Thymol supplier | CasNO.89-83-8

Name
Thymol
EINECS 201-944-8
CAS No. 89-83-8
Article Data217
CAS DataBase
Density 0.974 g/cm³
Solubility 0.1 g/100 mL (20 °C) in water
Melting Point 48-51 °C(lit.)
Formula C₁₀H₁₄O
Boiling Point 233 °C at 760 mmHg
Molecular Weight 150.221
Flash Point 102.2 °C
Transport Information UN 3261 8/PG 3
Appearance white crystals or powder with a pungent odour
Safety 26-28-36/37/39-45-61-28A
Risk Codes 22-34-51/53
Molecular Structure
Hazard Symbols C， N
Synonyms Thymol(8CI);1-Methyl-3-hydroxy-4-isopropylbenzene;2-Hydroxy-1-isopropyl-4-methylbenzene;2-Isopropyl-5-methylphenol;3-Hydroxy-p-cymene;3-Methyl-6-isopropylphenol;5-Methyl-2-(1-methylethyl)phenol;5-Methyl-2-isopropyl-1-phenol;5-Methyl-2-isopropylphenol;6-Isopropyl-3-methylphenol;6-Isopropyl-m-cresol;Apiguard;NSC 11215;NSC47821;NSC 49142;Thyme camphor;Thymol Chrystals;m-Thymol;p-Cymen-3-ol;Thymol;
PSA 20.23000
LogP 2.82400

Synthetic route

: 5333-40-4
2-isopropyl-5-methylphenoxyacetic acid

: 89-83-8
thymol

Conditions

Conditions	Yield
Stage #1: 2-isopropyl-5-methylphenoxyacetic acid With triethylamine In N,N-dimethyl-formamide; toluene for 3h; Curtius rearrangement; Heating; Stage #2: With potassium hydroxide; glycerol In ethanol; N,N-dimethyl-formamide; toluene for 2h; Heating; Further stages.;	99%

: 18612-99-2
2-isopropenyl-5-methylphenol

: 89-83-8
thymol

Conditions

Conditions	Yield
With hydrogen; nickel In ethanol at 30℃; under 2280 - 3800 Torr; Catalytic hydrogenation;	98%
With nickel at 140 - 160℃; Hydrogenation;
With palladium 10% on activated carbon; ammonium formate In ethanol; n-heptane at 20℃; for 6h; Reflux;	98 kg

: 1076-56-8
Thymol methyl ether

: 89-83-8
thymol

Conditions

Conditions	Yield
With aluminium trichloride In ethanethiol at 0℃; for 0.5h;	95.5%
With aluminium trichloride In ethanethiol at 0℃; for 0.5h;	95.5%

: 14002-90-5
4,7-dimethyl-coumarin

A: 18612-99-2
2-isopropenyl-5-methylphenol

B: 89-83-8
thymol

Conditions

Conditions	Yield
With potassium hydroxide In ethylene glycol for 1h; Mechanism; Reflux;	A 90% B 8%

: 89-68-9
4-chloro-2-isopropyl-5-methylphenol

: 89-83-8
thymol

Conditions

Conditions	Yield
With 1.5mol% Pd/C; hydrogen; sodium hydrogencarbonate In methanol at 20℃; for 1h; regioselective reaction;	80%
With alkaline solution; iron at 170 - 200℃;
With potassium hydroxide; sodium hydroxide; nickel-copper catalyst at 180℃; under 22800 Torr; Hydrogenation;
With potassium hydroxide; sodium hydroxide; nickel-manganese catalyst at 180℃; under 22800 Torr; Hydrogenation;

: 528-79-0
2-isopropyl-5-methylphenyl acetate

: 89-83-8
thymol

Conditions

Conditions	Yield
silica gel; toluene-4-sulfonic acid In water; toluene at 80℃; for 22h;	79%

: 187737-37-7
propene

: 108-39-4
3-methyl-phenol

: 89-83-8
thymol

Conditions

Conditions	Yield
With G-type solid acid catalyst at 180 - 200℃; under 1500.15 Torr; Temperature;	76.3%
at 150 - 350℃;
With boric acid; oxalic acid at 140℃;

