N,N-Dimethylformamide dimethyl acetal supplier

Name
N,N-Dimethylformamide dimethyl acetal
EINECS 225-063-3
CAS No. 4637-24-5
Article Data37
CAS DataBase
Density 0.906 g/cm³
Solubility hydrolysis with water
Melting Point -85 °C
Formula C₅H₁₃NO₂
Boiling Point 104.3 °C at 760 mmHg
Molecular Weight 119.164
Flash Point 7.2 °C
Transport Information UN 3271 3/PG 2
Appearance clear colourless liquid
Safety 16-26-36/37-36/37/39-33-29-7/9
Risk Codes 11-22-36/37/38-36/38-20-20/21/22-10
Molecular Structure
Hazard Symbols F, Xn, Xi
Synonyms Trimethylamine,1,1-dimethoxy- (6CI,7CI,8CI);(Dimethoxymethyl)dimethylamine;(Dimethylamino)dimethoxymethane;(Dimethylamino)formaldehyde dimethyl acetal;1,1-Dimethoxy-N,N-dimethylmethanamine;1,1-Dimethoxy-N,N-dimethylmethane amine;1,1-Dimethoxytrimethylamine;DMF dimethyl acetal;DMFDMA;Dimethoxy(dimethylamino)methane;Dimethoxy-N,N-dimethylmethanamine;Dimethyl dimethylformamide acetal;Methyl-8;N,N-Dimethyl-1,1-bis(methyloxy)methanamine;N,N-Dimethylformamide dimethylacetal;N-(Dimethoxymethyl)-N,N-dimethylamine;N-(Dimethoxymethyl)dimethylamine;a,a-Dimethoxytrimethylamine;N,N-dimethylformamide dimethyl acetal (DMF-DMA);
PSA 21.70000
LogP 0.12440

Synthetic route

: 124-41-4
sodium methylate

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

Conditions

Conditions	Yield
Stage #1: N,N-dimethyl-formamide With dimethyl sulfate at 20 - 70℃; for 4h; Stage #2: sodium methylate at 25℃; for 2h; Temperature;	85.4%

: 124-40-3
dimethyl amine

: 149-73-5
trimethyl orthoformate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

Conditions

Conditions	Yield
With acetyl chloride at 20℃; for 12h; Inert atmosphere;	95%

: 1196967-42-6
C14H21NO3

: 1196967-61-9
C31H32N4O9S

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

Conditions

Conditions	Yield
With sulfuric acid In 1,4-dioxane; water at 0℃; for 6h; Inert atmosphere;	80%

: 21511-55-7, 34643-89-5
(methoxymethylidene)dimethylammonium methyl sulfate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

Conditions

Conditions	Yield
With methanol; sodium methylate at 0 - 20℃; for 20h; Inert atmosphere;	59%

: 52117-32-5
chloro-dimethoxy-methane

: 124-40-3
dimethyl amine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

Conditions

Conditions	Yield
at 140 - 150℃; for 2h; Green chemistry;	86.8%

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 77-78-1
dimethyl sulfate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

Conditions

Conditions	Yield
With nitrogen at 80℃; for 2h;	100%
With sodium 1.) 3 h, 60-80 degC: 2.) 0 degC, methanol; Yield given. Multistep reaction;
at 60℃; for 3h;

: 124-41-4
sodium methylate

: 21511-55-7, 34643-89-5
(methoxymethylidene)dimethylammonium methyl sulfate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

Conditions

Conditions	Yield
In Petroleum ether at 0℃; for 2h;

: 1192-62-7
1-(2-furyl)-1-ethanone

A: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

B: 109482-86-2
(2E)-3-(dimethylamino)-1-furan-2-ylprop-2-en-1-one

: 350-03-8
methyl-3-pyridylketone

A: 55314-16-4, 75415-01-9, 123367-26-0
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

B: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 154147-42-9
2-butyl-2-imidazolin-5-one

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

Conditions

Conditions	Yield
With trichlorophosphate at 40℃; Condensation;

: 124-41-4
sodium methylate

: 1071-38-1
N,N,N',N'-Tetramethylformamidinium chloride

A: 1186-70-5
bis(dimethylamino)methoxymethane

B: 5762-56-1
tris(dimethylamino)methane

C: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

Conditions

Conditions	Yield
In tetrahydrofuran at 21℃; Title compound not separated from byproducts.;

...Expand

: 67-66-3
chloroform

: 124-41-4
sodium methylate

A: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

B: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
With N,N-dimethyl-formamide In methanol	A 48 % Chromat. B 38 % Chromat.

