Tetraethylenepentamine supplier

Name
1,4,7,10,13-Pentaazatridecane
EINECS 203-986-2
CAS No. 112-57-2
Article Data26
CAS DataBase
Density 0.973 g/cm³
Solubility Soluble in water
Melting Point -40 °C(lit.)
Formula C₈H₂₃N₅
Boiling Point 341.5 °C at 760 mmHg
Molecular Weight 189.304
Flash Point 185 °C
Transport Information UN 2320 8/PG 3
Appearance colourless to green-yellow viscous liquid
Safety 26-36/37/39-45-61
Risk Codes 21/22-34-43-51/53
Molecular Structure
Hazard Symbols C,N
Synonyms 1,2-Ethanediamine,N-(2-aminoethyl)-N'-[2-[(2-aminoethyl)amino]ethyl]- (9CI);Tetraethylenepentamine(8CI);1,11-Diamino-3,6,9-triazaundecane;1,4,7,10,13-Pentaazatridecane;3,6,9-Triaza-1,11-diaminoundecane;3,6,9-Triazaundecane-1,11-diamine;AncamineTEPA;Bis[2-(2-aminoethylamino)ethyl]amine;DEH 26;EthoxylatedTetraethylenepentamine;N-(2-Aminoethyl)-N'-(2-((2-aminoethyl)amino)ethyl)-1,2-ethanediamine;NSC 88603;T 11509;Tetren;
PSA 88.13000
LogP 0.24590

Synthetic route

: 107-06-2
1,2-dichloro-ethane

A: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

B: 107-15-3
ethylenediamine

Conditions

Conditions	Yield
With ammonia

: 111-40-0
1,5-diamino-3-azapentane

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With ammonia; water; 1,2-dichloro-ethane unter Druck;

: 151-56-4
ethyleneimine

: 112-24-3
triethylentetramine

A: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

B: 31295-46-2
tris(2-aminoethyl)-N,N,N'-ethyldiamine

Conditions

Conditions	Yield
With hydrogenchloride In water at 25℃; Kinetics; Thermodynamic data; acid-catalyzed ring opening reactions at various temperature, Ea, ΔH are given;
With hydrogenchloride In water at 55℃;	A 64.5 % Chromat. B 35.5 % Chromat.
With hydrogenchloride In water at 35℃;	A 61.4 % Chromat. B 38.6 % Chromat.

...Expand

: 23435-23-6
1-<2-<(2-aminoethyl)amino>ethyl>aziridine

: 107-15-3
ethylenediamine

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With hydrogen cation In water at 40 - 60℃; Rate constant; Thermodynamic data; Ea, ΔH;
With hydrogen cation In water

: 46467-99-6
{COFeC8H23N5}(2+)

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
In water in acidic medium;
In water in acidic medium;

: 1051939-66-2
diethylenetriaminediacetonitrile

A: 24028-46-4
1-<2-(2-aminoethyl)aminoethyl>piperazine

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With hydrogen; Cr-doped Raney cobalt In tetrahydrofuran at 120℃; under 75007.5 Torr; for 3h; Product distribution / selectivity; Autoclave;

: 107-06-2
1,2-dichloro-ethane

A: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

B: 107-15-3
ethylenediamine

C: 111-40-0
1,5-diamino-3-azapentane

D: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
Stage #1: 1,2-dichloro-ethane With ammonia Stage #2: With sodium hydroxide Product distribution / selectivity;
With ammonium hydroxide at 140℃; under 105011 Torr;

...Expand

: 107-06-2
1,2-dichloro-ethane

A: 110-85-0
piperazine

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

C: 107-15-3
ethylenediamine

D: 111-40-0
1,5-diamino-3-azapentane

E: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With ammonium hydroxide In water at 120℃; under 90009 Torr; Concentration;

...Expand

: 107-06-2
1,2-dichloro-ethane

A: 110-85-0
piperazine

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

C: 111-40-0
1,5-diamino-3-azapentane

D: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With ammonium hydroxide; ethylenediamine In water at 100℃; under 18751.9 Torr;

