N-Boc-L-Lysine supplier | CasNO.13734-28-6

Name
N-alpha-(tert-Butoxycarbonyl)-L-lysine
EINECS 237-303-4
CAS No. 13734-28-6
Article Data31
CAS DataBase
Density 1.113 g/cm³
Solubility Soluble in water. Slightly soluble in methanol.
Melting Point ~205 °C
Formula C₁₁H₂₂N₂O₄
Boiling Point 410.5 °C at 760 mmHg
Molecular Weight 246.307
Flash Point 202 °C
Transport Information
Appearance white to off-white powder
Safety 24/25-36-26
Risk Codes 20/21/22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms N2-((1,1-Dimethylethoxy)carbonyl)-L-lysine;Boc-Lys-OH;(2S)-6-azaniumyl-2-(tert-butoxycarbonylamino)hexanoate;Boc-L-Lys-OH;N-tert-Butoxycarbonyl lysine;N-α-Boc-L-lysine;N-a-(tert.-butoxycarbonyl)-L-lysine;
PSA 101.65000
LogP 2.18450

Synthetic route

: 2389-45-9
Boc-Lys(Z)-OH

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol for 0.0833333h; Ambient temperature;	95%
With magnesium; hydrazinium monoformate In methanol at 25℃; for 0.5h;	95%
With palladium on carbon; hydrogen In ethanol at 20℃; under 2172.08 Torr; for 0.5h; Inert atmosphere;	78%

: 54613-99-9
Boc-(S)-Lys(2-Cl-Z)-OH

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With ammonium formate; palladium on activated charcoal In methanol at 20℃; for 0.166667h; Hydrogenolysis;	95%
With magnesium; hydrazinium monoformate In methanol at 25℃; for 1.5h;	94%
With hydrogen; palladium on activated charcoal In acetic acid at 20℃;

: 56-87-1
L-lysine

: 24424-99-5
di-tert-butyl dicarbonate

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With triethylamine In water; acetone at 25℃; for 4.5h;	90%
With sodium hydrogencarbonate In water at 25℃; for 13h;	89.5%
With sodium hydroxide In isopropyl alcohol Ambient temperature;	76.5%

: 13734-29-7
Nα-tert-butoxycarbonyl-Nε-tosyl-L-lysine

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With 3-(4,8-dimethoxy-1-naphthyl)-propionic acid; ascorbic acid In ethanol for 2h; Irradiation;	79%

: 77236-13-6
N-α-tert-Butyloxycarbonyl-N-ε-carbobenzoxy-L-lysine benzyl ester

A: 2389-45-9
Boc-Lys(Z)-OH

B: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With bis(tri-n-butyltin)oxide In toluene at 70℃; for 36h;	A 60% B 10%

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 1155-64-2
N6-[(benzyloxy)carbonyl]-L-lysine

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
(i) aq. NaOH, dioxane, (ii) H2, Pd-C, aq. MeOH; Multistep reaction;

: 84624-27-1
Boc-Lys(Fmoc)-OH

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With piperidine; N,N-dimethyl-formamide for 0.05h;

: 104669-73-0
Nα-(tert-butoxycarbonyl)-Nε-(allyloxycarbonyl)-L-lysine

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride; bis-triphenylphosphine-palladium(II) chloride In dichloromethane Ambient temperature;	95 % Spectr.

: 78981-72-3
α-<(tert-butyloxycarbonyl)lysyl>amido>benzyloxycarbonyl>-p'-nitroanilide

A: 124-38-9
carbon dioxide

B: 623-04-1
4-aminobenzenemethanol

C: 13734-28-6
Boc-Lys-OH

D: 100-01-6
4-nitro-aniline

Conditions

Conditions	Yield
In water at 25℃; Product distribution; trypsin;

...Expand

Boc-Lys(Z)-OResin: Boc-Lys(Z)-OResin

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With cyclohexa-1,4-diene; palladium diacetate In N,N-dimethyl-formamide at 30 - 40℃; for 3h; Yield given;

: C6H5N3*2C11H22N2O4

A: 95-14-7
1,2,3-Benzotriazole

B: 2418-95-3
(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid

C: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
at 140℃; under 0.225023 Torr; for 3h; Product distribution / selectivity;