: 89-81-6, 4573-50-6, 6091-50-5, 6091-52-7
(+)-Piperitone

: 89-83-8
thymol

Conditions

Conditions	Yield
With N-Bromosuccinimide; N,N-dimethyl-formamide	75%

: 75-29-6
isopropyl chloride

: 108-39-4
3-methyl-phenol

: 89-83-8
thymol

Conditions

Conditions	Yield
With sulfuric acid; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 120 - 130℃; for 2h; Reagent/catalyst;	56.8%
With aluminium trichloride; 1,2-dichloro-ethane at -10℃;
With aluminium trichloride

: 256637-50-0
2-isopropyl-5-methylphenyl trifluoromethanesulfonate

A: 99-87-6
4-methylisopropylbenzene

B: 89-83-8
thymol

Conditions

Conditions	Yield
With lithium; nickel dichloride In tetrahydrofuran at 20℃; Reduction;	A 44% B 52%

: 89-78-1
menthol

A: 99-82-1, 1678-82-6, 6069-98-3, 129939-70-4, 129939-71-5
Menthane

B: 89-83-8
thymol

C: 10458-14-7
Menthone

Conditions

Conditions	Yield
With cerium(IV) oxide; aluminum oxide; copper nickel at 185℃; for 8h;	A 5% B 24% C 48%

...Expand

: 108-39-4
3-methyl-phenol

: 67-63-0
isopropyl alcohol

A: 89-83-8
thymol

B: 40625-96-5
2,4-diisopropyl-5-methylphenol

Conditions

Conditions	Yield
With carbon tetrabromide at 220 - 250℃; for 6h; Sealed tube;	A 32% B 48%

...Expand

: 528-79-0
2-isopropyl-5-methylphenyl acetate

A: 89-83-8
thymol

B: 37847-35-1
4-acetyl-2-isopropyl-5-methylphenol

Conditions

Conditions	Yield
In methanol at 25℃; for 6h; Irradiation;	A n/a B 41%

: 24545-81-1
3-thujen-2-one

A: 89-83-8
thymol

B: 15269-17-7
3,5-diisopropyl-4-methylphenol

C: 3228-03-3
3-isopropyl-5-methylphenol

D: 491-09-8
3-terpinolenone

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid for 40h; Ambient temperature; Irradiation; Further byproducts given;	A 39% B 12% C 21% D 5%

...Expand

: 24545-81-1
3-thujen-2-one

A: 89-83-8
thymol

B: 15269-17-7
3,5-diisopropyl-4-methylphenol

C: 3228-03-3
3-isopropyl-5-methylphenol

D: 15269-16-6
2,5-Diisopropyl-4-methylphenol

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid for 40h; Ambient temperature; Irradiation; Further byproducts given;	A 39% B 12% C 21% D 2%

...Expand

: 24545-81-1
3-thujen-2-one

A: 89-83-8
thymol

B: 15269-17-7
3,5-diisopropyl-4-methylphenol

C: 3228-03-3
3-isopropyl-5-methylphenol

D: 24760-21-2
4-methylbicyclo<3.1.0>hex-3-en-2-one

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid for 40h; Ambient temperature; Irradiation; Further byproducts given;	A 39% B 12% C 21% D 2%

...Expand

: 24545-81-1
3-thujen-2-one

A: 89-83-8
thymol

B: 15269-17-7
3,5-diisopropyl-4-methylphenol

C: 3228-03-3
3-isopropyl-5-methylphenol

D: 76138-70-0
2,5-diisopropyl-3-methylphenol

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid for 40h; Ambient temperature; Irradiation; Further byproducts given;	A 39% B 12% C 21% D 3%

...Expand

: 24545-81-1
3-thujen-2-one

A: 89-83-8
thymol

B: 15269-17-7
3,5-diisopropyl-4-methylphenol

C: 3228-03-3
3-isopropyl-5-methylphenol

D: 108-39-4
3-methyl-phenol

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid for 40h; Ambient temperature; Irradiation; Further byproducts given;	A 39% B 12% C 21% D 6%

...Expand

: 80356-10-1
Thymyl pentanoic acid esters

A: 89-83-8
thymol

B: 80356-11-2
1-(4-hydroxy-5-isopropyl-2-methyl-phenyl)-pentan-1-one

Conditions

Conditions	Yield
In methanol at 25℃; for 6h; Irradiation;	A n/a B 32%

: 1093943-08-8
2-isopropyl-5-methylphenyl 3-methyl-2-butenoate

A: 89-83-8
thymol

B: 2,2,5-trimethyl-8-isopropyl-4-chromanone

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In toluene Reflux;	A 30% B n/a

