N-Ethylformamide supplier | CasNO.627-45-2

Name
N-ETHYLFORMAMIDE
EINECS
CAS No. 627-45-2
Article Data34
CAS DataBase
Density 0.950 g/mL at 20 °C(lit.)
Solubility
Melting Point -60.43°C (estimate)
Formula C3H7 N O
Boiling Point 202-204 °C
Molecular Weight 73.0947
Flash Point 67°C
Transport Information
Appearance
Safety Moderately toxic by intraperitoneal and possibly other routes. When heated to decomposition it emits toxic vapors of NO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Ethylformamide;N-Ethylformamide; N-Formylethylamine; NSC 404522
PSA 29.10000
LogP 0.77910

Synthetic route

: 75-04-7
ethylamine

: 109-94-4
formic acid ethyl ester

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
for 2h; Ambient temperature;	96%
Heating;

: 64-18-6
formic acid

: 79-24-3
Nitroethane

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With gold nano particles supported on rutile TiO2 In toluene at 70℃; under 750.075 Torr; for 8h; Inert atmosphere; chemoselective reaction;	96%

: 64-18-6
formic acid

: 75-04-7
ethylamine

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With nano-sulfated titania In neat liquid at 20℃; for 0.5h; Green chemistry;	90%
With silica gel for 0.0263889h; microwave irradiation;	70%
for 0.5h; Heating;

: 75-04-7
ethylamine

: 122-51-0
orthoformic acid triethyl ester

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With dioxo[bis(sulfato-κO)]molybdenum In ethanol for 3.33333h; Reflux; Green chemistry;	78%

: 624-79-3
ethyl isocyanide

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With acetic acid

: 1493-02-3
formyl fluoride

: 75-04-7
ethylamine

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With diethyl ether

: 107-31-3
Methyl formate

: 75-04-7
ethylamine

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With water
at 45 - 145℃;

: 75-04-7
ethylamine

: 75-87-6
chloral

A: 67-66-3
chloroform

B: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
Destillation;
durch Destillation;

...Expand

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 75-05-8
acetonitrile

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With nickel at 125 - 145℃; under 100 - 36775.4 Torr; Hydrogenation;

: 624-79-3
ethyl isocyanide

: 64-19-7
acetic acid

A: 627-45-2
N-formylethylamine

B: 108-24-7
acetic anhydride

...Expand

: 75-05-8
acetonitrile

: 109-94-4
formic acid ethyl ester

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With nickel at 125 - 145℃; under 36775.4 - 73550.8 Torr; Hydrogenation;

: 109-90-0
ethyl isocyanate

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With formic acid

: 13162-05-5
n-vinylformamide

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal
With 1,4-diaza-bicyclo[2.2.2]octane; silver tetrafluoroborate; C15H4BClCoF18N6; hydrogen In tetrahydrofuran at 60℃; under 45603.1 Torr; for 10h;	99 %Chromat.

: 29291-84-7
Triformylorthoborat

: 75-04-7
ethylamine

: 627-45-2
N-formylethylamine

: 123-91-1
1,4-dioxane

: 624-79-3
ethyl isocyanide

: 7732-18-5
water

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
at 125℃; under 6251820 Torr;

...Expand

: 75-04-7
ethylamine

carbon monoxide: carbon monoxide

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With sodium ethanolate under 110326 Torr;

ethyl isocyanide hydrochloride: ethyl isocyanide hydrochloride

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With potassium hydroxide

formate ethylamine: formate ethylamine

: 627-45-2
N-formylethylamine

: ethyl isocyanide; trihydrochloride

KOH-solution: KOH-solution

A: 64-18-6
formic acid

B: 627-45-2
N-formylethylamine

C: 624-79-3
ethyl isocyanide

D: 75-04-7
ethylamine

...Expand

: 617-84-5
N-formyldiethylamine

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With microsomal P450 In water Enzyme kinetics; Further Variations:; Catalysts; deethylation;

: 75-04-7
ethylamine

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
In methanol

: 108-03-2
1-Nitropropane

A: 627-45-2
N-formylethylamine

B: 802294-64-0
propionic acid

C: 79-05-0
Propionamid

Conditions

Conditions	Yield
With acetic acid; potassium iodide In toluene at 110℃; for 24h;	A 10 %Spectr. B 70 %Spectr. C 20 %Spectr.

