthydryl-L-glutamine; Boc-His(Dnp)-OH Further stages;

14%

...Expand

: 4530-20-5
BOC-glycine

: 13734-41-3
t-Boc-L-valine

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 15761-38-3
L-N-Boc-Ala

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 15260-10-3
N-Boc-O-benzyl-L-threonine

: 13836-37-8
Boc-Arg(Tos)-OH

: Boc-Thr(benzyl)-PAM dicyclohexylammonium salt

: 23680-31-1
BOC-O-benzyl-L-serine

: 73821-95-1
Boc-Asp(O-cyclohexyl)-OH

: 73821-97-3
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester

: 47689-67-8
(S)-3-[4-(2-Bromo-benzyloxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionic acid

: 42294-52-0
S-<(4-methylphenyl)methyl>-L-cysteine

: 47355-10-2
Nα-tert-butoxycarbonyl-1-formyl-L-tryptophan

: 65420-40-8
(S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid

: 25024-53-7
Boc-His(Dnp)-OH

Boc-Lys(Pg)-OH: Boc-Lys(Pg)-OH

Boc-Gln(Pg)-OH: Boc-Gln(Pg)-OH

CSQFNDTLNVYLTAHNALGSSLHTAGVDLAKSLRIAAKIYSEADEAWRKAIDGLFT: CSQFNDTLNVYLTAHNALGSSLHTAGVDLAKSLRIAAKIYSEADEAWRKAIDGLFT

Conditions

Conditions	Yield
Stage #1: Boc-Thr(benzyl)-PAM dicyclohexylammonium salt With diisopropyl-carbodiimide In dichloromethane for 1h; Stage #2: With trifluoroacetic acid In dichloromethane for 0.0333333h; Stage #3: BOC-glycine; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-leucine; L-N-Boc-Ala; N-tert-butoxycarbonyl-L-phenylalanine; N-Boc-O-benzyl-L-threonine; Boc-Arg(Tos)-OH; BOC-O-benzyl-L-serine; Boc-Asp(O-cyclohexyl)-OH; N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester; (S)-3-[4-(2-Bromo-benzyloxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionic acid; S-<(4-methylphenyl)methyl>-L-cysteine; Nα-tert-butoxycarbonyl-1-formyl-L-tryptophan; (S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid; Boc-His(Dnp)-OH; Boc-Lys(Pg)-OH; Boc-Gln(Pg)-OH Further stages;	10.2%

Yield

Stage #1: Boc-Thr(benzyl)-PAM dicyclohexylammonium salt With diisopropyl-carbodiimide In dichloromethane for 1h;
Stage #2: With trifluoroacetic acid In dichloromethane for 0.0333333h;
Stage #3: BOC-glycine; t-Boc-L-valine; N-(tert-butyloxycarbonyl)-L-isoleucine; N-tert-butoxycarbonyl-L-leucine; L-N-Boc-Ala; N-tert-butoxycarbonyl-L-phenylalanine; N-Boc-O-benzyl-L-threonine; Boc-Arg(Tos)-OH; BOC-O-benzyl-L-serine; Boc-Asp(O-cyclohexyl)-OH; N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester; (S)-3-[4-(2-Bromo-benzyloxycarbonyloxy)-phenyl]-2-tert-butoxycarbonylamino-propionic acid; S-<(4-methylphenyl)methyl>-L-cysteine; Nα-tert-butoxycarbonyl-1-formyl-L-tryptophan; (S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid; Boc-His(Dnp)-OH; Boc-Lys(Pg)-OH; Boc-Gln(Pg)-OH Further stages;

