Product Name

  • Name

    3-CHLORO-6-(4-METHOXYPHENYL)-PYRIDAZINE

  • EINECS
  • CAS No. 58059-31-7
  • Article Data12
  • CAS DataBase
  • Density 1.246 g/cm3
  • Solubility
  • Melting Point 160 °C
  • Formula C11H9ClN2O
  • Boiling Point 407.764 °C at 760 mmHg
  • Molecular Weight 220.658
  • Flash Point 200.409 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 58059-31-7 (3-CHLORO-6-(4-METHOXYPHENYL)-PYRIDAZINE)
  • Hazard Symbols IrritantXi
  • Synonyms Pyridazine,3-chloro-6-(p-methoxyphenyl)- (7CI);3-Chloro-6-(4-methoxyphenyl)pyridazine;
  • PSA 35.01000
  • LogP 2.80560

Synthetic route

6-(4-methoxyphenyl)-2H-pyridazin-3-one
2166-33-8

6-(4-methoxyphenyl)-2H-pyridazin-3-one

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
With isocyanate de chlorosulfonyle In acetonitrile at 60 - 65℃; for 3.5h;82%
With trichlorophosphate at 85 - 95℃; for 4h;
With trichlorophosphate Heating;
tris(4-methoxyphenyl)bismuth
33397-21-6

tris(4-methoxyphenyl)bismuth

3-chloro-6-iodopyridazine
135034-10-5

3-chloro-6-iodopyridazine

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
With palladium diacetate; triphenylphosphine In N,N-dimethyl-formamide at 90℃; for 4h; Catalytic behavior; Reagent/catalyst; Inert atmosphere; chemoselective reaction;82%
4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

3-chloro-6-iodopyridazine
135034-10-5

3-chloro-6-iodopyridazine

A

3,6-bis-(4-methoxyphenyl)-pyridazine
2166-07-6

3,6-bis-(4-methoxyphenyl)-pyridazine

B

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,4-dioxane Suzuki Coupling; Heating; Inert atmosphere; chemoselective reaction;A 15%
B 70%
...Expand
3,6-dichlorpyridazine
141-30-0

3,6-dichlorpyridazine

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,4-dioxane Suzuki Coupling; Heating; Inert atmosphere; chemoselective reaction;58%
With potassium phosphate tribasic trihydrate; (2-mesityl-1H-inden-3-yl)dicyclohexyl phosphine; palladium diacetate; Aliquat 336 In water at 20 - 100℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;43%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene at 80℃; for 16h;
3,6-dichlorpyridazine
141-30-0

3,6-dichlorpyridazine

tris(4-methoxyphenyl)bismuth
33397-21-6

tris(4-methoxyphenyl)bismuth

A

4,4'-Dimethoxybiphenyl
2132-80-1

4,4'-Dimethoxybiphenyl

B

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
With palladium diacetate; triphenylphosphine; cesium fluoride In N,N-dimethyl-formamide at 90℃; Inert atmosphere; chemoselective reaction;A 17 %Chromat.
B 43%
...Expand
6-(4-methoxy-phenyl)-2H-pyridazin-3-one
2166-33-8

6-(4-methoxy-phenyl)-2H-pyridazin-3-one

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
With trichlorophosphate at 0℃; for 6h; Heating / reflux;40%
3,6-dichlorpyridazine
141-30-0

3,6-dichlorpyridazine

4-methoxyphenylzinc chloride
93296-09-4

4-methoxyphenylzinc chloride

A

3,6-bis-(4-methoxyphenyl)-pyridazine
2166-07-6

3,6-bis-(4-methoxyphenyl)-pyridazine

B

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; for 24h;
...Expand
3,6-dichlorpyridazine
141-30-0

3,6-dichlorpyridazine

tris(4-methoxyphenyl)bismuth
33397-21-6

tris(4-methoxyphenyl)bismuth

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
With palladium diacetate; triphenylphosphine; cesium fluoride In N,N-dimethyl-formamide at 90℃; Reagent/catalyst; Inert atmosphere; chemoselective reaction;
C11H12N2O2

C11H12N2O2

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
With trichlorophosphate
1-(4-methoxyphenyl)ethanone
100-06-1

1-(4-methoxyphenyl)ethanone

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid / Reflux
1.2: 2 h / Reflux
2.1: trichlorophosphate / Heating
View Scheme
phenylzinc(II) bromide
38111-44-3

phenylzinc(II) bromide

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-(4-methoxyphenyl)-6-phenylpyridazine
2166-04-3