: 69844-33-3
2-Isopropyl-5-methylphenyl 3-methylbutanoate

A: 89-83-8
thymol

B: 80356-12-3
1-(4-hydroxy-5-isopropyl-2-methyl-phenyl)-3-methyl-butan-1-one

Conditions

Conditions	Yield
In methanol at 25℃; for 6h; Irradiation;	A n/a B 28%

: 69844-32-2
Thymyl 2-methylbutenoic acid ester

A: 89-83-8
thymol

B: 80356-13-4
1-(4-Hydroxy-5-isopropyl-2-methyl-phenyl)-2-methyl-butan-1-one

Conditions

Conditions	Yield
In methanol at 25℃; for 6h; Irradiation;	A n/a B 16%

: 68098-06-6
1-<(4-Hydroxy-3-isopropyl-6-methyl-phenyl)-methyl>-pyrrolidin

A: 89-83-8
thymol

B: 85231-08-9
1-<(4-Hydroxy-3-isopropyl-6-methyl-phenyl)-methyl>-pyrrolidon-(2)

Conditions

Conditions	Yield
With edetate disodium; mercury(II) oxide for 1h;	A n/a B 9.5%

: 490-91-5
thymoquinone

: 63-74-1
sulfanilamide

A: 89-83-8
thymol

B: 114850-22-5
2-Isopropyl-5-methyl-1,4-benzochinon-4-(sulfamidophenyl)imin

Conditions

Conditions	Yield
With acetic acid In methanol for 5h; Ambient temperature;	A n/a B 1.2%

...Expand

: 91-22-5
quinoline

: 18427-47-9
2,6-Dibromo-2-isopropyl-5-methylcyclohexanone

: 89-83-8
thymol

Conditions

Conditions	Yield
optically inactive substance;
(+)-2.4-dibromo-menthone from l-menthone;

: 14002-90-5
4,7-dimethyl-coumarin

: 89-83-8
thymol

Conditions

Conditions	Yield
With sodium hydroxide; zinc

: 89-82-7, 3285-04-9, 3391-90-0, 15932-80-6
pulegone

: 89-83-8
thymol

Conditions

Conditions	Yield
With copper at 280℃;
With hydrogen at 350 - 360℃; beim Leiten ueber Nickel;
With nickel at 280℃;

: 3228-02-2
3-Methyl-4-isopropylphenol

: 89-83-8
thymol

Conditions

Conditions	Yield
at 380℃;
With carbon disulfide; aluminium trichloride at 40 - 50℃;
With sulfuric acid at 90 - 100℃; Erhitzen des Reaktionsgemisches mit Wasser auf 120-160grad unter Durchleiten von Wasserdampf;

: 5419-54-5
2,2-bis(2'-hydroxy-4'-methylphenyl)propane

A: 89-83-8
thymol

B: 108-39-4
3-methyl-phenol

Conditions

Conditions	Yield
katalytisch.Hydrogenation;
With metal hydroxides; hydrogen at 130 - 220℃;
With methallcarbonate; hydrogen at 130 - 220℃;

: 89-83-8
thymol

: 86031-16-5
6-Nitrothymol

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrate; lanthanum(III) nitrate In diethyl ether; water 3 to 8h;	100%

: 89-83-8
thymol

: 102-92-1
cinnamoyl chloride

: 111385-92-3
cinnamic acid-(2-isopropyl-5-methyl-phenyl ester)

Conditions

Conditions	Yield
With sodium hydroxide for 0.0416667h; microwave irradiation;	99%

: 89-83-8
thymol

: 98-88-4
benzoyl chloride

: 6380-29-6
2-isopropyl-5-methylphenyl benzoate

Conditions

Conditions	Yield
With sodium hydroxide for 0.0333333h; microwave irradiation;	99%
With triethylamine In dichloromethane at 0℃; for 3h; Reflux;	95%
With triethylamine In dichloromethane at 0 - 20℃; for 11h; Inert atmosphere;	85%

: 13089-11-7
methyl 3,3,3-trifluoropyruvate

: 89-83-8
thymol

: methyl 3,3,3-trifluoro-2-hydroxy-2-(4-hydroxy-5-isopropyl-2-methylphenyl)propionate