...Expand

: 67-66-3
chloroform

: 124-41-4
sodium methylate

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

B: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
	A 91 % Chromat. B 3 % Chromat.

...Expand

: 67-66-3
chloroform

: 124-41-4
sodium methylate

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

A: 201230-82-2
carbon monoxide

B: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

C: 149-73-5
trimethyl orthoformate

Conditions

Conditions	Yield
for 0.5h; Mechanism; methanol presence;

...Expand

: 108-33-8
5-methyl-1,3,4-thiadiazol-2-amine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 41077-44-5
2-(N,N-dimethylaminomethyleneamino)-5-methyl-1,3,4-thiadiazole

Conditions

Conditions	Yield
In toluene for 2h; Heating;	100%
In ethanol Heating;

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 759-58-0
ethyl isopropylidenecyanoacetate

: 65996-11-4
1-carbethoxy-1-cyano-2-methyl-4-dimethylamino-1,4-butadiene

Conditions

Conditions	Yield
In ethanol for 24h; Heating / reflux;	100%
In ethanol for 24h; Reflux;	74%
In ethanol

: 504-29-0
2-aminopyridine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 17175-39-2
N,N-dimethyl-N'-pyridin-2-yl-formamidine

Conditions

Conditions	Yield
at 150℃; for 0.116667h; Microwave;	100%
In methanol at 70℃; for 15h;	81%
for 6h; Reflux;	71%

: 109-12-6
2-aminopyrimidine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 6578-34-3
N,N-dimethyl-N'-pyrimidin-2-ylformamidine

Conditions

Conditions	Yield
In toluene Heating;	100%
for 6h; Reflux;	80%
In toluene for 2h; Heating;

: 5469-69-2
6-chloro-pyridazin-3-ylamine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 35053-55-5
N'-(6-chloropyridazin-3-yl)-N,N-dimethylmethanimidamide

Conditions

Conditions	Yield
at 105℃; for 2h;	100%
for 2h; Reflux;	81%
for 2h; Reflux;	81%

: 18699-87-1
2-methyl-3-nitropyridine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 65156-92-5
2-(3-nitro-2-pyridinyl)-N,N-dimethyletheneamine

Conditions

Conditions	Yield
	100%
In N,N-dimethyl-formamide at 90℃; for 4h; Inert atmosphere;	73%
In N,N-dimethyl-formamide at 115℃;
In N,N-dimethyl-formamide at 120℃; for 17h;

: 610-93-5
6-nitrophthalide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 3-dimethylaminomethylene-6-nitroisobenzofuran-1(3H)-one

Conditions

Conditions	Yield
With potassium tert-butylate for 0.0833333h; Heating;	100%

: 78-81-9
isobutylamine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 67161-18-6
N2-iso-butyl-N1,N1-dimethylformamidine

Conditions

Conditions	Yield
at 60℃;	100%

: 141-97-9
ethyl acetoacetate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 134653-70-6, 51145-57-4
ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

Conditions

Conditions	Yield
at 20℃;	100%
at 20℃;	100%
at 20℃;	100%

: 504-02-9
1,3-cylohexanedione

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 85302-07-4
2-(dimethylaminomethylene)cyclohexane-1,3-dione

Conditions

Conditions	Yield
for 1h; Heating;	100%
at 100℃; for 1h;	100%
at 95℃; for 1h;	100%

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 66129-60-0
ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate

Conditions

Conditions	Yield
at 110℃; for 0.666667h; Microwave irradiation;	100%
for 1h; Heating;	94%
In toluene at 60℃; for 24h;	92%

: 108-91-8
cyclohexylamine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 3459-75-4
N,N-dimethyl-N'-cyclohexylformamidine

