SPERMIDINE supplier | CasNO.124-20-9

Name
Spermidine
EINECS 204-689-0
CAS No. 124-20-9
Article Data28
CAS DataBase
Density 0.906 g/cm³
Solubility Miscible with water, ethanol and ether.
Melting Point 23-25 °C
Formula C₇H₁₉N₃
Boiling Point 246.57 °C at 760 mmHg
Molecular Weight 145.248
Flash Point 118.078 °C
Transport Information UN 2735 8/PG 2
Appearance Colorless clear liquid
Safety 26-36/37/39-45-27
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms 1,4-Butanediamine,N-(3-aminopropyl)- (8CI,9CI);Spermidine (6CI);1,5,10-Triazadecane;1,8-Diamino-4-azaoctane;4-Azaoctane-1,8-diamine;N-(3-Aminopropyl)-1,4-butanediamine;N-(3-Aminopropyl)-1,4-diaminobutane;N-(3-Aminopropyl)-4-aminobutylamine;N-(4-Aminobutyl)-1,3-diaminopropane;Spermidine;
PSA 64.07000
LogP 1.45520

Synthetic route

: 143565-69-9
4-aza-1,3-bis(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)octane

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With piperidine In methanol at 65℃;	90%

: 177085-34-6
[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamic acid tert-butyl ester

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 60℃; for 12h;	45%

: N-(3-bromo-propyl)-butanediyldiamine

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With ammonia

: 4-(2-cyano-ethylamino)-butyronitrile; hydrochloride

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With hydrogenchloride; platinum Hydrogenation;

: 34450-15-2, 120205-19-8
N8-acetylspermidine dihydrochloride

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With hydrogenchloride

: 4748-73-6
N-(cyanoethyl)-1,4-diaminobutane

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With ammonia; hydrogen; nickel In ethanol

: 71-44-3
Spermine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 109-76-2
Trimethylenediamine

Conditions

Conditions	Yield
With pyrroloquinoline quinone In water at 37℃; examination of PQQ oxidation effect; phosphate buffer (pH=7.2);

: 71-44-3
Spermine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 110-60-1
1,4-diaminobutane

C: 107-02-8
acrolein

Conditions

Conditions	Yield
With phosphate buffer In water at 37℃; Product distribution; bovine serum amine oxidase; other polyamines;

...Expand

: 525-79-1
kinetin

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 110-60-1
1,4-diaminobutane

Conditions

Conditions	Yield
at 30℃; for 24h; effect on poliamine content and ratio in rice embryos of Oryza sativa;

...Expand

: 14398-53-9
(R)-(-)-abscisic acid

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 110-60-1
1,4-diaminobutane

Conditions

Conditions	Yield
at 30℃; for 24h; effect on poliamine content and ratio in rice embryos of Oryza sativa;

...Expand

: 114916-04-0
N1,N5-di-(E)-coumaroyl-spermidine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 7400-08-0
para-coumaric acid

Conditions

Conditions	Yield
With hydrogenchloride at 100℃; for 4h;
With sodium hydroxide at 100℃; for 4h;

: N5,N10-di-(E,E)-feruloylspermidine

A: 1135-24-6
3-(4-hydroxy-3-methoxyphenyl)acrylic acid

B: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With sodium hydroxide at 100℃; for 4h;
With hydrogenchloride at 100℃; for 4h;

: 64482-04-8
tetrahydroperiphylline

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With potassium hydroxide Heating;

: 71-44-3
Spermine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 123-38-6
propionaldehyde

C: 109-76-2
Trimethylenediamine

Conditions

Conditions	Yield
With NaPi buffer; oxygen at 37℃; for 0.166667h; catalase and polyamine oxidase presence, pH 6.5, other polyamines and acetylpolyamines, kinetic constants Km (μM) and Vmax (μmol H2O2 formed μg protein-1 min-1);

...Expand

1-amino-4-<γ-bromo-propylamino>-butane: 1-amino-4-<γ-bromo-propylamino>-butane

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With ethanol; ammonia at 100℃;