Conditions

Conditions	Yield
With trifluoroacetic acid at 20℃; for 0.5h;	99%

: 89-83-8
thymol

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: thymoyl 1-thiocarbonylimidazolide

Conditions

Conditions	Yield
Ambient temperature;	99%
Ambient temperature; solid state reaction;	99%

: 89-83-8
thymol

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

C6H5CH2-X, X=halide: C6H5CH2-X, X=halide

: 69455-01-2
2-(benzyloxy)-1-isopropyl-4-methylbenzene

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: C6H5CH2-X, X=halide In benzene	99%

...Expand

: 89-83-8
thymol

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

CH3-X, X=halide: CH3-X, X=halide

: 1076-56-8
Thymol methyl ether

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: CH3-X, X=halide In benzene	99%

...Expand

: 75-77-4
chloro-trimethyl-silane

: 89-83-8
thymol

: 55012-80-1
trimethyl-5-methyl-2-(1-methylethylphenoxysilane)

Conditions

Conditions	Yield
With triethylamine In benzene	99%

: 2873-74-7
gloutaric dichloride

: 89-83-8
thymol

: pentanedioic acid bis-(2-isopropyl-5-methyl-phenyl) ester

Conditions

Conditions	Yield
With sodium hydroxide for 0.05h; microwave irradiation;	99%

: 89-83-8
thymol

: 543-20-4
succinoyl dichloride

: thymol succinate

Conditions

Conditions	Yield
With sodium hydroxide for 0.05h; microwave irradiation;	99%

: 89-83-8
thymol

: 111-50-2
Adipic acid dichloride

: hexanedioic acid bis-(2-isopropyl-5-methyl-phenyl) ester

Conditions

Conditions	Yield
With sodium hydroxide for 0.05h; microwave irradiation;	99%

: 89-83-8
thymol

: 1663-67-8
malonoyl dichloride

: malonic acid bis-(2-isopropyl-5-methyl-phenyl) ester

Conditions

Conditions	Yield
With sodium hydroxide for 0.0333333h; microwave irradiation;	99%

: 89-83-8
thymol

C6H5CH2X, X = Hal: C6H5CH2X, X = Hal

: 69455-01-2
2-(benzyloxy)-1-isopropyl-4-methylbenzene

Conditions

Conditions	Yield
With sodium hydroxide for 0.0833333h; microwave irradiation;	99%

: 89-83-8
thymol

CH2=CHCH2X, X = Hal: CH2=CHCH2X, X = Hal

: 29652-99-1
2-(allyloxy)-1-isopropyl-4-methylbenzene

Conditions

Conditions	Yield
With sodium hydroxide for 0.0833333h; microwave irradiation;	99%

: 89-83-8
thymol

CH3(CH2)2CH2X, X = Hal: CH3(CH2)2CH2X, X = Hal

: 327040-47-1
2-butoxy-4-methyl-1-(propan-2-yl) benzene

Conditions

Conditions	Yield
With sodium hydroxide for 0.0666667h; microwave irradiation;	99%

: 89-83-8
thymol

: 13019-31-3
2-bromo-6-isopropyl-3-methylphenol

Conditions

Conditions	Yield
With tetraethylammonium bromide In acetonitrile Product distribution; anodic bromination - anode potential 0.85V, 96.5 C, AgClO4, other solvent, other bromide, other anode potential;	98.1%
With N-Bromosuccinimide In chloroform at 40 - 50℃;	65%
With bromine; tert-butylamine
With N-Bromosuccinimide; diisopropylamine at 20℃;

: 89-83-8
thymol

: 89-68-9
4-chloro-2-isopropyl-5-methylphenol

Conditions

Conditions	Yield
With oxygen; lithium chloride; copper dichloride In acetic acid at 80℃; for 6h; regioselective reaction;	98%
With oxygen; lithium chloride; copper dichloride In acetic acid at 80℃; under 760.051 Torr; for 4h;	87%
With sulfuryl dichloride In tetrachloromethane at 0 - 20℃; for 0.75h;	79%

: 89-83-8
thymol

: 75-36-5
acetyl chloride

: 528-79-0
2-isopropyl-5-methylphenyl acetate

Conditions

Conditions	Yield
With sodium hydroxide for 0.0416667h; microwave irradiation;	98%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 3.26667h;	93%
Stage #1: thymol With pyridine at 20℃; for 0.333333h; Stage #2: acetyl chloride at 10 - 20℃;	90%

