Nicardipine supplier | CasNO.55985-32-5

Name
Nicardipine
EINECS 259-932-3
CAS No. 55985-32-5
Article Data13
CAS DataBase
Density 1.23 g/cm³
Solubility
Melting Point 136-138 ºC
Formula C26H29 N3 O6
Boiling Point 603.4 °C at 760 mmHg
Molecular Weight 479.533
Flash Point 318.7 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl2-[methyl(phenylmethyl)amino]ethyl ester (9CI); (?à)-Nicardipine; Nicardipine; Perpidine
PSA 113.69000
LogP 4.52980

Synthetic route

: 103785-48-4
2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-[2-(toluene-4-sulfonyloxy)-ethyl] ester

: 103-67-3
benzyl-methyl-amine

: 55985-32-5
Nicardipine

Conditions

Conditions	Yield
for 8h; Heating;	77%

: 101-98-4
2-(N-benzyl-N-methyl)amino-1-ethanol

: (S)-1,1-Dibenzyl-3-[(R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-piperidinium; bromide

: 55985-32-5
Nicardipine

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran at 25℃; for 24h;	67%

: 101-98-4
2-(N-benzyl-N-methyl)amino-1-ethanol

: (S)-1-Benzyl-3-[(R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-1-methyl-piperidinium; iodide

: 55985-32-5
Nicardipine

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran at 25℃;	32%

: 101-98-4
2-(N-benzyl-N-methyl)amino-1-ethanol

: (S)-1-Allyl-1-benzyl-3-[(R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-piperidinium; bromide

: 55985-32-5
Nicardipine

Conditions

Conditions	Yield
With potassium hydroxide In tetrahydrofuran at 25℃;	26%

: 3-Imino-butyric acid methyl ester; compound with acetic acid

: 2-Amino-4-(3-cyano-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-(3-nitrooxy-propyl) ester

: 55985-32-5
Nicardipine

Conditions

Conditions	Yield
With sodium methylate In isopropyl alcohol Heating;

: (R)-2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-((S)-1-benzyl-piperidin-3-yl) ester 5-methyl ester

: 55985-32-5
Nicardipine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 93 percent / CHCl3 / Heating 2: 67 percent / KOH / tetrahydrofuran / 24 h / 25 °C View Scheme
Multi-step reaction with 2 steps 1: 95 percent / CHCl3 / Heating 2: 26 percent / KOH / tetrahydrofuran / 25 °C View Scheme
Multi-step reaction with 2 steps 1: 94 percent / acetone / 8 h / Heating 2: 32 percent / KOH / tetrahydrofuran / 25 °C View Scheme

: 88488-49-7
3-nitrooxypropyl acetoacetate

: 55985-32-5
Nicardipine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 38 percent / piperidine / benzene / 11 h / Heating 2: 30 percent / sodium methoxide / propan-2-ol / Heating 3: sodium methoxide / propan-2-ol / Heating View Scheme

: 170748-98-8
3-nitroxypropyl 2-(3-cyanobenzylidene)acetoacetate

: 55985-32-5
Nicardipine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 30 percent / sodium methoxide / propan-2-ol / Heating 2: sodium methoxide / propan-2-ol / Heating View Scheme

: 85677-95-8
2-hydroxyethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

: 55985-32-5
Nicardipine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / 1.) Et3N; 2.) H2O / tetrahydrofuran / 1.) 1 h; 2.) 0.5 h 2: 77 percent / 8 h / Heating View Scheme

: (+)-2,6-dimethyl-3-methoxysulfonyl-4-(3-nitrophenyl)-5-carboxy-1,4-dihydropyridine

: 55985-32-5
Nicardipine

: 55985-32-5
Nicardipine

: 106-95-6
allyl bromide

: Allyl-benzyl-{2-[5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-ethyl}-methyl-ammonium; iodide

Conditions

Conditions	Yield
In chloroform Heating;	99%

: 55985-32-5
Nicardipine

: 74-88-4
methyl iodide

: Benzyl-{2-[5-methoxycarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonyloxy]-ethyl}-dimethyl-ammonium; iodide

Conditions

Conditions	Yield
In acetone Heating;	93%

: 55985-32-5
Nicardipine

: 59875-58-0
3-{2-[benzyl(methyl)amino]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Conditions

Conditions	Yield
With potassium phosphate; ethylenediaminetetraacetic acid; Emulgen 911; human liver cytochrome b5; human liver HL 39 lipid extract; rabbit liver NADPH-P-450 reductase; yeast P-450 IIIA4; magnesium chloride In water Rate constant; other human liver enzymes;
With nitric acid at 55 - 60℃; Yield given;

: 55985-32-5
Nicardipine

: 59875-59-1
2-(N-benzyl-N-methylamino)ethyl methyl 4-(m-aminophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Conditions

