Product Name

  • Name

    Sodium cromoglycate

  • EINECS 239-926-7
  • CAS No. 15826-37-6
  • Article Data25
  • CAS DataBase
  • Density
  • Solubility Soluble in water to 100mg/ml
  • Melting Point 241-242 °C
  • Formula C23H14Na2O11
  • Boiling Point 752.3 °C at 760 mmHg
  • Molecular Weight 512.337
  • Flash Point 263.9 °C
  • Transport Information
  • Appearance white crystalline powder
  • Safety 26-36
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 15826-37-6 (Sodium cromoglycate)
  • Hazard Symbols IrritantXi
  • Synonyms Aarane;Allergocrom;Altoderm;Colimune;Cromolyn disodium salt;Cromovet;DSCG;Disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol;Disodium chromoglycate;
  • PSA 179.37000
  • LogP -0.55490

Synthetic route

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane
16150-45-1

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane

disodium cromoglicate
15826-37-6

disodium cromoglicate

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 65℃; for 5h; Temperature;97.1%
methacrylamide propyl trimethyl ammonium chloride

methacrylamide propyl trimethyl ammonium chloride

2-hydroxypropyl methacrylate
923-26-2

2-hydroxypropyl methacrylate

EDMA
97-90-5

EDMA

methacryloxyethyl succinic acid

methacryloxyethyl succinic acid

disodium cromoglicate
15826-37-6

disodium cromoglicate

Conditions
ConditionsYield
With azobisisobutyronitrile; nitrogen
With azobisisobutyronitrile; nitrogen
With azobisisobutyronitrile; nitrogen
...Expand
2,6-dihydroxylacetophenone
699-83-2

2,6-dihydroxylacetophenone

disodium cromoglicate
15826-37-6

disodium cromoglicate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium ethanolate / ethanol / 10 h / 60 °C
2: isopropyl alcohol / 10 h / 100 °C
3: sodium hydroxide / ethanol; water / 5 h / 65 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium ethanolate / ethanol / 10 h / 60 °C
2: isopropyl alcohol / 6 h / 75 °C
3: sodium hydroxide / ethanol; water / 5 h / 65 °C
View Scheme
5-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester
50521-64-7

5-hydroxy-4-oxo-4H-benzopyran-2-carboxylic acid ethyl ester

disodium cromoglicate
15826-37-6

disodium cromoglicate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: isopropyl alcohol / 10 h / 100 °C
2: sodium hydroxide / ethanol; water / 5 h / 65 °C
View Scheme
ethanol
64-17-5

ethanol

disodium cromoglicate
15826-37-6

disodium cromoglicate

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane
16150-45-1

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane

Conditions
ConditionsYield
With hydrogenchloride at 95 - 100℃; for 28h; Inert atmosphere;80%
With hydrogenchloride In water at 100℃; for 24h; Sealed tube;76%
With hydrogenchloride In water at 100℃; for 24h; Sealed tube;76%
disodium cromoglicate
15826-37-6

disodium cromoglicate

disodium cromoglycate-3,3'-d2

disodium cromoglycate-3,3'-d2

Conditions
ConditionsYield
With rhodium(III) chloride; water-d2 In N,N-dimethyl-formamide at 108℃;77%
disodium cromoglicate
15826-37-6

disodium cromoglicate

cromoglicinic acid
16110-51-3

cromoglicinic acid

Conditions
ConditionsYield
With hydrogenchloride In water pH=3;66%
With hydrogenchloride In water pH=3;66%
With hydrogenchloride In water at 20℃; pH=2;
disodium cromoglicate
15826-37-6

disodium cromoglicate

(1-{2-[3-(2-acetyl-3-hydroxy-phenoxy)-2-hydroxypropoxy]-6-hydroxy-phenyl}-ethanone)
16150-44-0

(1-{2-[3-(2-acetyl-3-hydroxy-phenoxy)-2-hydroxypropoxy]-6-hydroxy-phenyl}-ethanone)

Conditions
ConditionsYield
With sodium hydroxide for 0.333333h; Heating;59.7%
With potassium hydroxide In water for 2h; Reflux;
disodium cromoglicate
15826-37-6

disodium cromoglicate

C23H12(3)H2O11(2-)*2Na(1+)
92588-95-9

C23H12(3)H2O11(2-)*2Na(1+)