: 358-23-6
trifluoromethylsulfonic anhydride

: 89-83-8
thymol

: 256637-50-0
2-isopropyl-5-methylphenyl trifluoromethanesulfonate

Conditions

Conditions	Yield
With pyridine In dichloromethane Inert atmosphere;	98%
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;	93%
With pyridine at 20℃; for 25h; Substitution;

: 89-83-8
thymol

: 102-92-1
cinnamoyl chloride

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

: 111385-92-3
cinnamic acid-(2-isopropyl-5-methyl-phenyl ester)

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: cinnamoyl chloride	98%

...Expand

: 89-83-8
thymol

: 98-88-4
benzoyl chloride

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

: 6380-29-6
2-isopropyl-5-methylphenyl benzoate

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: benzoyl chloride	98%

...Expand

: 89-83-8
thymol

: 543-20-4
succinoyl dichloride

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

: thymol succinate

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: succinoyl dichloride In benzene	98%

...Expand

: 89-83-8
thymol

: 75-36-5
acetyl chloride

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

: 528-79-0
2-isopropyl-5-methylphenyl acetate

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: acetyl chloride	98%

...Expand

: 89-83-8
thymol

: 1663-67-8
malonoyl dichloride

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

: malonic acid bis-(2-isopropyl-5-methyl-phenyl) ester

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: malonoyl dichloride In benzene	98%

...Expand

: 89-83-8
thymol

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

CH2=CHCH2-X, X=halide: CH2=CHCH2-X, X=halide

: 29652-99-1
2-(allyloxy)-1-isopropyl-4-methylbenzene

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: CH2=CHCH2-X, X=halide In benzene	98%

...Expand

: 89-83-8
thymol

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

(CH3)2CH2-X, X=halide: (CH3)2CH2-X, X=halide

: 96294-85-8
4-methyl-1-(propan-2-yl)-2-(propan-2-yloxy)benzene

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: (CH3)2CH2-X, X=halide In benzene	98%

...Expand

: 89-83-8
thymol

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

CH3CH2CH2CH2-X, X=halide: CH3CH2CH2CH2-X, X=halide

: 327040-47-1
2-butoxy-4-methyl-1-(propan-2-yl) benzene

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: CH3CH2CH2CH2-X, X=halide In benzene	98%

...Expand

: 89-83-8
thymol

Amberlite IRA-400 (chloride form) resin: Amberlite IRA-400 (chloride form) resin

CH3CH2CH2-X, X=halide: CH3CH2CH2-X, X=halide

: 96294-83-6
(2-isopropyl-5-methyl-phenyl)-propyl ether

Conditions

Conditions	Yield
Stage #1: thymol; Amberlite IRA-400 (chloride form) resin With sodium hydroxide Stage #2: CH3CH2CH2-X, X=halide In benzene	98%

...Expand

Thymol Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Thymol Specification

1. Introduction of Thymol

Thymol (CAS No.89-83-8), it also can be called 2-Isopropyl-5-methyl phenol ; 5-Methyl-2-(1-methylethyl)phenol ; 1-Hydroxy-5-methyl-2-isopropylbenzene ; 1-Methyl-3-hydroxy-4-isopropylbenzene ; 2-Hydroxy-1-isopropyl-4-methylbenzene ; 3-Hydroxy-1-methyl-4-isopropylbenzene ; 3-Hydroxy-p-cymene ; 3-Methyl-6-isopropylphenol ; 3-p-cymenol . It is white crystals or powder with a pungent odour. It is the active antiseptic ingredient in the toothpaste Euthymol.