...Expand

: 56-87-1
L-lysine

: 34619-03-9
tert-butyldicarbonate

A: 2418-95-3
(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid

B: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With sodium hydroxide; dmap In tetrahydrofuran; water at 0℃; pH=12; Product distribution / selectivity;

...Expand

: 24424-99-5
di-tert-butyl dicarbonate

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1N NaOH 2: 79 percent / ascorbic acid, 3-(4,8-dimethoxy-1-naphthyl)-propionic acid / aq. ethanol / 2 h / Irradiation View Scheme
Multi-step reaction with 2 steps 1: 89 percent / aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature 2: H2 / 5percent Pd/C / methanol; H2O / 24 h / 2585.7 Torr View Scheme
Multi-step reaction with 9 steps 1: chloro-trimethyl-silane / 14 h / 0 - 20 °C / Inert atmosphere 2: dmap / acetonitrile / 14 h / 20 °C 3: diisobutylaluminium hydride / diethyl ether / 0.83 h / -78 °C 4: methanol; sodium tetrahydroborate / 0.75 h / 0 °C 5: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 20 °C 6: N,N-dimethyl-formamide / 16 h / 20 °C 7: trifluoroacetic acid / dichloromethane / 0 °C 8: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C 9: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

: 2130-76-9
(S)-2-amino-6-(4-methylphenylsulfonamido)hexanoic acid

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1N NaOH 2: 79 percent / ascorbic acid, 3-(4,8-dimethoxy-1-naphthyl)-propionic acid / aq. ethanol / 2 h / Irradiation View Scheme

: 1155-64-2
N6-[(benzyloxy)carbonyl]-L-lysine

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 89 percent / aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature 2: H2 / 5percent Pd/C / methanol; H2O / 24 h / 2585.7 Torr View Scheme

: 227006-27-1
Boc-L-Lys-OGp

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With Bacillus cereus recombinant His-tagged alkaline D-peptidase; water; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid In N,N-dimethyl-formamide at 30℃; pH=8.0; Reactivity; Enzymatic reaction;

: 56-86-0
L-glutamic acid

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1: chloro-trimethyl-silane / 14 h / 0 - 20 °C / Inert atmosphere 2: dmap / acetonitrile / 14 h / 20 °C 3: diisobutylaluminium hydride / diethyl ether / 0.83 h / -78 °C 4: methanol; sodium tetrahydroborate / 0.75 h / 0 °C 5: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 20 °C 6: N,N-dimethyl-formamide / 16 h / 20 °C 7: trifluoroacetic acid / dichloromethane / 0 °C 8: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C 9: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

Yield

Multi-step reaction with 9 steps
1: chloro-trimethyl-silane / 14 h / 0 - 20 °C / Inert atmosphere
2: dmap / acetonitrile / 14 h / 20 °C
3: diisobutylaluminium hydride / diethyl ether / 0.83 h / -78 °C
4: methanol; sodium tetrahydroborate / 0.75 h / 0 °C
5: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 20 °C
6: N,N-dimethyl-formamide / 16 h / 20 °C
7: trifluoroacetic acid / dichloromethane / 0 °C
8: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C
9: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr
View Scheme

: 59279-60-6, 130622-05-8
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: dmap / acetonitrile / 14 h / 20 °C 2: diisobutylaluminium hydride / diethyl ether / 0.83 h / -78 °C 3: methanol; sodium tetrahydroborate / 0.75 h / 0 °C 4: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 20 °C 5: N,N-dimethyl-formamide / 16 h / 20 °C 6: trifluoroacetic acid / dichloromethane / 0 °C 7: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C 8: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

Yield

Multi-step reaction with 8 steps
1: dmap / acetonitrile / 14 h / 20 °C
2: diisobutylaluminium hydride / diethyl ether / 0.83 h / -78 °C
3: methanol; sodium tetrahydroborate / 0.75 h / 0 °C
4: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 20 °C
5: N,N-dimethyl-formamide / 16 h / 20 °C
6: trifluoroacetic acid / dichloromethane / 0 °C
7: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C
8: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr
View Scheme

