Piperazine-1,4-diethylamine supplier

Name
Piperazine-1,4-diethylamine
EINECS 229-428-8
CAS No. 6531-38-0
Article Data19
CAS DataBase
Density 1.006g/cm³
Solubility
Melting Point 40 °C
Formula C₈H₂₀N₄
Boiling Point 302.2 °C at 760 mmHg
Molecular Weight 172.274
Flash Point 151.4 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Piperazine,1,4-bis(2-aminoethyl)- (7CI,8CI);1,4-Bis(2-aminoethyl)-1,4-diazacyclohexane;1,4-Bis(2-aminoethyl)piperazine;1,4-Piperazinediethylamine;N,N'-Bis(2-aminoethyl)piperazine;[2-[4-(2-Aminoethyl)piperazin-1-yl]ethyl]amine;
PSA 58.52000
LogP -0.20220

Synthetic route

: 5623-99-4
2‐[4‐(cyanomethyl)piperazin‐1‐yl]acetonitrile

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 4h; Reflux;	87%
Stage #1: 2‐[4‐(cyanomethyl)piperazin‐1‐yl]acetonitrile With lithium aluminium tetrahydride In tetrahydrofuran for 3h; Heating / reflux; Stage #2: With potassium hydroxide In tetrahydrofuran; water	80%
With ammonia; hydrogen; nickel In ethanol at 20℃;	73%

: 20541-87-1
N,N'-bis(2-phthalimidoethyl)piperazine

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

Conditions

Conditions	Yield
With potassium hydroxide; sodium hydroxide at 300 - 330℃;	75%
With hydrogenchloride at 130℃; im Rohr;
With hydrazine hydrate
With hydrazine

: 151-56-4
ethyleneimine

: 140-31-8
aminoethylpiperazine

A: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

B: 24028-46-4
1-<2-(2-aminoethyl)aminoethyl>piperazine

Conditions

Conditions	Yield
With hydrogenchloride In water at 50℃;	A 79.5 % Chromat. B 20.5 % Chromat.
With hydrogenchloride In water at 25℃; Kinetics; Thermodynamic data; acid-catalyzed ring opening reactions at various temperature, Ea, ΔH are given;
With hydrogenchloride In water at 40℃;	A 80.0 % Chromat. B 20.0 % Chromat.

...Expand

piperazine-N.N'-diacetic acid dinitrile: piperazine-N.N'-diacetic acid dinitrile

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

Conditions

Conditions	Yield
With ethanol; sodium

: 131543-46-9
Glyoxal

: 112-24-3
triethylentetramine

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol at -10℃; for 2h;
With sodium tetrahydroborate
With sodium tetrahydroborate In ethanol at 0℃; for 2h;

: 84429-08-3
N,N'-Bis(2-phthalimidoethyl)ethylene diamine

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 61 percent / potassium carbonate / 0.17 h / 132 °C 2: 75 percent / aq.sodium hydroxide, potassium hydroxide / 300 - 330 °C View Scheme

: 112-24-3
triethylentetramine

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 65 percent / 195 °C 2: 61 percent / potassium carbonate / 0.17 h / 132 °C 3: 75 percent / aq.sodium hydroxide, potassium hydroxide / 300 - 330 °C View Scheme

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: C15H11NO3

: C38H38N6O4

Conditions

Conditions	Yield
In ethanol at 80℃; for 8h;	92%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: nickel(II) perchlorate hexahydrate

: (3-[4-(3-aminopropyl)-piperazin-1-yl]-propylamine)nickel(II) perchlorate

Conditions

Conditions	Yield
In methanol refluxed for 2 h; ppt. filtered, washed with cold MeOH, dried; elem. anal.;	90%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 37942-07-7
3,5-di-tert-butyl-2-hydroxybenzaldehyde

: N,N'-bis{2-[(2-ethylimino)methyl]-4,6-di-tert-butylphenol}piperazine

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	87%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 90-02-8
salicylaldehyde

: 80744-39-4
1,4-bis(2-salicylideneaminoethyl)piperazine

Conditions

Conditions	Yield
In methanol for 3h; Cooling with ice;	87%

: 98-03-3
thiophene-2-carbaldehyde

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 1207281-39-7
N,N'-bis[2-(thiophen-2-ylmethyleneamino)ethyl]piperazine

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	86%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 1761-61-1
5-bromosalicyclaldehyde