...Expand

: 141-43-5
ethanolamine

A: 110-85-0
piperazine

B: 103-76-4
1-(2-hydroxyethyl)piperazine

C: 140-31-8
aminoethylpiperazine

D: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

E: 107-15-3
ethylenediamine

F: 111-40-0
1,5-diamino-3-azapentane

G: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With ammonia; hydrogen In water at 92℃; under 26463 Torr; Temperature;

...Expand

: 107-15-3
ethylenediamine

: 111-42-2
2,2'-iminobis[ethanol]

A: 1965-29-3
2-[2-(2-aminoethylamino)ethylamino]ethanol

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With imidazolidone at 270℃; for 5h; Inert atmosphere;

...Expand

: 107-06-2
1,2-dichloro-ethane

A: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

B: 107-15-3
ethylenediamine

Conditions

Conditions	Yield
With ammonia

: 111-40-0
1,5-diamino-3-azapentane

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With ammonia; water; 1,2-dichloro-ethane unter Druck;

: 151-56-4
ethyleneimine

: 112-24-3
triethylentetramine

A: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

B: 31295-46-2
tris(2-aminoethyl)-N,N,N'-ethyldiamine

Conditions

Conditions	Yield
With hydrogenchloride In water at 25℃; Kinetics; Thermodynamic data; acid-catalyzed ring opening reactions at various temperature, Ea, ΔH are given;
With hydrogenchloride In water at 55℃;	A 64.5 % Chromat. B 35.5 % Chromat.
With hydrogenchloride In water at 35℃;	A 61.4 % Chromat. B 38.6 % Chromat.

...Expand

: 23435-23-6
1-<2-<(2-aminoethyl)amino>ethyl>aziridine

: 107-15-3
ethylenediamine

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With hydrogen cation In water at 40 - 60℃; Rate constant; Thermodynamic data; Ea, ΔH;
With hydrogen cation In water

: 46467-99-6
{COFeC8H23N5}(2+)

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
In water in acidic medium;
In water in acidic medium;

: 1051939-66-2
diethylenetriaminediacetonitrile

A: 24028-46-4
1-<2-(2-aminoethyl)aminoethyl>piperazine

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With hydrogen; Cr-doped Raney cobalt In tetrahydrofuran at 120℃; under 75007.5 Torr; for 3h; Product distribution / selectivity; Autoclave;

: 107-06-2
1,2-dichloro-ethane

A: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

B: 107-15-3
ethylenediamine

C: 111-40-0
1,5-diamino-3-azapentane

D: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
Stage #1: 1,2-dichloro-ethane With ammonia Stage #2: With sodium hydroxide Product distribution / selectivity;
With ammonium hydroxide at 140℃; under 105011 Torr;

...Expand

: 107-06-2
1,2-dichloro-ethane

A: 110-85-0
piperazine

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

C: 107-15-3
ethylenediamine

D: 111-40-0
1,5-diamino-3-azapentane

E: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With ammonium hydroxide In water at 120℃; under 90009 Torr; Concentration;

...Expand

: 107-06-2
1,2-dichloro-ethane

A: 110-85-0
piperazine

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

C: 111-40-0
1,5-diamino-3-azapentane

D: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With ammonium hydroxide; ethylenediamine In water at 100℃; under 18751.9 Torr;

...Expand

: 141-43-5
ethanolamine

A: 110-85-0
piperazine

B: 103-76-4
1-(2-hydroxyethyl)piperazine

C: 140-31-8
aminoethylpiperazine

D: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

E: 107-15-3
ethylenediamine

F: 111-40-0
1,5-diamino-3-azapentane

G: 112-24-3
triethylentetramine

Conditions

Conditions	Yield
With ammonia; hydrogen In water at 92℃; under 26463 Torr; Temperature;

...Expand

: 107-15-3
ethylenediamine

: 111-42-2
2,2'-iminobis[ethanol]

A: 1965-29-3
2-[2-(2-aminoethylamino)ethylamino]ethanol

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
With imidazolidone at 270℃; for 5h; Inert atmosphere;