Conditions
ConditionsYield
With rhodium(III) chloride; tritium oxide In N,N-dimethyl-formamide at 108℃;
disodium cromoglicate
15826-37-6

disodium cromoglicate

ethyl iodide
75-03-6

ethyl iodide

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane
16150-45-1

1,3-bis(2-carboethoxychromon-5-yloxy)-2-hydroxypropane

Conditions
ConditionsYield
In N,N-dimethyl-formamide 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight;136 g
disodium cromoglicate
15826-37-6

disodium cromoglicate

methyl iodide
74-88-4

methyl iodide

1,3-bis(2-methoxycarbonylchromon-5-yloxy)propan-2-ol
51471-26-2

1,3-bis(2-methoxycarbonylchromon-5-yloxy)propan-2-ol

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 40℃; for 4h;1.44 g
disodium cromoglicate
15826-37-6

disodium cromoglicate

4,4'-(2-Hydroxypropan-1,3-diyldioxy)bis[4-(3-acetyl-2-hydroxyphenylazo)benzolsulfonsaeure], Dinatriumsalz

4,4'-(2-Hydroxypropan-1,3-diyldioxy)bis[4-(3-acetyl-2-hydroxyphenylazo)benzolsulfonsaeure], Dinatriumsalz

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 59.7 percent / aq. NaOH / 0.33 h / Heating
2.1: aq. HCl; NaNO2 / H2O / cooling
2.2: 33 percent / aq. NaOH / 0.17 h
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

C28H25NO12*ClH
110816-81-4

C28H25NO12*ClH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.44 g / dimethylformamide / 4 h / 40 °C
2: 1.) 4-dimethylaminopyridine, dicyclohexylcarbodiimide, 2.) HCl-ethanol / 1.) dichloromethane
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

C29H27NO12*ClH
114014-39-0

C29H27NO12*ClH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 136 g / dimethylformamide / 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight
2: 1.) 4-dimethylaminopyridine, dicyclohexylcarbodiimide, 2.) HCl-ethanol / 1.) dichloromethane
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

C30H29NO12*ClH
110816-82-5

C30H29NO12*ClH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 136 g / dimethylformamide / 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight
2: 1.) 4-dimethylaminopyridine, dicyclohexylcarbodiimide, 2.) HCl-ethanol / 1.) dichloromethane
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

C32H33NO12*ClH
110816-89-2

C32H33NO12*ClH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 136 g / dimethylformamide / 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight
2: 1.) 4-dimethylaminopyridine, dicyclohexylcarbodiimide, 2.) HCl-ethanol / 1.) dichloromethane
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

C33H35NO12*ClH
110816-90-5

C33H35NO12*ClH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 136 g / dimethylformamide / 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight
2: 1.) 4-dimethylaminopyridine, dicyclohexylcarbodiimide, 2.) HCl-ethanol / 1.) dichloromethane
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

C33H35NO12*ClH
114014-40-3

C33H35NO12*ClH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 136 g / dimethylformamide / 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight
2: 1.) 4-dimethylaminopyridine, dicyclohexylcarbodiimide, 2.) HCl-ethanol / 1.) dichloromethane
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

2--1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane
110838-56-7

2--1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 136 g / dimethylformamide / 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight
2: 4.7 g / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / CH2Cl2 / 3 h
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

(S)-Pyrrolidine-2-carboxylic acid 2-(2-ethoxycarbonyl-4-oxo-4H-chromen-5-yloxy)-1-(2-ethoxycarbonyl-4-oxo-4H-chromen-5-yloxymethyl)-ethyl ester; hydrochloride
114014-41-4

(S)-Pyrrolidine-2-carboxylic acid 2-(2-ethoxycarbonyl-4-oxo-4H-chromen-5-yloxy)-1-(2-ethoxycarbonyl-4-oxo-4H-chromen-5-yloxymethyl)-ethyl ester; hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 136 g / dimethylformamide / 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight
2: 1.) 4-dimethylaminopyridine, dicyclohexylcarbodiimide, 2.) HCl-ethanol / 1.) dichloromethane
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride
110816-78-9

2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 136 g / dimethylformamide / 1.) 64-70 deg C, 5 h, 2.) 4-6 deg C, overnight
2: 4.7 g / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / CH2Cl2 / 3 h
3: 16 g / 5N HCl-ethanol / CHCl3 / 0.83 h
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

A

cromoglicinic acid
16110-51-3

cromoglicinic acid

B

[(2-hydroxytrimethylene)dioxy]bis(4-oxo-4H-1-benzopyran-2-carboxylic acid)

[(2-hydroxytrimethylene)dioxy]bis(4-oxo-4H-1-benzopyran-2-carboxylic acid)

