PHENYL CARBITOL supplier | CasNO.104-68-7

Name
2-(2-phenoxyethoxy)ethanol
EINECS
CAS No. 104-68-7
Article Data14
CAS DataBase
Density 1.092g/cm³
Solubility 35g/L at 20℃
Melting Point -49.9°C
Formula C10H14 O3
Boiling Point 309.3°Cat760mmHg
Molecular Weight 182.219
Flash Point 140.9°C
Transport Information
Appearance
Safety Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Some glycol ethers have dangerous human reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-(2-Phenoxyethoxy)ethanol;Diethylene glycol monophenyl ether; Diethylene glycol phenyl ether; NSC 406593;Phenoxydiglycol; Phenyl Di Glycol; Phenyl carbitol; Sunfine PH 20
PSA 38.69000
LogP 1.07430

Synthetic route

: 57641-66-4
2-(2-bromoethoxy)ethan-1-ol

: 108-95-2
phenol

: 104-68-7
2-(2-phenoxyethoxy)ethanol

Conditions

Conditions	Yield
Stage #1: phenol With potassium hydroxide In acetonitrile at 60℃; for 2h; Inert atmosphere; Stage #2: 2-(2-bromoethoxy)ethan-1-ol With potassium iodide In acetonitrile at 60℃; for 10h; Inert atmosphere;	72%

: 108-86-1
bromobenzene

: 62-53-3
aniline

: 111-46-6
diethylene glycol

A: 104-68-7
2-(2-phenoxyethoxy)ethanol

B: 122-39-4
diphenylamine

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; potassium carbonate at 110℃; for 8h; Catalytic behavior; Reagent/catalyst; Inert atmosphere;	A 28% B 70%

...Expand

: 75-21-8
oxirane

: 139-02-6
sodium phenoxide

: 104-68-7
2-(2-phenoxyethoxy)ethanol

Conditions

Conditions	Yield
at 95℃; for 2h;	69%

: 108-86-1
bromobenzene

: 100-01-6
4-nitro-aniline

: 111-46-6
diethylene glycol

A: 836-30-6
4-ntrophenyl(phenyl)amine

B: 104-68-7
2-(2-phenoxyethoxy)ethanol

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; potassium carbonate at 110℃; for 20h; Inert atmosphere;	A 68% B 22%

...Expand

: 108-86-1
bromobenzene

: 111-46-6
diethylene glycol

: 104-68-7
2-(2-phenoxyethoxy)ethanol

Conditions

Conditions	Yield
With N-Methyldicyclohexylamine; C46H67BN2; nickel dibromide In N,N-dimethyl-formamide at 60℃; for 24h;	65%

: 108-86-1
bromobenzene

: 95-53-4
o-toluidine

: 111-46-6
diethylene glycol

A: 104-68-7
2-(2-phenoxyethoxy)ethanol

B: 1205-39-6
N-phenyl-2-methylaniline

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; potassium carbonate at 110℃; for 12h; Inert atmosphere;	A 33% B 63%

...Expand

: 108-86-1
bromobenzene

: 24544-04-5
2,6-diisopropylbenzenamine

: 111-46-6
diethylene glycol

A: 104-68-7
2-(2-phenoxyethoxy)ethanol

B: (2,6-diisopropyl-N-phenyl)phenylamine

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; potassium carbonate at 110℃; for 20h; Inert atmosphere;	A 30% B 11%

...Expand

: 75-21-8
oxirane

: 108-95-2
phenol

: 104-68-7
2-(2-phenoxyethoxy)ethanol

Conditions

Conditions	Yield
With sodium phenoxide at 200℃;

: 139-02-6
sodium phenoxide

: 108-95-2
phenol

: 104-68-7
2-(2-phenoxyethoxy)ethanol

Conditions

Conditions	Yield
at 100℃; Einleiten von Aethylenoxyd;

: 31603-33-5
bis(phenoxyethoxyethyl) peroxydicarbonate

A: 124-38-9
carbon dioxide

B: 622-87-7
β,β'-Bis(phenoxyethyl)ether

C: 104-68-7
2-(2-phenoxyethoxy)ethanol

D: 141-46-8
Glycolaldehyde

E: Carbonic acid 2-hydroxy-1-(2-phenoxy-ethoxy)-ethyl ester 2-(2-phenoxy-ethoxy)-ethyl ester

Conditions

Conditions	Yield
In benzene at 60℃; Rate constant; Kinetics; var. temp., also with inhibiting addition of styrene or α-naphthol, Eact;

...Expand

: 628-89-7
2-(2-Chloroethoxy)ethanol

: 108-95-2
phenol

: 104-68-7
2-(2-phenoxyethoxy)ethanol

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile
Williamson ether synthesis; Inert atmosphere;

