Phloroglucinol supplier | CasNO.108-73-6

Name
Phloroglucinol
EINECS 203-611-2
CAS No. 108-73-6
Article Data203
CAS DataBase
Density 1.488 g/cm³
Solubility 11.17g/L(room temperature)
Melting Point 215-220 °C
Formula C₆H₆O₃
Boiling Point 331.1 °C at 760 mmHg
Molecular Weight 126.112
Flash Point 174.9 °C
Transport Information UN 1170 3/PG 2
Appearance white to light yellow crystal
Safety 7-16-24/25-45-36/37/39-26
Risk Codes 11-36/37/38-34
Molecular Structure
Hazard Symbols F,Xi
Synonyms 5-Oxyresorcinolphloroglucin;1,3,5-Trihydroxycyclohexatriene;Benzene, trihydroxy;s-Trihydroxybenzene;4-06-00-07361 (Beilstein Handbook Reference);Spasfon-Lyoc;See also 1,3,5-Benzenetriol;Benzene-s-triol;Benzene-1,3,5-triol;sym-Trihydroxybenzene;1,3, 5-Trihydroxybenzene;1,3,5-benzenetriol;Dilospan S;1,3,5-Trihydroxybenzene;1,3,5-THB;Floroglucin [Czech];1.3.5-Trihydroxybenzene;5-Oxyresorcinol;Floroglucinol [Czech];5-Hydroxyresorcinol;5-Benzenetriol;Benzene, 1,3,5-trihydroxy-;1,3,5-Triol;3,5-Dihydroxyphenol;1,3,5-Trihydroxybenzene anhydrate;Phloroglucinol Anhydrous;m-Trihydroxybenzene;Phloroglucinol Dihydrate;1,3,5-trihydroxy benzene;
PSA 60.69000
LogP 0.80340

Synthetic route

: 10586-12-6
phloroglucinol tris(trimethylsilyl) ether

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.116667h; Green chemistry;	98%
With methanol at 20℃; for 0.333333h;	87%

: 480-66-0
2,4,6-trihydroxyacetophenone

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With tin(IV) chloride In 1,2-dichloro-ethane Heating;	95%

: 591-35-5
3,5-dichlorophenol

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With aluminum (III) chloride; palladium 10% on activated carbon; potassium hydroxide In toluene at 120℃; for 8h; Temperature; Reagent/catalyst; Inert atmosphere;	87.4%

: 2999-40-8
1,3,5-triacetoxybenzene

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With amberlyst-15 In methanol at 20℃; for 4h;	87%

: 621-23-8
1,2,3-trimethoxybenzene

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With sulfuric acid at 65℃; for 2h; Temperature; Large scale;	87%
With aluminum (III) chloride In chlorobenzene for 8h; Solvent; Reflux;	80%
Stage #1: 1,2,3-trimethoxybenzene With aluminum (III) chloride In chlorobenzene at 90℃; for 2h; Stage #2: With sulfuric acid In water at 0 - 5℃; for 0.5h; Reagent/catalyst; Temperature;	74.7%

: 500-99-2
3,5-dimethoxyphenol

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With hexamethyldisilathiane; sodium methylate In various solvent(s) at 185℃; for 24h;	83%

: 2161-86-6
2,4-diacetylphloroglucinol

: 108-46-3
recorcinol

A: 89-84-9
2',4'-dihydroxy-4-acetophenone

B: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With cell-free E. coli extract containing the recombinant acyltransferase from Pseudomonas protegens In aq. phosphate buffer; dimethyl sulfoxide at 35℃; for 0.5h; pH=7.5; Catalytic behavior; Solvent; pH-value; Temperature; Enzymatic reaction;	A 65% B n/a

...Expand

: 626-43-7
3,5-Dichloroaniline

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
Stage #1: 3,5-Dichloroaniline With ammonia; copper(l) iodide In water at 180℃; under 30003 Torr; for 24h; Stage #2: With hydrogenchloride; water at 0 - 120℃; for 20h; pH=1; Product distribution / selectivity;	60%
Stage #1: 3,5-Dichloroaniline With ammonia; copper(l) chloride In water at 190℃; under 27752.8 Torr; for 24h; Stage #2: With sulfuric acid; water at 110℃; for 20h; Product distribution / selectivity;
Stage #1: 3,5-Dichloroaniline With ammonia; copper(l) iodide In water at 190℃; under 30003 Torr; for 24h; Stage #2: With hydrogenchloride; water at 110℃; for 20h; Product distribution / selectivity;

