Sodium cyclamate supplier | CasNO.139-05-9

Name
Sodium N-cyclohexylsulfamate
EINECS 205-348-9
CAS No. 139-05-9
Density 1.32 g/cm³
Solubility water: >=10 g/100 mL at 20 oC
Melting Point >300 °C(lit.)
Formula C₆H₁₂NNaO₃S
Boiling Point
Molecular Weight 201.222
Flash Point
Transport Information
Appearance White powder
Safety 36/37
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms Cyclohexanesulfamicacid, monosodium salt (8CI);Sulfamic acid, cyclohexyl-, monosodium salt (9CI);Acofarinas;Assugrin;Asugryn;Azucrona;Cyclamate sodium;Cyclohexylsulfamatesodium;Cyclohexylsulfamic acid sodium salt;N-Cyclohexylsulfamic acid sodium salt;
PSA 77.61000
LogP 1.84060

Synthetic route

: 104-74-5
N-dodecylpyridinium chloride

: 139-05-9
sodium cyclamate

: 1403558-43-9
1-dodecylpyridinium cyclamate

Conditions

Conditions	Yield
In water at 20℃; for 24h;	99%

: C12H20NO(1+)*Cl(1-)

: 139-05-9
sodium cyclamate

: 1-hexyloxymethylpyridinium cyclamate

Conditions

Conditions	Yield
In water at 20℃; for 24h;	96%

: 139-05-9
sodium cyclamate

: 21379-35-1
1-Dodecyloxymethylpyridinium-chlorid

: 1-dodecyloxymethylpyridinium cyclamate

Conditions

Conditions	Yield
In water at 20℃; for 24h;	96%

: 7173-51-5
didecyldimethylammonium chloride

: 139-05-9
sodium cyclamate

: 1403558-45-1
didecyldimethylammonium cyclamate

Conditions

Conditions	Yield
In water at 20℃; for 24h;	95%

: 139-05-9
sodium cyclamate

: 79917-90-1
1-butyl-3-methylimidazolium chloride

: 1403558-48-4
1-butyl-3-methylimidazolium cyclamate

Conditions

Conditions	Yield
In water at 20℃; for 24h;	95%

: 22843-12-5
1-Undecyloxymethylpyridinium-chlorid

: 139-05-9
sodium cyclamate

: C17H30NO(1+)*C6H12NO3S(1-)

Conditions

Conditions	Yield
In water at 20℃; for 24h;	94%

: C11H18NO(1+)*Cl(1-)

: 139-05-9
sodium cyclamate

: C11H18NO(1+)*C6H12NO3S(1-)

Conditions

Conditions	Yield
In water at 20℃; for 24h;	93%

: 1-methyl-3-tetradecyloxymethylimidazolim chloride

: 139-05-9
sodium cyclamate

: 1-methyl-3-tetradecyloxymethylimidazolium cyclamate

Conditions

Conditions	Yield
In water at 20℃; for 24h;	93%

: 139-05-9
sodium cyclamate

: 52043-72-8
1-Tetradecyloxymethylpyridinium-chlorid

: C20H36NO(1+)*C6H12NO3S(1-)

Conditions

Conditions	Yield
In water at 20℃; for 24h;	92%

: 139-05-9
sodium cyclamate

: 23693-43-8
1-Nonyloxymethyl-pyridinium; chloride

: C15H26NO(1+)*C6H12NO3S(1-)

Conditions

Conditions	Yield
In water at 20℃; for 24h;	90%

: 139-05-9
sodium cyclamate

: 13501-48-9
1-Decyloxymethylpyridinium-chlorid

: 1403558-42-8
C16H28NO(1+)*C6H12NO3S(1-)

Conditions

Conditions	Yield
In water at 20℃; for 24h;	89%

: 856958-20-8
C10H16NO(1+)*Cl(1-)

: 139-05-9
sodium cyclamate

: C10H16NO(1+)*C6H12NO3S(1-)

Conditions

Conditions	Yield
In water at 20℃; for 24h;	87%

: 139-05-9
sodium cyclamate

: 1-Heptyloxymethyl-pyridinium; chloride

: C13H22NO(1+)*C6H12NO3S(1-)

