• Name

  Phloroglucinol dihydrate

• EINECS 203-611-2
• CAS No. 6099-90-7
• Article Data2
• CAS DataBase
• Density
• Solubility slightly soluble in water
• Melting Point 218-221 °C (A)(lit.)
• Formula C₆H₁₀O₅
• Boiling Point 331.1 °C at 760 mmHg
• Molecular Weight 162.142
• Flash Point 174.9 °C
• Transport Information
• Appearance off-white powder
• Safety 37/39-26-36
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 1,3,5-Benzenetriol,dihydrate (9CI);Phloroglucinol, dihydrate (8CI);1,3,5-Benzènetriol dihydrate;1,3,5-benzenetriol, hydrate (1:2);1,3,5-Benzoltrioldihydrat;Benzene-1,3,5-triol dihydrate;Benzol-1,3,5-trioldihydrat;
• PSA 79.15000
• LogP 0.67480

Synthetic route

109-99-9

tetrahydrofuran

222165-10-8

1,1'-bis(ethenyl-4-pyridyl)ferrocene

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

1,1'-bis(ethenyl-4-pyridyl)ferrocene phlorglucinol tetrahydrofuran

Conditions

Conditions	Yield
In ethanol at room temp. for 7 d; elem. anal.;	100%

...Expand

64-17-5

ethanol

222165-10-8

1,1'-bis(ethenyl-4-pyridyl)ferrocene

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

1,1'-bis(ethenyl-4-pyridyl)ferrocene phlorglucinol ethanol

Conditions

Conditions	Yield
In ethanol at room temp. for 7 d; elem. anal.;	100%

...Expand

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

68-12-2, 33513-42-7

N,N-dimethyl-formamide

487-70-7

2,4,6-trihydroxybenzaldehyde

Conditions

Conditions	Yield
With trichlorophosphate In ethyl acetate at 20℃; for 1h; Vilsmeier-Haack Formylation; Cooling with ice;	98%

324-03-8

6-fluoroisatin

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

82260-62-6

acide 6-fluoro-1,3-dihydroacridine-9-carboxylique

Conditions

Conditions	Yield
With sodium hydroxide Heating;	92%

317-20-4

7-fluoro-1H-indole-2,3-dione

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

82260-61-5

acide 5-fluoro-1,3-dihydroacridine-9-carboxylique

Conditions

Conditions	Yield
With sodium hydroxide for 5h; Heating;	92%

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

75-36-5

acetyl chloride

2161-87-7

1,3,5-triacetyl-2,4,6-trihydroxybenzene

Conditions

Conditions	Yield
With aluminum (III) chloride for 1h; Reagent/catalyst; Time; Fries Phenol Ester Rearrangement; Reflux;	91%
With aluminum (III) chloride for 1h; Reflux;	91%

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

372-31-6

ethyl 4,4,4-trifluoroacetoacetate

82747-44-2

5,7-Dihydroxy-4-trifluoromethylcoumarin

Conditions

Conditions	Yield
With trifluoroacetic acid for 15h; Heating;	80%

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

82747-28-2

dihydro-2,2 oxo-3 F-octanoate d'ethyle

F-pentyl-4 dihydroxy-5,7 coumarine

Conditions

Conditions	Yield
With trifluoroacetic acid for 15h; Heating;	75%

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

82747-29-3

dihydro-2,2 oxo-3 F-decanoate d'ethyle

F-heptyl-4 dihydroxy-5,7 coumarine

Conditions

Conditions	Yield
With trifluoroacetic acid for 15h; Heating;	73%

443-69-6

5-fluoro-1H-indole-2,3-dione

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

82260-63-7

acide 7-fluoro-1,3-dihydroacridine-9-carboxylique

Conditions

Conditions	Yield
With sodium hydroxide Heating;	72%

336-62-9

(2,2,3,3,4,4,4-heptafluorobutanoyl)acetic acid ethyl ester

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

F-propyl-4 dihydroxy-5,7 coumarine

Conditions

Conditions	Yield
With trifluoroacetic acid for 15h; Heating;	70%

485-47-2

indan-1,2,3-trione hydrate

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

(trihydroxy-2,4,6 phenyl)-2 hydroxy-2 indanedione-1,3 monohydrate

Conditions

Conditions	Yield
In water for 0.1h; Heating;	67%

3249-68-1

ethyl butyroyl acetate

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

66346-59-6

5,7-dihydroxy-4-propylcoumarin

Conditions

Conditions	Yield
With sulfuric acid In ethyl acetate
With sulfuric acid In ethyl acetate
With sulfuric acid In ethyl acetate
In ethyl acetate
With sulfuric acid In ethyl acetate

108-73-6

3,5-dihydroxyphenol

3354-82-3

2,4,6-tribromophloroglucinol

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

814-68-6

acryloyl chloride

217825-79-1

tribromophloroglucinol triacrylate

Conditions

Conditions	Yield
With bromine; triethylamine In n-heptane; dichloromethane; acetone; acetonitrile