2. Properties of Thymol

(1) H bond acceptors: 1 (2) H bond donors: 1 (3) Freely Rotating Bonds: 2
(4) Polar Surface Area: 20.23 Å2 (5) Index of Refraction: 1.523 (6) Molar Refractivity: 47.14 cm3
(7) Molar Volume: 154.2 cm3 (8) Surface Tension: 34.9 dyne/cm (9) Density: 0.974 g/cm3
(10) Flash Point: 101 °C (11) Melting Point: 48-52 ºC (12) Enthalpy of Vaporization: 48.88 kJ/mol
(13) Boiling Point: 233 °C at 760 mmHg (14) Vapour Pressure: 0.0376 mmHg at 25°C

3. Structure descriptors of Thymol

IUPAC Name: 5-methyl-2-propan-2-ylphenol

InChI: InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3

InChIKey: MGSRCZKZVOBKFT-UHFFFAOYSA-N

Canonical SMILES : CC1=CC(=C(C=C1)C(C)C)O

4. Uses of Thymol

1. It has been used to successfully control varroa mites and prevent fermentation and the growth of mould in bee colonies.
2. It laso has a minor use in bookbinding: before rebinding, books with mold damage can be sealed in bags with thymol crystals to kill fungal spores.
3. Thymol has been used in alcohol solutions and in dusting powders for the treatment of tinea (ringworm) infections.
4. Thymol was used to treat hookworm infections in the US.
5. It is also used as a preservative in halothane, an anaesthetic, and as an antiseptic in mouthwash.

5.Safety information of Thymol

Hazard Codes: Corrosive , Dangerous
Risk Statements: 22-34-51/53
R22:Harmful if swallowed.
R34:Causes burns.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 26-28-36/37/39-45-61-28
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
S28:After contact with skin, wash immediately with plenty of soap-suds.
RIDADR: UN 3261 8/PG 3
WGK Germany: 2
RTECS: XP2275000
HazardClass: 8
PackingGroup: III
HS Code: 29071900
Hazardous Substances Data: 89-83-8(Hazardous Substances Data)

6. Toxicity data of Thymol

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source

cat LDLo oral 250mg/kg (250mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.

dog LDLo intravenous 150mg/kg (150mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Therapie. Vol. 3, Pg. 109, 1948.

frog LDLo subcutaneous 150mg/kg (150mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.

guinea pig LD50 oral 880mg/kg (880mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: GASTRITIS

BEHAVIORAL: COMA Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

guinea pig LDLo intraperitoneal 300mg/kg (300mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.

guinea pig LDLo subcutaneous 1100mg/kg (1100mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.

mouse LD50 intraperitoneal 110mg/kg (110mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA Quarterly Journal of Crude Drug Research. Vol. 19, Pg. 1, 1981.

mouse LD50 intravenous 100mg/kg (100mg/kg) BEHAVIORAL: SLEEP Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.

mouse LD50 oral 640mg/kg (640mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. Vol. 5, Pg. 111, 1956.

mouse LD50 subcutaneous 243mg/kg (243mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. Vol. 5, Pg. 111, 1956.

rabbit LDLo intravenous 60mg/kg (60mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.

rabbit LDLo oral 750mg/kg (750mg/kg) Journal of Pharmacology and Experimental Therapeutics. Vol. 17, Pg. 261, 1921.

rat LD50 oral 980mg/kg (980mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: COMA Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

rat LDLo subcutaneous 1600mg/kg (1600mg/kg) "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.

Product Name

Thymol

Synthetic route

Thymol Consensus Reports

Thymol Specification

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Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	250mg/kg (250mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.
dog	LDLo	intravenous	150mg/kg (150mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Therapie. Vol. 3, Pg. 109, 1948.
frog	LDLo	subcutaneous	150mg/kg (150mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.
guinea pig	LD50	oral	880mg/kg (880mg/kg)	BEHAVIORAL: TREMOR GASTROINTESTINAL: GASTRITIS BEHAVIORAL: COMA	Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
guinea pig	LDLo	intraperitoneal	300mg/kg (300mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.
guinea pig	LDLo	subcutaneous	1100mg/kg (1100mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.
mouse	LD50	intraperitoneal	110mg/kg (110mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Quarterly Journal of Crude Drug Research. Vol. 19, Pg. 1, 1981.
mouse	LD50	intravenous	100mg/kg (100mg/kg)	BEHAVIORAL: SLEEP	Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.
mouse	LD50	oral	640mg/kg (640mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. Vol. 5, Pg. 111, 1956.
mouse	LD50	subcutaneous	243mg/kg (243mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. Vol. 5, Pg. 111, 1956.
rabbit	LDLo	intravenous	60mg/kg (60mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.
rabbit	LDLo	oral	750mg/kg (750mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 17, Pg. 261, 1921.
rat	LD50	oral	980mg/kg (980mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: COMA	Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
rat	LDLo	subcutaneous	1600mg/kg (1600mg/kg)		"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 172, 1959.