: 2174-64-3
5-methoxyresorcinol

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With hydrogenchloride In water for 36h;	56%
With hydrogenchloride

: 108-70-3
1,3,5-trichlorobenzene

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
Stage #1: 1,3,5-trichlorobenzene With ammonia; copper(l) iodide In water at 180℃; under 30003 Torr; for 24h; Stage #2: With hydrogenchloride; water at 0 - 120℃; for 20h; Product distribution / selectivity;	40%

: 480-66-0
2,4,6-trihydroxyacetophenone

: 108-46-3
recorcinol

A: 89-84-9
2',4'-dihydroxy-4-acetophenone

B: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With cell-free E. coli extract containing the recombinant acyltransferase from Pseudomonas protegens In aq. phosphate buffer; dimethyl sulfoxide at 35℃; for 0.5h; pH=7.5; Enzymatic reaction;	A 13% B n/a

...Expand

: 17397-82-9
2,4,6-triacetoxypropiophenone

A: 108-73-6
3,5-dihydroxyphenol

B: propylphloroglucinol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol Product distribution;	A 8.5% B 10.1%

: 42385-89-7
acetic acid 4-[3-oxo-3-(2,4,6-triacetoxy-phenyl)propyl]phenyl ester

A: 108-73-6
3,5-dihydroxyphenol

B: 10210-17-0
3-(4-hydroxyphenyl)propan-1-ol

C: 127265-09-2
2-(3-(4-hydroxyphenyl)propyl)benzene-1,3,5-triol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol Product distribution;	A 7.5% B 6% C 6%

...Expand

: 504-15-4
orcinol

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With sodium hydroxide beim Verschmelzen;

: 99-35-4
1,3,5-trinitrobenzene

: 118-96-7
2,4,6-Trinitrotoluene

: 108-73-6
3,5-dihydroxyphenol

: 99-35-4
1,3,5-trinitrobenzene

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
ueber mehrere Stufen;

: 621-23-8
1,2,3-trimethoxybenzene

: 628-13-7
pyridine hydrochloride

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
at 200 - 220℃;
at 200 - 220℃;

: 10135-18-9
diethyl 2,4,6-trihydroxyisophthalate

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With potassium carbonate beim Schmelzen;
With potassium hydroxide at 100℃; for 2.5h; labelled comp.; Yield given;

: 623-11-0
1-methyl-4-nitrosobenzene

: 480-66-0
2,4,6-trihydroxyacetophenone

: 108-73-6
3,5-dihydroxyphenol

: 10425-09-9
(2,4‐dihydroxyphenyl)(3,4,5‐trihydroxyphenyl)methanone

A: 108-73-6
3,5-dihydroxyphenol

B: 99-50-3
3,4-Dihydroxybenzoic acid

Conditions

Conditions	Yield
With sulfuric acid at 120℃;
With potassium hydroxide

: 60-82-2
3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-on

A: 108-73-6
3,5-dihydroxyphenol

B: 501-97-3
4-hydroxyphenylpropionic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 129-66-8
2,4,6-trinitrobenzoic acid

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With hydrogenchloride; tin Kochen der neutralisierten Reaktionsfluessigkeit mit Natronlauge;
Multi-step reaction with 2 steps 1: Fe; HCl 2: H2SO4 / 108 °C View Scheme
Multi-step reaction with 2 steps 1: palladium on activated charcoal; hydrogen 2: water; hydrogenchloride View Scheme

: 779-90-8
1,3,5-triacetylbenzene

: 108-73-6
3,5-dihydroxyphenol

: 484-20-8
bergapten

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
bei der Kalischmelze;

: 608-80-0
benzenehexol

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With sodium amalgam; water unter Wasserstoff auf dem Dampfbad;
With water; platinum at 50 - 55℃; Hydrogenation;

