Phenyltrimethylammonium chloride supplier

Name
Trimethylphenylammonium chloride
EINECS 205-319-0
CAS No. 138-24-9
Article Data6
CAS DataBase
Density 1.0683 (rough estimate)
Solubility soluble in water
Melting Point 246-248 °C (dec.)(lit.)
Formula C₉H₁₄N^.Cl
Boiling Point 283.2°C (rough estimate)
Molecular Weight 171.67
Flash Point
Transport Information UN 2811 6.1/PG 3
Appearance White or greyish-blue crystalline powder
Safety 53-25-39-45
Risk Codes 24/25
Molecular Structure
Hazard Symbols T
Synonyms Ammonium,trimethylphenyl-, chloride (8CI);Benzenaminium, N,N,N-trimethyl-, chloride(9CI);Trimethylphenylammonium chloride (6CI,7CI);Ammonyx 200;N,N,N-Trimethylanilinium chloride;Trimethylanilinium chloride;
PSA 0.00000
LogP -1.11270

Synthetic route

: 5293-94-7
bis(chloromethyl)mercury

: 121-69-7
N,N-dimethyl-aniline

A: 138-24-9
phenyltrimethylammonium chloride

B: 101-61-1
4,4'-methylene-bis(N,N-dimethylaniline)

Conditions

Conditions	Yield
In dibutyl ether at 100℃; for 48h;	A n/a B 96%

...Expand

: 98-04-4
phenyltrimethylammonium iodide

: 138-24-9
phenyltrimethylammonium chloride

Conditions

Conditions	Yield
With silver(I) chloride

: 74-87-3
methylene chloride

: 121-69-7
N,N-dimethyl-aniline

: 138-24-9
phenyltrimethylammonium chloride

Conditions

Conditions	Yield
trichlorophosphate

: 4-trimethylammoniumbenzene diazonium tetrafluoroborate chloride

: 138-24-9
phenyltrimethylammonium chloride

Conditions

Conditions	Yield
With pyrene In acetonitrile Irradiation; CIDNP effects of the photochemical dediazonation; reaction in the absence of pyrene in dioxane;

: C29H38N6O4*C9H14N(1+)*Cl(1-)

A: 138-24-9
phenyltrimethylammonium chloride

B: 232279-44-6
Trp-Aib-Gly-Leu-NHPh

Conditions

Conditions	Yield
In chloroform-d1 at 24.84℃; Equilibrium constant; complex formation;

: C31H42N6O4*C9H14N(1+)*Cl(1-)

A: 138-24-9
phenyltrimethylammonium chloride

B: 271770-12-8
Trp-Aib-Gly-Leu-NH-C6H3(3,5-Me2)

Conditions

Conditions	Yield
In chloroform-d1 at 24.84℃; Equilibrium constant; complex formation;

: 100-61-8
N-methylaniline

platinum: platinum

A: 138-24-9
phenyltrimethylammonium chloride

B sarpagyne: sarpagyne

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 42 percent / tetrahydrofuran / 36 h / 20 °C 2: dibutyl ether / 48 h / 100 °C View Scheme

...Expand

: 62-53-3
aniline

: 333-27-7
methyl trifluoromethanesulfonate

A: 2739-12-0
N-methylaniline hydrochloride

B: 138-24-9
phenyltrimethylammonium chloride

C: 142-04-1
aniline hydrochloride

D: 5882-44-0
N,N-dimethylaniline hydrochloride

Conditions

Conditions	Yield
Stage #1: aniline; methyl trifluoromethanesulfonate With 1,1,1,3',3',3'-hexafluoro-propanol In d(4)-methanol at 20℃; for 1h; Stage #2: With hydrogenchloride In water for 1h;

...Expand

: 138-24-9
phenyltrimethylammonium chloride

: 57-27-2
MORPHIN

: 52-28-8
codeine phosphate

Conditions

Conditions	Yield
Stage #1: phenyltrimethylammonium chloride; MORPHIN With potassium phosphate In acetone at 50 - 60℃; for 25h; Heating / reflux; Stage #2: With phosphoric acid In water; acetone at 20℃; for 0.5h; Product distribution / selectivity;	100%
Stage #1: phenyltrimethylammonium chloride; MORPHIN With potassium hydrogencarbonate In toluene at 50 - 115℃; for 8 - 28h; Heating / reflux; Stage #2: With phosphoric acid In ethanol; water; toluene at 20℃; for 0.5h; Product distribution / selectivity;	90%
Stage #1: phenyltrimethylammonium chloride; MORPHIN With potassium phosphate In toluene at 70 - 115℃; for 2h; Heating / reflux; Stage #2: With phosphoric acid In ethanol; water; toluene at 20 - 30℃; for 0.75h; Product distribution / selectivity;	82%