: 1111644-29-1
N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 10563-23-2
N-ethyl-1,3-diaminopropane

C: 13910-48-0
N-benzyl-1,3-diaminopropane

D: N-(3-aminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

E: 100-46-9
benzylamine

F: N1-(3-ethylaminopropyl)butane-1,4-diamine

G: N-{3-[(4-aminobutyl)amino]propyl}(phenylmethyl)amine

Conditions

Conditions	Yield
With spermine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

...Expand

: N-(3-aminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
With spermine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

: N-(3-aminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 10563-23-2
N-ethyl-1,3-diaminopropane

D: N1-(3-ethylaminopropyl)butane-1,4-diamine

Conditions

Conditions	Yield
With recombinant human polyamine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

...Expand

: N(1)-(3-(ethylamino)propyl)butane-1,4-diamine trihydrochloride

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 10563-23-2
N-ethyl-1,3-diaminopropane

C: 110-60-1
1,4-diaminobutane

Conditions

Conditions	Yield
With recombinant human polyamine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

...Expand

: N1-(3-aminopropyl)-N4-(3-(benzylamino)propyl)butane-1,4-diamine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 100-46-9
benzylamine

D: N-{3-[(4-aminobutyl)amino]propyl}(phenylmethyl)amine

Conditions

Conditions	Yield
With recombinant human polyamine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

...Expand

: N1-(3-aminopropyl)-N4-(3-(benzylamino)propyl)butane-1,4-diamine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 100-46-9
benzylamine

Conditions

Conditions	Yield
With spermine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

: N-{3-[(4-aminobutyl)amino]propyl}(phenylmethyl)amine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 13910-48-0
N-benzyl-1,3-diaminopropane

C: 110-60-1
1,4-diaminobutane

Conditions

Conditions	Yield
With spermine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

...Expand

: N-{3-[(4-aminobutyl)amino]propyl}(phenylmethyl)amine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 110-60-1
1,4-diaminobutane

Conditions

Conditions	Yield
With recombinant human polyamine oxidase pH=9.5; Kinetics; pH-value; Reagent/catalyst; Enzymatic reaction;

: 71-44-3
Spermine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 352-92-1
3-aminopropanal

Conditions

Conditions	Yield
Stage #1: Spermine With recombinant human flavin-dependent spermine oxidase at 25℃; for 0.00166667h; pH=8.3; aq. buffer; Inert atmosphere; Enzymatic reaction; Stage #2: With oxygen at 25℃; pH=8.3; Kinetics; Mechanism; pH-value; Time; aq. buffer; Enzymatic reaction;
With recombinant mouse spermine oxidase at 25℃; pH=8.5; Kinetics; Reagent/catalyst; aq. phosphate buffer;
With Saccharomyces cerevisiae recombinant polyamine oxidase Fms1; water; oxygen at 25℃; pH=9.35; Kinetics; Reagent/catalyst; Concentration; Enzymatic reaction;

: glutathionylspermidine disulfide

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 70-18-8
GLUTATHIONE

Conditions

Conditions	Yield
With glutathionylspermidine synthetase/amidase; GSH reductase; water; NADP at 25℃; pH=7.3; aq. buffer; Enzymatic reaction;

: 1111644-29-1
N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: spermine oxidase / pH 9.5 / Enzymatic reaction 2: spermine oxidase / pH 9.5 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction 2: spermine oxidase / pH 9.5 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: spermine oxidase / pH 9.5 / Enzymatic reaction 2: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction View Scheme

: 1111644-29-1
N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 71-44-3
Spermine

C: 10563-23-2
N-ethyl-1,3-diaminopropane

D: N1-(3-ethylaminopropyl)butane-1,4-diamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: spermine oxidase / pH 9.5 / Enzymatic reaction 2: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction View Scheme
Multi-step reaction with 2 steps 1: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction 2: recombinant human polyamine oxidase / pH 9.5 / Enzymatic reaction View Scheme