Conditions

Conditions	Yield
at 60℃;	100%
In methanol at 25℃; for 12h;	98%
1.) 50 deg C, 5 h, 2.) room temperature, 12 h;	92%
In benzene for 1h; Heating;	64%

: 126-81-8
dimedone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 75039-59-7
2-dimethylaminomethylene-5,5-dimethylcyclohexane-1,3-dione

Conditions

Conditions	Yield
for 1h; Heating;	100%
In 5,5-dimethyl-1,3-cyclohexadiene for 3h; Reflux;	100%
at 100℃; for 1h;	100%

: 107-10-8
propylamine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 32150-25-7
N2-n-propyl-N1,N1-dimethylformamidine

Conditions

Conditions	Yield
at 60℃;	100%

: 493-72-1
5-phenyl-cyclohexane-1,3-dione

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 85302-08-5
2-((dimethylamino)methylene)-5-phenyl-cyclohexane-1,3-dione

Conditions

Conditions	Yield
for 2h; Reflux;	100%
at 100℃; for 1h;	100%
for 1h; Heating;	98%

: 69304-44-5
3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 120853-22-7
2-N-(Dimethylaminomethylene)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 20h; Ambient temperature;	100%
In N,N-dimethyl-formamide at 20℃; for 6h;	84%

: 542-05-2
acetonedicarboxylic acid

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 25299-40-5
1,5-bis(dimethylamino)-1,4-pentadien-3-one

Conditions

Conditions	Yield
at 70℃; for 1h;	100%

: 21906-39-8
3-(trifluoromethyl)phenylacetone

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 67382-34-7, 72833-79-5
1-dimethylamino-2-(m-trifluoromethylphenyl)-1-buten-3-one

Conditions

Conditions	Yield
for 12h; Heating;	100%

: 111-26-2
hexan-1-amine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 85599-94-6
N2-n-hexyl-N1,N1-dimethylformamidine

Conditions

Conditions	Yield
at 60℃;	100%

: 41051-15-4
4-methoxyacetoacetic acid methylester

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 127958-23-0
methyl 2-[(dimethylamino)methylene]-4-methoxy-3-oxobutanoate

Conditions

Conditions	Yield
at 20℃; for 24h;	100%
at 20℃; for 24h;	100%
In N,N-dimethyl-formamide at 120℃; for 0.5h; Inert atmosphere; microwave irradiation;	97%

: 1067-73-8
diethyl (2-oxobutyl)phosphonate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 98934-29-3
{1-[1-Dimethylamino-meth-(Z)-ylidene]-2-oxo-butyl}-phosphonic acid diethyl ester

Conditions

Conditions	Yield
With calcium chloride for 2h; Heating;	100%

: 66187-85-7
diethyl (2-ethoxycarbonyl)-2-oxoethylphosphonate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 98934-35-1
(Z)-3-(Diethoxy-phosphoryl)-4-dimethylamino-2-oxo-but-3-enoic acid ethyl ester

Conditions

Conditions	Yield
With calcium chloride Ambient temperature;	100%

: 5396-89-4
benzyl acetoacetate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 93552-75-1
benzyl 2-((dimethylamino)methylene)-3-oxobutanoate

Conditions

Conditions	Yield
at 20℃;	100%
at 20℃;	100%
In toluene at 20℃; for 16h;	100%

: 606-20-2
2,6-dinitrotoluene

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 78283-21-3
3-nitro-trans-2-[β-(dimethylamino)vinyl]-nitrobenzene

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 4h; Heating;	100%
In N,N-dimethyl-formamide at 115℃; for 6h;	96%
With copper(l) iodide; N,N-dimethyl-formamide at 180℃; under 6000.6 - 7500.75 Torr; for 0.166667h; microwave irradiation;	85%

: 343-94-2
tryptamine hydochloride

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: N'-[2-(1H-Indol-3-yl)-ethyl]-N,N-dimethyl-formamidine

Conditions

Conditions	Yield
for 21h; Heating;	100%

: 78064-64-9
1-methyl-2'-deoxy-5'-O-tritylpseudouridine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 78064-66-1
1,3-Dimethyl-2'-deoxy-5'-O-tritylpseudouridine