...Expand

: 820-57-5
methallyl formate

: 75-04-7
ethylamine

A: 627-45-2
N-formylethylamine

B: 513-42-8
3-hydroxy-2-methyl-1-propene

Conditions

Conditions	Yield
With aluminum oxide at 10 - 15℃; Large scale;	A 1320 g B 1410 g

...Expand

: 56-41-7
L-alanin

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With 3,5,5-Trimethylcyclohex-2-en-1-one at 130℃; for 24h; Sealed tube;	99 %Chromat.

: 201230-82-2
carbon monoxide

: 75-04-7
ethylamine

: 627-45-2
N-formylethylamine

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 80℃; under 18751.9 Torr; for 5h; Solvent; Temperature; Pressure; Autoclave;

: 627-45-2
N-formylethylamine

: 104-87-0
4-methyl-benzaldehyde

: N-ethyl-4-methylbenzothioamide

Conditions

Conditions	Yield
With sulfur; triethylamine; sodium phosphate In water at 80℃; for 5h; Schlenk technique; Inert atmosphere;	99%
With sulfur; sodium carbonate; triethylamine In water at 120℃; for 12h; Inert atmosphere; Sealed tube;	89%

: 627-45-2
N-formylethylamine

: 123-76-2
levulinic acid

: 57211-16-2
1-ethyl-5-methylpyrrolidin-2-one

Conditions

Conditions	Yield
With water at 160℃; for 4h; Autoclave; Green chemistry;	94%

: 627-45-2
N-formylethylamine

: 139-66-2
diphenyl sulfide

: N-ethyl-N-(phenylthio)formamide

Conditions

Conditions	Yield
With 1,4-diaza-bicyclo[2.2.2]octane; zirconocene dichloride; pyridinium p-toluenesulfonate; copper(II) bis(trifluoromethanesulfonate) In 1,4-dioxane at 80℃; for 9h;	92.8%
With 1,4-diaza-bicyclo[2.2.2]octane; bis(n-butylcyclopentadienyl)zirconium dichloride; 5,10,15,20-tetraphenyl-21H,23H-porphine; copper trifluoromethanesulfonate In 1,4-dioxane at 80℃; for 9h; Reagent/catalyst; Solvent;	78.1%

: 627-45-2
N-formylethylamine

: 62-53-3
aniline

: 103-70-8
Formanilid

Conditions

Conditions	Yield
With [2,2]bipyridinyl; boron trifluoride diethyl etherate; oxygen; palladium diacetate; Trimethylacetic acid In toluene at 120℃; for 24h;	91%

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 627-45-2
N-formylethylamine

: 1699-52-1
2-formyl-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
With cobalt(II) acetate at 150℃; for 3h; Inert atmosphere;	89%
With manganese(II) chloride tetrahydrate at 150℃; for 10h; Sealed tube; Microwave irradiation; Inert atmosphere;	89%
With graphene oxide at 150℃; for 18h; Sealed tube;	85%

: 627-45-2
N-formylethylamine

: 64-04-0
phenethylamine

: 23069-99-0
N-(2-phenylethyl)formamide

Conditions

Conditions	Yield
With manganese(II) chloride tetrahydrate at 150℃; for 10h; Inert atmosphere; Sealed tube;	89%

: 627-45-2
N-formylethylamine

: 22629-75-0
N-ethyl-thioformamide

Conditions

Conditions	Yield
With Lawessons reagent In tetrahydrofuran at 20℃; for 0.0833333h;	88%

