Sulfacetamide sodium anhydrous supplier

Name
Sulfacetamide sodium
EINECS 204-848-4
CAS No. 127-56-0
Density
Solubility Soluble in water
Melting Point 257 °C
Formula C₈H₉N₂NaO₃S
Boiling Point 450.8 °C at 760 mmHg
Molecular Weight 236.227
Flash Point 226.4 °C
Transport Information UN 3249
Appearance White crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Sulfacetamide sodium;N-Acetylsulfanilamide Sodium Salt Hydrate;N-Acetyl-4-aminobenzenesulfonamide Sodium Salt Hydrate;SulfacetaMide SodiuM Salt Hydrate;sodium,acetyl-(4-aminophenyl)sulfonylazanide;
PSA 88.85000
LogP 1.93230

Synthetic route

: 123-03-5
cetylpyridinium chloride

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 934544-27-1
hexadecylpyridinium sulfacetamide

Conditions

Conditions	Yield
In water for 0.5h; Heating / reflux;	99.22%

: 41167-60-6
4-(4-fluorophenyl)-4-oxo-2-hydroxy-2-butenoic acid methyl ester

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 900325-79-3
2-hydroxy-4-oxo-4-(4-fluorophenyl)-2-butenoic acid N-(4-(acetylaminosulfonyl)phenyl)amide

Conditions

Conditions	Yield
With acetic acid Reflux;	95%

: 541-41-3
chloroformic acid ethyl ester

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 81865-29-4
C11H14N2O5S

Conditions

Conditions	Yield
Ambient temperature;	91.5%

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 105-39-5
chloroacetic acid ethyl ester

: 81865-32-9
N-Sulfanilyl-N-carbethoxymethylacetamine

Conditions

Conditions	Yield
In ethanol for 4h; Ambient temperature;	89.7%

: 2-(4-fluorophenyl)-3-(4-fluorophenyl)-5-phenyl-2H-tetrazolium chloride

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: C19H13F2N4(1+)*C8H9N2O3S(1-)

Conditions

Conditions	Yield
In methanol; water at 20℃; for 2h;	88%

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 2390-68-3
N,N-didecyl-N,N-dimethylammonium bromide

: 934544-26-0
didecyldimethylammonium sulfacetamide

Conditions

Conditions	Yield
In water for 0.5h;	87.74%

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 96-34-4
methyl chloroacetate

: 81865-31-8
[Acetyl-(4-amino-benzenesulfonyl)-amino]-acetic acid methyl ester

Conditions

Conditions	Yield
Ambient temperature;	87.5%

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 79-22-1
methyl chloroformate

: 81865-28-3
C10H12N2O5S

Conditions

Conditions	Yield
Ambient temperature;	85.8%

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 5018-38-2
4,6-dichloro-5-methoxypyrimidine

: 5018-23-5
4-(p-aminobenzenesulfonamido)-5-methoxy-6-chloropyrimidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 88 - 90℃; for 3h;	85.3%

: 934063-39-5
C11H8Cl2O4

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 1610537-08-0
2-hydroxy-4-(2,4-dichlorophenyl)-4-oxo-2-butenoic acid N-(4-acetylaminosulfonylphenyl)amide

Conditions

Conditions	Yield
With acetic acid Reflux;	83%

: 298-96-4
triphenyltetrazolium chloride

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: C19H15N4(1+)*C8H9N2O3S(1-)

Conditions

Conditions	Yield
In methanol; water at 20℃; for 2h;	83%

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 2-hydroxy-4-(3-methoxyphenyl)-4-oxo-but-2-enoic acid methyl ester

: 900310-00-1
2-hydroxy-4-(3-methoxyphenyl)-4-oxo-2-butenoic acid N-(4-acetylaminosulfonylphenyl)amide

Conditions

Conditions	Yield
With acetic acid Reflux;	81%

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 79-11-8
chloroacetic acid

: 81865-30-7
[Acetyl-(4-amino-benzenesulfonyl)-amino]-acetic acid

Conditions

Conditions	Yield
	80.3%

: 41167-59-3
4-(4-chlorophenyl)-2-hydroxy-4-oxo-but-2-enoic acid methyl ester

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 1610537-06-8
2-hydroxy-4-oxo-4-(4-chlorophenyl)-2-butenoic acid N-(4-acetylaminosulfonylphenyl)amide

Conditions

Conditions	Yield
With acetic acid Reflux;	79%

: 41167-58-2
2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 1610537-07-9
2-hydroxy-4-oxo-4-phenyl-2-butenoic acid N-(4-acetylaminosulfonylphenyl)amide

Conditions

Conditions	Yield
With acetic acid Reflux;	76%

: 67090-34-0
6,8-dibromo-2-phenyl-3,1-benzoxazin-4-one

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: C22H14Br2N3O4S(1-)*Na(1+)

Conditions

Conditions	Yield
at 150℃; for 2h;	75%

: 487-89-8
Indole-3-carboxaldehyde

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: C17H14N3O3S(1-)*Na(1+)

Conditions

Conditions	Yield
In ethanol for 1h; Reflux;	72%

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 66357-59-3, 71130-06-8
ranitidine hydrochloride

: ranitidinium sulfacetamide

Conditions

Conditions	Yield
In water at 40℃; for 24h;	50%

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: N,N'-bis(acetyl)azoxybenzene-p,p'-disulphonamide

