Oxytocin supplier | CasNO.50-56-6

Name
Oxytocin
EINECS 200-048-4
CAS No. 50-56-6
Article Data38
CAS DataBase
Density 1.27 g/cm³
Solubility Soluble in water.
Melting Point 192-194 °C
Formula C₄₃H₆₆N₁₂O₁₂S₂
Boiling Point 1533.3 °C at 760 mmHg
Molecular Weight 1007.2
Flash Point 881.1 °C
Transport Information UN 3249
Appearance White Solid
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 3-Isoleucine-8-leucine vasopressin;Alpha-hypophamine;Atonin O;Di-sipidin;Endopituitrina;Hyphotocin;Intertocine S;Nobitocin S;Orasthin;Partocon;Perlacton;Pitocin;Piton S;Presoxin;Synpitan;Synpitan forte;Synthetic oxytocin;Syntocin;Syntocinon;Syntocinone;Uteracon;Vasopressin, 3-L-isoleucine-8-L-leucine-;[1-Hemicystine]-oxytocin;a-Hypophamine;Oxytocin Acetate;Oxytocin Acetate USP30;
PSA 450.13000
LogP 1.55630

Synthetic route

: 151937-33-6
1,Cys(SH)6>-oxytocin

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Stage #1: 1,Cys(SH)6>-oxytocin With iodine In acetic acid at 20℃; Stage #2: With isoascorbic acid In acetic acid	98.5%
With dimethyl sulfoxide; methoxybenzene; trifluoroacetic acid for 1h;	69 % Chromat.

: 17912-60-6
H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With [Pt(en)2Cl2](2+); ethylenediaminetetraacetic acid; sodium chloride In phosphate buffer pH=4 - 7;	98%
With molybdophosphoric acid hydrate In dimethyl sulfoxide at 20℃; for 24h;	90%
With ammonium hydroxide; acetic acid In water for 6h; pH=7;	63%

: Boc-Cys(Acm)(O)-Tyr-Ile-Gln-Asn-Cys(MBzl)-Pro-Leu-Gly-NH2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With dimethylsulfide In trifluoroacetic acid 1.) ice bath, 60 min; 2.) 25 deg C, 60 min;	86%

: C90H109N12O14PolS2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With chlorotriisopropylsilane; trifluoroacetic acid In water for 0.5h; Rink Amide AM resin;	85.22%

: Boc-Cys(MBzl)-Tyr-Ile-Gln-Asn-Cys(MBzl)-Pro-Leu-Gly-NH2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With dimethyl sulfoxide; methoxybenzene; trifluoroacetic acid at 25℃; for 12h;	73.5%

: 133383-08-1
1,6>-oxytocin

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With chloro-trimethyl-silane; 1,1'-sulfinylbisbenzene; methoxybenzene; trifluoroacetic acid at 25℃; for 0.166667h;	69%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 35661-60-0
Fmoc-Leu-OH

: 71989-31-6
Fmoc-Pro-OH

: 71989-23-6
Fmoc-Ile-OH

: 71989-38-3
Fmoc-Tyr(tBu)-OH

: 132388-59-1
L-Asn(Trt)

: 132327-80-1
Fmoc-L-Gln(Trt)-OH

: 73724-43-3
3-[(1,1-dimethylethyl)dithio]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Stage #1: 3-[(1,1-dimethylethyl)dithio]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Automated synthesizer; Stage #2: With piperidine In N,N-dimethyl-formamide Inert atmosphere; Automated synthesizer; Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Leu-OH; Fmoc-Pro-OH; Fmoc-Ile-OH; Fmoc-Tyr(tBu)-OH; L-Asn(Trt); Fmoc-L-Gln(Trt)-OH; 3-[(1,1-dimethylethyl)dithio]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine Reagent/catalyst; Further stages;	65%