...Expand

: 3699-54-5
2-oxo-imidazolidine-1-ethanol

: 6281-42-1
2-aminoethylimidazolidone

: 111-40-0
1,5-diamino-3-azapentane

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
Stage #1: 2-oxo-imidazolidine-1-ethanol; 2-aminoethylimidazolidone; 3-azapentane-1,5-diamine at 270℃; under 3375.34 - 10501.1 Torr; for 9h; Autoclave; Inert atmosphere; Stage #2: With water; sodium hydroxide at 200℃; under 2550.26 Torr; for 4h; Autoclave; Inert atmosphere;

...Expand

: 3699-54-5
2-oxo-imidazolidine-1-ethanol

: 111-40-0
1,5-diamino-3-azapentane

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
at 270℃; under 2475.25 - 7125.71 Torr; for 6h; Autoclave; Inert atmosphere;

: U1TEPA

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
Stage #1: U1TEPA With water at 235 - 270℃; under 22502.3 Torr; for 5h; Inert atmosphere; Stage #2: With water; sodium hydroxide at 220℃; for 2.5h; Concentration; Temperature; Inert atmosphere;

: U1TEPA

A: DU1,3TEPA

B: DU1,4TEPA

C: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
at 220 - 280℃; under 2.25023 - 12.7513 Torr; for 10h;

...Expand

: U2TEPA

A: DU1,3TEPA

B: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

Conditions

Conditions	Yield
at 220 - 280℃; under 2.25023 - 12.7513 Torr; for 10h;

: 383-63-1
ethyl trifluoroacetate,

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 936720-60-4
N,N'-(((azanediylbis(ethane-2,1-diyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(2,2,2-trifluoroacetamide)

Conditions

Conditions	Yield
In methanol at -78 - 20℃; for 25h;	100%
In dichloromethane at 0 - 20℃; for 1.5h;
In dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;

: 50-01-1
guanidine hydrochloride

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 638-53-9
tridecanoic acid

: C37H77N11O2*ClH

Conditions

Conditions	Yield
Stage #1: N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine; tridecanoic acid With toluene-4-sulfonic acid at 155℃; for 2.75h; Stage #2: guanidine hydrochloride at 152 - 176℃; for 5h;	98.5%

...Expand

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 112-76-5
Stearoyl chloride

: Octadecanoic acid bis-{2-[octadecanoyl-(2-octadecanoylamino-ethyl)-amino]-ethyl}-amide

Conditions

Conditions	Yield
With triethylamine In acetone for 3h; Ambient temperature;	98%

: 1755-15-3
2-acetyldimedone

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 936720-58-0
1,13-bis[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-tetraethylenepentamine

Conditions

Conditions	Yield
With molecular sieve In ethanol at 20℃; for 24h;	98%

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 122174-22-5
2-hydroxy-3-(2-(2-methoxyethoxy)ethoxy)benzaldehyde

: 155990-29-7
NH(CH2CH2NHCH2CH2NCHC6H3(OH)OCH2CH2OCH2CH2OCH3)2

Conditions

Conditions	Yield
In methanol for 2h; Heating;	96%

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 155990-24-2
2-Hydroxy-3-{2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-benzaldehyde

: 155990-31-1
NH(CH2CH2NHCH2CH2NCHC6H3(OH)OCH2(CH2OCH2)5CH2OH)2

Conditions

Conditions	Yield
In methanol for 2h; Heating;	96%

: nickel(II) chloride hexahydrate

: tetrabutylammonium hexachlororhenate(IV)

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 840454-35-5
[Ni(tetraethylpentamine)][ReCl6]

Conditions

Conditions	Yield
In methanol a soln. of Ni-salt and pentamine in methanol was added dropwise to the hot (50°C) soln. of (N(C4H9)4)2ReCl6 in methanol, the mixt. was slowly heated up to 50°C for about 0.5 h; filtered, washed with methanol and diethyl ether; elem. anal.;	96%

...Expand

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 155990-23-1
2-Hydroxy-3-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-benzaldehyde