Conditions

Conditions	Yield
In water at 20℃; for 24h;	85%

: 139-05-9
sodium cyclamate

: 56049-77-5
1-Octyloxymethyl-pyridinium; chloride

: C14H24NO(1+)*C6H12NO3S(1-)

Conditions

Conditions	Yield
In water at 20℃; for 24h;	84%

: 123-03-5
cetylpyridinium chloride

: 139-05-9
sodium cyclamate

: 1403558-44-0
1-hexadecylpyridinium cyclamate

Conditions

Conditions	Yield
In water at 20℃; for 24h;	82%

: 1336-21-6
ammonium hydroxide

: 139-05-9
sodium cyclamate

: platinum(II) chloride

: Cl(1-)*C6H18N3O3PtS(1+)

Conditions

Conditions	Yield
In methanol for 1h; pH=7 - 8;	72%

...Expand

: 1336-21-6
ammonium hydroxide

: vanadium(III) chloride

: 7732-18-5
water

: 139-05-9
sodium cyclamate

: C12H29N3O7S2V(1+)*Cl(1-)

Conditions

Conditions	Yield
In methanol for 1h; pH=7 - 8;	71%

...Expand

: 10026-03-6
selenium tetrachloride

: 139-05-9
sodium cyclamate

: C12H24Cl2N2O6S2Se

Conditions

Conditions	Yield
With ammonium hydroxide In methanol for 1h; pH=7 - 8;	70%

: gold(III) chloride

: 7732-18-5
water

: 139-05-9
sodium cyclamate

: C6H12AuCl2NO3S*H2O

Conditions

Conditions	Yield
With ammonium hydroxide In methanol for 1h; pH=7 - 8;	69%

...Expand

: ruthenium trichloride

: 7732-18-5
water

: 139-05-9
sodium cyclamate

: C6H16Cl2NO5RuS

Conditions

Conditions	Yield
With ammonium hydroxide In methanol for 1h; pH=7 - 8;	67%

...Expand

: 139-05-9
sodium cyclamate

A: 930-68-7
cyclohexenone

B: 4998-76-9
cyclohexylamine hydrochloride

C: 108-94-1
cyclohexanone

D: 110-83-8
cyclohexene

Conditions

Conditions	Yield
With hydrogenchloride for 3h; pH=3; Hydrolysis; Heating;	A n/a B 10% C n/a D n/a

...Expand

: 139-05-9
sodium cyclamate

A: 930-68-7
cyclohexenone

B: 108-94-1
cyclohexanone

C: 110-83-8
cyclohexene

Conditions

Conditions	Yield
In water at 20℃; for 96h; Product distribution; Further Variations:; pH-values; without irradiation, time; Elimination; hydrolysis; Irradiation;	A 0.0008% B 0.69% C 0.0002%

...Expand

: 139-05-9
sodium cyclamate

: 10314-35-9
cyclohexylsulfamoyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride In benzene for 2h; Heating;
With trichlorophosphate In 1,2-dichloro-ethane at 80℃; for 18h;

: 139-05-9
sodium cyclamate

cyclohexanesulfamate*β-cyclodextrin complex: cyclohexanesulfamate*β-cyclodextrin complex

Conditions

Conditions	Yield
With β‐cyclodextrin; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid Equilibrium constant; pH=7.0;

: 139-05-9
sodium cyclamate

cyclohexanesulfamate*C-6,6'-(bisimidazol-1-yl)-β-cyclodextrin*Zn(2+) complex: cyclohexanesulfamate*C-6,6'-(bisimidazol-1-yl)-β-cyclodextrin*Zn(2+) complex

Conditions

Conditions	Yield
With C-6,6'-(bisimidazol-1-yl)-β-cyclodextrin*Zn(2+); N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid Equilibrium constant; pH=7.0;

: 139-05-9
sodium cyclamate

cyclohexanesulfamate*C-6,6'-(bisimidazol-1-yl)-β-cyclodextrin complex: cyclohexanesulfamate*C-6,6'-(bisimidazol-1-yl)-β-cyclodextrin complex

Conditions

Conditions	Yield
With C-6,6'-(bisimidazol-1-yl)-β-cyclodextrin; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid Equilibrium constant; pH=7.0;