...Expand

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

620-79-1

Ethyl 2-benzylacetoacetate

219551-85-6

3-benzyl-5,7-dihydroxy-4-methyl-2H-chromen-2-one

Conditions

Conditions	Yield
With hydrogenchloride In ethanol
With hydrogenchloride In ethanol

91-04-3

2,6-bis(hydroxymethyl)-4-methylphenol

6192-52-5

p-toluenesulfonic acid monohydrate

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

2,6-bis[(2,4,6-trihydroxyphenyl)methyl]-4-methylphenol

Conditions

Conditions	Yield
In water

...Expand

597544-31-5

5-5-ferrocenylpyrimidine

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

([5-ferrocenylpyrimidine]*phloroglucinol*2H2O)n

Conditions

Conditions	Yield
In acetonitrile addn. of soln. of phloroglucinol*2H2O (1 equiv.) in MeCN to soln. of 5-ferrocenylpyrimidine (1 equiv.) in MeCN; crystn. for a few days at room temp. in air; elem. anal.;

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

1,3,5-triacetyl-2,4,6-tris(5'-azidopentyloxy)benzene

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aluminum (III) chloride / 1 h / Reflux 2: potassium carbonate / acetonitrile / 48 h / Reflux 3: sodium azide / acetone; water / 8 h / Reflux View Scheme

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

1,3,5-triacetyl-2,4,6-tris(5'-aminopentyloxy)benzene trihydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / 1 h / Reflux 2.1: potassium carbonate / acetonitrile / 48 h / Reflux 3.1: sodium azide / acetone; water / 8 h / Reflux 4.1: ammonium chloride; zinc / water; ethanol / 0.25 h / Reflux 4.2: 3 h View Scheme

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

C33H51N3O9

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: aluminum (III) chloride / 1 h / Reflux 2.1: potassium carbonate / acetonitrile / 48 h / Reflux 3.1: sodium azide / acetone; water / 8 h / Reflux 4.1: ammonium chloride; zinc / water; ethanol / 0.25 h / Reflux 4.2: 3 h 5.1: dmap; pyridine / 20 °C View Scheme

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

478-48-8

1-4,6-dihydroxy-2-methoxy-3-methylphenylbutan-1-one

Conditions

Conditions

Yield

Multi-step reaction with 6 steps 1.1: trichlorophosphate / ethyl acetate / 1 h / 20 °C / Cooling with ice 2.1: hydrogenchloride; zinc / ethyl acetate; diethyl ether / 0.17 h / Cooling with ice 3.1: aluminum (III) chloride / nitrobenzene / 0.5 h 3.2: 24 h / 65 °C / Inert atmosphere 4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 3 h / Cooling with ice 5.1: potassium carbonate 6.1: sodium hydroxide / methanol; water / 2.5 h / 40 °C / Inert atmosphere View Scheme

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

88-03-9

2,4,6-trihydroxytoluene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: trichlorophosphate / ethyl acetate / 1 h / 20 °C / Cooling with ice 2: hydrogenchloride; zinc / ethyl acetate; diethyl ether / 0.17 h / Cooling with ice View Scheme

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

1509-06-4

1-(2,4,6-trihydroxy-3-methylphenyl)butan-1-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: trichlorophosphate / ethyl acetate / 1 h / 20 °C / Cooling with ice 2.1: hydrogenchloride; zinc / ethyl acetate; diethyl ether / 0.17 h / Cooling with ice 3.1: aluminum (III) chloride / nitrobenzene / 0.5 h 3.2: 24 h / 65 °C / Inert atmosphere View Scheme

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

C19H26O6

Conditions

Conditions

Yield

Multi-step reaction with 4 steps 1.1: trichlorophosphate / ethyl acetate / 1 h / 20 °C / Cooling with ice 2.1: hydrogenchloride; zinc / ethyl acetate; diethyl ether / 0.17 h / Cooling with ice 3.1: aluminum (III) chloride / nitrobenzene / 0.5 h 3.2: 24 h / 65 °C / Inert atmosphere 4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 3 h / Cooling with ice View Scheme

6099-90-7

1,3,5-Trihydroxybenzene dihydrate

C20H28O6

Conditions

Conditions

Yield

Multi-step reaction with 5 steps 1.1: trichlorophosphate / ethyl acetate / 1 h / 20 °C / Cooling with ice 2.1: hydrogenchloride; zinc / ethyl acetate; diethyl ether / 0.17 h / Cooling with ice 3.1: aluminum (III) chloride / nitrobenzene / 0.5 h 3.2: 24 h / 65 °C / Inert atmosphere 4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 3 h / Cooling with ice 5.1: potassium carbonate View Scheme

Phloroglucinol dihydrate Chemical Properties

Phloroglucinol dihydrate Toxicity Data With Reference

Phloroglucinol dihydrate Safety Profile

Phloroglucinol dihydrate Specification