Yield

Stage #1: 3-[(1,1-dimethylethyl)dithio]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Automated synthesizer;
Stage #2: With piperidine In N,N-dimethyl-formamide Inert atmosphere; Automated synthesizer;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Leu-OH; Fmoc-Pro-OH; Fmoc-Ile-OH; Fmoc-Tyr(tBu)-OH; L-Asn(Trt); Fmoc-L-Gln(Trt)-OH; 3-[(1,1-dimethylethyl)dithio]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine Reagent/catalyst; Further stages;

65%

...Expand

: 104523-34-4
1,6>-oxytocin

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With chloro-trimethyl-silane; 1,1'-sulfinylbisbenzene; methoxybenzene; trifluoroacetic acid at 25℃; for 0.166667h;	64%

: 104523-33-3
1,6>-oxytocin

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With chloro-trimethyl-silane; 1,1'-sulfinylbisbenzene; methoxybenzene; trifluoroacetic acid at 25℃; for 0.166667h;	56%
With hydrogenchloride; silver trifluoromethanesulfonate; methoxybenzene 1.) TFA, 4 deg C, 1.5 h, 2.) DMSO, r.t., 7 h; Yield given. Multistep reaction;

: 111193-50-1
Z(OMe)-Cys(MBzl)-Tyr-Ile-Gln-Asn-Cys(MBzl)-Pro-Leu-Gly-NH2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With thallium(III) trifluoroacetate In trifluoroacetic acid for 1h;	27%
With methoxybenzene; thallium(III) trifluoroacetate In trifluoroacetic acid at 0℃; for 1h;	27%

: Z(OMe)-Cys(Acm)-Tyr-Ile-Gln-Asn-Cys(Acm)-Pro-Leu-Gly-NH2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With thallium(III) trifluoroacetate In trifluoroacetic acid for 1h;	22%

: Boc-Cys(Acm)-Tyr-Ile-Gln-Asn-Cys(Acm)-Pro-Gly-NH2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With methoxybenzene; thallium(III) trifluoroacetate In trifluoroacetic acid at 0℃; for 1h;	22%

: 35661-60-0
Fmoc-Leu-OH

: 67436-13-9
(R)-3-tert-Butylsulfanyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid

: 115057-30-2
{4-[[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-(4-methoxy-phenyl)-methyl]-2-methyl-phenoxy}-acetic acid

: 71989-31-6
Fmoc-Pro-OH

: 50-56-6
oxytocin

Conditions

Conditions	Yield
solid phase synthesis; the next amino acids are: Fmoc-Asn-OH, Fmoc-Gln-OH, Fmoc-Ile-OH and Fmoc-Tyr(tBu)-OH; Yield given. Multistep reaction;

...Expand

: 5068-30-4
S,S'-Dihydrooxytocin hydrochloride

: 50-56-6
oxytocin

Conditions

Conditions	Yield
In water for 360h;

: 1675-08-7, 3274-73-5, 3410-72-8, 4587-31-9, 6739-39-5, 7165-55-1, 7776-64-9, 106765-66-6, 106819-71-0, 106819-72-1
Z-Cys(Bzl)-Tyr-Ile-Gln-Asn-Cys(Bzl)-Pro-Leu-Gly-NH2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With potassium hexacyanoperferrate; sodium 1.) fl. NH3; Yield given. Multistep reaction;

: 78221-69-9
benzyloxycarbonyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With air; hydrogen fluoride; methoxybenzene 1) 0 degC, 30 min, 2) H2O, 1 h; Yield given. Multistep reaction;

: 1,6>-oxytocin

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With dimethyl sulfoxide; methoxybenzene; trifluoroacetic acid for 2h;	86 % Chromat.

