Product Name

  • Name

    Oxetan-3-ol

  • EINECS 663-648-9
  • CAS No. 7748-36-9
  • Article Data17
  • CAS DataBase
  • Density 1.255 g/cm3
  • Solubility
  • Melting Point
  • Formula C3H6O2
  • Boiling Point 153.124 °C at 760 mmHg
  • Molecular Weight 74.0794
  • Flash Point 77.266 °C
  • Transport Information
  • Appearance
  • Safety 26-39
  • Risk Codes 22-37/38-41
  • Molecular Structure Molecular Structure of 7748-36-9 (Oxetan-3-ol)
  • Hazard Symbols Xn
  • Synonyms 2-Propanol,1,3-epoxy- (7CI,8CI);3-Hydroxyoxetane;3-Oxetanol;
  • PSA 29.46000
  • LogP -0.62250

Synthetic route

3-(benzyloxy)oxetane
95257-22-0

3-(benzyloxy)oxetane

oxetan-3-ol
7748-36-9

oxetan-3-ol

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 40℃; under 7600.51 Torr; for 24h; Autoclave;95.84%
3-(1-Ethoxyethoxy)oxetane
85328-36-5

3-(1-Ethoxyethoxy)oxetane

oxetan-3-ol
7748-36-9

oxetan-3-ol

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol at 15 - 18℃; for 0.75h;95%
With toluene-4-sulfonic acid In methanol at 0 - 20℃; for 1h; Reagent/catalyst; Solvent; Large scale;79.2%
With toluene-4-sulfonic acid In methanol at 20℃; for 1h; Reagent/catalyst; Large scale;79%
3-tetrahydropyranyloxyoxetane
85328-34-3

3-tetrahydropyranyloxyoxetane

oxetan-3-ol
7748-36-9

oxetan-3-ol

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol deprotection;
3-chloro-2-hydroxy-1-propyl acetate
24573-30-6

3-chloro-2-hydroxy-1-propyl acetate

ethyl vinyl ether
109-92-2

ethyl vinyl ether

epichlorohydrin
106-89-8

epichlorohydrin

oxetan-3-ol
7748-36-9

oxetan-3-ol

Conditions
ConditionsYield
With sodium hydroxide; iron(III) chloride; toluene-4-sulfonic acid In water; acetic acid
...Expand
3-chloro-2-hydroxy-1-propyl acetate
24573-30-6

3-chloro-2-hydroxy-1-propyl acetate

epichlorohydrin
106-89-8

epichlorohydrin

oxetan-3-ol
7748-36-9

oxetan-3-ol

oxetan-3-one
6704-31-0

oxetan-3-one

oxetan-3-ol
7748-36-9

oxetan-3-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In tetrahydrofuran at 25℃; for 4h;1 g
With sodium tetrahydroborate In tetrahydrofuran at 25℃; for 4h;1 g
oxetan-3-ol
7748-36-9

oxetan-3-ol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

oxetan-3-yl methane sulfonate
148430-81-3

oxetan-3-yl methane sulfonate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 3h;100%
Stage #1: oxetan-3-ol With triethylamine In dichloromethane at 0℃; for 0.333333h;
Stage #2: methanesulfonyl chloride In dichloromethane at 20℃; for 12h;		75.7%
With triethylamine In dichloromethane at 20℃; for 5.5h; Cooling with ice; Inert atmosphere;68%
oxetan-3-ol
7748-36-9

oxetan-3-ol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

oxetan-3-yl 4-methylbenzenesulfonate
26272-83-3

oxetan-3-yl 4-methylbenzenesulfonate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 2h;95%
With triethylamine In water at 20℃; for 18h;94%
With sodium hydroxide In water ice-bath cooling;93%
oxetan-3-ol
7748-36-9

oxetan-3-ol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

3-oxetyl tosylate

3-oxetyl tosylate

Conditions
ConditionsYield
With sodium hydroxide In water94%
oxetan-3-ol
7748-36-9

oxetan-3-ol

N,N-phenyl-p-toluenesulfonylbenzamide
74542-54-4

N,N-phenyl-p-toluenesulfonylbenzamide

oxetan-3-yl benzoate

oxetan-3-yl benzoate

Conditions
ConditionsYield
With cesium fluoride In acetonitrile at 100℃; for 15h; Sealed tube;94%
oxetan-3-ol
7748-36-9

oxetan-3-ol

2-chloronaphthalene
91-58-7

2-chloronaphthalene

C13H12O2

C13H12O2

Conditions
ConditionsYield
With N1,N2-bis(naphthalen-1-ylmethyl)oxalamide; potassium tert-butylate; copper diacetate In 1,4-dioxane at 100℃; for 24h; Schlenk technique; Inert atmosphere; Molecular sieve;94%
5-fluoropicolinonitrile
327056-62-2

