Olsalazine supplier | CasNO.15722-48-2

Name
Olsalazine
EINECS 605-089-5
CAS No. 15722-48-2
Article Data10
CAS DataBase
Density 1.557 g/cm³
Solubility 11.49ug/L(25 oC)
Melting Point >300 °C(Solv: acetic acid (64-19-7); water (7732-18-5))
Formula C₁₄H₁₀N₂O₆
Boiling Point 653.233 °C at 760 mmHg
Molecular Weight 302.243
Flash Point 348.863 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms Benzoicacid, 3,3'-azobis[6-hydroxy- (9CI);C.I. Mordant Yellow 5 (8CI);Salicylicacid, 5,5'-azodi- (6CI);3,3'-Azobis(6-hydroxybenzoic acid);3,3'-Dicarboxy-4,4'-dihydroxyazobenzene;5,5'-Azobis(salicylic acid);5,5'-Azodisalicylic acid;Azodisal;
PSA 139.78000
LogP 2.90960

Synthetic route

: 101351-60-4
olsalazine methyl ester

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
With water; sodium hydroxide at 90 - 95℃; for 2h;	97.6%
With sodium hydroxide

: 3,3'-azo[bis(6-hydroxybenzoic acid)] disodium salt

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃; for 0.0833333h; pH=Ca.0;	90%

: 2516-96-3
2-chloro-5-nitrobenzoic acid

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
With sodium hydroxide; zinc beim Erhitzen der erhaltenen 4.4'-Dichlor-azobenzol-dicarbonsaeure-(3.3') mit Kupfer und wss. Natronlauge auf 150grad;

: 89-57-6
5-Aminosalicylic Acid

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
With pyridine; chromium chloride bei der Diazotierung des erhaltenen Komplexes und anschliessenden Umsetzung mit Salicylsaeure;
Multi-step reaction with 3 steps 1: sulfuric acid / 75 - 80 °C 2: acetic acid / 20 °C 3: water; sodium hydroxide / 2 h / 90 - 95 °C View Scheme
Multi-step reaction with 4 steps 1: sulfuric acid / 75 - 80 °C 2: oxone\|\|potassium monopersulfate triple salt / dichloromethane; water / 2 h / 20 °C 3: acetic acid / 20 °C 4: water; sodium hydroxide / 2 h / 90 - 95 °C View Scheme

: 6,6'-dihydroxy-3,3'-azo-di-benzoic acid diethyl ester

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
With potassium hydroxide

: 69-72-7
salicylic acid

diazotized. 6-chloro-3-amino-benzoic acid: diazotized. 6-chloro-3-amino-benzoic acid

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
With sodium hydroxide; copper(I) sulfate; copper(II) sulfate at 140℃;

: 62773-65-3
ethyl 5-amino-2-hydroxybenzoate

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid; hydrogen peroxide 2: aqueous KOH-solution View Scheme

: 119-36-8
methyl salicylate

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaNO2; aqueous ethanol 2: aq. NaOH solution View Scheme

: 89-57-6
5-Aminosalicylic Acid

: 69-72-7
salicylic acid

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
Stage #1: 5-Aminosalicylic Acid With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h; Stage #2: salicylic acid With sodium hydroxide In water for 1h; Cooling with ice;
With hydrogenchloride; sodium nitrite In water at 0℃;

: 42753-75-3
methyl 5-amino-2-hydroxybenzoate

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid / 20 °C 2: water; sodium hydroxide / 2 h / 90 - 95 °C View Scheme
Multi-step reaction with 3 steps 1: oxone\|\|potassium monopersulfate triple salt / dichloromethane; water / 2 h / 20 °C 2: acetic acid / 20 °C 3: water; sodium hydroxide / 2 h / 90 - 95 °C View Scheme

: 17302-46-4
methyl 2-hydroxy-5-nitrobenzoate

: 15722-48-2
olsalazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid / 20 °C 2: water; sodium hydroxide / 2 h / 90 - 95 °C View Scheme

: 106-31-0
butanoic acid anhydride

: 15722-48-2
olsalazine

: 3,3'-azobis(6-hydroxybenzoic acid)dibutyrate

Conditions

Conditions	Yield
at 81 - 82℃; for 2h;	95.7%

: 15722-48-2
olsalazine

: C14H8N2O6(2-)*Ca(2+)

Conditions

Conditions	Yield
With calcium(II) nitrate tetrahydrate; sodium hydroxide In water at 90℃; Reagent/catalyst; Solvent;	85.1%

: 553-26-4
4,4'-bipyridine

: zinc(II) nitrate hexahydrate

: 15722-48-2
olsalazine

: 7732-18-5
water

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 3C14H6N2O6(4-)*6Zn(2+)*4H2O*4C3H7NO*3C10H8N2

Conditions

Conditions	Yield
at 115℃; for 72h;	80%

...Expand

: 15722-48-2
olsalazine

: C14H6N2O6(4-)*2Mg(2+)

Conditions

Conditions	Yield
With magnesium(II) nitrate hexahydrate In ethanol; N,N-dimethyl-formamide at 120℃; for 24h; Sealed tube;	80%

: 919-30-2
3-aminopropyltriethoxysilane

: 15722-48-2
olsalazine

: C23H31N3O8Si

Conditions

Conditions	Yield
Stage #1: olsalazine With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 20h; Inert atmosphere; Stage #2: 3-aminopropyltriethoxysilane In tetrahydrofuran for 24h; Inert atmosphere;	80%

: 17364-00-0
1,3-dibutanoyloxy-2-propanol

: 15722-48-2
olsalazine

: C36H46N2O14

Conditions

Conditions	Yield
Stage #1: 1,3-dibutanoyloxy-2-propanol; olsalazine With dmap In dichloromethane at 0℃; for 0.333333h; Stage #2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 22 - 25℃; for 16h;	49.5%