: C71H88N12O12S2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
With piperidine In N,N-dimethyl-formamide

: 17912-60-6
H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2

: 64806-05-9
Captopril disulfide

A: 50-56-6
oxytocin

B: 62571-86-2
captopril

Conditions

Conditions	Yield
In water at 25℃; for 5h; Equilibrium constant; pH 7.0;

...Expand

: C52H81N13O15S3

: C52H81N13O15S3

A: 50-56-6
oxytocin

B: 62571-86-2
captopril

Conditions

Conditions	Yield
In water at 25℃; for 5h; Rate constant; Equilibrium constant; pH 7.0;

...Expand

: C48H77N13O14S3

: C48H77N13O14S3

A: 52-66-4
DL-Penicillamin

B: 50-56-6
oxytocin

Conditions

Conditions	Yield
In water at 25℃; for 5h; Rate constant; Equilibrium constant; pH 7.0;

...Expand

: 141437-69-6
α-Boc,Cys(t-Bu)1,6>-oxytocin

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 91 percent / TFA, anisole / 1 h 2: 64 percent / TFA, Me3SiCl, PhS(O)Ph, anisole / 0.17 h / 25 °C View Scheme

: Nα-tert-Butoxycarbonyl-S,S'-dibenzyloxytocin

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 0.45 g / metallic sodium / liquid ammonia / Heating 2: 0.408 g / 2.58 N HCl / acetic acid / 0.07 h 3: H2O / 360 h View Scheme

: Nα-BOC-S,S'-dihydrooxytocin

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.408 g / 2.58 N HCl / acetic acid / 0.07 h 2: H2O / 360 h View Scheme

: 1391105-08-0
Boc-Cys(Trt)-Pro-Leu-Gly-OMe

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: ammonia / methanol / 24 h / Inert atmosphere 2.1: chlorotriisopropylsilane; water; trifluoroacetic acid; phenol / 1.5 h / 20 °C / Inert atmosphere 3.1: sodium dihydrogenphosphate; tris-(2-carboxyethyl)-phosphine hydrochloride / pH 7.2 / Inert atmosphere 3.2: Inert atmosphere 4.1: ammonium hydroxide; acetic acid / water / 6 h / pH 7 View Scheme

: 41089-31-0
H-Cys-Pro-Leu-Gly-NH2

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium dihydrogenphosphate; tris-(2-carboxyethyl)-phosphine hydrochloride / pH 7.2 / Inert atmosphere 1.2: Inert atmosphere 2.1: ammonium hydroxide; acetic acid / water / 6 h / pH 7 View Scheme

: 27610-07-7, 62188-56-1
(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)acetate

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere 2.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere 3.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere 4.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere 5.1: ammonia / methanol / 24 h / Inert atmosphere 6.1: chlorotriisopropylsilane; water; trifluoroacetic acid; phenol / 1.5 h / 20 °C / Inert atmosphere 7.1: sodium dihydrogenphosphate; tris-(2-carboxyethyl)-phosphine hydrochloride / pH 7.2 / Inert atmosphere 7.2: Inert atmosphere 8.1: ammonium hydroxide; acetic acid / water / 6 h / pH 7 View Scheme

Yield

Multi-step reaction with 8 steps
1.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere
2.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere
4.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere
5.1: ammonia / methanol / 24 h / Inert atmosphere
6.1: chlorotriisopropylsilane; water; trifluoroacetic acid; phenol / 1.5 h / 20 °C / Inert atmosphere
7.1: sodium dihydrogenphosphate; tris-(2-carboxyethyl)-phosphine hydrochloride / pH 7.2 / Inert atmosphere
7.2: Inert atmosphere
8.1: ammonium hydroxide; acetic acid / water / 6 h / pH 7
View Scheme

: 27560-15-2, 119621-63-5, 120089-68-1
methyl 2-(2-amino-4-methylpentanamido)acetate

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere 2.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere 3.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere 4.1: ammonia / methanol / 24 h / Inert atmosphere 5.1: chlorotriisopropylsilane; water; trifluoroacetic acid; phenol / 1.5 h / 20 °C / Inert atmosphere 6.1: sodium dihydrogenphosphate; tris-(2-carboxyethyl)-phosphine hydrochloride / pH 7.2 / Inert atmosphere 6.2: Inert atmosphere 7.1: ammonium hydroxide; acetic acid / water / 6 h / pH 7 View Scheme