: 1207281-37-5
N,N'-bis{2-[(2-ethylimino)methyl]-5-bromophenol}piperazine

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	85%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 85-44-9
phthalic anhydride

: 20541-87-1
N,N'-bis(2-phthalimidoethyl)piperazine

Conditions

Conditions	Yield
In acetic acid Condensation; Heating;	80%

: 1121-60-4
pyridine-2-carbaldehyde

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 917590-68-2
N-((1-pyridin-2-yl)formylidene)-N'-[2-(4-[2-[((1-pyridin-2-yl)formylidene)amino]ethyl]piperazin-1-yl)ethyl]amine

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	80%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 90-02-8
salicylaldehyde

: 78186-31-9
N,N'-bis{2-[(2-ethylimino)methyl]phenol}piperazine

Conditions

Conditions	Yield
In ethanol for 3h; Reflux;	80%
In methanol for 3h; Cooling with ice;

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 91-02-1
phenyl(pyridin-2-yl)methanone

: 959850-48-7
N-((1-pyridin-2-yl)benzylidene)-N'-[2-(4-[2-[((1-pyridin-2-yl)benzylidene)amino]ethyl]piperazin-1-yl)-ethyl]amine

Conditions

Conditions	Yield
for 7h; Reflux;	79.1%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 343247-31-4
9-methylphenazine-1-carboxylic acid imidazolide

: C36H36N8O2

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃;	77%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 86-98-6
4,7-dichloroquinoline

: 1416359-97-1
N-(2-(4-(2-aminoethyl)piperazin-1-yl)ethyl)-7-chloroquinolin-4-amine

Conditions

Conditions	Yield
In neat (no solvent) at 80 - 125℃; for 3h;	76%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 3027-38-1
3-nitro-1,8-naphthalic anhydride

: 500865-45-2
C32H26N6O8

Conditions

Conditions	Yield
In ethanol; toluene for 4h; Reflux;	73%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 16807-48-0
3‐acetyl‐2‐hydroxy‐6‐methyl‐4H‐pyran‐4‐one

: ((3E,3'E)-3,3'-(((piperazine-1,4-diylbis(ethane-2,1-diyl))bis(azanediyl))bis(ethan1-yl-1-ylidene))bis(6-methyl-2H-pyran-2,4(3H)-dione))

Conditions

Conditions	Yield
In ethanol for 24h;	63%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 521973-02-4
5-((Z)-4-hydroxybenzylidene)-2-methylmercapto-4-thiazolidinone

: 1415582-35-2
(5Z,5'Z)-2,2'-[piperazine-1,4-diylbis(ethane-2,1-diylimino)]bis(5-(4-hydroxybenzylidene)-1,3-thiazol-4(5H)-one)

Conditions

Conditions	Yield
In ethanol for 8h; Reflux;	58%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 89459-23-4
9-Chloro-N-<2-(dimethylamino)ethyl>acridine-4-carboxamide

: C44H54N10O2

Conditions

Conditions	Yield
In phenol at 125℃; for 2h;	48%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 87001-32-9
p-benzyloxybenzenesulfonyl chloride

: N,N'-(2,2'-(piperazine-1,4-diyl)bis(ethane-2,1-diyl))bis(4-(benzyloxy)benzenesulfonamide)

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2h;	47%

: 1121-60-4
pyridine-2-carbaldehyde

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: cobalt(II) perchlorate hexahydrate

: CoBrC4H8N2(CH2CH2NCHC5H4N)2(1+)*ClO4(1-)=CoBrC4H8N2(CH2CH2NCHC5H4N)2ClO4

Conditions

Conditions	Yield
With NaOH In methanol abs. MeOH soln. of NaOH added to abs. MeOH soln. of piperazine deriv.; stirred at room temp. for a few min; filtered off; washed with abs. MeOH;added dropwise to hot abs. MeOH soln. of Co(ClO4)2, and py-2-CHO over a period of 1 h; refluxed for 18 h; concd.; pptd. by addn. of Et2O; filtered; washed with cold Et2O; dried; elem. anal.;	43%

...Expand

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 1030022-78-6
N-(N-methylpiperidin-4-yl)-9-chloroacridine-4-carboxamide

: 1030022-76-4
N,N-bis{4-[N-(N-methylpiperidin-4-yl)carbamoyl]acridin-9-yl}-[1,4-bis(2-aminoethyl)-piperazine]