...Expand

: 1111644-29-1
N-(3-benzylaminopropyl)-N'-(3-ethylaminopropyl)butane-1,4-diamine

A: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

B: 13910-48-0
N-benzyl-1,3-diaminopropane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: spermine oxidase / pH 9.5 / Enzymatic reaction 2: spermine oxidase / pH 9.5 / Enzymatic reaction View Scheme

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 83392-10-3
N1,N8-bis(tert-butoxycarbonyl)spermidine

Conditions

Conditions	Yield
In tetrahydrofuran at 0℃; for 1h;	100%
In tetrahydrofuran at 0℃; for 4h; Inert atmosphere;	95%
In tetrahydrofuran for 1h;	86%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 1521-38-6
2,3-dimethoxybenzoic acid

: 78217-75-1
N1,N8-Bis(2,3-bis(methyloxy)benzoyl)spermidine

Conditions

Conditions	Yield
With 1,1'-carbonyldiimidazole In dichloromethane	100%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 530-62-1
1,1'-carbonyldiimidazole

: 75-65-0
tert-butyl alcohol

: 83392-10-3
N1,N8-bis(tert-butoxycarbonyl)spermidine

Conditions

Conditions	Yield
Stage #1: 1,1'-carbonyldiimidazole; tert-butyl alcohol With potassium hydroxide In toluene at 60℃; for 3h; Inert atmosphere; Stage #2: N-(3-aminopropyl)-1,4-diaminobutane In toluene at 60℃; for 3h; Inert atmosphere;	100%
Stage #1: 1,1'-carbonyldiimidazole; tert-butyl alcohol With potassium hydroxide In toluene at 60℃; for 3h; Stage #2: N-(3-aminopropyl)-1,4-diaminobutane In toluene at 60℃; for 3h;	20.22 g

...Expand

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 5532-86-5
benzyl cyanoformate

: 89965-56-0
<3-<<4-(carboxyamino)butyl>amino>propyl>carbamic acid, dibenzyl ester

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h;	99%
In dichloromethane at 0℃; for 2h;	95%
In chloroform at 23℃; for 16h;	71%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: N-tetradecanoyl-L-proline

: C45H85N5O4

Conditions

Conditions	Yield
Stage #1: N-tetradecanoyl-L-proline With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 20℃; for 1.5h; Stage #2: N-(3-aminopropyl)-1,4-diaminobutane In dichloromethane for 20h;	99%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 5-benzoyl-3-(cyclopent-1-en-1-yl)-5-phenyl-1,5-dihydro-4H-pyrazol-4-one

: 73038-07-0
N1,N8-bis(benzoyl)spermidine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 24h; regioselective reaction;	98%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 75-07-0
acetaldehyde

: 82995-34-4
1-<4'-(N-ethylidene)aminobutyl>-2-methylhexahydropyrimidine

Conditions

Conditions	Yield
In chloroform at 5 - 10℃; for 0.0833333h;	97%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 110-17-8
(2E)-but-2-enedioic acid

: spermidine fumarate

Conditions

Conditions	Yield
In water for 0.25h;	97%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 202266-40-8
2-phenyl-2,3-dihydro[1]benzofuro[2,3-e][1,2,4]triazin-3-one

: 1,5,10-tris[6-(2-hydroxyphenyl)-3-oxo-2-phenyl-1,2,4-triazin-5-yl]-1,5,10-triazadecane

Conditions

Conditions	Yield
In chloroform at 50℃; for 18h;	96.3%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 22509-74-6
N-ethoxycarbonylphthalimide

: 104435-58-7
N1,N10-bisphthaloylspermidine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 2.5h;	96%
In dichloromethane at 25℃; for 2h;	90%
In chloroform at 20 - 25℃; for 0.75h;	75%
at 20 - 25℃;
In chloroform Acylation;

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 383-63-1
ethyl trifluoroacetate,