: 206128-03-2
(S)-dimethyl 2-(bis(tert-butoxycarbonyl)amino)pentanedioate

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: diisobutylaluminium hydride / diethyl ether / 0.83 h / -78 °C 2: methanol; sodium tetrahydroborate / 0.75 h / 0 °C 3: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 20 °C 4: N,N-dimethyl-formamide / 16 h / 20 °C 5: trifluoroacetic acid / dichloromethane / 0 °C 6: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C 7: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

Yield

Multi-step reaction with 7 steps
1: diisobutylaluminium hydride / diethyl ether / 0.83 h / -78 °C
2: methanol; sodium tetrahydroborate / 0.75 h / 0 °C
3: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 20 °C
4: N,N-dimethyl-formamide / 16 h / 20 °C
5: trifluoroacetic acid / dichloromethane / 0 °C
6: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C
7: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr
View Scheme

: 192314-71-9
methyl (S)-2-N,N-di(tert-butoxycarbonyl)amino-5-oxopentanoate

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: methanol; sodium tetrahydroborate / 0.75 h / 0 °C 2: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 20 °C 3: N,N-dimethyl-formamide / 16 h / 20 °C 4: trifluoroacetic acid / dichloromethane / 0 °C 5: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C 6: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

: 367968-06-7
methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}-5-hydroxypentanoate

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: triphenylphosphine; 1H-imidazole; iodine / tetrahydrofuran / 20 °C 2: N,N-dimethyl-formamide / 16 h / 20 °C 3: trifluoroacetic acid / dichloromethane / 0 °C 4: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C 5: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

: methyl (2S)-2-{(tert-butoxy)-N-[(tert-butyl)oxycarbonyl]carbonylamino}-5-iodopentanoate

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: N,N-dimethyl-formamide / 16 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 0 °C 3: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C 4: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

: (S)-methyl 2-bis(tert-butoxycarbonyl)amino-5-cyanopentanoate

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: trifluoroacetic acid / dichloromethane / 0 °C 2: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C 3: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

: (S)-methyl 2-tert-butoxycarbonylamino-5-cyanopentanoate

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: lithium hydroxide / 1,4-dioxane; water / 3 h / 20 °C 2: platinum(IV) oxide; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr View Scheme

: 291758-39-9
(S)-2-tert-butoxycarbonylamino-5-cyanopentanoic acid

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With platinum(IV) oxide; hydrogen In methanol at 20℃; under 760.051 Torr; for 16h;

: 6404-26-8
(S)-6-acetamido-2-((tertbutoxycarbonyl)amino)hexanoic acid

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine; trichlorophosphate / tetrahydrofuran / 3 h / Cooling with ice 2: C73H93N15O19S2 / aq. phosphate buffer / 1 h / 30 °C / Enzymatic reaction 3: trypsin; water / aq. phosphate buffer / 1 h / 30 °C / Enzymatic reaction View Scheme

: 233691-67-3
N-(4-methyl-7-coumarinyl)-N-α-(tert-butyloxycarbonyl)-N-ω-acetyl-lysinamide

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: C73H93N15O19S2 / aq. phosphate buffer / 1 h / 30 °C / Enzymatic reaction 2: trypsin; water / aq. phosphate buffer / 1 h / 30 °C / Enzymatic reaction View Scheme

: N-(4-methyl-7-coumarinyl)-N-α-(tert-butyloxycarbonyl)-lysinamide

: 13734-28-6
Boc-Lys-OH

Conditions

Conditions	Yield
With water; trypsin In aq. phosphate buffer at 30℃; for 1h; Enzymatic reaction;

: 13734-28-6
Boc-Lys-OH

: 614-68-6
2-tolyl isocyanate

: 131451-45-1
2-(S)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexanoic acid

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethyl acetate; N,N-dimethyl-formamide for 4h; Ambient temperature;	100%
With sodium hydroxide for 3h; Ambient temperature;	94%
With sodium hydroxide for 15h;	92%
In N,N-dimethyl-formamide Addition;	60%
With sodium hydroxide In 1,4-dioxane; water at 0 - 20℃;	1.2 g

: 50-00-0
formaldehyd

: 13734-28-6
Boc-Lys-OH

: 65671-53-6
N-boc dimethyl-L-lysine

Conditions

Conditions	Yield
With hydrogen; palladium 10% on activated carbon In water at 25℃; under 2585.81 Torr; for 96h;	100%
Stage #1: formaldehyd; Boc-Lys-OH In ethanol; water at 0℃; for 0.166667h; Stage #2: With sodium cyanoborohydride In ethanol; water at 20℃; for 12h;	71%