: 155990-30-0
NH(CH2CH2NHCH2CH2NCHC6H3(OH)OCH2(CH2OCH2)4CH2OCH3)2

Conditions

Conditions	Yield
In methanol for 2h; Heating;	95%

: 67-56-1
methanol

: nickel(II) chloride hexahydrate

: tetrabutylammonium hexachlororhenate(IV)

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 840454-36-6
[Ni(tetraethylpentamine)][ReCl6]*CH3OH

Conditions

Conditions	Yield
In methanol a soln. of Ni-salt and pentamine in methanol was added dropwise to the soln. of (N(C4H9)4)2ReCl6 in methanol, the mixt. was stirred at room temp.; filtered, washed with methanol and diethyl ether; elem. anal.;	92%

...Expand

: 81-88-9
rhodamine B

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 1313741-43-3
N-(rhodamine B)lactam-tetraethylenepentamine

Conditions

Conditions	Yield
In ethanol at 80℃; for 12h; Solvent; Temperature;	90.8%
In ethanol at 80℃; Inert atmosphere;	87%
at 80℃; Inert atmosphere;	87%
In ethanol for 12h; Reflux;	72%

: 81-88-9
rhodamine B

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: C36H53N7O2

Conditions

Conditions	Yield
In ethanol for 12h; Reflux;	90.8%

: 75482-16-5
4-amino-2-methoxy-1-methyl-5-nitroso-6-oxo-1,6-dihydropyrimidine

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: C18H31N13O4

Conditions

Conditions	Yield
In methanol at 20℃;	90%

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 107-13-1
acrylonitrile

: 3-(Bis-{2-[{2-[bis-(2-cyano-ethyl)-amino]-ethyl}-(2-cyano-ethyl)-amino]-ethyl}-amino)-propionitrile

Conditions

Conditions	Yield
In water for 24h; Heating;	89%

: 90-02-8
salicylaldehyde

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 1427062-13-2
C29H35N5O3

Conditions

Conditions	Yield
In ethanol for 8h; Reflux;	89%
In ethanol

: 53901-95-4, 108608-06-6, 58523-18-5
p-acetoxycinnamoyl chloride

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 364049-01-4
N1,N4,N7,N10,N13-penta(4-o-acetylcoumaroyl)tetraethylenepentamine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	87%

: 10034-85-2
hydrogen iodide

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: lead(II) iodide

: C8H23N5*Pb(2+)*5I(1-)*3H(1+)

Conditions

Conditions	Yield
In ethanol; water at 150℃; for 96h;	87%

...Expand

: 2457-47-8
3,5-dichloropyridine

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

A: N-(2-aminoethyl)-N'-{2-{{2-[(5-chloropyridin-3-yl)amino]ethyl}amino}ethyl}ethane-1,2-diamine

B: N,N'-bis-(2-{2-[2-(2-amino-ethylamino)-ethylamino]-ethylamino}-ethyl)-pyridine-3,5-diamine

Conditions

Conditions	Yield
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane for 5h; Heating;	A 86% B 14%

...Expand

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: C58H73N5O20

Conditions

Conditions	Yield
With potassium carbonate In water; ethyl acetate	85%

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: silver(I) iodide

: lead(II) iodide

: [(tepa)(PbAg2I4)]n

Conditions

Conditions	Yield
With potassium iodide In N,N-dimethyl-formamide at 90℃; for 72h; Autoclave;	85%

...Expand

: 75-15-0
carbon disulfide

: 753-73-1
dimethyltin dichloride

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 1228345-48-9
tetraethylenepentamine bis(dithiocarbamate) dimethyltin(IV)

Conditions

Conditions	Yield
With KOH In methanol addn. of CS2 to methanolic soln. of amine deriv. at 0°C, addn. ofmethanolic soln. of KOH, stirring for 3 h at 4°C, addn. of metha nolic soln. of tin compd., stirring for 3 h at room temp.; evapn., washing with methanol and diethyl ether, drying in vac. over P2O5, elem. anal.;	81%

