N,N-Dimethylglycine hydrochloride supplier

Name
N,N-Dimethylglycine hydrochloride
EINECS 219-648-2
CAS No. 2491-06-7
Article Data4
CAS DataBase
Density 1.069g/cm3
Solubility 100 g/L (20 °C) in water
Melting Point 189-194 °C(lit.)
Formula C₄H₉NO₂^.HCl
Boiling Point 175.2 °C at 760 mmHg
Molecular Weight 139.582
Flash Point 59.8 °C
Transport Information
Appearance white crystalline powder
Safety 22-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Glycine,N,N-dimethyl-, hydrochloride (6CI,8CI,9CI);(Dimethylamino)acetic acidhydrochloride;Dimethylglycine hydrochloride;N,N-Dimethylaminoacetic acidhydrochloric acid;
PSA 40.54000
LogP 0.43460

Synthetic route

: 7148-06-3
N,N-dimethylglycine methyl ester

: 2491-06-7
N,N-dimethylglycine hydrochoride

Conditions

Conditions	Yield
With hydrogenchloride for 24h; Heating;	99%

: 124-40-3
dimethyl amine

: 79-11-8
chloroacetic acid

: 2491-06-7
N,N-dimethylglycine hydrochoride

Conditions

Conditions	Yield
Stage #1: dimethyl amine; chloroacetic acid In water at 25 - 55℃; for 11h; Stage #2: With hydrogenchloride In water at 40℃;

: 1118-68-9
dimethylaminoacetic acid

: 2491-06-7
N,N-dimethylglycine hydrochoride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water; acetone

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 100-46-9
benzylamine

: 76733-71-6
N-benzyl-2-(dimethylamino)acetamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; Inert atmosphere;	98%

: 1,2:5,6-bis-O-(1-methylethylidene)-4-O-Val-3-O-methyl-D-chiro-inositol

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 1,2:5,6-bis-O-(1-methylethylidene)-4-O-{[2-(dimethylamino)acetamido]-Val}-3-O-methyl-D-chiro-inositol

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃;	96%

: 233684-38-3
C22H34N4O3

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 233684-39-4
C26H41N5O4

Conditions

Conditions	Yield
With triethylamine; diethyl dicarbonate In dichloromethane at 20℃; for 13h;	95%

: 2491-06-7
N,N-dimethylglycine hydrochoride

: C31H52O

: C35H59NO2

Conditions

Conditions	Yield
With pyridine; 2-chloro-1,3-dimethylimidazolinium chloride In dichloromethane at 20℃; for 96h; Esterification;	92%

: C26H25N3O4S

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 543-27-1
isobutyl chloroformate

A: C31H33N3O6S

B: C30H32N4O5S

Conditions

Conditions	Yield
Stage #1: N,N-dimethylglycine hydrochoride With triethylamine In dichloromethane; butan-1-ol at 20℃; for 1h; Inert atmosphere; Stage #2: isobutyl chloroformate In dichloromethane; butan-1-ol at -15℃; for 2h; Inert atmosphere; Stage #3: C26H25N3O4S In dichloromethane; butan-1-ol at 20℃; for 19h; Inert atmosphere;	A 91% B 6%

...Expand

: 6-bromo-1'-pentylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

: 7681-65-4
copper(I) iodide

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 108-95-2
phenol

: 912668-11-2
1'-pentyl-6-phenoxyspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Conditions

Conditions	Yield
With caesium carbonate In 1,4-dioxane	87%

...Expand

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 100-51-6
benzyl alcohol

: 30379-57-8
2-(dimethylamino)acetic acid benzyl ester

Conditions

Conditions	Yield
With 4-methyl-morpholine; dmap; dicyclohexyl-carbodiimide In dichloromethane at 0℃; Inert atmosphere;	87%

: 1346224-49-4
(3R,4R)-3,4-bis((9Z,12Z)-octadec-9,12-dienyloxy)pyrrolidine

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 1346224-72-3
(3R,4R)-1-(2-(dimethylamino)acetyl)-3,4-bis((9Z,12Z)-octadec-9,12-dienyloxy)pyrrolidine

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In chloroform at 20℃; for 1.5h;	86.8%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In chloroform at 20℃; for 1.5h;	86.8%

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 544-63-8
n-tetradecanoic acid

: calcium(II) N,N-dimethylglycine tetradecanoate

Conditions

Conditions	Yield
Stage #1: N,N-dimethylglycine hydrochoride With sodium hydroxide In ethanol at 20℃; for 0.5h; Stage #2: n-tetradecanoic acid With calcium hydroxide In ethanol at 20℃; for 4h;	84.33%