Conditions

Conditions	Yield
In phenol at 125℃; for 2h;	35%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 646072-61-9
N-[2-(4-morpholinyl)ethyl]-9-chloroacridine-4-carboxamide

: C48H58N10O4

Conditions

Conditions	Yield
In phenol at 125℃; for 2h;	31%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 1021869-65-7
3-(butylamino)-5-(1H-imidazole-1-carbonyl)-2-phenoxybenzenesulfonamide

: 1021869-54-4
C25H38N6O4S

Conditions

Conditions	Yield
In dichloromethane at 25℃; under 760.051 Torr;	20.46%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 50-00-0
formaldehyd

: 135-19-3
β-naphthol

: (13,13'-piperazine-(N,N,N''',N'''-tetra((2-hydroxynaphthyl)methyl))ethane)amine

Conditions

Conditions	Yield
In methanol; water for 0.5h; Condensation;	13%

...Expand

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 31767-15-4
ethyl (2E)‐2‐(hydroxyimino)acetate

: (2E)-2-(N-hydroxyimino)-N-[2-(4-{2-[(2E)-2-(N-hydroxyimino)acetamido]ethyl}piperazin-1-yl)ethyl]acetamide

Conditions

Conditions	Yield
In ethanol at 90℃; for 48h;	10%

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 856095-00-6
4-bromo-6-methoxy-2-methylquinoline

A: 1-(2-amino-ethyl)-4-[2-(6-methoxy-2-methyl-[4]quinolylamino)-ethyl]-piperazine

B: 1,4-bis-[2-(6-methoxy-2-methyl-[4]quinolylamino)-ethyl]-piperazine

Conditions

Conditions	Yield
at 170℃;

...Expand

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 856095-00-6
4-bromo-6-methoxy-2-methylquinoline

: 1,4-bis-[2-(6-methoxy-2-methyl-[4]quinolylamino)-ethyl]-piperazine

Conditions

Conditions	Yield
at 160℃;

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 1,4-bis-(2-isocyano-ethyl)-piperazine

Conditions

Conditions	Yield
With sodium hydroxide; chloroform

: 6531-38-0
1,4-bis(2-aminoethyl)piperazine

: 1207-69-8
9-Chloroacridine

: 97614-83-0
C34H34N6

Conditions

Conditions	Yield
With phenol at 100℃;

Piperazine-1,4-diethylamine Specification

The Piperazine-1,4-diethylamine, with CAS registry number 6531-38-0, belongs to the following product categorie: Piperidine. It has the systematic name of 2,2'-piperazine-1,4-diyldiethanamine. And its IUPAC name is 2-[4-(2-aminoethyl)piperazin-1-yl]ethanamine. What's more, its EINECS is 229-428-8.

Physical properties about this chemical are: (1)ACD/LogP: -1.97; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -6.09; (4)ACD/LogD (pH 7.4): -5.95; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 12.96 Å²; (13)Index of Refraction: 1.511; (14)Molar Refractivity: 51.3 cm³; (15)Molar Volume: 171 cm³; (16)Polarizability: 20.33×10^-24cm³; (17)Surface Tension: 41 dyne/cm; (18)Enthalpy of Vaporization: 54.24 kJ/mol; (19)Vapour Pressure: 0.00101 mmHg at 25°C.

Preparation: this chemical can be prepared by piperazine-1,4-diyl-bis-acetonitrile. This reaction will need reagent H₂, NH₃. The temperature of this chemical is 20 ℃. The yield is about 73%.

Uses of Piperazine-1,4-diethylamine: it can be used to produce N,N'-(2,2'-piperazine-1,4-diyl-diethyl)-bis-phthalimide. This reaction will need reagent Condensation and solvent acetic acid. The yield is about 80%.

You can still convert the following datas into molecular structure:
(1)SMILES: NCCN1CCN(CC1)CCN
(2)InChI: InChI=1/C8H20N4/c9-1-3-11-5-7-12(4-2-10)8-6-11/h1-10H2
(3)InChIKey: PAOXFRSJRCGJLV-UHFFFAOYAC
(4)Std. InChI: InChI=1S/C8H20N4/c9-1-3-11-5-7-12(4-2-10)8-6-11/h1-10H2
(5)Std. InChIKey: PAOXFRSJRCGJLV-UHFFFAOYSA-N

Product Name

Piperazine-1,4-diethylamine

Synthetic route

Piperazine-1,4-diethylamine Specification

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