Conditions

Conditions	Yield
at 95 - 100℃; for 2h;	100%

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 138998-47-7
ethyl α<(N,N-dimethylamino)methylene>-2,3,4,5-tetrafluoro-β-oxobenzenepropanoate

Conditions

Conditions	Yield
With acetic anhydride for 0.5h;	100%
In toluene at 115 - 120℃; for 1h;	91%

: 133648-45-0
2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 141437-72-1
N2-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 5h; Ambient temperature;	100%

: 115413-26-8
Methyl 2-oxo-3-phenylthiopropionate

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 115412-99-2
Methyl 4-dimethylamino-2-oxo-3-phenylthio-3-butenoate

Conditions

Conditions	Yield
In toluene for 1.5h; Ambient temperature;	100%

: 115413-21-3
1-Phenylsulfanyl-3-(2,2,2-trichloro-ethoxy)-propan-2-one

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 115413-30-4
(Z)-4-Dimethylamino-3-phenylsulfanyl-1-(2,2,2-trichloro-ethoxy)-but-3-en-2-one

Conditions

Conditions	Yield
at 70℃; for 1.5h;	100%

N,N-Dimethylformamide dimethyl acetal Chemical Properties

The Molecular Structure of N,N-Dimethylformamide dimethyl acetal (CAS NO.4637-24-5):

Empirical Formula: C₅H₁₃NO₂
Molecular Weight: 119.1622
IUPAC Name: 1,1-dimethoxy-N,N-dimethylmethanamine
Appearance: clear colourless liquid
Nominal Mass: 119 Da
Average Mass: 119.1622 Da
Monoisotopic Mass: 119.094629 Da
Index of Refraction: 1.407
Molar Refractivity: 32.38 cm³
Molar Volume: 131.4 cm³
Surface Tension: 24.8 dyne/cm
Density: 0.906 g/cm³
Flash Point: 7.2 °C
Enthalpy of Vaporization: 34.33 kJ/mol
Boiling Point: 104.3 °C at 760 mmHg
Vapour Pressure: 31.1 mmHg at 25°C
Storage temp: Fammables area
Water Solubility: hydrolysis
Sensitive: Moisture Sensitive
InChI
InChI=1/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3
Smiles
O(C(OC)N(C)C)C
Product Categories: blocks;BuildingBlocks;Aliphatics;(intermediate of zaleplon);Biochemistry;Nucleosides, Nucleotides & Related Reagents;Protecting Agents for Hydroxyl and Amino Groups;Protecting Agents, Phosphorylating Agents & Condensing Agents;Analytical Chemistry;Esterification & Alkylation (GC Derivatizing Reagents);GC Derivatizing Reagents;N,N-Dimethylformamide Dialkylacetals (GC Derivatizing Reagents)

N,N-Dimethylformamide dimethyl acetal Uses

N,N-Dimethylformamide dimethyl acetal (CAS NO.4637-24-5) can be used as intermediates of Zaleplon,also can be used as condensating agent.

N,N-Dimethylformamide dimethyl acetal Safety Profile

Hazard Codes: F Irritant XiXn
Risk Statements :
R11: Highly Flammable
R36/37/38: Irritating to eyes, respiratory system and skin
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
R10: Flammable
Safety Statements :
S16: Keep away from sources of ignition - No smoking
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S33: Take precautionary measures against static discharges
S29: Do not empty into drains
S7/9 :Keep container tightly closed and in a well-ventilated place
RIDADR: UN 3271 3/PG 2

N,N-Dimethylformamide dimethyl acetal Specification

N,N-Dimethylformamide dimethyl acetal (CAS NO.4637-24-5) is also called as Dimethylformamide-dimethylacetal ; 1,1-Dimethoxytrimethylamine ; Methanamine, 1,1-dimethoxy-N,N-dimethyl- .

Product Name

N,N-Dimethylformamide dimethyl acetal

Synthetic route

N,N-Dimethylformamide dimethyl acetal Chemical Properties

N,N-Dimethylformamide dimethyl acetal Uses

N,N-Dimethylformamide dimethyl acetal Safety Profile

N,N-Dimethylformamide dimethyl acetal Specification

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