5-fluoropicolinonitrile

oxetan-3-ol
7748-36-9

oxetan-3-ol

5-(oxetan-3-yloxy)picolinonitrile

5-(oxetan-3-yloxy)picolinonitrile

Conditions
ConditionsYield
Stage #1: oxetan-3-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: 5-fluoropicolinonitrile In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;		92.41%
oxetan-3-ol
7748-36-9

oxetan-3-ol

2-fluoro-3-chloro-4-iodopyridine

2-fluoro-3-chloro-4-iodopyridine

3-chloro-4-iodo-2-(oxetan-3-yloxy)pyridine

3-chloro-4-iodo-2-(oxetan-3-yloxy)pyridine

Conditions
ConditionsYield
Stage #1: oxetan-3-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 1h;
Stage #2: 3-chloro-2-fluoro-4-iodopyridine In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;		91%
With caesium carbonate In dimethyl sulfoxide at 100℃; for 1.5h;37%
oxetan-3-ol
7748-36-9

oxetan-3-ol

2-fluoro-5-nitrobenzonitrile
17417-09-3

2-fluoro-5-nitrobenzonitrile

5-nitro-2-(oxetan-3-yloxy)benzonitrile

5-nitro-2-(oxetan-3-yloxy)benzonitrile

Conditions
ConditionsYield
Stage #1: oxetan-3-ol With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.333333h; Inert atmosphere;
Stage #2: 2-fluoro-5-nitrobenzonitrile In tetrahydrofuran at 0 - 20℃; for 1.16667h;		90%
oxetan-3-ol
7748-36-9

oxetan-3-ol

ethyl 6-chloro-2-(3-iodophenyl)pyrimidine-4-carboxylate

ethyl 6-chloro-2-(3-iodophenyl)pyrimidine-4-carboxylate

2-(3-iodophenyl)-6-(oxetan-3-yloxy)pyrimidine-4-carboxylic acid

2-(3-iodophenyl)-6-(oxetan-3-yloxy)pyrimidine-4-carboxylic acid

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;88%
Stage #1: oxetan-3-ol With sodium hydride In tetrahydrofuran Inert atmosphere;
Stage #2: ethyl 6-chloro-2-(3-iodophenyl)pyrimidine-4-carboxylate In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
oxetan-3-ol
7748-36-9

oxetan-3-ol

5-bromo-2-chlorophenol
183802-98-4

5-bromo-2-chlorophenol

3-(5-bromo-2-chlorophenoxy)oxetane

3-(5-bromo-2-chlorophenoxy)oxetane

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h;87%
oxetan-3-ol
7748-36-9

oxetan-3-ol

3-bromo-5-methylphenol
74204-00-5

3-bromo-5-methylphenol

3-(3-bromo-5-methyl phenoxy)oxetane

3-(3-bromo-5-methyl phenoxy)oxetane

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h;86%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h;86%
oxetan-3-ol
7748-36-9

oxetan-3-ol

2-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-6-morpholin-4-yl-pyridine-3-carboxylic acid amide
1373489-42-9

2-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-6-morpholin-4-yl-pyridine-3-carboxylic acid amide

N-[(3-fluorophenyl)-methyl]-4-methyl-6-morpholin-4-yl-2-(oxetan-3-yloxy)-pyridine-3-carboxylic acid amide
1373488-90-4

N-[(3-fluorophenyl)-methyl]-4-methyl-6-morpholin-4-yl-2-(oxetan-3-yloxy)-pyridine-3-carboxylic acid amide

Conditions
ConditionsYield
Stage #1: oxetan-3-ol With potassium tert-butylate In tetrahydrofuran at 50℃; for 0.25h;
Stage #2: 2-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-6-morpholin-4-yl-pyridine-3-carboxylic acid amide In tetrahydrofuran at 80℃; for 8h;		84%
oxetan-3-ol
7748-36-9

oxetan-3-ol

6-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-2-morpholin-4-yl-pyridine-3-carboxylic acid amide
1373489-41-8