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 60853-81-8
N,N-dimethylaminoacetyl chloride hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 78℃; for 0.5h;	84%
With phosphorus pentachloride	82%
With oxalyl dichloride In dichloromethane at 20℃; for 2h;

: 2491-06-7
N,N-dimethylglycine hydrochoride

: calcium(II) N,N-dimethylglycine sulfate

Conditions

Conditions	Yield
Stage #1: N,N-dimethylglycine hydrochoride With sodium hydroxide In ethanol at 20℃; for 0.5h; Stage #2: With sulfuric acid; calcium hydroxide In ethanol at -20 - 20℃; for 4h;	83.67%

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 80594-03-2
1,8,17,24-tetraoxa-33,34,35,36-tetrakis(hydroxymethyl)<8.8>(1,4)naphthalenophane

: 80594-02-1
1,8,17,24-tetraoxa-33,34,35,36-tetrakis(N,N-dimethylglycyloxymethyl)<8.8>(1,4)naphthalenophane

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In pyridine for 4h; Ambient temperature;	82%

: 2491-06-7
N,N-dimethylglycine hydrochoride

: C-acridin-4-yl-methylamine; hydrochloride

: N-acridin-4-ylmethyl-2-dimethylaminoacetamide

Conditions

Conditions	Yield
Stage #1: C-acridin-4-yl-methylamine; hydrochloride With ammonia In water Stage #2: N,N-dimethylglycine hydrochoride With benzotriazol-1-ol; triethylamine In dichloromethane for 48h;	80%

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 59-02-9
Tocopherol

: d-α-tocopheryl N,N-dimethylaminoacetate hydrochloride

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In pyridine for 24h; Ambient temperature;	79%

: 14291-31-7
3,5-seco-4-nor-cholestane-5-one-3-ol

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 878193-63-6
C30H53NO3

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h;	78%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h;	78%

: Capadenoson

: 1118-68-9
dimethylaminoacetic acid

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 1112459-44-5
2-(4-{2-({[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyano-6-[(N,N-dimethylglycyl)-amino]pyridin-4-yl}phenoxy)ethyl N,N-dimethylglycinate

Conditions

Conditions	Yield
Stage #1: Capadenoson; N,N-dimethylglycine hydrochoride With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane Reflux; Stage #2: dimethylaminoacetic acid With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane Reflux; Stage #3: With sodium hydrogencarbonate In dichloromethane	78%

...Expand

: 2491-06-7
N,N-dimethylglycine hydrochoride

: calcium(II) N,N-dimethylglycine phosphate

Conditions

Conditions	Yield
With phosphoric acid; sodium hydroxide; calcium hydroxide In ethanol at 20℃; for 4h;	77.53%

WSC.HCl: WSC.HCl

: 2-aminomethyl-5-methyl-2,3,6,7-tetrahydrofuro[2,3-f]quinoline-7-one

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 156935-37-4
2-(N,N-Dimethylglycyl)aminomethyl-5-methyl-2,3,6,7-tetrahydrofuro-[2,3-f]quinoline-7-one.HCl

Conditions

Conditions	Yield
With benzotriazol-1-ol In N-methyl-acetamide	77%

...Expand

: 1143621-30-0
2,5-bis-[5-{2-(N-hydroxyamidino)-pyridyl}]selenophene

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 1143621-33-3
2,5-bis-[5-{2-N-(N,N-dimethylaminoacetoxyamidino)-pyridyl}]selenophene

Conditions

Conditions	Yield
Stage #1: N,N-dimethylglycine hydrochoride With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 60℃; for 2h; Stage #2: 2,5-bis-[5-{2-(N-hydroxyamidino)-pyridyl}]selenophene In N,N-dimethyl-formamide at 0 - 20℃; for 12h;	77%

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 80593-97-1
1,4-bis(propynyloxy)-2,3-bis(hydroxymethyl)naphthalene

: 80593-96-0
1,4-bis(propynyloxy)-2,3-bis(N,N-dimethylglycyloxymethyl)naphthalene

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 5h; Ambient temperature;	76%

: 1738-68-7
Gly-OBz

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 1227930-08-6
benzyl 2-(2-(dimethylamino)acetamido)acetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide at 20℃; for 16h;	76%

: 103-90-2
4-acetaminophenol

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 1314962-36-1
4-acetamidophenyl 2-(dimethylamino)acetate hydrochloride

Conditions

Conditions	Yield
With pyridine; dicyclohexyl-carbodiimide at 20℃;	75%

: C26H25N3O4S

: 2491-06-7
N,N-dimethylglycine hydrochoride

: C30H32N4O5S

Conditions

Conditions	Yield
Stage #1: C26H25N3O4S; N,N-dimethylglycine hydrochoride In methanol at 0℃; for 1h; Inert atmosphere; Stage #2: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In methanol at 20℃; for 38h; Inert atmosphere;	75%