: 57-27-2, 143-70-4, 6912-73-8, 16206-77-2, 27067-73-8, 65165-99-3, 70982-47-7
morphine

: 138-24-9
phenyltrimethylammonium chloride

: 52-28-8, 4478-25-5, 17682-64-3, 56050-09-0, 76034-17-8
codeine phosphate

Conditions

Conditions	Yield
Stage #1: morphine; phenyltrimethylammonium chloride With potassium hydrogencarbonate In toluene at 50 - 115℃; for 29h; Heating / reflux; Stage #2: In toluene at 20℃; activated carbon (charcoal); Stage #3: With phosphoric acid In ethanol; water at 20℃; for 0.5h;	99.6%
Stage #1: morphine; phenyltrimethylammonium chloride With potassium hydrogencarbonate In toluene at 50 - 115℃; for 9h; Heating / reflux; Stage #2: In toluene at 20℃; activated carbon (charcoal); Stage #3: With phosphoric acid In ethanol; water at 20℃; for 0.5h;	99.8%

: 138-24-9
phenyltrimethylammonium chloride

: 57-27-2
MORPHIN

: 76-57-3
codeine

Conditions

Conditions	Yield
With potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene	99%
With potassium carbonate In toluene	99%
With potassium carbonate In toluene	98%

: 138-24-9
phenyltrimethylammonium chloride

: 93296-09-4
4-methoxyphenylzinc chloride

: 613-37-6
4-methoxylbiphenyl

Conditions

Conditions	Yield
With C27H22Cl2N3NiP In tetrahydrofuran; 1-methyl-pyrrolidin-2-one for 12h; Inert atmosphere; Schlenk technique; Heating;	95%
With C38H34Br2N4Ni2P2; potassium iodide In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 65℃; for 12h; Inert atmosphere; Schlenk technique;	90%
With C32H26ClN2NiP In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 85℃; for 12h; Inert atmosphere;	74%

: 15172-46-0, 17479-85-5
N-formyl-2-hydroxy-3-methoxy-6-oxomorphinan

: 138-24-9
phenyltrimethylammonium chloride

: N-formyl-2,3-dimethoxy-6-oxomorphinan

Conditions

Conditions	Yield
With sodium methylate In 1,4-dioxane; N,N-dimethyl-formamide at 80℃; for 12h;	93%

: 98-54-4
para-tert-butylphenol

: 138-24-9
phenyltrimethylammonium chloride

A: 5396-38-3
1-(tert-butyl)-4-methoxybenzene

B: 121-69-7
N,N-dimethyl-aniline

Conditions

Conditions	Yield
With caesium carbonate In toluene for 27h; Heating;	A 92% B n/a

...Expand

: 138-24-9
phenyltrimethylammonium chloride

: 220556-53-6
14-benzyloxy-17-cyclopropylmethyl-4-hydroxymorphinan-6-one

: 14-benzyloxy-17-cyclopropylmethyl-4-hydroxymorphinan-6-one hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; potassium carbonate In N,N-dimethyl-formamide for 7h;	92%

: 114395-69-6
tris(trifluoromethanesulfonyl)methide potassium salt

: 138-24-9
phenyltrimethylammonium chloride

: 1345491-96-4
C4F9O6S3(1-)*C9H14N(1+)

Conditions

Conditions	Yield
In ethyl acetate at 20℃; for 1h;	90.2%

: 138-24-9
phenyltrimethylammonium chloride

: 93296-10-7
(4-(dimethylamino)phenyl)zinc(II) chloride

: 1137-79-7
N,N-dimethyl-4-biphenylamine

Conditions

Conditions	Yield
With bis(tricyclohexylphosphine)nickel(II) dichloride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 90℃; for 8h; Negishi coupling reaction; Inert atmosphere;	90%