Yield

Multi-step reaction with 7 steps
1.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere
2.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere
3.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere
4.1: ammonia / methanol / 24 h / Inert atmosphere
5.1: chlorotriisopropylsilane; water; trifluoroacetic acid; phenol / 1.5 h / 20 °C / Inert atmosphere
6.1: sodium dihydrogenphosphate; tris-(2-carboxyethyl)-phosphine hydrochloride / pH 7.2 / Inert atmosphere
6.2: Inert atmosphere
7.1: ammonium hydroxide; acetic acid / water / 6 h / pH 7
View Scheme

: 118408-13-2, 118408-15-4, 33900-31-1
Boc-Pro-Leu-Gly-OMe

: 50-56-6
oxytocin

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere 2.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere 3.1: ammonia / methanol / 24 h / Inert atmosphere 4.1: chlorotriisopropylsilane; water; trifluoroacetic acid; phenol / 1.5 h / 20 °C / Inert atmosphere 5.1: sodium dihydrogenphosphate; tris-(2-carboxyethyl)-phosphine hydrochloride / pH 7.2 / Inert atmosphere 5.2: Inert atmosphere 6.1: ammonium hydroxide; acetic acid / water / 6 h / pH 7 View Scheme

Yield

Multi-step reaction with 6 steps
1.1: trifluoroacetic acid / chloroform / 1 h / Inert atmosphere
2.1: tert-butylisonitrile; benzotriazol-1-ol / chloroform / 20 °C / Inert atmosphere
3.1: ammonia / methanol / 24 h / Inert atmosphere
4.1: chlorotriisopropylsilane; water; trifluoroacetic acid; phenol / 1.5 h / 20 °C / Inert atmosphere
5.1: sodium dihydrogenphosphate; tris-(2-carboxyethyl)-phosphine hydrochloride / pH 7.2 / Inert atmosphere
5.2: Inert atmosphere
6.1: ammonium hydroxide; acetic acid / water / 6 h / pH 7
View Scheme

: 623-65-4
palmitic anhydride

: 50-56-6
oxytocin

: N-palmitoyloxytocin

Conditions

Conditions	Yield
With triethylamine In dichloromethane; N,N-dimethyl-formamide for 3h;	96%

: 50-56-6
oxytocin

: 769884-11-9
mono-6-deoxy-6-carboxy-β-cyclodextrin

: 1024982-27-1
C85H132N12O47S2

Conditions

Conditions	Yield
Stage #1: mono-6-deoxy-6-carboxy-β-cyclodextrin With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 0 - 4℃; for 1h; Stage #2: oxytocin In N,N-dimethyl-formamide at 20℃; for 48h; Further stages.;	30%

: 52-90-4
L-Cysteine

: 50-56-6
oxytocin

A: 56-89-3
L-cystine

B: 17912-60-6
H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2

Conditions

Conditions	Yield
With potassium chloride In water at 25℃; Equilibrium constant; Rate constant; pH = 7;

...Expand

: 70-18-8
GLUTATHIONE

: 50-56-6
oxytocin

A: 27025-41-8
Oxidized glutathione

B: 17912-60-6
H-Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2

Conditions

Conditions	Yield
With potassium chloride In water at 25℃; Equilibrium constant; Rate constant; pH = 7;

...Expand

: 50-56-6
oxytocin

: 60-24-2
2-hydroxyethanethiol

: C45H72N12O13S2

Conditions

Conditions	Yield
at 80℃; Kinetics;

: 52-66-4
DL-Penicillamin

: 50-56-6
oxytocin

A: C48H77N13O14S3

B: C48H77N13O14S3

Conditions

Conditions	Yield
In water at 25℃; for 5h; Rate constant; Equilibrium constant; pH 7.0;