: 479-21-0
cotoin

A: 108-73-6
3,5-dihydroxyphenol

B: 65-85-0
benzoic acid

Conditions

Conditions	Yield
With sulfuric acid

: 634-94-6
1,2,3,5-tetrahydroxybenzene

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With sodium amalgam; water unter Wasserstoff auf dem Dampfbad;

: 487-70-7
2,4,6-trihydroxybenzaldehyde

: 108-73-6
3,5-dihydroxyphenol

Conditions

Conditions	Yield
With potassium hydroxide at 250 - 270℃;

: 108-73-6
3,5-dihydroxyphenol

: 1-(p-toluenesulfonyl)-3-methylimidazolium triflate

: 20032-61-5
1,3,5-tris<(p-toluenesulfonyl)oxy>benzene

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole In tetrahydrofuran 1) 0 deg C, 1 h, 2) RT, 10 h;	100%

: 108-73-6
3,5-dihydroxyphenol

: 142841-88-1
1-(benzenesulfonyl)-3-methylimidazolium triflate

: 3840-04-8
1,3,5-tris<(benzenesulfonyl)oxy>benzene

Conditions

Conditions	Yield
With 1-methyl-1H-imidazole In tetrahydrofuran 1) 0 deg C, 30 min, 2) RT, 6 h;	100%

: 108-73-6
3,5-dihydroxyphenol

: 28917-44-4
3,5-dibenzyloxylbenzoyl chloride

: 159507-48-9
C69H54O12

Conditions

Conditions	Yield
With dmap In dichloromethane at 20℃; for 120h;	100%
With dmap In dichloromethane at 20℃;

: 108-73-6
3,5-dihydroxyphenol

: 116223-46-2
trans-4-butoxy-4'-stilbazole

: 4-[(E)-2-(4-Butoxy-phenyl)-vinyl]-pyridine; compound with benzene-1,3,5-triol

Conditions

Conditions	Yield
In acetone	100%
In acetone

: 108-73-6
3,5-dihydroxyphenol

: (E)-4-((4-(propyloxy)phenyl)diazenyl)pyridine

: C6H6O3*3C14H15N3O

Conditions

Conditions	Yield
In acetone	100%
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: (E)-4-((4-(hexyloxy)phenyl)diazenyl)pyridine

: C6H6O3*3C17H21N3O

Conditions

Conditions	Yield
In acetone	100%
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: C15H17N3O

: C6H6O3*3C15H17N3O

Conditions

Conditions	Yield
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: C16H19N3O

: 3C16H19N3O*C6H6O3

Conditions

Conditions	Yield
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: (E)-4-((4-(hexyloxy)phenyl)diazenyl)pyridine

: C17H21N3O*C6H6O3

Conditions

Conditions	Yield
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: (E)-4-((4-(hexyloxy)phenyl)diazenyl)pyridine

: 2C17H21N3O*C6H6O3

Conditions

Conditions	Yield
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: C18H23N3O

: 3C18H23N3O*C6H6O3

Conditions

Conditions	Yield
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: C19H25N3O

: 3C19H25N3O*C6H6O3

Conditions

Conditions	Yield
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: C20H27N3O

: 3C20H27N3O*C6H6O3

Conditions

Conditions	Yield
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: (E)-4-[(4-decyloxyphenyl)diazenyl]pyridine

: C6H6O3*3C21H29N3O

Conditions

Conditions	Yield
at 120℃; for 0.0111111h;	100%

: 108-73-6
3,5-dihydroxyphenol

: C20H27N3O

: 3C20H27N3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C21H29N3O

: 3C21H29N3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C22H31N3O

: 3C22H31N3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: 1352742-56-3
4-(4-dodecyloxyphenylazo)pyridine

: 3C23H33N3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C17H20FN3O

: 3C17H20FN3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C19H24FN3O

: 3C19H24FN3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C17H20FN3O

: 3C17H20FN3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C19H24FN3O

: 3C19H24FN3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C20H26FN3O

: 3C20H26FN3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C21H28FN3O

: 3C21H28FN3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C22H30FN3O

: 3C22H30FN3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: 4-(3-fluoro-4-dodecyloxyphenylazo)pyridine