Conditions

Conditions	Yield
With dipotassium peroxodisulfate In water at 34.9℃; Kinetics; Mechanism; Thermodynamic data; ΔG(excit.), ΔH(excit.), ΔS(excit.); other temperatures, salt effect (K2SO4), pH and dielectric constant dependence, inhibition by diphenyl picryl hydrazyl;

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 6325-93-5
p-nitrobenzenesulfonamide

Conditions

Conditions	Yield
With Cu(2+)2HO(1-)H3IO6(1-)*K(1+) In water at 29.84℃; Kinetics; Mechanism; Temperature;

: 50-00-0
formaldehyd

: 82410-32-0
ganciclovir

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: C18H22N7O7S(1-)*Na(1+)

Conditions

Conditions	Yield
In ethanol at 0℃; Mannich Aminomethylation; Reflux;

...Expand

: 7732-18-5
water

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: silver nitrate

: [Ag(sulfacetamide sodium)(NO3)(H2O)]·3H2O

Conditions

Conditions	Yield
In methanol at 60℃; for 2h;

...Expand

: 7732-18-5
water

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 10108-64-2
cadmium(II) chloride

: [Cd(sulfacetamide sodium)(Cl)2]·10H2O

Conditions

Conditions	Yield
In methanol at 60℃; for 2h;

...Expand

: copper(II) chloride pentahydrate

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: [Cu(sulfacetamide sodium)2(Cl)2]

Conditions

Conditions	Yield
In methanol; water at 60℃; for 2h;

: 2751-90-8
tetraphenylphosphonium bromide

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: C24H20P(1+)*C8H9N2O3S(1-)

Conditions

Conditions	Yield
In dichloromethane; water at 20℃; for 24h;	3 g

: 106-41-2
4-bromo-phenol

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 603-35-0
triphenylphosphine

: C8H9N2O3S(1-)*C24H20OP(1+)

Conditions

Conditions	Yield
Stage #1: 4-bromo-phenol; triphenylphosphine In ethylene glycol at 180℃; for 5h; Stage #2: sodium 4-aminobenzenesulfonylacetamide In dichloromethane; water at 20℃; for 24h;	4 g

...Expand

: ruthenium trichloride

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: [Ru(SD2)2(Cl)2(H2O)2]Cl·2H2O

Conditions

Conditions	Yield
In methanol at 60℃; Reflux;

: 547-91-1
8-hydroxy-7-iodo-quinoline-5-sulfonic acid

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: C17H12IN4O7S2(1-)*Na(1+)

Conditions

Conditions	Yield
Stage #1: sodium 4-aminobenzenesulfonylacetamide With hydrogenchloride; sodium nitrite In water at 15℃; Stage #2: 8-hydroxy-7-iodo-quinoline-5-sulfonic acid With ammonium hydroxide In water for 0.166667h; Reagent/catalyst; Time;

: C18H19N2(1+)*Cl(1-)

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: C18H19N2(1+)*C8H9N2O3S(1-)

Conditions

Conditions	Yield
In dichloromethane; water at 20℃; for 24h;	3 g

: 127-56-0
sodium 4-aminobenzenesulfonylacetamide

: 144-80-9
sulphaacetamide

Conditions

Conditions	Yield
With hydrogenchloride In water pH=2 - 3;

Sulfacetamide sodium anhydrous Consensus Reports

Reported in EPA TSCA Inventory.

Sulfacetamide sodium anhydrous Specification

The Sulfacetamide sodium anhydrous, with the CAS registry number 127-56-0,is also known as Sodium sulfacetamide; N-Sulfanilylacetamide monosodium salt; N-(4-Aminophenylsulfonyl)acetamide sodium salt. It belongs to the product categories of Antibiotics for Research and Experimental Use;Biochemistry.Its EINECS number is 204-848-4. This chemical's molecular formula is C₈H₉N₂NaO₃S and molecular weight is 236.22. What's more,Its systematic name is Sulfacetamide sodium.It is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. The Sulfacetamide sodium is irritating to eyes, respiratory system and skin.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.When you use it,you should wear suitable protective clothing.

Physical properties about Sulfacetamide sodium anhydrous are:
(1)ACD/LogP: -0.964; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.18; (4)ACD/LogD (pH 7.4): -2.51; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 4.29; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 5; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 2; (12)Flash Point: 226.4 °C; (13)Enthalpy of Vaporization: 74.79 kJ/mol ; (14)Boiling Point: 450.8 °C at 760 mmHg; (15)Vapour Pressure: 6.51E-09 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:[Na+].O=S(=O)([N-]C(=O)C)c1ccc(N)cc1;
(2)Std. InChI:InChI=1S/C8H10N2O3S.Na/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;/h2-5H,9H2,1H3,(H,10,11);/q;+1/p-1;
(3)Std. InChIKey:PQMSFAORUFMASU-UHFFFAOYSA-M.

The toxicity data of Sulfacetamide sodium anhydrous as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	subcutaneous	6gm/kg (6000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 286, 1959.
mouse	LDLo	intravenous	800mg/kg (800mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 127, 1943.

Product Name

Sulfacetamide sodium

Synthetic route

Sulfacetamide sodium anhydrous Consensus Reports

Sulfacetamide sodium anhydrous Specification

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