...Expand

Oxytocin Specification

1. Introduction of Oxytocin
Oxytocin is a white powder. The IUPAC Name of this chemical is (2S)-1-[(1R,4S,7S,10S,13S,16R)-16-Amino-4-(2-amino-2-oxoethyl)-7-(3-amino-3-oxopropyl)-10-[(2S)-butan-2-yl]-13-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-18,19-dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide. Besides, Oxytocin belongs the product categories which is Amino Acid Derivatives; Organics; Amino Acids 13C, 2H, 15N; Peptide; Amino Acids & Derivatives; Intermediates & Fine Chemicals; Pharmaceuticals; Vasopressin and Oxytocin receptor; Peptide Receptors.

The Classification Code of Oxytocin is Drug / Therapeutic Agent; Hormone; Human Data; Oxytocic; Oxytocics; Reproductive Control Agents; Reproductive Effect. Furthermore, Oxytocin can soluble in water.

2. Properties of Oxytocin
Physical properties about Oxytocin are:
(1)Melting point: 192-194 °C; (2)Storage temp.: 2-8 °C; (3)Merck: 13,7049; (4)Density: 1.27 g/cm³; (5)Flash Point: 881.1 °C;(6)Index of Refraction: 1.554; (7)Surface Tension: 51.8 dyne/cm; (8)Appearance: lyophilized powder; (9)Enthalpy of Vaporization: 245.93 kJ/mol; (10)Boiling Point: 1533.3 °C at 760 mmHg; (11)XLogP3-AA: -2.6; (12)H-Bond Donor: 12; (13)H-Bond Acceptor: 15.

3. Structure Descriptors of Oxytocin
(1)Canonical SMILES: CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
(2)Isomeric SMILES: CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N
[C@H](C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N
(3)InChI: InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
(4)InChIKey: XNOPRXBHLZRZKH-DSZYJQQASA-N
(5)Smiles: CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)Cc2ccc(cc2)O)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N

4. Toxicity of Oxytocin

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intravenous	5800ug/kg (5.8mg/kg)	Drugs in Japan Vol. 6, Pg. 151, 1982.
mouse	LD50	oral	> 514mg/kg (514mg/kg)	Drugs in Japan Vol. -, Pg. 230, 1990.
mouse	LD50	subcutaneous	> 514mg/kg (514mg/kg)	Drugs in Japan Vol. -, Pg. 230, 1990.
rat	LD50	intravenous	2275ug/kg (2.275mg/kg)	Drugs in Japan Vol. -, Pg. 230, 1990.
rat	LD50	oral	> 20520ug/kg (20.52mg/kg)	Drugs in Japan Vol. -, Pg. 230, 1990.
rat	LD50	subcutaneous	> 20520ug/kg (20.52mg/kg)	Drugs in Japan Vol. -, Pg. 230, 1990.

ivn-mus LD₅₀:5800 µg/kg

NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),151.

5. Physical Properties of Oxytocin

Physical Property	Value	Units	Temp (deg C)	Source
log P (octanol-water)	-6.270	(none)		EST
Atmospheric OH Rate Constant	5.33E-10	cm3/molecule-sec	25	EST

6. Safety information of Oxytocin
Poison by intravenous route. Experimental reproductive effects. A pituitary hormone which stimulates uterine contraction and milk production. The principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland. Note: Unlike vasopressin which occurs in at least two forms, Oxytocin from beef and hog sources shows no difference in amino acid composition. When heated to decomposition it emits toxic fumes of SO_x and NO_x.
Hazard Codes: Irritant

Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 3
F: 3-8-10-23
HazardClass: 6.1(a)
PackingGroup: II
RTECS: RS7534000

7. Uses of Oxytocin
Oxytocin (CAS NO.50-56-6) is the principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland.It is released in large amounts after distension of the cervix and vagina during labor, and after stimulation of the nipples, facilitating birth and breastfeeding, respectively. It is a mammalian hormone that also acts as a neurotransmitter in the brain.

Product Name

Oxytocin

Synthetic route

Oxytocin Specification

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