: 627-45-2
N-formylethylamine

: 13456-80-9
3-aminobenzanthrone

: 1415583-97-9
3-N-(N’-ethylformamidino)benzanthrone

Conditions

Conditions	Yield
With trichlorophosphate at 90 - 100℃; for 3h;	85%

: 636-98-6
p-nitrobenzene iodide

: 627-45-2
N-formylethylamine

: 3665-80-3
N-Ethyl-4-nitroanilin

Conditions

Conditions	Yield
With potassium hydroxide In neat (no solvent) at 100℃; for 24h; Sealed tube;	85%

: 4053-40-1
4-methylquinoline 1-oxide

: 627-45-2
N-formylethylamine

: C13H14N2O2

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(I) bromide In decane; dimethyl sulfoxide at 60℃; regioselective reaction;	85%

: 1613-37-2
Quinoline N-oxide

: 627-45-2
N-formylethylamine

: C12H12N2O2

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; 2.9-dimethyl-1,10-phenanthroline; copper(I) bromide In dimethyl sulfoxide at 20℃;	83%
With tert.-butylhydroperoxide; copper(I) bromide In decane; dimethyl sulfoxide at 60℃; regioselective reaction;	81%

: 627-45-2
N-formylethylamine

: (3R,4R,5S,6R,9S,10S,12S,E)-12-hydroxy-1-iodo-4,10-dimethoxy-3,5,9,13-tetramethyltetradec-1-en-6-yl (R)-tetrahydrofuran-2-carboxylate

: (3R,4R,5S,6R,9S,10S,12S,E)-1-(N-ethylformamido)-12-hydroxy-4,10-dimethoxy-3,5,9,13-tetramethyltetradec-1-en-6-yl (R)-tetrahydrofuran-2-carboxylate

Conditions

Conditions	Yield
With 1,10-Phenanthroline; copper(I) thiophene-2-carboxylate; caesium carbonate In N,N-dimethyl acetamide at 80℃; for 16h; Goldberg Reaction; Inert atmosphere;	83%

: 4053-38-7
8-methylquinoline 1-oxide

: 627-45-2
N-formylethylamine

: C13H14N2O2

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(I) bromide In decane; dimethyl sulfoxide at 60℃; regioselective reaction;	80%

: 90924-16-6
5-methoxyquinoline N-oxide

: 627-45-2
N-formylethylamine

: C13H14N2O3

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(I) bromide In decane; dimethyl sulfoxide at 60℃; regioselective reaction;	80%

: 494-55-3
N-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline

: 627-45-2
N-formylethylamine

: N-Hydrohydrastinyl-N-ethyl-formamid

Conditions

Conditions	Yield
In benzene for 0.5h;	79%

: 627-45-2
N-formylethylamine

: 120-66-1
N-(2-methylphenyl)acetamide

: 77501-28-1
N-Ethyl-N'-o-tolyl-formamidine

Conditions

Conditions	Yield
With trichlorophosphate at 100℃; for 0.5h;	79%

: 4053-42-3
6-methylquinoline-N-oxide

: 627-45-2
N-formylethylamine

: C13H14N2O2

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(I) bromide In decane; dimethyl sulfoxide at 60℃; regioselective reaction;	79%

: 627-45-2
N-formylethylamine

: 108-98-5
thiophenol

: N-ethyl-N-(phenylthio)formamide

Conditions

Conditions	Yield
With copper(l) iodide; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; oxygen In toluene at 100℃; for 12h; Green chemistry;	78%

: 75-91-2
tert.-butylhydroperoxide

: 627-45-2
N-formylethylamine

: 402-50-6
1-trifluoromethyl-4-vinyl-benzene

: 3-(tert-butylperoxy)-N-ethyl-3-(4-(trifluoromethyl)phenyl)propanamide

Conditions

Conditions	Yield
With iron(III) chloride; benzoic acid In decane at 65℃; for 2h;	77%

