Sodium phenylacetate supplier

Name
Sodium phenylacetate
EINECS 204-052-7
CAS No. 114-70-5
Article Data12
CAS DataBase
Density 1.257g/cm3
Solubility 1000g/L at 25℃
Melting Point -37oC
Formula C₈H₇NaO₂
Boiling Point 265.5 °C at 760 mmHg
Molecular Weight 158.132
Flash Point 156.2 °C
Transport Information
Appearance Clear yellow to brown.
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Aceticacid, phenyl-, Na salt (5CI);Acetic acid, phenyl-, sodium salt (8CI);Benzeneacetic acid, sodium salt (9CI);Sodium benzeneacetate;
PSA 40.13000
LogP -0.02100

Synthetic route

: 103-81-1
Benzeneacetamide

: 114-70-5
sodium phenylacetate

Conditions

Conditions	Yield
Stage #1: Benzeneacetamide With hydrogenchloride; water Heating; Stage #2: With sodium hydroxide Reagent/catalyst;	99.5%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 100-44-7
benzyl chloride

A: 538-86-3
benzyl methyl ether

B: 114-70-5
sodium phenylacetate

Conditions

Conditions	Yield
With sodium hydroxide; dicobalt octacarbonyl at 60 - 65℃; under 760.051 - 2280.15 Torr;	A n/a B 97%

...Expand

: 1121-53-5
benzyl sodium

: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

: 114-70-5
sodium phenylacetate

: 103-82-2
phenylacetic acid

: 114-70-5
sodium phenylacetate

Conditions

Conditions	Yield
With sodium methylsulfinylmethanide In dimethyl sulfoxide
With sodium hydroxide In water
With sodium hydroxide In water pH=8.0;
With sodium hydroxide In water pH=9 - 10;

: 101-97-3
Ethyl 2-phenylethanoate

sodium: sodium

A: 114-70-5
sodium phenylacetate

B: 141-78-6
ethyl acetate

C hydrogen: hydrogen

...Expand

: 4606-15-9
propyl phenylacetate

sodium: sodium

A: 109-60-4
1-Propyl acetate

B: 114-70-5
sodium phenylacetate

...Expand

: 98078-08-1
2-oxo-2-phenylethyl 2-phenylacetate

A: 114-70-5
sodium phenylacetate

B: 98-86-2
acetophenone

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide; sodium carbonate; triethylamine at 20℃; for 12h; Product distribution; Further Variations:; Reagents; Solvents; time periods; Photolysis;

: 124-38-9
carbon dioxide

: 1121-53-5
benzyl sodium

: 114-70-5
sodium phenylacetate

Conditions

Conditions	Yield
In toluene

: 103-82-2
phenylacetic acid

: 1310-73-2
sodium hydroxide

: 114-70-5
sodium phenylacetate

Conditions

Conditions	Yield
In water at 70℃;

: 114-70-5
sodium phenylacetate

: 103-82-2
phenylacetic acid

Conditions

Conditions	Yield
With sulfuric acid at 70 - 75℃; pH=1.5;	99.75%
With hydrogenchloride In water; toluene pH=2;

: 16156-52-8
n-octyl methanesulfonate

: 114-70-5
sodium phenylacetate

: 122-45-2
phenylacetic acid octyl ester

Conditions

Conditions	Yield
With sodium hydroxide; tetrahexylammonium chloride In water; benzene at 60℃; for 24h;	95%
With cyclophosphazenic polypodand In chlorobenzene at 60℃; Rate constant; different catalysts;

: 114-70-5
sodium phenylacetate

: 100-52-7
benzaldehyde

Conditions

Conditions	Yield
With potassium 12-tungstocobaltate(III) In water; acetonitrile for 0.133333h; Microwave irradiation;	94%

: 114-70-5
sodium phenylacetate

: 70-11-1
α-bromoacetophenone

: 98078-08-1
2-oxo-2-phenylethyl 2-phenylacetate

Conditions

Conditions	Yield
With triethylamine; sodium iodide In acetone Heating;	93%

: 114-70-5
sodium phenylacetate

: 60043-16-5
tri(p-tolyl)antimony dibromide

: bis-(2-phenylacetato)tris-(p-tolyl)antimony(V)

Conditions

Conditions	Yield
In toluene at 20℃; for 12h;	91%

: 50690-11-4
2,5-dimethylphenacyl chloride

: 114-70-5
sodium phenylacetate

: 378215-25-9
2,5-dimethylphenacyl phenylacetate

Conditions

Conditions	Yield
With triethylamine; sodium iodide In acetone Esterification; Heating;	84%

: 114-70-5
sodium phenylacetate

: 4407-36-7
(2E)-3-phenyl-2-propen-1-ol

: 133871-04-2
(E)-cinnamyl phenylacetate

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; triethylamine In N,N-dimethyl-formamide for 5h; Heating;	80%