: N1,N8-bis(trifluoroacetyl)spermidinetriamine trifluoacetate

Conditions

Conditions	Yield
With water In acetonitrile Heating;	96%
In water; acetonitrile Heating;	92%
With water In acetonitrile for 7h;	89%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 1755-15-3
2-acetyldimedone

: 193334-87-1
N(1),N(8)-bis[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-spermidine

Conditions

Conditions	Yield
With triethylamine In ethanol for 8h; Heating;	96%

: 50-00-0
formaldehyd

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 73453-98-2
1-(4-aminobutyl)-1,2,3,4,5,6-hexahydropyrimidine

Conditions

Conditions	Yield
	95%
In water at 20℃; for 1h;	94%
In water for 1h;	91%

: 30189-36-7
N,N'-di-t-butyloxycarbonyl-(S)-lysine N-hydroxysuccinimide ester

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: (5-{3-[4-(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-butylamino]-propylcarbamoyl}-5-tert-butoxycarbonylamino-pentyl)-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 24h;	95%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 76045-30-2
(S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid

: 133817-93-3
N1,N8-bis(desferrithiocinoyl) spermidine

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran for 15h; Ambient temperature;	93%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 75-05-8
acetonitrile

: 82414-35-5
N1,N3-spermidinebis(acetamide)

Conditions

Conditions	Yield
With water; dihydridotetrakis(triphenylphosphine)ruthenium In 1,2-dimethoxyethane at 160℃; for 24h;	93%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

poly(3-acyl-2-oxazolone)((R=Me): poly(3-acyl-2-oxazolone)((R=Me)

: 82414-35-5
N1,N3-spermidinebis(acetamide)

Conditions

Conditions	Yield
In tetrahydrofuran for 6h; Ambient temperature;	93%

: 613-90-1
benzoyl cyanide

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 73038-07-0
N1,N8-bis(benzoyl)spermidine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h;	92%
In dichloromethane for 15h; Ambient temperature;	92%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 6047-90-1
(3E)-2-oxo-4-phenylbutenenitrile

: 41590-65-2
N1,N8-dicinnamoyl spermidine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 3h;	92%
In dichloromethane for 15h; Ambient temperature;	92%
In dichloromethane Ambient temperature;	92%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 383-63-1
ethyl trifluoroacetate,

: 158474-89-6
N-[4-(trifluoroacetamido)butyl]-N-[3-(trifluoroacetamido)propyl]amine

Conditions

Conditions	Yield
In water; acetonitrile for 12h; Heating;	92%
With water In acetonitrile for 7h; Heating;	89%
With water In acetonitrile Heating;

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

hexachlorocyclotriphosphazene (N3P3Cl6): hexachlorocyclotriphosphazene (N3P3Cl6)

: 90510-43-3
(2,4,4,6,6-Pentachloro-2λ5,4λ5,6λ5-[1,3,5,2,4,6]triazatriphosphinin-2-yl)-[4-(2,2,4,4-tetrachloro-1,3,5,7,11-pentaaza-2λ5,4λ5,6λ5-triphospha-spiro[5.5]undeca-1(6),2,4-trien-7-yl)-butyl]-amine

Conditions

Conditions	Yield
With triethylamine In diethyl ether; hexane for 96h; Ambient temperature;	91.6%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 407-25-0
trifluoroacetic anhydride

: 65372-69-2
tris(trifluoroacetyl)spermidine

Conditions

Conditions	Yield
With pyridine for 0.25h; Ambient temperature;	91.1%
With pyridine

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 156660-01-4
3-(2,2'-dimethoxybiphenyl)-3-carbonyl-1,3-thiazolidine-2-thione

: 156660-02-5
C37H43N3O6

Conditions

Conditions	Yield
In dichloromethane for 12h; Ambient temperature;	91%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: C7H16Cl3N3P3

Conditions

Conditions	Yield
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine In chloroform for 48h; Ambient temperature;	90.7%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 178244-37-6
N-acetyl-N-(2-isopropyl-4-oxo-4H-quinazolin-3-yl)acetamide