6-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-2-morpholin-4-yl-pyridine-3-carboxylic acid amide

N-[(3-fluorophenyl)-methyl]-4-methyl-6-morpholin-4-yl-2-(oxetan-3-yloxy)-pyridine-3-carboxylic acid amide
1373488-90-4

N-[(3-fluorophenyl)-methyl]-4-methyl-6-morpholin-4-yl-2-(oxetan-3-yloxy)-pyridine-3-carboxylic acid amide

Conditions
ConditionsYield
Stage #1: oxetan-3-ol With potassium tert-butylate at 50℃; for 0.25h;
Stage #2: 6-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-2-morpholin-4-yl-pyridine-3-carboxylic acid amide In tetrahydrofuran at 80℃; for 8h;		84%
oxetan-3-ol
7748-36-9

oxetan-3-ol

benzyl bromide
100-39-0

benzyl bromide

3-(benzyloxy)oxetane
95257-22-0

3-(benzyloxy)oxetane

Conditions
ConditionsYield
Stage #1: oxetan-3-ol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 0.5h;
Stage #2: benzyl bromide In tetrahydrofuran at 60℃;		84%
Stage #1: oxetan-3-ol With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: benzyl bromide In tetrahydrofuran at 0 - 20℃; Inert atmosphere;		63%
oxetan-3-ol
7748-36-9

oxetan-3-ol

N-benzyl-N-(tert-butoxycarbonyl)-benzamide
85909-02-0

N-benzyl-N-(tert-butoxycarbonyl)-benzamide

oxetan-3-yl benzoate

oxetan-3-yl benzoate

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 23℃; for 12h; Schlenk technique;84%
oxetan-3-ol
7748-36-9

oxetan-3-ol

2,6-dichloropyridine-4-carboxylic acid
5398-44-7

2,6-dichloropyridine-4-carboxylic acid

2-chloro-6-(oxetan-3-yloxy)isonicotinic acid

2-chloro-6-(oxetan-3-yloxy)isonicotinic acid

Conditions
ConditionsYield
Stage #1: oxetan-3-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 2,6-dichloropyridine-4-carboxylic acid In N,N-dimethyl-formamide; mineral oil at 50℃;		83%
oxetan-3-ol
7748-36-9

oxetan-3-ol

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 2-(oxetan-3-yloxy)acetate

ethyl 2-(oxetan-3-yloxy)acetate

Conditions
ConditionsYield
Stage #1: oxetan-3-ol With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 2h; Inert atmosphere;
Stage #2: ethyl bromoacetate In tetrahydrofuran; mineral oil at 0 - 20℃; for 12h; Inert atmosphere;		82%
Stage #1: oxetan-3-ol With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: ethyl bromoacetate In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere;		59%
oxetan-3-ol
7748-36-9

oxetan-3-ol

2-Bromo-5-chlorophenol
13659-23-9

2-Bromo-5-chlorophenol

3-(2-bromo-5-chlorophenoxy)oxetane

3-(2-bromo-5-chlorophenoxy)oxetane

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h;82%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h;82%
oxetan-3-ol
7748-36-9

oxetan-3-ol

4-chloro-3-nitropyridine
13091-23-1

4-chloro-3-nitropyridine

3-nitro-4-(oxetan-3-yloxy)pyridine

3-nitro-4-(oxetan-3-yloxy)pyridine

Conditions
ConditionsYield
Stage #1: oxetan-3-ol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 4-chloro-3-nitropyridine In tetrahydrofuran at 20℃; for 1h;		81%
Stage #1: oxetan-3-ol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 4-chloro-3-nitropyridine In tetrahydrofuran at 20℃; for 1h;		81%
Stage #1: oxetan-3-ol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 4-chloro-3-nitropyridine In tetrahydrofuran at 20℃; for 1h;		81%
Stage #1: oxetan-3-ol With sodium hydride In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: 4-chloro-3-nitropyridine In tetrahydrofuran at 20℃; for 1h;		81%
4-nitro-1H-pyrazole
2075-46-9