: 3C23H32FN3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C17H19F2N3O

: 3C17H19F2N3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C19H23F2N3O

: 3C19H23F2N3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: C17H21N3O

: 3C17H21N3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

: 108-73-6
3,5-dihydroxyphenol

: 4-(4-octyloxyphenylazo)pyridine

: 3C19H25N3O*C6H6O3

Conditions

Conditions	Yield
In acetone	100%

Phloroglucinol Chemical Properties

Molecular Structure of Phloroglucinol (CAS NO.108-73-6):

IUPAC Name: benzene-1,3,5-triol
Molecular formula: C₆H₆O₃
Molecular Weight: 126.11
EINECS: 203-611-2
H bond acceptors: 3
H bond donors: 3
Freely Rotating Bonds: 3
Polar Surface Area: 27.69 Å²
Index of Refraction: 1.676
Molar Refractivity: 31.89 cm³
Molar Volume: 84.7 cm³
Surface Tension: 78.6 dyne/cm
Density: 1.488 g/cm³
Flash Point: 174.9 °C
Enthalpy of Vaporization: 59.65 kJ/mol
Boiling Point: 331.1 °C at 760 mmHg
Vapour Pressure: 8.27E-05 mmHg at 25°C
Melting point: 215-220 ^°C
Storage temp: Dark Room
Sensitive: Light Sensitive & Hygroscopic
Appearance: white to light yellow crystal
Product Categories: Aromatic Phenols; Active pharmaceutical ingredients; Phenol&Thiophenol&Mercaptan; Benzene derivates; Aromatics Compounds; Biochemistry; Plant Growth Regulators; Plant Growth Trgulators (Others); Aromatics

Phloroglucinol Uses

Phloroglucinol is an organic compound that is used in the synthesis of pharmaceuticals and explosives.

Phloroglucinol Toxicity Data With Reference

1.	mrc-smc 3 g/L	MUREAV Mutation Research. 135 (1984),109.
2.	cyt-ham:ovr 3 g/L	CALEDQ Cancer Letters (Shannon, Ireland). 14 (1981),251.
3.	orl-rat LD50:5200 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),740.
4.	ipr-rat LD50:3180 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),740.
5.	scu-rat LD50:4850 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),740.
6.	orl-mus LD50:4550 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 3 (1969),187.
7.	ipr-mus LD50:4050 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 3 (1969),187.
8.	scu-gpg LDLo:1000 mg/kg	RMSRA6 Revue Medicale de la Suisse Romande. 15 (1895),561.

Phloroglucinol Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Phloroglucinol Safety Profile

Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in diazo-type printing and textile dyeing, in microscopy as a bone specimen decalcifier.
Hazard Codes: F, Xi
WGK Germany: 2
RIDADR: UN 1170 3/PG 2
The Risk Statements information of Phloroglucinol :
11: Highly Flammable
34: Causes burns
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of Phloroglucinol :
7: Keep container tightly closed
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
24/25: Avoid contact with skin and eyes
36/37/39: Wear suitable protective clothing, gloves and eye/face protection

Phloroglucinol Specification

Phloroglucinol , with CAS number of 108-73-6, can be called 5-Oxyresorcinolphloroglucin ; 1,3,5-Trihydroxycyclohexatriene ; Benzene, trihydroxy ; s-Trihydroxybenzene ; 4-06-00-07361 (Beilstein Handbook Reference) ; See also 1,3,5-Benzenetriol ; 1,3,5-Cyclohexanetrione ; 1,3,5-Trihydroxybenzene ; 1,3,5-Trihydroxybenzene anhydrate ; 1,3,5-trihydroxy benzene ; Phloroglucinol Dihydrate ; Phloroglucinol . It is a white to light yellow crystal.

Product Name

Phloroglucinol

Synthetic route

Phloroglucinol Chemical Properties

Phloroglucinol Uses

Phloroglucinol Toxicity Data With Reference

Phloroglucinol Consensus Reports

Phloroglucinol Safety Profile

Phloroglucinol Specification

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