Conditions	Yield
With hydrogen; nickel In tetrahydrofuran Ambient temperature; Yield given;

: 55985-32-5
Nicardipine

: C4H9N2O2*ClH

: 59875-58-0
3-{2-[benzyl(methyl)amino]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Conditions

Conditions	Yield
With Britton-Robinson buffer In water; N,N-dimethyl-formamide at 37℃; pH=7.4; Kinetics;

: 55985-32-5
Nicardipine

A: 2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(benzyl-formyl-amino)-ethyl] ester 5-methyl ester

B: 59875-58-0
3-{2-[benzyl(methyl)amino]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

C: 54527-90-1
2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-benzylamino-ethyl) ester 5-methyl ester

Conditions

Conditions	Yield
In methanol Product distribution; Quantum yield; Further Variations:; Solvents; wavelengths; presence of air; Irradiation;

...Expand

: 55985-32-5
Nicardipine

: 74936-72-4
5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 99 percent / CHCl3 / Heating 2: 72 percent / NaOH / H2O / 40 °C View Scheme

: 55985-32-5
Nicardipine

: 39562-70-4
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid ethyl methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 93 percent / acetone / Heating 2: 92 percent / KOH / ethanol / 25 °C View Scheme

: 55985-32-5
Nicardipine

: 59875-61-5
methyl 2-(N-methylamino)ethyl 4-(m-aminophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogen / Raney- Ni / tetrahydrofuran / Ambient temperature 2: hydrogen / 10percent Pd/C / methanol / Ambient temperature View Scheme

: 55985-32-5
Nicardipine

: 335321-56-7
C26H23(2)H6N3O6

Conditions

Conditions	Yield
With water-d2; trifluoroacetic anhydride In chloroform-d1; [(2)H6]acetone at 57℃; for 168h;

: 21829-25-4
nifedipine

: 55985-32-5
Nicardipine

: 63675-72-9
nisoldipine

: 55985-32-5
Nicardipine

A: (-)-Nicardipine

B: (+)-Nicardipine

Conditions

Conditions	Yield
With Chiralpak IC In hexane; isopropyl alcohol Reagent/catalyst; Solvent; Resolution of racemate;

Nicardipine Chemical Properties

IUPAC Name: 3-O-[2-[benzyl(methyl)amino]ethyl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms Methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Product Categories: Active Pharmaceutical Ingredients
Molecular Structure: m-nitrobenzaldehyde as raw materials, condensation of acetyl chloride acid methyl ester with the amino-crotonic to get 2,6 - dimethyl -4 - (Inter-nitrophenyl) -1,4 - dihydro-pyridine 3,5 - 2-carboxylic acid - (2 - chloro) ethyl -5 - methyl ester, then condensation with benzyl amine nicardipine.
Molecular Formula: C₂₆H₂₉N3O₆
Molecular Weight : 479.52
CAS NO: 55985-32-5
EINECS : 259-932-3
Mol File: 55985-32-5.mol
Melting point 136-138 ºC
Index of Refraction: 1.581
Surface Tension: 48.7 dyne/cm
Density: 1.23 g/cm³
Flash Point: 318.7 °C
Enthalpy of Vaporization: 89.75 kJ/mol
Boiling Point: 603.4 °C at 760 mmHg
Vapour Pressure: 1.63E-14 mmHg at 25°C
Appearance: Nicardipine Hydrochloride (CAS NO.55985-32-5) is yellow-green crystalline powder.

Nicardipine Uses

Nicardipine Hydrochloride (CAS NO.55985-32-5) is a new calcium antagonist, vasodilator,mainly used for ischemic cerebrovascular disease and the treatment of essential hypertension.

Nicardipine Production

M-Nitrobenzaldehyde as raw materials, condensation of acetyl chloride acid methyl ester with the amino-crotonic to get 2,6 - dimethyl -4 - (Inter-nitrophenyl) -1,4 - dihydro-pyridine 3,5 - 2-carboxylic acid - (2 - chloro) ethyl -5 - methyl ester, then condensation with benzyl amine nicardipine. Get Nicardipine Hydrochloride (CAS NO.55985-32-5) .

Nicardipine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	1250ug/kg (1.25mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	American Journal of Emergency Medicine. Vol. 18, Pg. 581, 2000.
mouse	LD50	intravenous	9700ug/kg (9.7mg/kg)		United States Patent Document. Vol. #4672068,
mouse	LD50	oral	305mg/kg (305mg/kg)		United States Patent Document. Vol. #4824855,
rat	LD50	intravenous	11800ug/kg (11.8mg/kg)		United States Patent Document. Vol. #4710505,
rat	LD50	oral	320mg/kg (320mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 35, Pg. 915, 1985.

Product Name

Nicardipine

Synthetic route

Nicardipine Chemical Properties

Nicardipine Uses

Nicardipine Production

Nicardipine Toxicity Data With Reference

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