: 1517-05-1
2-azidoethanol

: 32315-10-9
bis(trichloromethyl) carbonate

: 13734-28-6
Boc-Lys-OH

: 1167421-24-0
(S)-15-azido-2,2-dimethyl-4,12-dioxo-3,13-dioxa-5,11-diazapentadecane-6-carboxylic acis

Conditions

Conditions	Yield
With hydrogenchloride; NaOH In tetrahydrofuran	100%

...Expand

: 13734-28-6
Boc-Lys-OH

: 172611-72-2
2-(1-hydroxy-3-methylbutylidene)-5,5-dimethylcyclohexane-1,3-dione

: 862847-44-7
C24H40N2O6

Conditions

Conditions	Yield
With triethylamine In ethanol Reflux;	100%

: bis(2,5-dioxopyrrolidine-1-yl) 5-(3-(3-oxo-1-phenyl-2,7,10-trioxa-4-azadodecane-12-yl)ureido)isophthalate

: 13734-28-6
Boc-Lys-OH

: (2S,2'S)-6,6'-((5-(3-(3-oxo-1-phenyl-2,7,10-trioxa-4-azadodecane-12-yl)ureido)isophthaloyl)bis(azanediyl))bis(2-((tert-butoxycarbonyl)mino)hexanoic acid)

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 10h;	100%

: 75-77-4
chloro-trimethyl-silane

: 13734-28-6
Boc-Lys-OH

: 89106-11-6
C17H38N2O4Si2

Conditions

Conditions	Yield
With triethylamine In benzene Ambient temperature;	99%
With triethylamine In benzene Ambient temperature;	99%
With triethylamine In dichloromethane at 60℃;

: 70-34-8
2,4-Dinitrofluorobenzene

: 13734-28-6
Boc-Lys-OH

: 6-((2,4-dinitrophenyl)amino)-(2S)-2-(((1,1-dimethylmethoxy)carbonyl)amino)hexanoic acid

Conditions

Conditions	Yield
In acetonitrile at 90℃; for 6h;	99%
With phosphate buffer In water at 40℃; for 2h; pH=6.9; Arylation;

: 67-56-1
methanol

: 13734-28-6
Boc-Lys-OH

: 13515-95-2, 15445-34-8, 26348-70-9, 34015-48-0, 67396-08-1, 130336-19-5
lysine methyl ester dihydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 20℃; for 24h; Schlenk technique; Inert atmosphere;	99%

: 13734-28-6
Boc-Lys-OH

: 51513-74-7
Boc3(K-ε-K)-OSu

: 51513-75-8
(10S,17S,24S)-10,17,24-tris((tert-butoxycarbonyl)amino)-2,2-dimethyl-4,11,18-trioxo-3-oxa-5,12,19-triazapentacosan-25-oic acid

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 20℃; for 72h;	98.56%

: 13734-28-6
Boc-Lys-OH

: dicyclohexylammonium N-tert-butyloxycarbonyl-2-amino-6-azidohexanoate

Conditions

Conditions	Yield
With copper(ll) sulfate pentahydrate; triflic azide; potassium carbonate In methanol; water at 20℃; pH=9.5;	98%
With benzotriazol-1-yl-sulfonyl azide; triethylamine In water; acetonitrile at 20℃; for 6h;	63%
With triflic azide; potassium carbonate; copper(II) sulfate In methanol; dichloromethane	50%

: 13734-28-6
Boc-Lys-OH

: 75141-72-9
N-hydroxysuccinimidyl (2S)-3-(tert-butoxy)-2-(tert-butoxycarbonylamino)-propanoate

: (2S)-2-(tert-butoxycarbonylamino)-6-((2S)-3-(tert-butoxy)-2-(tert-butoxycarbonylamino)-propanamido)-hexanoic acid

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h;	98%

: N-hydroxysuccinimidyl (2R,3S)-3-(tert-butoxy)-2-(tert-butoxycarbonyl-amino)-butanoate