...Expand

: 627-45-2
N-formylethylamine

: 2‐bromo‐3‐aminobenzanthrone

: C20H15BrN2O

Conditions

Conditions	Yield
With trichlorophosphate at 90 - 100℃; for 3h;	77%

: 860720-24-7
7-bromoquinoline 1-oxide

: 627-45-2
N-formylethylamine

: C12H11BrN2O2

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(I) bromide In decane; dimethyl sulfoxide at 60℃; regioselective reaction;	77%

: 75-91-2
tert.-butylhydroperoxide

: 627-45-2
N-formylethylamine

: 2628-16-2
p-acetoxystyrene

: 4-(1-(tert-butylperoxy)-3-(ethylamino)-3-oxopropyl)phenyl acetate

Conditions

Conditions	Yield
With iron(III) chloride; benzoic acid In decane at 65℃; for 2h;	75%

...Expand

: 627-45-2
N-formylethylamine

: 586-78-7
para-nitrophenyl bromide

: 3665-80-3
N-Ethyl-4-nitroanilin

Conditions

Conditions	Yield
With potassium hydroxide In neat (no solvent) at 100℃; for 24h; Sealed tube;	75%

: 6563-10-6
6-chloroquinoline N-oxide

: 627-45-2
N-formylethylamine

: C12H11ClN2O2

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(I) bromide In decane; dimethyl sulfoxide at 60℃; regioselective reaction;	75%

: 6563-13-9
6-methoxyquinoline N-oxide

: 627-45-2
N-formylethylamine

: C13H14N2O3

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(I) bromide In decane; dimethyl sulfoxide at 60℃; regioselective reaction;	75%

: 64-18-6
formic acid

: magnesium(II) chloride hexahydrate

: 627-45-2
N-formylethylamine

: Mg(2+)*3CHO2(1-)*C2H7N*H(1+)

Conditions

Conditions	Yield
In water for 24h; Autoclave; Heating;	74%

...Expand

N-Ethylformamide Chemical Properties

Chemistry informtion about N-Ethylformamide (CAS NO.627-45-2) is:
IUPAC Name: N-Ethylformamide
Synonyms: Ethylformamide ; Formamide, N-Ethyl- ; N-Aethylformamid ; N-Ethyl-Formamid ; N-Formylethylamine ; N-Ethylformamide ; N-Formylethylamine 98+% ; Monoethylformamide
MF: C₃H₇NO
MW: 73.09
EINECS: 211-001-2
Density: 0.868 g/cm³
Flash Point: 86.3 °C
Boiling Point: 185.7 °C at 760 mmHg
Vapour Pressure: 0.689 mmHg at 25°C
Enthalpy of Vaporization: 42.19 kJ/mol
Refractive Index: n20/D 1.432
Following is the molecular structure of N-Ethylformamide (CAS NO.627-45-2) is:

N-Ethylformamide Toxicity Data With Reference

Safty information about N-Ethylformamide (CAS NO.627-45-2) is:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD	intraperitoneal	> 1200mg/kg (1200mg/kg)		Therapie. Vol. 27, Pg. 873, 1972.
rat	LD50	unreported	3gm/kg (3000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 645, 1968.

N-Ethylformamide Consensus Reports

Reported in EPA TSCA Inventory.

N-Ethylformamide Safety Profile

Moderately toxic by intraperitoneal and possibly other routes. When heated to decomposition it emits toxic vapors of NO_x.
Safety Statements:
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
RTECS: LQ2725000

N-Ethylformamide Specification

To protect yourself, you can put on eyeshields and gloves.

Product Name

N-ETHYLFORMAMIDE

Synthetic route

N-Ethylformamide Chemical Properties

N-Ethylformamide Toxicity Data With Reference

N-Ethylformamide Consensus Reports

N-Ethylformamide Safety Profile

N-Ethylformamide Specification

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