: 111-46-6
diethylene glycol

η6-chlorobenzene(cyclopentadienyl)iron(II) hexafluorophosphate: η6-chlorobenzene(cyclopentadienyl)iron(II) hexafluorophosphate

: 104-68-7
2-(2-phenoxyethoxy)ethanol

Conditions

Conditions	Yield
With sodium hydride 1.) THF, r.t., 4 h, 2.) hν; Yield given. Multistep reaction;

: 107-07-3
2-chloro-ethanol

sodium-<2-phenoxy ethylate>: sodium-<2-phenoxy ethylate>

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 75-21-8
oxirane

: 108-95-2
phenol

A: 122-99-6
2-Phenoxyethanol

B: 104-68-7
2-(2-phenoxyethoxy)ethanol

Conditions

Conditions	Yield
pyridine at 165℃; under 2311.54 - 3345.86 Torr; for 0.333333h; Product distribution / selectivity; Inert atmosphere;
anion exchange resin A (Cl-type) In 2-methoxy-ethanol at 90 - 100℃; for 7h; Autoclave;	A 98.6 %Chromat. B 1.4 %Chromat.
anion exchange resin A (Cl-type) at 100℃; for 9h; Autoclave;	A 95 %Chromat. B 4.9 %Chromat.

...Expand

: 75-21-8
oxirane

: 108-95-2
phenol

A: 122-99-6
2-Phenoxyethanol

B: 104-68-7
2-(2-phenoxyethoxy)ethanol

C: 7204-16-2
2-(2-(2-phenoxyethoxy)ethoxy)ethan-1-ol

Conditions

Conditions	Yield
sodium hydroxide at 160℃; for 5.00333 - 5.01167h; Product distribution / selectivity;
sodium hydroxide In water at 140℃; for 5.00333 - 5.01167h; Product distribution / selectivity;

...Expand

: 75-21-8
oxirane

: 108-95-2
phenol

A: 122-99-6
2-Phenoxyethanol

B: 104-68-7
2-(2-phenoxyethoxy)ethanol

C: 7204-16-2
2-(2-(2-phenoxyethoxy)ethoxy)ethan-1-ol

D: 36366-93-5
2-<2-<2-(2-phenoxyethoxy)ethoxy>ethoxy>ethanol

Conditions

Conditions	Yield
trifluoroacetic acid at 160℃; for 5.00333 - 5.01167h; Product distribution / selectivity;
at 140℃; for 5.00333 - 5.01167h; Product distribution / selectivity;

...Expand

: 591-50-4
iodobenzene

: 62-53-3
aniline

: 111-46-6
diethylene glycol

A: 104-68-7
2-(2-phenoxyethoxy)ethanol

B: 122-39-4
diphenylamine

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; potassium carbonate at 110℃; for 20h; Inert atmosphere;

...Expand

: 591-50-4
iodobenzene

: 104-94-9
4-methoxy-aniline

: 111-46-6
diethylene glycol

A: 104-68-7
2-(2-phenoxyethoxy)ethanol

B: 1208-86-2
N-(4-methoxyphenyl)phenylamine

Conditions

Conditions	Yield
With copper(II) acetate monohydrate; potassium carbonate at 110℃; for 8h; Inert atmosphere;

...Expand

: 75-44-5
phosgene

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 81731-00-2
phenoxyethoxyethyl chloroformate

Conditions

Conditions	Yield
at 3 - 5℃; for 3h;	99%

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 108-24-7
acetic anhydride

: C12H16O4

Conditions

Conditions	Yield
at 120℃; for 6h;	98%
at 90 - 120℃; for 6h;	98%
at 90 - 120℃; for 6h;	98%
at 90 - 120℃; for 6h;	98%

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 154591-45-4
2',3'-di-O-acetylnicotinamide mononucleotide

: 1193377-76-2
C25H31N2O12P

Conditions

Conditions	Yield
With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride In N,N-dimethyl-formamide at 25℃; for 6h; Inert atmosphere;	89%

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 123824-56-6
(2-(2-bromoethoxy)ethoxy)benzene

Conditions

Conditions	Yield
With phosphorus tribromide In pyridine at 0 - 50℃;	62%

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-hydroxy-1H-1,2,4-triazol-1-yl)phenyl)acetamide

: 2-chloro-N-(4-(5-(3,4-dichlorophenyl)-3-(2-(2-phenoxyethoxy)ethoxy)-1H-1,2,4-triazol-1-yl)phenyl)acetamide

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃; for 5h;	28%

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 292638-85-8
acrylic acid methyl ester