A: 82414-35-5
N1,N3-spermidinebis(acetamide)

B: 144522-58-7
3-acetylamino-2-isopropylquinazolin-4(3H)-one

Conditions

Conditions	Yield
In dichloromethane	A n/a B 90%

...Expand

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 207276-64-0
[(3aR,4S,6R,6aS)-6-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-dithioacetic acid methyl ester

: 1-N,8-N-bis[2-C-(2,3:5,6-di-O-isopropylidene)-β-D-mannofuranosylethanethioyl]spermidine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 24h;	90%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 10381-82-5
8-bromocaffeine

: 8-(4-(3-aminopropylamino)-butylamino)caffeine

Conditions

Conditions	Yield
In ethanol for 26h; Reflux;	90%
In ethanol

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 74058-85-8
1,10-Bis-(2-thioxo-thiazolidin-3-yl)-decane-1,10-dione

: 74059-41-9
1,5,10-Triaza-cycloicosane-11,20-dione

Conditions

Conditions	Yield
In dichloromethane for 2h; Ambient temperature;	89%

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 1-hydroxy-2-oxo-3-(3-aminopropyl)-3-(4-aminobutyl)-1-triazene

Conditions

Conditions	Yield
With nitrogen(II) oxide In acetonitrile under 3800 Torr; for 23h; Ambient temperature;	88%

SPERMIDINE Chemical Properties

IUPAC Name: N-(3-aminopropyl)Butane-1,4-diamine
Synonyms N-(3-Aminopropyl)-1,4-Butanediamine ; 1,8-Diamino-4-azaoctane
Molecular Structure:
Molecular Formula : C₇H₁₉N₃
Molecular Weight: 145.25
CAS : 124-20-9
EINECS: 204-689-0
Density : 0.925
Melting point: 22-25 ºC
Boiling point : 128-130 ºC
Refractive index : 1.4785-1.4805
Flash point: 112 ºC
Surface Tension: 37.5 dyne/cm
Enthalpy of Vaporization: 48.37 kJ/mol
Vapour Pressure: 0.0269 mmHg at 25°C
Storage temp: 2-8°C
Solubility : H₂O: 1 M at 20 °C, clear, colorless
Appearance: Colorless clear liquid
Sensitive : Air Sensitive
Merck: 14,8742
BRN : 1698591
Stability: Stable, but air-sensitive and very hygroscopic - store under argon. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.

SPERMIDINE Uses

Spermidine (CAS NO.124-20-9 ) has a protective effect of salt and senility.

SPERMIDINE Production

Spermidine (CAS NO.124-20-9 ) is widely distributed in vivo,and can be derived by biosynthesis of putrescine (putrescine) and adenosine-L-methionine

SPERMIDINE Toxicity Data With Reference

1.	oms-bcs 50 mg/L	MGGEAE Molecular and General Genetics. 178 (1980),21.
2.	dnd-ham:ovr 300 µmol/L	CNREA8 Cancer Research. 46 (1986),175.
3.	ivn-mus LD50:78 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 198 (1972),36.

SPERMIDINE Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

SPERMIDINE Safety Profile

Hazard Codes C
Risk Statements 34
34: Causes burns
Safety Statements 26-36/37/39-45-27
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
RIDADR UN 2735 8/PG 2
WGK Germany 3
RTECS EJ7000000
F 3-10-34
HazardClass 8
PackingGroup III

SPERMIDINE Specification

Corrosive C1.

R34:Causes burns.

S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
2.Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use foam, dry chemical, or carbon dioxide
3.Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
4.Storage: Store Spermidine (CAS NO.124-20-9 ) in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4°C/39°F.) Store under an inert atmosphere.

Product Name

Spermidine

Synthetic route

SPERMIDINE Chemical Properties

SPERMIDINE Uses

SPERMIDINE Production

SPERMIDINE Toxicity Data With Reference

SPERMIDINE Consensus Reports

SPERMIDINE Safety Profile

SPERMIDINE Specification

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