4-nitro-1H-pyrazole

oxetan-3-ol
7748-36-9

oxetan-3-ol

4-nitro-1-(oxetan-3-yl)-1H-pyrazole

4-nitro-1-(oxetan-3-yl)-1H-pyrazole

Conditions
ConditionsYield
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;80%
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 16h;74%
oxetan-3-ol
7748-36-9

oxetan-3-ol

tert-butyl benzoyl(phenyl)carbamate
101137-69-3

tert-butyl benzoyl(phenyl)carbamate

oxetan-3-yl benzoate

oxetan-3-yl benzoate

Conditions
ConditionsYield
With cesium fluoride In acetonitrile at 100℃; for 15h; Sealed tube;80%
oxetan-3-ol
7748-36-9

oxetan-3-ol

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

tert-butyl dimethyl(oxetan-3-yloxy)silane

tert-butyl dimethyl(oxetan-3-yloxy)silane

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;79%
oxetan-3-ol
7748-36-9

oxetan-3-ol

2-(3'-bromobiphenyl-3-yl)[1,3]dioxolane

2-(3'-bromobiphenyl-3-yl)[1,3]dioxolane

2-[3'-(oxetan-3-yloxy)biphenyl-3-yl][1,3]dioxolane

2-[3'-(oxetan-3-yloxy)biphenyl-3-yl][1,3]dioxolane

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; tert-butyl XPhos In toluene at 90℃; Inert atmosphere;79%
oxetan-3-ol
7748-36-9

oxetan-3-ol

1,3-dioxoisoindolin-2-yl 2-methyl-2-phenylpropanoate

1,3-dioxoisoindolin-2-yl 2-methyl-2-phenylpropanoate

3-[(2-phenylpropan-2-yl)oxy]oxetane

3-[(2-phenylpropan-2-yl)oxy]oxetane

Conditions
ConditionsYield
With lithium tetrafluoroborate; 12-phenyl-12H-benzo[b]phenothiazine In acetonitrile at 0.4℃; for 24h; Irradiation; Inert atmosphere;79%
oxetan-3-ol
7748-36-9

oxetan-3-ol

tert-butyl benzoyl(tert-butoxycarbonyl)carbamate
135364-97-5

tert-butyl benzoyl(tert-butoxycarbonyl)carbamate

oxetan-3-yl benzoate

oxetan-3-yl benzoate

Conditions
ConditionsYield
With cesium fluoride In acetonitrile at 100℃; for 15h; Sealed tube;77%
oxetan-3-ol
7748-36-9

oxetan-3-ol

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

ethyl 2-(3-Amino-5-bromopyridin-2-yl)acetate
1379312-86-3

ethyl 2-(3-Amino-5-bromopyridin-2-yl)acetate

ethyl 2-(5-bromo-3-(((oxetan-3-yloxy)carbonyl)amino)pyridin-2-yl)acetate

ethyl 2-(5-bromo-3-(((oxetan-3-yloxy)carbonyl)amino)pyridin-2-yl)acetate

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate With pyridine In dichloromethane at 0℃; for 0.166667h;
Stage #2: oxetan-3-ol In dichloromethane for 1h;
Stage #3: ethyl 2-(3-Amino-5-bromopyridin-2-yl)acetate With pyridine In dichloromethane at 20℃;		75%
...Expand

Oxetan-3-Ol Chemical Properties

Empirical Formula: C3H6O2
Molecular Weight: 74.0785
Nominal Mass: 74 Da
Average Mass: 74.0785 Da
Monoisotopic Mass: 74.036779 Da 
Index of Refraction: 1.489
Molar Refractivity: 17.031 cm3
Molar Volume: 59.008 cm3
Surface Tension: 43.414 dyne/cm
Density: 1.255 g/cm3
Flash Point: 77.266 °C
Enthalpy of Vaporization: 45.417 kJ/mol
Boiling Point: 153.124 °C at 760 mmHg
Vapour Pressure: 1.255 mmHg at 25 °C
Structure of Oxetan-3-Ol (CAS NO.7748-36-9):
                         
Product Category of Oxetan-3-Ol (CAS NO.7748-36-9): Alcohols and Derivatives;Heterocycles;API intermediates

Oxetan-3-Ol Specification

 Oxetan-3-Ol , its cas register number is 7748-36-9. It also can be called 2-Propanol,1,3-epoxy- (7CI,8CI) ; 3-Oxetanol ; and 3-Hydroxyoxetane .

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