: 13734-28-6
Boc-Lys-OH

: (2S)-2-(tert-butoxycarbonylamino)-6-((2R,3S)-3-(tert-butoxy)-2-(tert-butoxycarbonylamino)-butanamido)-hexanoic acid

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h;	97%

: 2148-14-3
9-phenoxyacridine

: 13734-28-6
Boc-Lys-OH

: 153647-47-3
Nα-Boc Nε-acridin-9-yl lysine

Conditions

Conditions	Yield
In methanol for 16h;	96%

: 13734-28-6
Boc-Lys-OH

: 78269-85-9
carbonic acid 2,5-dioxo-pyrrolidin-1-yl ester 2-(trimethylsilanyl)-ethyl ester

: 85167-76-6
Nα-(tert-butyloxycarbonyl)-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water Ambient temperature;	96%

: 3397-62-4
2-Chloro-4,6-diamino-1,3,5-triazine

: 13734-28-6
Boc-Lys-OH

: 1354418-23-7
(S)-2-((tert-butoxycarbonyl)amino)-6-((4,6-diamino-1,3,5-triazin-2-yl)amino)hexanoic acid

Conditions

Conditions	Yield
Stage #1: 2-Chloro-4,6-diamino-1,3,5-triazine; Boc-Lys-OH With sodium hydroxide In water at 85℃; Stage #2: With hydrogenchloride In water at 0℃; pH=5;	95%

: 79-03-8
propionyl chloride

: 13734-28-6
Boc-Lys-OH

: 1416785-82-4
N2-(tert-butoxycarbonyl)-N6-propionyl-L-lysine

Conditions

Conditions	Yield
With triethylamine In methanol for 2h;	95%
Stage #1: Boc-Lys-OH With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 0.05h; Sonication; Stage #2: propionyl chloride In tetrahydrofuran at 20℃; for 1h;	73%
With sodium hydroxide In tetrahydrofuran; water at 20℃; Cooling with ice; Inert atmosphere;

: 2,5-dioxopyrrolidin-1-yl (2-(3-methyl-3H-diazirin-3-yl)ethyl) carbonate

: 13734-28-6
Boc-Lys-OH

: 2-((tert-butoxycarbonyl)amino)-6-(((2-(3-methyl-3H-diazirin-3-yl)ethoxy)carbonyl)amino)hexanoic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 30h; Inert atmosphere;	95%

: N-succinimidyl 4-(4’-iodophenyl)butanoate

: 13734-28-6
Boc-Lys-OH

: C16H23IN2O3*ClH

Conditions

Conditions	Yield
Stage #1: N-succinimidyl 4-(4’-iodophenyl)butanoate; Boc-Lys-OH With sodium hydrogencarbonate In tetrahydrofuran; water at 25℃; for 0.25h; Stage #2: With trifluoroacetic acid In dichloromethane at 25℃; for 0.25h;	95%

: 30189-36-7
N,N'-di-t-butyloxycarbonyl-(S)-lysine N-hydroxysuccinimide ester

: 13734-28-6
Boc-Lys-OH

: 51513-72-5
(S)-6-((S)-2,6-bis((tert-butoxycarbonyl)amino)hexanamido)-2-((tert-butoxycarbonyl)amino)hexanoic acid

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 20℃; for 72h;	93.91%
In tetrahydrofuran; water at 20℃; for 2h;	79%
In tetrahydrofuran; water at 20℃; for 2h;	79%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 13734-28-6
Boc-Lys-OH

: 84624-27-1
Boc-Lys(Fmoc)-OH

Conditions

Conditions	Yield
With sodium hydrogencarbonate In 1,4-dioxane; water for 16h;	93%

: 13734-28-6
Boc-Lys-OH

: 80149-80-0
2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate

: 85167-76-6
Nα-(tert-butyloxycarbonyl)-Nε-<<2-(trimethylsilyl)ethoxy>carbonyl>-L-lysine

Conditions

Conditions	Yield
With sodium carbonate for 48h; Ambient temperature;	93%

: benzo[h]quinolin-2-ylmethyl(2,5-dioxopyrrolidin-1-yl)carbonate

: 13734-28-6
Boc-Lys-OH

: (S)-6-(((benzo[h]quinolin-2-ylmethoxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;	93%