10.2%

...Expand

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 13734-41-3
t-Boc-L-valine

: 13139-15-6
N-tert-butoxycarbonyl-L-leucine

: 15761-38-3
L-N-Boc-Ala

: 13726-85-7
Boc-Gln-OH

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 13836-37-8
Boc-Arg(Tos)-OH

: 2-(decyldisulfanyl)pyridine

: 23680-31-1
BOC-O-benzyl-L-serine

: 122889-11-6, 83792-48-7
O-benzyl-N-Fmoc-L-serine

: 73821-97-3
N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester

: 54613-99-9
Boc-(S)-Lys(2-Cl-Z)-OH

: 25024-53-7
Boc-His(Dnp)-OH

: fmoc-S-4-methoxytrityl-L-cysteine

: C151H256N48O39S

Conditions

Conditions	Yield
Stage #1: Boc-Arg(Tos)-OH With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide for 2h; Stage #2: With piperidine In 1-methyl-pyrrolidin-2-one for 0.5h; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-tert-butoxycarbonyl-L-leucine; L-N-Boc-Ala; Boc-Gln-OH; N-(fluoren-9-ylmethoxycarbonyl)glycine; N-tert-butoxycarbonyl-L-phenylalanine; 2-(decyldisulfanyl)pyridine; BOC-O-benzyl-L-serine; O-benzyl-N-Fmoc-L-serine; N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester; Boc-(S)-Lys(2-Cl-Z)-OH; Boc-His(Dnp)-OH; fmoc-S-4-methoxytrityl-L-cysteine Further stages;	10.2%

Yield

Stage #1: Boc-Arg(Tos)-OH With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate In N,N-dimethyl-formamide for 2h;
Stage #2: With piperidine In 1-methyl-pyrrolidin-2-one for 0.5h;
Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; N-tert-butoxycarbonyl-L-leucine; L-N-Boc-Ala; Boc-Gln-OH; N-(fluoren-9-ylmethoxycarbonyl)glycine; N-tert-butoxycarbonyl-L-phenylalanine; 2-(decyldisulfanyl)pyridine; BOC-O-benzyl-L-serine; O-benzyl-N-Fmoc-L-serine; N-α-tert-butyloxycarbonyl-glutamic acid, γ-cyclohexyl ester; Boc-(S)-Lys(2-Cl-Z)-OH; Boc-His(Dnp)-OH; fmoc-S-4-methoxytrityl-L-cysteine Further stages;

10.2%

...Expand

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 25024-53-7
Boc-His(Dnp)-OH

: 50439-81-1
Boc-His(DNP)-ONSu

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 5℃; for 2.5h;	5.06 g

: 15761-39-4
1-(tert-butoxycarbonyl)-L-proline

: 34622-39-4
(2S)-6-oxopipecolic acid

: 25024-53-7
Boc-His(Dnp)-OH

: 57818-01-6, 57884-93-2, 57884-94-3
<*>Aad-His-Pro-NH2

Conditions

Conditions	Yield
Yield given. Multistep reaction;

...Expand

: 23680-31-1
BOC-O-benzyl-L-serine

: 13139-14-5
Boc-Trp-OH

: 25024-53-7
Boc-His(Dnp)-OH

: 98-79-3
L-Pyroglutamic acid

: 77124-58-4
pGlu-His-Trp-Ser

Conditions

Conditions	Yield
Yield given. Multistep reaction;

...Expand

: 100-02-7
4-nitro-phenol

: 25024-53-7
Boc-His(Dnp)-OH

: 51782-61-7
Nα-(tert-Butyloxycarbonyl)-N(im)-(2,4-dinitrophenyl)-L-histidine p-nitrophenyl ester

Conditions

Conditions	Yield
With pyridine; dicyclohexyl-carbodiimide In tetrahydrofuran for 24h; Ambient temperature;

: 132271-76-2
isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoate*HCl

: 25024-53-7
Boc-His(Dnp)-OH

: (3S,4S)-4-{(S)-2-tert-Butoxycarbonylamino-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionylamino}-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 14h; Ambient temperature;

: 2131-00-2, 3726-98-5, 3726-99-6, 3796-85-8, 94582-52-2
2HCl*H-LeuΨ(CH2NH)Met-NH2

: 25024-53-7
Boc-His(Dnp)-OH

: 136484-03-2
Boc-His(Dnp)-LeuΨ(CH2NH)Met-NH2

Conditions

Conditions	Yield
With 4-methyl-morpholine

: 144800-02-2
p-(bromoacetamido)azobenzene

: 25024-53-7
Boc-His(Dnp)-OH

: (S)-2-tert-Butoxycarbonylamino-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionic acid (4-phenylazo-phenylcarbamoyl)-methyl ester

Conditions

Conditions	Yield
With 15-crown-5; sodium methylate In methanol; N,N-dimethyl-formamide at 50℃; for 0.5h;