: 138-24-9
phenyltrimethylammonium chloride

: 135-19-3
β-naphthol

A: 93-04-9
2-Methoxynaphthalene

B: 121-69-7
N,N-dimethyl-aniline

Conditions

Conditions	Yield
With caesium carbonate In toluene for 2h; Heating;	A 89% B n/a

...Expand

: 100-02-7
4-nitro-phenol

: 138-24-9
phenyltrimethylammonium chloride

A: 100-17-4
para-methoxynitrobenzene

B: 121-69-7
N,N-dimethyl-aniline

Conditions

Conditions	Yield
With caesium carbonate In toluene for 48h; Heating;	A 88% B n/a

...Expand

: 90-15-3
α-naphthol

: 138-24-9
phenyltrimethylammonium chloride

A: 121-69-7
N,N-dimethyl-aniline

B: 2216-69-5
1-Methoxynaphthalene

Conditions

Conditions	Yield
With caesium carbonate In toluene for 21h; Heating;	A n/a B 87%

...Expand

: 138-24-9
phenyltrimethylammonium chloride

: 476-70-0
boldine

: 475-81-0
glaucine

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 90℃; for 16h;	87%

: 89-83-8
thymol

: 138-24-9
phenyltrimethylammonium chloride

: 1076-56-8
Thymol methyl ether

Conditions

Conditions	Yield
With diethylene glycol dimethyl ether; potassium carbonate at 150 - 155℃; for 0.5h;	86%

: 138-24-9
phenyltrimethylammonium chloride

: 78072-08-9
(-)-3,14-dimethoxy-4-hydroxy-N-methylmorphinan-6-one

: 92055-62-4
(-)-3,4,14-trimethoxy-N-methylmorphinan-6-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 5h;	85%

: 138-24-9
phenyltrimethylammonium chloride

: 106-48-9
4-chloro-phenol

A: 623-12-1
4-chloromethoxybenzene

B: 121-69-7
N,N-dimethyl-aniline

Conditions

Conditions	Yield
With caesium carbonate In toluene for 6h; Heating;	A 85% B n/a

...Expand

: 138-24-9
phenyltrimethylammonium chloride

: 342622-12-2
5,6-didehydro-4,14β-dihydroxy-3-methoxy-17-methylmorphinan-6-carbonitrile

: 5,6-didehydro-14β-hydroxy-3,4-dimethoxy-17-methylmorphinan-6-carbonitrile

Conditions

Conditions	Yield
With nitrogen; potassium carbonate In N,N-dimethyl-formamide for 5h; Heating;	85%

: 138-24-9
phenyltrimethylammonium chloride

: 165673-73-4
3-(benzyloxy)-14-ethoxy-4-hydroxy-N-methylmorphinan-6-one

: 165673-74-5
3-(benzyloxy)-14-ethoxy-4-methoxy-N-methylmorphinan-6-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 3h;	84%

: 57-27-2, 143-70-4, 6912-73-8, 16206-77-2, 27067-73-8, 65165-99-3, 70982-47-7
morphine

: 138-24-9
phenyltrimethylammonium chloride

: 76-57-3, 509-64-8, 7235-41-8, 16206-70-5, 27067-72-7, 64520-25-8, 70982-46-6
4,5α-epoxy-3-methoxy-17-methyl-morphin-7-en-6α-ol

Conditions

Conditions	Yield
With sodium hydrogencarbonate In toluene at 50 - 115℃; for 49h; Heating / reflux;	84%
Stage #1: morphine; phenyltrimethylammonium chloride With potassium dihydrogenphosphate In toluene at 50 - 115℃; for 7.5h; Heating / reflux; Stage #2: With sodium hydroxide In Isopropyl acetate; water; acetic acid at 20℃; pH=14; activated carbon (charcoal);	82%
Stage #1: morphine; phenyltrimethylammonium chloride With potassium dihydrogenphosphate In toluene at 50 - 115℃; for 3.5h; Heating / reflux; Stage #2: In water; acetic acid at 20℃; activated carbon (charcoal); Stage #3: With sodium hydroxide In water pH=12;

: copper(II) choride dihydrate

: 138-24-9
phenyltrimethylammonium chloride

: bis(trimethylphenylammonium)tetrachloridocuprate(II)

Conditions

Conditions	Yield
With hydrogenchloride In water; isopropyl alcohol for 0.5h; Reflux;	83%

: 138-24-9
phenyltrimethylammonium chloride

: C27H27NO4

: C28H29NO4

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;	82%

: allopseudomorphine

: 138-24-9
phenyltrimethylammonium chloride

: 466-96-6, 509-55-7, 16206-67-0, 16206-74-9, 49751-24-8
allopseudocodeine

Conditions

Conditions	Yield
With sodium ethanolate In toluene Reflux;	80%

: 1426260-31-2
8-bromo-6-methoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinolin-7-ol

: 138-24-9
phenyltrimethylammonium chloride

: 1426260-91-4
8-bromo-6,7-dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 70℃; for 8h; Inert atmosphere;	79%
With potassium tert-butylate In N,N-dimethyl-formamide at 60 - 70℃; for 8h; Inert atmosphere;	79%