: 24424-99-5
di-tert-butyl dicarbonate

: 13734-28-6
Boc-Lys-OH

: 2483-46-7
Boc-Lys(Boc)-OH

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane; water for 18h; Cooling with ice;	93%

: 870-73-5
ethyl dithioacetate

: 13734-28-6
Boc-Lys-OH

: 1125843-10-8
N2-(tert-butoxycarbonyl)-N6-ethanethioyl-L-lysine

Conditions

Conditions	Yield
With sodium carbonate In ethanol	92.4%
With sodium carbonate In ethanol; water at 0 - 20℃; for 4h;	68%
With sodium carbonate In ethanol; water at 20℃; for 12h;

: 13734-28-6
Boc-Lys-OH

: N1-(tert-butyloxycarbonyl)-N6-hydroxy-L-lysine

Conditions

Conditions	Yield
With Oxone; silica gel In water for 0.000277778h; Oxidation; microwave irradiation;	92%

: 35718-08-2
propargyl chloroformate

: 13734-28-6
Boc-Lys-OH

: 1202704-91-3
N2-(tert-butoxycarbonylamino)-N6-[(prop-2-yn-1-yloxy)carbonyl]-L-lysine

Conditions

Conditions	Yield
Stage #1: Boc-Lys-OH With sodium hydrogencarbonate; sodium hydroxide In water Stage #2: propargyl chloroformate In water at 0 - 20℃; Stage #3: With potassium hydrogensulfate In water pH=2 - 3;	92%
With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃; for 10h;	83%
Stage #1: Boc-Lys-OH With sodium hydroxide In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: propargyl chloroformate In tetrahydrofuran at 25℃;	74%
In tetrahydrofuran; NaOH; ethyl acetate
With sodium hydroxide In tetrahydrofuran at 0 - 20℃; for 14.5h;

: 1304056-26-5
(1R,2R)-2-azidocyclopentyl carbonochloridate

: 13734-28-6
Boc-Lys-OH

: 1304056-27-6
(S)-6-(((1R,2R)-2-azidocyclopentyloxy)carbonylamino)-2-(tert-butoxycarbonylamino)hexanoic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water at 0 - 20℃; for 18h;	92%

: C37H21N3O5

: 13734-28-6
Boc-Lys-OH

: C48H41N5O8

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 100℃; for 3h; Inert atmosphere;	92%

N-Boc-L-Lysine Specification

The Boc-Lys-OH, with the CAS registry number 13734-28-6, is also known as N2-((1,1-Dimethylethoxy)carbonyl)-L-lysine. It belongs to the product categories of Amino Acids; Lysine [Lys, K]; Boc-Amino Acids and Derivative; Amino Acids (N-Protected); Biochemistry; Boc-Amino Acids; Boc-Amino Acid Series. Its EINECS registry number is 237-303-4. This chemical's molecular formula is C₁₁H₂₂N₂O₄ and molecular weight is 246.30338. Its IUPAC name is called 6-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid. This chemical is white to off-white powder.

Physical properties of Boc-Lys-OH: (1)ACD/LogP: 0.74; (2)ACD/LogD (pH 5.5): -1.76; (3)ACD/LogD (pH 7.4): -1.76; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 6; (9)#H bond donors: 4; (10)#Freely Rotating Bonds: 9; (11)Index of Refraction: 1.485; (12)Molar Refractivity: 63.4 cm³; (13)Molar Volume: 221.1 cm³; (14)Surface Tension: 42.8 dyne/cm; (15)Density: 1.113 g/cm³; (16)Flash Point: 202 °C; (17)Enthalpy of Vaporization: 72.72 kJ/mol; (18)Boiling Point: 410.5 °C at 760 mmHg; (19)Vapour Pressure: 6.91E-08 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing. Finally, you must avoid contacting it with skin and eyes.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CC(C)(C)OC(=O)NC(CCCCN)C(=O)O
(2)InChI: InChI=1S/C11H22N2O4/c1-11(2,3)17-10(16)13-8(9(14)15)6-4-5-7-12/h8H,4-7,12H2,1-3H3,(H,13,16)(H,14,15)
(3)InChIKey: DQUHYEDEGRNAFO-UHFFFAOYSA-N

Product Name

N-alpha-(tert-Butoxycarbonyl)-L-lysine

Synthetic route

N-Boc-L-Lysine Specification

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