Conditions
ConditionsYield
In disodium salt of cromolyn
methanol
67-56-1

methanol

disodium cromoglicate
15826-37-6

disodium cromoglicate

1,3-bis(2-methoxycarbonylchromon-5-yloxy)propan-2-ol
51471-26-2

1,3-bis(2-methoxycarbonylchromon-5-yloxy)propan-2-ol

Conditions
ConditionsYield
With hydrogenchloride In water for 2h; Reflux;
disodium cromoglicate
15826-37-6

disodium cromoglicate

5'DLCG

5'DLCG

Conditions
ConditionsYield
Stage #1: disodium cromoglicate With hydrogenchloride In water at 20℃;
Stage #2: With lithium hydroxide In water Heating;
disodium cromoglicate
15826-37-6

disodium cromoglicate

5.5’-[(2-hydroxy-1,3-propanediyl)bis-(oxy)]bis-[4-oxo-4H-1-benzopyran-2-ethanol]

5.5’-[(2-hydroxy-1,3-propanediyl)bis-(oxy)]bis-[4-oxo-4H-1-benzopyran-2-ethanol]

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water / 24 h / 100 °C / Sealed tube
2: sodium tetrahydroborate; methanol / dichloromethane / 6 h / 25 °C
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

5,5’-[(2-hydroxy-1,3-propanediyl)bis-(oxy)]bis-[4-oxo-4H-1-benzopyran-2-carboxylic acid]bis-[(2,2-dimethyl-1-oxopropoxy)methyl]ester

5,5’-[(2-hydroxy-1,3-propanediyl)bis-(oxy)]bis-[4-oxo-4H-1-benzopyran-2-carboxylic acid]bis-[(2,2-dimethyl-1-oxopropoxy)methyl]ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water / 24 h / 100 °C / Sealed tube
2: sodium tetrahydroborate; methanol / dichloromethane / 6 h / 25 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 60 °C
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

5,5’-[(2-hydroxy-1,3-propanediyl)bis-(oxy)]bis-[4-oxo-4H-1-benzopyran-2-ethanol]triacetate

5,5’-[(2-hydroxy-1,3-propanediyl)bis-(oxy)]bis-[4-oxo-4H-1-benzopyran-2-ethanol]triacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water / 24 h / 100 °C / Sealed tube
2: sodium tetrahydroborate; methanol / dichloromethane / 6 h / 25 °C
3: pyridine / 3 h / 0 - 20 °C
View Scheme
disodium cromoglicate
15826-37-6

disodium cromoglicate

2Na(1+)*C23H18O13(2-)

2Na(1+)*C23H18O13(2-)

Conditions
ConditionsYield
With sodium hydroxide at 70℃; for 1h;

Sodium cromoglycate Chemical Properties

IUPAC Name: Disodium 5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
Product Categories: Drug bulk;Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Formula: C23H14O11·2 Na
Molecular Weight: 512.35
EINECS: 239-926-7
Melting Point: 241-2420 °C
Boiling Point: 752.3 °C at 760 mmHg
Flash Point: 263.9 °C
Enthalpy of Vaporization: 115.04 kJ/mol
Vapour Pressure: 8.92E-24 mmHg at 25°C 
Appearance: White Crystalline Powder
Cromoglycate disodium's (15826-37-6) Synonyms: DSCG ; DISODIUM CROMOGLYCATE ; Disodium 5,5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4h-1-benzopyran-2-carboxylate] ; Disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol ; CROMOGLYCATE SODIUM SALT ; CROMOGLYCIC ACID SODIUM SALT ; CROMOLYN SODIUM ; CROMOLYN SODIUM SALT
Cromoglycate disodium's (15826-37-6) Molecular Structure:

Sodium cromoglycate Uses

Chromone complex which blocks mast cell degranulation.

Sodium cromoglycate Toxicity Data With Reference

1.    

orl-wmn TDLo:96 mg/kg/6D-I:SKN

     BMJOAE    British Medical Journal. 289 (1984),470.
2.    

orl-hmn TDLo:34 mg/kg/4W:PUL

     BMJOAE    British Medical Journal. 2 (1976),916.
3.    

scu-rat LD50:6 g/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244.
4.    

ipr-mus LD50:4100 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244.
5.    

scu-mus LD50:4400 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244.
6.    

ivn-mus LD50:3300 mg/kg

     NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),244.
7.    

ivn-rbt LD50:2 g/kg

     KSRNAM    Kiso to Rinsho. Clinical Report. 4 (1970),189.

Sodium cromoglycate Safety Profile

Moderately toxic by intravenous route. Mildly toxic by subcutaneous and intraperitoneal routes. Human systemic effects by ingestion: allergic dermatitis, respiratory depression and other lung effects. When heated to decomposition it emits toxic fumes of Na2O.

Safety Information of Cromoglycate disodium(15826-37-6)
Hazard Codes:  Xi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 2
RTECS: DJ2380000
HazardClass: 6.1(b)
PackingGroup: III 

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View