: 138-24-9
phenyltrimethylammonium chloride

: 81165-09-5
4,14-dihydroxy-N-methylmorphinan-6-one

: 81182-02-7
(-)-4-methoxy-14-hydroxy-6-keto-N-methylmorphinan

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide	77%

: 138-24-9
phenyltrimethylammonium chloride

: 5-methyldihydrothebainone

: (-)-3,4-dimethoxy-5,17-dimethylmorphinan-6-one hydrobromide

Conditions

Conditions	Yield
With hydrogen bromide; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 6h;	76%

: 138-24-9
phenyltrimethylammonium chloride

: 76786-95-3
(+/-)-2,4-dihydroxy-N-formylmorphinan-6-one

: 2,4-dimethoxy-N-formylmorphinan-6-one

Conditions

Conditions	Yield
With sodium methylate In 1,4-dioxane; N,N-dimethyl-formamide at 80℃; for 16h;	74%

: 92055-58-8
(-)-4-hydroxy-14-methoxy-N-methylmorphinan-6-one

: 138-24-9
phenyltrimethylammonium chloride

: 92055-59-9
(-)-4,14-dimethoxy-N-methylmorphinan-6-one

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 2h;	73%

: 138-24-9
phenyltrimethylammonium chloride

: C18H23NO3

: (-)-3,4-dimethoxy-N-methyl-6-oxomorphinan

Conditions

Conditions	Yield
With sodium methylate In 1,4-dioxane for 24h; Heating;	73%

: 138-24-9
phenyltrimethylammonium chloride

: (-)-4,14β-dihydroxy-5β,17-dimethyl-3-methoxymorphinan-6-one

: (-)-3,4-dimethoxy-N-5-dimethylmorphinan-6-one hydrobromide

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide for 3h;	73%

Phenyltrimethylammonium chloride Chemical Properties

IUPAC Name: Benzenaminium, N,N,N-trimethyl-, chloride
The MF of Benzenaminium, N,N,N-trimethyl-, chloride (138-24-9) is C₉H₁₄ClN.

The MW of Benzenaminium, N,N,N-trimethyl-, chloride (138-24-9) is 171.67.
Synonyms of Benzenaminium, N,N,N-trimethyl-, chloride (138-24-9): Ammonium, phenyltrimethyl-, chloride ; Benzenaminium, N,N,N-trimethyl-, chloride ; N,N,N-Trimethylanilinium chloride ; N,N,N-Trimethylbenzenaminium chloride ; Phenyltrimethylammonium chloride
Product Categories: Ammonium Chlorides (Quaternary);Quaternary Ammonium Compounds
Form: White or greyish-bleu crystalline powder
Melting Point: 246-248 °C (dec.)(lit.)
Water Solubility: soluble
Sensitive: Hygroscopic
EINECS: 205-319-0
BRN: 3572527

Phenyltrimethylammonium chloride Uses

Benzenaminium, N,N,N-trimethyl-, chloride (138-24-9) is used as pharmaceutical Intermediates.

Phenyltrimethylammonium chloride Toxicity Data With Reference

1.		orl-mus LDLo:200 mg/kg		JPETAB Journal of Pharmacology and Experimental Therapeutics. 43 (1931),413.
2.		ivn-mus LDLo:15 mg/kg		JPETAB Journal of Pharmacology and Experimental Therapeutics. 43 (1931),413.

Phenyltrimethylammonium chloride Consensus Reports

Reported in EPA TSCA Inventory.

Phenyltrimethylammonium chloride Safety Profile

Poison by ingestion and intravenous routes. When heated to decomposition it emits very toxic fumes of NO_x, NH₃, and Cl⁻.
Safety information of Benzenaminium, N,N,N-trimethyl-, chloride (138-24-9):
Hazard Codes T
Risk Statements
24/25 Toxic in contact with skin and if swallowed
Safety Statements
53 Avoid exposure - obtain special instruction before use
25 Avoid contact with eyes
39 Wear eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR UN 2811 6.1/PG 3
WGK Germany 1
RTECS BT2190000
HazardClass 6.1
PackingGroup III
HS Code 29239000

Product Name

Trimethylphenylammonium chloride

Synthetic route

Phenyltrimethylammonium chloride Chemical Properties

Phenyltrimethylammonium chloride Uses

Phenyltrimethylammonium chloride Toxicity Data With Reference

Phenyltrimethylammonium chloride Consensus Reports

Phenyltrimethylammonium chloride Safety Profile

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