3-(4-methoxyphenyl)-6-phenylpyridazine

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 60℃;80%
3-HYDROXYPYRIDINE
109-00-2

3-HYDROXYPYRIDINE

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-hydroxy-1-<6-(4-methoxyphenyl)-3-pyridazinyl>pyridinium chloride

3-hydroxy-1-<6-(4-methoxyphenyl)-3-pyridazinyl>pyridinium chloride

Conditions
ConditionsYield
In butan-1-ol for 4h; Heating;79.4%
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-(4-hydroxypiperidino)-6-(4-methoxyphenyl)pyridazine
93181-98-7

3-(4-hydroxypiperidino)-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
In butan-1-ol for 3h; Heating;75%
1H-imidazole
288-32-4

1H-imidazole

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-(1H-imidazol-1-yl)-6-(4-methoxyphenyl)pyridazine

3-(1H-imidazol-1-yl)-6-(4-methoxyphenyl)pyridazine

Conditions
ConditionsYield
Stage #1: 1H-imidazole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;
Stage #2: 3-chloro-6-(4-methoxyphenyl)pyridazine In N,N-dimethyl-formamide; mineral oil at 100℃; for 6h;		60%
acetic acid hydrazide
1068-57-1

acetic acid hydrazide

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

6-(4-Methoxy-phenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine
76970-05-3

6-(4-Methoxy-phenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine

Conditions
ConditionsYield
In butan-1-ol for 48h; Heating;51%
formic acid hydrazide
624-84-0

formic acid hydrazide

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

6-(4-methoxyphenyl)-1,2,4-triazolo<4,3-b>pyridazine
117979-38-1

6-(4-methoxyphenyl)-1,2,4-triazolo<4,3-b>pyridazine

Conditions
ConditionsYield
With triethylamine hydrochloride In xylene for 2h; Heating / reflux;27%
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

4-(2-hydroxy-ethoxy)-benzaldehyde
22042-73-5

4-(2-hydroxy-ethoxy)-benzaldehyde

4-{2-[6-(4-methoxy-phenyl)-pyridazin-3-yloxy]-ethoxy}-benzaldehyde
935692-89-0

4-{2-[6-(4-methoxy-phenyl)-pyridazin-3-yloxy]-ethoxy}-benzaldehyde

Conditions
ConditionsYield
Stage #1: 4-(2-hydroxy-ethoxy)-benzaldehyde With sodium In tetrahydrofuran at 60℃; for 2h;
Stage #2: 3-chloro-6-(4-methoxyphenyl)pyridazine In tetrahydrofuran for 10h; Heating / reflux;		9%
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-hydrazino-6-(p-methoxyphenyl)pyridazine
18772-76-4

3-hydrazino-6-(p-methoxyphenyl)pyridazine

Conditions
ConditionsYield
With hydrazine hydrate In butan-1-ol at 100℃; for 6h;
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

6-endo-cyano-8-<6-(4-methoxyphenyl)-3-pyridazinyl>-8-azabicyclo<3.2.1>oct-3-en-2-one

6-endo-cyano-8-<6-(4-methoxyphenyl)-3-pyridazinyl>-8-azabicyclo<3.2.1>oct-3-en-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 79.4 percent / butan-1-ol / 4 h / Heating
2: Et3N
3: 45 percent / hydroquinone / acetonitrile / 48 h / Heating
View Scheme
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

6-endo-phenyl-8-<6-(4-methoxyphenyl)-3-pyridazinyl>-8-azabicyclo<3.2.1>oct-3-en-2-one

6-endo-phenyl-8-<6-(4-methoxyphenyl)-3-pyridazinyl>-8-azabicyclo<3.2.1>oct-3-en-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 79.4 percent / butan-1-ol / 4 h / Heating
2: 40 percent / Et3N, hydroquinone / 48 h / Heating
View Scheme
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

(1R,2S,6R,7R)-3,11-Bis-[6-(4-methoxy-phenyl)-pyridazin-3-yl]-3,11-diaza-tricyclo[5.3.1.12,6]dodeca-4,9-diene-8,12-dione

(1R,2S,6R,7R)-3,11-Bis-[6-(4-methoxy-phenyl)-pyridazin-3-yl]-3,11-diaza-tricyclo[5.3.1.12,6]dodeca-4,9-diene-8,12-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 79.4 percent / butan-1-ol / 4 h / Heating
2: Et3N
View Scheme
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-hydroxy-1-<6-(4-methoxyphenyl)-3-pyridazinyl>pyridinium maleate