: (2R,3S)-3-Amino-4-cyclohexyl-1-(pyridin-2-yloxy)-butan-2-ol; hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: {(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(pyridin-2-yloxy)-propylcarbamoyl]-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 14h; Ambient temperature;

: (2R,3S)-3-Amino-4-cyclohexyl-1-(pyridin-2-ylsulfanyl)-butan-2-ol; hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: {(S)-1-[(1S,2R)-1-Cyclohexylmethyl-2-hydroxy-3-(pyridin-2-ylsulfanyl)-propylcarbamoyl]-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 14h; Ambient temperature;

: (2S,3S)-2-Amino-1-cyclohexyl-5-(pyridin-2-yloxy)-pentan-3-ol; hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: {(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(pyridin-2-yloxy)-butylcarbamoyl]-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 14h; Ambient temperature;

: (2S,3S)-2-Amino-1-cyclohexyl-6-(pyridin-2-ylsulfanyl)-hexan-3-ol; hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: {(S)-1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-5-(pyridin-2-ylsulfanyl)-pentylcarbamoyl]-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 14h; Ambient temperature;

: (3S,4S)-4-Amino-5-cyclohexyl-3-hydroxy-pentanoic acid phenylamide; hydrochloride

: 25024-53-7
Boc-His(Dnp)-OH

: {(S)-1-((1S,2S)-1-Cyclohexylmethyl-2-hydroxy-3-phenylcarbamoyl-propylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 14h; Ambient temperature;

: Leu-Cys(Dpm)-Gly-OMe*Trifluoracetat

: 25024-53-7
Boc-His(Dnp)-OH

: Boc-His(Dnp)-Leu-Cys(Dpm)-Gly-OMe

Conditions

Conditions	Yield
With 4-methyl-morpholine; isobutyl chloroformate 1) THF, -30 to -15 degC, 12 min; 2) THF, -30 degC, 1 h; room temp., overnight; Yield given. Multistep reaction;

: 25024-53-7
Boc-His(Dnp)-OH

: 543-27-1
isobutyl chloroformate

: C22H27N5O10

Conditions

Conditions	Yield
With 4-methyl-morpholine In ethyl acetate at -23℃; for 0.5h;

N-(tert-Butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine Chemical Properties

IUPAC Name:(2S)-3-[1-(2,4-dinitrophenyl)imidazol-4-yl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
Molecular Formula:C₁₇H₁₉N₅O₈
Molecular Weight:421.36146 g/mol
Density:1.49 g/cm³
Melting Point:98-100 °C(dec.)
Boiling Point:663.2°C at 760 mmHg
Flash Point:354.9 °C
storage temp.:-20°C
EINECS:246-569-0
Synonyms of Boc-L-His(Dnp)-OH(25024-53-7):
N-ALPHA-BOC-NIM-DINITROPHENYL-L-HISTIDINE;N-ALPHA-BOC-NIM-2,4-DINITROPHENYL-L-HISTIDINE;N-ALPHA-T-BOC-N-IM-2,4-DINITROPHENYL-L-HISTIDINE;N-ALPHA-T-BOC-N-IM-DINITROPHENYL-L-HISTIDINE;TBOC-L-HISTIDINE (DNP);n-[(1,1-dimethylethoxy)carbonyl]-1-(2,4-dinitrophenyl)-l-histidin;BOC-HIS(DNP)-OH;BOC-L-DINITROPHENYL HISTIDINE;BOC-HIS(DNP)-OH
Categories of Boc-L-His(Dnp)-OH(25024-53-7):
Amino Acid Derivatives;Amino Acids;Histidine [His, H];Boc-Amino Acids and Derivative;Boc-Amino acid series

N-(tert-Butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine Uses

Boc-L-His(Dnp)-OH(25024-53-7) is used as a pharmaceutical intermediate.

N-(tert-Butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine Safety Profile

Safety Information of Boc-L-His(Dnp)-OH(25024-53-7):
Safety Statements:22-24/25
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
WGK Germany:3
F:8

Product Name

BOC-HIS(DNP)-OH

Synthetic route

N-(tert-Butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine Chemical Properties

N-(tert-Butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine Uses

N-(tert-Butoxycarbonyl)-1-(2,4-dinitrophenyl)-L-histidine Safety Profile

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