: 61630-25-9
1-acryloyloxy-2-(2-phenoxy-ethoxy)-ethane

Conditions

Conditions	Yield
With sulfuric acid; hydroquinone Entfernung des entstehenden Methanols;
With toluene-4-sulfonic acid; hydroquinone Entfernung des entstehenden Methanols;

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 140-88-5
ethyl acrylate

: 61630-25-9
1-acryloyloxy-2-(2-phenoxy-ethoxy)-ethane

Conditions

Conditions	Yield
With sulfuric acid; hydroquinone Entfernung des entstehenden Aethanols;
With toluene-4-sulfonic acid; hydroquinone Entfernung des entstehenden Aethanols;

: 104-68-7
2-(2-phenoxyethoxy)ethanol

A: 333382-85-7
2-(2-(4-bromophenoxy)ethoxy)ethanol

B: 2-[2-(2-Bromo-phenoxy)-ethoxy]-ethanol

Conditions

Conditions	Yield
With n-dodecyl sulfate; bromine In water for 48h; Yields of byproduct given;
With bromine; cetyltrimethylammonim bromide In water for 48h; Yields of byproduct given;

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 98-59-9
p-toluenesulfonyl chloride

: 50964-17-5
Toluene-4-sulfonic acid 2-(2-phenoxy-ethoxy)-ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 31603-33-5
bis(phenoxyethoxyethyl) peroxydicarbonate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 99 percent / 3 h / 3 - 5 °C 2: 62 percent / aq. Na2O2 / diethyl ether / 0.5 h / 0 - 5 °C View Scheme

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 220128-92-7
{4-[2-(2-Phenoxy-ethoxy)-ethoxy]-phenyl}-methanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NEt3 / CH2Cl2 2: K2CO3 / acetonitrile View Scheme

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 220128-94-9
1-Chloromethyl-4-[2-(2-phenoxy-ethoxy)-ethoxy]-benzene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NEt3 / CH2Cl2 2: K2CO3 / acetonitrile 3: SOCl2, pyridine / CH2Cl2 View Scheme

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: C27H27N2O3(1+)*F6P(1-)

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: NEt3 / CH2Cl2 2: K2CO3 / acetonitrile 3: SOCl2, pyridine / CH2Cl2 4: 2.) NH4PF6 / 1.) MeCN, 2.) Me2CO, H2O View Scheme

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: C38H36N4O3(2+)*2F6P(1-)

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: NEt3 / CH2Cl2 2: K2CO3 / acetonitrile 3: SOCl2, pyridine / CH2Cl2 4: 2.) NH4PF6 / 1.) MeCN, 2.) Me2CO, H2O 5: 2.) NH4PF6 / 2.) Me2CO, H2O View Scheme

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 7204-16-2
2-(2-(2-phenoxyethoxy)ethoxy)ethan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 62 percent / phosphorous tribromide / pyridine / 0 - 50 °C 2: 67 percent / 1.) potassium hydroxide / H2O / 1.) 115 deg C, 1h; 2.) 120 deg C, 1h View Scheme

: 104-68-7
2-(2-phenoxyethoxy)ethanol

: 36366-93-5
2-<2-<2-(2-phenoxyethoxy)ethoxy>ethoxy>ethanol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 62 percent / phosphorous tribromide / pyridine / 0 - 50 °C 2: 67 percent / 1.) potassium hydroxide / H2O / 1.) 115 deg C, 1h; 2.) 120 deg C, 1h 3: 48 percent / phosphorous tribromide / pyridine / 0 - 50 °C 4: 72 percent / 1.) potassium hydroxide / H2O / 1.) 115 deg C, 1h; 2.) 120 deg C, 1h View Scheme

PHENYL CARBITOL Chemical Properties

MF: C₁₀H₁₄O₃
MW: 182.21636
EINECS: 203-227-5

PHENYL CARBITOL Toxicity Data With Reference

1.	skn-rbt 505 mg open MLD	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 8/16 ,1961.
2.	eye-rbt 2 mg open SEV	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
3.	orl-rat LD50:2140 mg/kg	AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. 10 (1954),61.
4.	skn-rbt LD50:2120 mg/kg	UCDS** Union Carbide Data Sheet. (Industrial Medicine and Toxicology Dept., Union Carbide Corp., 270 Park Ave., New York, NY 10017) 8/16 ,1961.

RTECS: KM0875000

PHENYL CARBITOL Consensus Reports

Glycol ether compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory.

PHENYL CARBITOL Safety Profile

Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Some glycol ethers have dangerous human reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.

Product Name

2-(2-phenoxyethoxy)ethanol

Synthetic route

PHENYL CARBITOL Chemical Properties

PHENYL CARBITOL Toxicity Data With Reference

PHENYL CARBITOL Consensus Reports

PHENYL CARBITOL Safety Profile

Related Products

Hot Products