: 57-88-5
cholesterol

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 123191-82-2
cholesteryl 2-(dimethylamino)acetate

Conditions

Conditions	Yield
Stage #1: cholesterol; N,N-dimethylglycine hydrochoride With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.0833333h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	74.6%
Stage #1: cholesterol; N,N-dimethylglycine hydrochoride With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.0833333h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 104-15-4
toluene-4-sulfonic acid

: calcium(II) N,N-dimethylglycine p-toluenesulfonate

Conditions

Conditions	Yield
Stage #1: N,N-dimethylglycine hydrochoride With sodium hydroxide In ethanol at 20℃; for 0.5h; Stage #2: toluene-4-sulfonic acid With calcium hydroxide In ethanol at 20℃; for 4h;	74.23%

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 110-17-8
(2E)-but-2-enedioic acid

: zinc(II) hydroxide

: copper(II) N,N-dimethylglycine fumarate

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 4h;	73.06%

...Expand

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 620612-16-0
acridin-4-ylmethanol

: acridin-4-ylmethyl 2-(N,N-dimethylamino)acetate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In acetone at 20℃; for 96h;	73%

: 2491-06-7
N,N-dimethylglycine hydrochoride

: FR901469 hydrochloride

: C75H123N15O24

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	72%

: 937042-71-2
5-(2-benzyl-2H-indazol-6-yl)-7-morpholin-2-ylpyrrolo[2,1-f][1,2,4]triazin-4-amine

: 2491-06-7
N,N-dimethylglycine hydrochoride

: 5-(2-benzyl-2H-indazol-6-yl)-7-{4-[(dimethylamino)acetyl]morpholin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine

Conditions

Conditions	Yield
With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In tetrahydrofuran at 20℃; for 1h;	71%

N,N-Dimethylglycine hydrochloride Chemical Properties

The Molecular formula of N-METHYLSARCOSINE HYDROCHLORIDE (2491-06-7):C₄H₁₀ClNO₂
The Molecular Weight of N-METHYLSARCOSINE HYDROCHLORIDE (2491-06-7):139.58
The Molecular Structure of N-METHYLSARCOSINE HYDROCHLORIDE (2491-06-7) is:
Density:1.069g/cm³
Melting point:189-194 ^°C(lit.)
Boiling point:175.2 ^°C at 760 mmHg
Flash point:59.8^°C
Solubility in water:100 g/L (20 ^°C
Sensitive:Hygroscopic
Merck:14,3244
BRN:3910578
Enthalpy of Vaporization:45.38 kJ/mol
Vapour Pressure: 0.556 mmHg at 25^°C
Appearance:white crystalline powder
IUPAC Name: 2-(dimethylamino)acetic acid hydrochloride
Synonyms: n,n-dimethyl-glycinhydrochloride ; N,N-DIMETHYLAMINOACETIC ACID HYDROCHLORIDE ; N,N-DIMETHYL-GLY-OH HCL ; N,N-DIMETHYLGLYCINE HCL ; N,N-DIMETHYLGLYCINE HYDROCHLORIDE ; DMG HYDROCHLORIDE ; DIMETHYLGLYCINE HCL ; n-methylsarcosinehydrochloride

N,N-Dimethylglycine hydrochloride Uses

It is used as a raw material for medicine and health care products.It also used as chemical intermediates for health care products.

N,N-Dimethylglycine hydrochloride Toxicity Data With Reference

orl-rat LD50:3900 mg/kg

JACTDZ Journal of the American College of Toxicology. 1 (1992),198.

N,N-Dimethylglycine hydrochloride Consensus Reports

Reported in EPA TSCA Inventory.

N,N-Dimethylglycine hydrochloride Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x and HCl.

Risk Statements
R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Statements
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
WGK Germany:2
RTECS:MB9995000

N,N-Dimethylglycine hydrochloride Specification

Conditions to Avoid: Incompatible materials, strong oxidants.
Chemical Stability:Stable under normal temperatures and pressures.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Product Name

N,N-Dimethylglycine hydrochloride

Synthetic route

N,N-Dimethylglycine hydrochloride Chemical Properties

N,N-Dimethylglycine hydrochloride Uses

N,N-Dimethylglycine hydrochloride Toxicity Data With Reference

N,N-Dimethylglycine hydrochloride Consensus Reports

N,N-Dimethylglycine hydrochloride Safety Profile

N,N-Dimethylglycine hydrochloride Specification

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