: nickel(II) perchlorate hexahydrate

: 2,6-bis((2-(2-hydroxyethylamino)-ethylimino)methyl)-4-methylphenol

: 114-70-5
sodium phenylacetate

: C17H27N4O3(1-)*2Ni(2+)*2C8H7O2(1-)*ClO4(1-)*CH4O*H2O

Conditions

Conditions	Yield
Stage #1: nickel(II) perchlorate hexahydrate; 2,6-bis{(2-(2-hydroxyethylamino)-ethylimino)methyl}-4-methylphenol With air In methanol at 20℃; for 0.25h; Stage #2: sodium phenylacetate In methanol; water for 1.5h; Reflux;	78%

...Expand

: copper(II) perchlorate hexahydrate

: 2,6-bis((2-(2-hydroxyethylamino)-ethylimino)methyl)-4-methylphenol

: 114-70-5
sodium phenylacetate

: [Cu6(μ-2,6-bis{(2-(2-hydroxyethylamino)ethylimino)methyl}-4-methylphenol)2(μ3-OH)2(μ1,3-O2CCH2Ph)4(ClO4)2](ClO4)2·2H2O

Conditions

Conditions	Yield
In methanol for 1.91667h; Reflux;	76%

...Expand

: 114-70-5
sodium phenylacetate

: 101382-55-2
7-methoxy-2-oxo-1,2-dihydro-quinoline-3-carbaldehyde

: 7-Methoxy-3-phenyl-1-oxa-9-aza-anthracen-2-one

Conditions

Conditions	Yield
In acetic anhydride at 170 - 180℃; for 8h;	75%

: 114-70-5
sodium phenylacetate

: 101382-56-3
6,7-Dimethoxy-2-oxo-1,2-dihydro-quinoline-3-carbaldehyde

: 6,7-Dimethoxy-3-phenyl-1-oxa-9-aza-anthracen-2-one

Conditions

Conditions	Yield
In acetic anhydride at 170 - 180℃; for 8h;	75%

: 114-70-5
sodium phenylacetate

: 101382-53-0
6-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde

: 6-Methyl-3-phenyl-1-oxa-9-aza-anthracen-2-one

Conditions

Conditions	Yield
In acetic anhydride at 170 - 180℃; for 8h;	73%

: 114-70-5
sodium phenylacetate

: 91301-03-0
3-formyl-2-quinolone

: 3-Phenyl-1-oxa-9-aza-anthracen-2-one

Conditions

Conditions	Yield
In acetic anhydride at 170 - 180℃; for 8h;	73%

: 114-70-5
sodium phenylacetate

: 80231-41-0
7-methyl-2-oxo-1,2-dihydroquinoline-3-carboxaldehyde

: 7-Methyl-3-phenyl-1-oxa-9-aza-anthracen-2-one

Conditions

Conditions	Yield
In acetic anhydride at 170 - 180℃; for 8h;	73%

: 1253853-75-6
C17H12N2O4

: 114-70-5
sodium phenylacetate

: 1253853-82-5
C25H16N2O4

Conditions

Conditions	Yield
With acetic anhydride at 170 - 180℃; for 8h;	72%

: [Cu2(μ2-OH)(μ-2,6-bis[(3-hydroxypropylimino)methyl]-4-methylphenol)(μ1,3-NO3)][Cu2(μ2-OH)(μ-2,6-bis[(3-hydroxypropylimino)methyl]-4-methylphenol)(μ-NO3)(H2O)](NO3)2 dihydrate

: 114-70-5
sodium phenylacetate

: 1428987-74-9
[Cu4(μ4-O)(μ-2,6-bis[(3-hydroxypropylimino)methyl]-4-methylphenol)2(μ1,3-phenylacetate)4]

Conditions

Conditions	Yield
In methanol for 0.25h;	71%

: 114-70-5
sodium phenylacetate

: 106206-62-6
5-acetyl-2-benzoyl-6-hydroxy-3-methylbenzo[b]furan

: 2-benzoyl-3,5-dimethyl-6-phenyl-7H-furo<3,2-g><1>benzopyran-7-one

Conditions

Conditions	Yield
With acetic anhydride for 24h; Heating;	70%

: 114-70-5
sodium phenylacetate

: 106206-63-7
2-(p-methoxybenzoyl)-3-methyl-5-acetyl-6-hydroxybenzofuran

: 106536-43-0
2-(p-methoxybenzoyl)-3,5-dimethyl-6-phenyl-7H-furo<3,2-g><1>benzopyran-7-one

Conditions

Conditions	Yield
With acetic anhydride for 24h; Heating;	70%

: 114-70-5
sodium phenylacetate

: 60-12-8
2-phenylethanol

Conditions

Conditions	Yield
With CZYE medium (Biolife) In water for 24h; Colletotrichum gloeosporoides CBS 193.32;	70%