: 15663-27-1
cisplatin

: 15722-48-2
olsalazine

: C14H18N6O6Pt2

Conditions

Conditions	Yield
With sodium carbonate; silver nitrate In N,N-dimethyl-formamide at 20℃; for 24h; Darkness;	49%

: 1259528-75-0
C26H34N4O5

: 15722-48-2
olsalazine

: 1259528-76-1
C40H42N6O10

Conditions

Conditions	Yield
Stage #1: olsalazine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: C26H34N4O5 In N,N-dimethyl-formamide at 20℃; for 24h;	45%

: 15722-48-2
olsalazine

: 108-24-7
acetic anhydride

: 6,6'-diacetoxy-3,3'-azo-di-benzoic acid

: chromium potassium sulfate dodecahydrate

: 15722-48-2
olsalazine

: Cr(3+)*C14H7N2O6(3-)*2H2O={CrC14H7N2O6(H2O)2}

Conditions

Conditions	Yield
In sodium hydroxide addn. of hot aq. soln. of chromium alum to boiling soln. of 5.5'-azosalicylic acid in aq. NaOH, boiling react.-soln. for 3 h;; pptn., washing with large amt. of hot H2O, drying at 70 °C;;

: 1259528-78-3
C36H40N4O5

: 15722-48-2
olsalazine

: 1259528-72-7
C50H48N6O10

Conditions

Conditions	Yield
Stage #1: olsalazine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: C36H40N4O5 In N,N-dimethyl-formamide at 20℃; for 24h;

: 1259528-74-9
NapFFK

: 15722-48-2
olsalazine

A: 89-57-6
5-Aminosalicylic Acid

B: 1259528-71-6
C43H45N5O7

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C 1.2: 24 h / 20 °C 2.1: sodium dithionite / water / 1 h / 37 °C / pH 5 / aq. buffer View Scheme

...Expand

: 1259528-74-9
NapFFK

: 15722-48-2
olsalazine

: 1259528-70-5
C50H48N6O10

Conditions

Conditions	Yield
Stage #1: olsalazine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.25h; Stage #2: NapFFK In N,N-dimethyl-formamide at 20℃; for 24h;

: 15722-48-2
olsalazine

: iron(II) chloride

: C14H6N2O6(4-)*2Fe(2+)

Conditions

Conditions	Yield
Stage #1: olsalazine; iron(II) chloride With methanol In N,N-dimethyl-formamide at 100℃; for 16h; Glovebox; Sealed tube; Stage #2: at 120℃; Glovebox; Sealed tube;

: cobalt(II) nitrate hexahydrate

: 15722-48-2
olsalazine

: C14H6N2O6(4-)*2Co(2+)

Conditions

Conditions	Yield
In ethanol; N,N-dimethyl acetamide; water at 100℃; for 24h; Sealed tube;

: nickel(II) nitrate hexahydrate

: 15722-48-2
olsalazine

: C14H6N2O6(4-)*2Ni(2+)

Conditions

Conditions	Yield
In ethanol; water at 100℃; for 24h; Sealed tube;

: copper(II) nitrate pentahydrate

: 15722-48-2
olsalazine

: C14H6N2O6(4-)*2Cu(2+)

Conditions

Conditions	Yield
In ethanol; water at 100℃; for 24h; Sealed tube;

: zinc(II) nitrate hexahydrate

: 15722-48-2
olsalazine

: C14H6N2O6(4-)*2Zn(2+)

Conditions

Conditions	Yield
In ethanol; N,N-dimethyl acetamide at 100℃; for 24h; Sealed tube;

: 15722-48-2
olsalazine

: C14H6N2O6(4-)*Ca(2+)*2H(1+)

Conditions

Conditions	Yield
Stage #1: olsalazine With water; sodium hydroxide Stage #2: With calcium(II) nitrate tetrahydrate at 90℃;

Olsalazine Chemical Properties

Molecular Structure of Olsalazine (CAS NO.15722-48-2):

IUPAC Name: 5-[(2Z)-2-(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2-hydroxybenzoic acid
Empirical Formula: C₁₄H₁₀N₂O₆
Molecular Weight: 302.239
H bond acceptors: 8
H bond donors: 4
Freely Rotating Bonds: 6
Polar Surface Area: 139.78 Å²
Index of Refraction: 1.678
Molar Refractivity: 73.187 cm³
Molar Volume: 194.099 cm³
Surface Tension: 68.71 dyne/cm
Density: 1.557 g/cm³
Flash Point: 348.863 °C
Enthalpy of Vaporization: 101.121 kJ/mol
Boiling Point: 653.233 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
InChI
InChI=1/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+
Smiles
c1cc(\N=N\c2cc(c(cc2)O)C(O)=O)cc(C(O)=O)c1O
Classification Code: Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Drug / Therapeutic Agent; Gastrointestinal Agents; Human Data; Peripheral Nervous System Agents; Sensory System Agents

Olsalazine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	1714mg/kg/34W (1714mg/kg)	KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS	American Journal of Medicine. Vol. 100, Pg. 238, 1996.

Olsalazine Specification

Olsalazine , with CAS number of 15722-48-2, can be called 3,3'-Azobis(6-hydroxybenzoic acid) ; 5,5'-Azobis(salicylic acid) ; Azodisal ; C.I. Mordant Yellow 5 ; Dipentium ; Salicylic acid, 5,5'-azodi- ; Rasal .

Product Name

Olsalazine

Synthetic route

Olsalazine Chemical Properties

Olsalazine Toxicity Data With Reference

Olsalazine Specification

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