: 139-05-9
sodium cyclamate

: 454219-20-6
N-cyclohexyl-N'-[4-[2-[[(2R)-2-hydroxy-2-(3-pyridinyl)ethyl]amino]-2-methylpropyl]phenyl]-sulfamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: POCl3 / 1,2-dichloro-ethane / 18 h / 80 °C 2: pyridine / 1,2-dichloro-ethane / -35 - 60 °C 3: tetrabutylammonium fluoride / tetrahydrofuran View Scheme

: 139-05-9
sodium cyclamate

: N-[4-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]phenyl]-N'-cyclohexyl-sulfamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: POCl3 / 1,2-dichloro-ethane / 18 h / 80 °C 2: pyridine / CH2Cl2 / -35 - 60 °C 3: KOH / ethanol / 80 °C View Scheme

Sodium cyclamate Chemical Properties

IUPAC Name: Sodium N-cyclohexylsulfamate
Synonyms of Sodium cyclamate (CAS NO.139-05-9): Assugrin ; Assurgrin feinsuss ; Assurgrin vollsuss ; Cyclamate de sodium ; Cyclohexanesulfamic acid, monosodium salt ; Cyclohexanesulphamic acid, monosodium salt ; Monosodium cyclohexylsulfamate ; N-Cyklohexylsulfamat sodny ; Sodium cyclohexylsulphamidate ; Sulfamic acid, cylclohexyl-, monosodium salt
CAS NO: 139-05-9
Molecular Formula: C₆H₁₂NNaO₃S
Molecular Weight: 201.22
Molecular Structure:
EINECS: 205-348-9
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 65.99 Å²
Melting point: >300 °C(lit.)
Water Solubility: >=10 g/100 mL at 20 °C
Appearance: White powder
Product Categories: Food & Feed ADDITIVES
SMILES: [Na+].O=S([O-])(=O)NC1CCCCC1
InChI: InChI=1/C6H13NO3S.Na/c8-11(9,10)7-6-4-2-1-3-5-6;/h6-7H,1-5H2,(H,8,9,10);/q;+1/p-1
InChIKey: UDIPTWFVPPPURJ-REWHXWOFAV
Std. InChI: InChI=1S/C6H13NO3S.Na/c8-11(9,10)7-6-4-2-1-3-5-6;/h6-7H,1-5H2,(H,8,9,10);/q;+1/p-1
Std. InChIKey: UDIPTWFVPPPURJ-UHFFFAOYSA-M

Sodium cyclamate Uses

Sodium cyclamate (CAS NO.139-05-9) is often used synergistically with other artificial sweeteners, especially saccharin.

Sodium cyclamate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	1154mg/kg (1154mg/kg)	Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973,
mouse	LD50	intravenous	4800mg/kg (4800mg/kg)	Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968.
mouse	LD50	oral	17gm/kg (17000mg/kg)	Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968.
rat	LD50	intraperitoneal	1350mg/kg (1350mg/kg)	Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973,
rat	LD50	intravenous	3500mg/kg (3500mg/kg)	Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968.
rat	LD50	oral	1280mg/kg (1280mg/kg)	Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

Sodium cyclamate Consensus Reports

IARC Cancer Review: Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 178.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 22 ,1980,p. 55.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Sodium cyclamate Safety Profile

Safety Information about Sodium cyclamate (CAS NO.139-05-9):
Hazard Codes: Harmful

Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 36/37
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS: GV7350000
HS Code: 29299000
Sodium cyclamate has moderately toxic by intravenous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic, tumorigenic, and teratogenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Na₂O, SO_x, and NO_x.

Sodium cyclamate Specification

Sodium cyclamate is incompatible with strong oxidizing agents, strong acids and strong bases. It is also incompatible with nitrites in acid solution. And it has only limited compatibility with potassium salts .

Product Name

Sodium N-cyclohexylsulfamate

Synthetic route

Sodium cyclamate Chemical Properties

Sodium cyclamate Uses

Sodium cyclamate Toxicity Data With Reference

Sodium cyclamate Consensus Reports

Sodium cyclamate Safety Profile

Sodium cyclamate Specification

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