: 824-42-0
2-methoxy-3-methylbenzaldehyde

: 114-70-5
sodium phenylacetate

: 95517-85-4
8-methyl-3-phenyl-2H-chromen-2-one

Conditions

Conditions	Yield
In acetic anhydride at 180 - 190℃; for 5h;	70%

: 114-70-5
sodium phenylacetate

: 71932-99-5
2,2-dimethylhex-4-yn-3-one

: Phenyl-acetic acid (E)-5,5-dimethyl-4-oxo-hex-2-enyl ester

Conditions

Conditions	Yield
With phenylacetic acid; triphenylphosphine In toluene at 80℃; for 24h; Addition;	70%

: 114-70-5
sodium phenylacetate

: 23326-27-4
Methyl 2-butynoate

: (E)-4-Phenylacetoxy-but-2-enoic acid methyl ester

Conditions

Conditions	Yield
With phenylacetic acid; triphenylphosphine In toluene at 80℃; for 24h; Addition;	70%

: 114-70-5
sodium phenylacetate

: 709014-40-4
3-formyl-4-methyl-2-quinoline

: 5-methyl-3-phenyl-2H-pyrano[2,3-b]quinolin-2-one

Conditions

Conditions	Yield
With acetic anhydride at 170 - 180℃; for 8h; Perkin reaction;	70%

: 114-70-5
sodium phenylacetate

: 709014-39-1
6-methyl-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carbaldehyde

: 6-methyl-3,10-diphenyl-1-oxa-9-aza-anthracen-2-one

Conditions

Conditions	Yield
With acetic anhydride at 170 - 180℃; for 8h; Perkin reaction;	70%

: 114-70-5
sodium phenylacetate

: 845536-14-3
2-oxo-4-p-tolyl-1,2-dihydro-quinoline-3-carbaldehyde

: 3-phenyl-10-p-tolyl-1-oxa-9-aza-anthracen-2-one

Conditions

Conditions	Yield
With acetic anhydride at 170 - 180℃; for 8h; Perkin reaction;	70%

: 114-70-5
sodium phenylacetate

: 845536-15-4
4-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-quinoline-3-carbaldehyde

: 10-(4-methoxy-phenyl)-3-phenyl-1-oxa-9-aza-anthracen-2-one

Conditions

Conditions	Yield
With acetic anhydride at 170 - 180℃; for 8h; Perkin reaction;	70%

: 114-70-5
sodium phenylacetate

: 709014-38-0
6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carbaldehyde

: 6-chloro-3,10-diphenyl-1-oxa-9-aza-anthracen-2-one

Conditions

Conditions	Yield
With acetic anhydride at 170 - 180℃; for 8h; Perkin reaction;	70%

: 197230-68-5
C16H10N2O4

: 114-70-5
sodium phenylacetate

: 1253853-84-7
C24H14N2O4

Conditions

Conditions	Yield
With acetic anhydride at 170 - 180℃; for 8h;	70%

Sodium phenylacetate Chemical Properties

IUPAC Name: Sodium 2-phenylacetate
Synonyms : Phenylacetic acid sodium salt
Molecular Structure of Sodium benzeneacetate (CAS NO: 114-70-5) :
Molecular Formula of Sodium benzeneacetate (CAS NO: 114-70-5) : C₈H₇NaO₂
Molecular Weight of Sodium benzeneacetate (CAS NO: 114-70-5) : 158.13
CAS NO: 114-70-5
EINECS : 204-052-7
Mol File: 114-70-5.mol
Stability: n/a
Flash Point: 156.2 °C
Enthalpy of Vaporization: 53.18 kJ/mol
Boiling Point: 265.5 °C at 760 mmHg
Vapour Pressure: 0.00456 mmHg at 25°C
Appearance:Sodium benzeneacetate (CAS NO: 114-70-5) is white powder bulk solids.

Sodium phenylacetate Uses

Sodium benzeneacetate (CAS NO: 114-70-5) is used in the pharmaceutical industry, primarily for the manufacture of penicillin.

Sodium phenylacetate Toxicity Data With Reference

1.		ipr-mus LD50:2710 mg/kg		DECRDP Drugs under Experimental and Clinical Research. 12 (Suppl 1)(1986),11.
2.		ivn-mus LD50:1500 mg/kg		ARZNAD Arzneimittel-Forschung. Drug Research. 12 (1962),751.

Sodium phenylacetate Consensus Reports

Reported in EPA TSCA Inventory.

Sodium phenylacetate Safety Profile

Moderately toxic by intraperitoneal and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors.

Product Name

Sodium phenylacetate

Synthetic route

Sodium phenylacetate Chemical Properties

Sodium phenylacetate Uses

Sodium phenylacetate Toxicity Data With Reference

Sodium phenylacetate Consensus Reports

Sodium phenylacetate Safety Profile

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