3-hydroxy-1-<6-(4-methoxyphenyl)-3-pyridazinyl>pyridinium maleate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 79.4 percent / butan-1-ol / 4 h / Heating
2: Et3N
3: 91 percent / tetrahydrofuran / 14 h / Heating
View Scheme
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-hydroxy-1-<6-(4-methoxyphenyl)-3-pyridazinyl>pyridinium fumarate

3-hydroxy-1-<6-(4-methoxyphenyl)-3-pyridazinyl>pyridinium fumarate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 79.4 percent / butan-1-ol / 4 h / Heating
2: Et3N
3: 85 percent / dioxane / 14 h / Heating
View Scheme
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

2-(3-carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium bromide
104104-50-9

2-(3-carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium bromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrazine hydrate / butan-1-ol / 6 h / 100 °C
2: H2 / Raney Ni / methanol / 20 °C / 760 Torr
3: dimethylformamide / 8 h / 80 °C
4: 48percent HBr / acetic acid / 10 h / 100 °C
View Scheme
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

6-Amino-1-(3-ethoxycarbonyl-propyl)-3-(4-methoxy-phenyl)-pyridazin-1-ium; bromide
105538-31-6

6-Amino-1-(3-ethoxycarbonyl-propyl)-3-(4-methoxy-phenyl)-pyridazin-1-ium; bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrazine hydrate / butan-1-ol / 6 h / 100 °C
2: H2 / Raney Ni / methanol / 20 °C / 760 Torr
3: dimethylformamide / 8 h / 80 °C
View Scheme
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-amino-6-(4'-methoxyphenyl)pyridazine
4776-87-8

3-amino-6-(4'-methoxyphenyl)pyridazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrazine hydrate / butan-1-ol / 6 h / 100 °C
2: H2 / Raney Ni / methanol / 20 °C / 760 Torr
View Scheme
3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-chloro-6-(4-hydroxyphenyl)pyridazine
99708-46-0

3-chloro-6-(4-hydroxyphenyl)pyridazine

Conditions
ConditionsYield
With boron tribromide In dichloromethane at 20℃; for 16h;
3,4,5-trimethoxybenzohydrazide
3291-03-0

3,4,5-trimethoxybenzohydrazide

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-(3,4,5-trimethoxyphenyl)-6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazine

3-(3,4,5-trimethoxyphenyl)-6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazine

Conditions
ConditionsYield
In butan-1-ol Heating; Microwave irradiation;
C10H14N2O4
1153791-73-1

C10H14N2O4

3-chloro-6-(4-methoxyphenyl)pyridazine
58059-31-7

3-chloro-6-(4-methoxyphenyl)pyridazine

3-(2,3,4-trimethoxyphenyl)-6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazine

3-(2,3,4-trimethoxyphenyl)-6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazine

Conditions
ConditionsYield
In butan-1-ol Heating; Microwave irradiation;

Pyridazine,3-chloro-6-(4-methoxyphenyl)- Specification

The Pyridazine, 3-chloro-6-(4-methoxyphenyl)-, with the CAS registry number of 58059-31-7, is also known as Pyridazine, 3-chloro-6-(p-methoxyphenyl)- (7CI). This chemical's molecular formula is C11H9ClN2O and molecular weight is 220.65. What's more, its systematic name is called 3-Chloro-6-(4-methoxyphenyl)pyridazine.

Physical properties about Pyridazine, 3-chloro-6-(4-methoxyphenyl)- are: (1)ACD/LogP: 2.30; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2; (4)ACD/LogD (pH 7.4): 2; (5)ACD/BCF (pH 5.5): 11; (6)ACD/BCF (pH 7.4): 11; (7)ACD/KOC (pH 5.5): 188; (8)ACD/KOC (pH 7.4): 188; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 35.01 Å2; (13)Index of Refraction: 1.576; (14)Molar Refractivity: 58.601 cm3; (15)Molar Volume: 177.119 cm3; (16)Surface Tension: 46.079 dyne/cm; (17)Density: 1.246 g/cm3; (18)Flash Point: 200.409 °C; (19)Enthalpy of Vaporization: 63.404 kJ/mol; (20)Boiling Point: 407.764 °C at 760 mmHg; (21)Vapour Pressure: 0 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: COc1ccc(cc1)c2ccc(Cl)nn2
(2) InChI: InChI=1/C11H9ClN2O/c1-15-9-4-2-8(3-5-9)10-6-7-11(12)14-13-10/h2-7H,1H3
(3) InChIKey: TZBSFHQGJIBFLX-UHFFFAOYAX

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View