...Expand

: 86119-84-8, 7664-38-2
phosphoric acid

: 7732-18-5
water

: 5970-45-6
zinc(II) acetate dihydrate

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 6Zn(2+)*5PO4(3-)*HPO4(2-)*H2N(CH2CH2NH2CH2CH2NH3)2(5+)*5H2O=[Zn6(PO4)5(HPO4)][H2N(CH2CH2NH2CH2CH2NH3)2]*5H2O

Conditions

Conditions	Yield
In water High Pressure; Zn(OAc)2*2H2O dispersed into H2O; H3PO4 slowly added; tetraethylenepentamine added dropwise with stirring; heated in autoclave at 393 K for 2 dsunder autogenous pressure; filtered; washed (H2O); dried at room temp.; elem. anal.;	80%

...Expand

: cis-3-(6-bromohexyl)-8-(4-isopropyl-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one trifluoroacetate

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: cis-8-(4-isopropyl-cyclohexyl)-3-(7,10,14,17,20-pentaazaeicosanyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one trifluoroacetate

Conditions

Conditions	Yield
In ethanol at 20℃; for 24h;	78%

: 1121-60-4
pyridine-2-carbaldehyde

: copper(II) choride dihydrate

: 7732-18-5
water

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: [Cu(C5H4NCHNCH2CH2(NHCH2CH2)3NCHC5H4N)](2+)*2Cl(1-)*H2O=[Cu(C5H4NCHNCH2CH2(NHCH2CH2)3NCHC5H4N)]Cl2*H2O

Conditions

Conditions	Yield
In methanol polyamine (2 mmol) and 2-pyridinecarboxaldehyde (4 mmol) refluxed in MeOH, MeOH soln. of CuCl2*2H2O (2 mmol) added, mixt. refluxed for 1 h; concd., ppt. filtered off, washed (Et2O), dried (vac.), elem. anal.;	78%

...Expand

: 12093-10-6
ferrocenecarboxaldehyde

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 217494-67-2
1,15-diferrocenyl-2,5,8,11,14-pentaazapentadecane

Conditions

Conditions	Yield
Stage #1: ferrocenecarboxaldehyde; N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine In methanol at 70℃; for 24h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 12.5h; Inert atmosphere;	77%
With LiAlH4 In tetrahydrofuran; ethanol refluxing the aldehyde and the amine in EtOH for 3 h, evapn. to dryness,dissoln. (THF), addn. of LiAlH4, reflux under argon for 1 h, quenching with H2O; filtration, evapn. to dryness, addn. of basic H2O and CH2Cl2, drying (Na2SO4), chromy. (alumina; CH2Cl2, then CH2Cl2/MeOH); elem. anal.;	70%

: 201230-82-2
carbon monoxide

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: {COFeC8H23N5}(2+)*2I(1-)={COFeC8H23N5}I2

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen iodide; iron(II) sulfate In water at room temp. under CO pressure of 3 atm for 6 d; washing with ethanol, then ether, drying in vacuum;	76%
With HI; FeSO4; NaOH In water at room temp. under CO pressure of 3 atm for 6 d; washing with ethanol, then ether, drying in vacuum;	76%
With sodium hydroxide; hydrogen iodide; iron(II) sulfate In water at room temp. under CO pressure of 3 atm for 3 d; washing with ethanol, then ether, drying in vacuum;	57%
With FeSO4; HI; NaOH In water at room temp. under CO pressure of 3 atm for 3 d; washing with ethanol, then ether, drying in vacuum;	57%

: 7782-49-2
selenium

: tin (IV) chloride pentahydrate

: cobalt(II) chloride hexahydrate

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: [Co(tetraethylenepentamine)]2(μ2-Sn2Se6)

Conditions

Conditions	Yield
In water High Pressure; mixt. of CoCl26H2O, SnCl45H2O, Se amine and water heated in sealed tube at 157°C for 1 d; washed with EtOH, dried in vac.; elem. anal.;	75%

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: manganese(II) chloride tetrahydrate

: germanium dioxide

: 7704-34-9
sulfur

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: [Mn(II)(tetraetylenepentamine)]2(μ2-Ge2S6)

Conditions

Conditions	Yield
In water High Pressure; tetraethylenepentamine/H2O soln. heated at 180 °C for 7 d in container under autogenous pressure; filtration, washing (ethanol, diethyl ether), drying and stored under vac., elem. anal.;	75%

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: 36801-99-7
dimethyl 5,5'-(oxybis(methylene))bis(furan-2-carboxylate)

: 112-57-2
N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine

: 102432-83-7
1,4,7-Trioxa-10,13,16,19,22-pentaazadifuro<2,1,5-a,x:2,1,5-f,g>cyclotetraeicosane-9,23-dione

Conditions

Conditions	Yield
In ethanol for 20h; Heating;	73.8%

Tetraethylenepentamine Consensus Reports

Reported in EPA TSCA Inventory.

Tetraethylenepentamine Standards and Recommendations

DOT Classification: 8; Label: Corrosive

Tetraethylenepentamine Specification

The Tetraethylenepentamine, with the CAS registry number 112-57-2,is also known as 1,11-Diamino-3,6,9-triazaundecane; 1,4,7,10,13-Pentaazatridecane; 3,6,9-Triaza-1,11-undecanediamine; 3,6,9-Triazaundecamethylenediamine. It belongs to the product categories of Chemical Synthesis;Nitrogen Compounds;Organic Building .Its EINECS number is 203-986-2. This chemical's molecular formula is C₈H₂₃N₅ and molecular weight is 189.30. What's more,Its systematic name is Tetraethylenepentamine.It is a colourless to green-yellow viscous liquid. Slightly less dense than water. Vapors heavier than air. Corrosive to the eyes, skin, mouth, throat and stomach. Vapors irritate the eyes and corrosive to the upper respiratory tract. Vapors may irritate the eyes.

Physical properties about Tetraethylenepentamine are:
(1)ACD/LogP: -2.241; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -7.36; (4)ACD/LogD (pH 7.4): -7.15; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 5; (10)#H bond donors: 7; (11)#Freely Rotating Bonds: 12; (12)Index of Refraction: 1.498; (13)Molar Refractivity: 56.967 cm³; (14)Molar Volume: 194.392 cm³; (15)Surface Tension: 41.1599998474121 dyne/cm; (16)Density: 0.974 g/cm³; (17)Flash Point: 185 °C; (18)Enthalpy of Vaporization: 58.516 kJ/mol; (19)Boiling Point: 341.499 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C;

You can still convert the following datas into molecular structure:
(1)SMILES:C(CNCCNCCNCCN)N;
(2)Std. InChI:InChI=1S/C8H23N5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h11-13H,1-10H2;
(3)Std. InChIKey:FAGUFWYHJQFNRV-UHFFFAOYSA-N.

Safety Information of Tetraethylenepentamine:
The Tetraethylenepentamine may cause nausea and slight irritation by inhale.The compound is a sensitizer, and prolonged contact may cause asthma. And it can cause burns of mouth, esophagus, and possibly stomach. Contact with eyes or skin may cause burns by assimilate. Repeated skin contact may cause dermatitis.So when you use it ,wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Or if you feel unwell, seek medical advice immediately (show the label whenever possible.).Avoid release to the environment. Refer to special instructions / safety data sheets.

The toxicity data of Tetraethylenepentamine as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intravenous	320mg/kg (320mg/kg)	U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03522,
rabbit	LD50	skin	660uL/kg (.66mL/kg)	Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 60, 1949.
rat	LD50	intraperitoneal	205mg/kg (205mg/kg)	Inorganica Chimica Acta. Vol. 91, Pg. L51, 1984.
rat	LD50	oral	3990mg/kg (3990mg/kg)	Union Carbide Data Sheet. Vol. 3/20/1973,

Product Name

1,4,7,10,13-Pentaazatridecane

Synthetic route

Tetraethylenepentamine Consensus Reports

Tetraethylenepentamine Standards and Recommendations

Tetraethylenepentamine Specification

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