Triisopropyl orthoformate supplier

Name
Triisopropyl orthoformate
EINECS 224-688-9
CAS No. 4447-60-3
Article Data11
CAS DataBase
Density 0.888 g/cm³
Solubility
Melting Point
Formula C₁₀H₂₂O₃
Boiling Point 166.999 °C at 760 mmHg
Molecular Weight 190.283
Flash Point 63.43 °C
Transport Information UN 3272 3/PG 3
Appearance clear colorless liquid
Safety 26-36-37/39-16
Risk Codes 10-36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Orthoformicacid, triisopropyl ester (6CI,7CI,8CI);Tri-iso-propyl orthoformate;
PSA 27.69000
LogP 2.54500

Synthetic route

: 75-46-7
trifluoromethan

: 67-63-0
isopropyl alcohol

: 4447-60-3
Triisopropoxymethan

Conditions

Conditions	Yield
With sodium hydride In mineral oil at 120℃; under 2585.81 Torr; for 24h;	90%

: 108-20-3
di-isopropyl ether

: 625-55-8
isopropyl formate

: 4447-60-3
Triisopropoxymethan

Conditions

Conditions	Yield
With boron trifluoride In Hexadecane at 110℃; for 8h; Autoclave;	88%

: 74-90-8
hydrogen cyanide

: 67-63-0
isopropyl alcohol

: 4447-60-3
Triisopropoxymethan

Conditions

Conditions	Yield
Stage #1: hydrogen cyanide With hydrogenchloride In isopropyl alcohol; mineral oil at -3 - 30℃; for 2.33333h; Stage #2: isopropyl alcohol In mineral oil at 35 - 53℃; for 5h; Inert atmosphere;	71.84%

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 67-63-0
isopropyl alcohol

: 4447-60-3
Triisopropoxymethan

Conditions

Conditions	Yield
With benzoyl chloride In Petroleum ether at 0 - 40℃; for 2.25h;	58%

: 75-46-7
trifluoromethan

: 67-63-0
isopropyl alcohol

A: 4447-60-3
Triisopropoxymethan

B: 141-53-7
sodium formate

Conditions

Conditions	Yield
With sodium hydroxide at 120℃; under 2585.81 Torr; for 24h;	A 10% B 40%

...Expand

: 5780-15-4
4-(Methoxymethylene)-morpholinium methyl sulfate

: 67-63-0
isopropyl alcohol

: 4447-60-3
Triisopropoxymethan

Conditions

Conditions	Yield
1) 16h, 2) 4h, 40 deg C;	2.9%

: 98-03-3
thiophene-2-carbaldehyde

: 4447-60-3
Triisopropoxymethan

: 1146221-06-8
C11H18O2S

Conditions

Conditions	Yield
With cerium triflate In isopropyl alcohol; toluene at 20℃; for 0.5h;	99%

: 4447-60-3
Triisopropoxymethan

: 1428963-73-8
tert-butyl 2'-bromo-5'-formyl-4'-methoxybiphenyl-2-ylcarbamate

: 1428963-58-9
tert-butyl 2'-bromo-5'-(diisopropoxymethyl)-4'-methoxybiphenyl-2-ylcarbamate

Conditions

Conditions	Yield
With N-Bromosuccinimide In dichloromethane; isopropyl alcohol at 20℃; for 6h;	99%

: 104-53-0
3-phenyl-propionaldehyde

: 4447-60-3
Triisopropoxymethan

: 64245-42-7
3-phenylpropionaldehyde diisopropyl acetal

Conditions

Conditions	Yield
With cerium triflate In isopropyl alcohol; toluene at 20℃; for 0.0833333h;	98%

: 4447-60-3
Triisopropoxymethan

: (3-oxopropyl)triphenylphosphonium iodide

: (3,3-diisopropoxypropyl)triphenylphosphonium iodide

Conditions

Conditions	Yield
With hydrogenchloride In dichloromethane; isopropyl alcohol at 0 - 20℃;	97%

: 4447-60-3
Triisopropoxymethan

: 591-24-2, 625-96-7
3-Methylcyclohexanone

: 1146221-01-3
C13H26O2

Conditions

Conditions	Yield
With cerium triflate In isopropyl alcohol; toluene at 20℃; for 0.5h;	95%

: tetrafluoroboric acid

: 16205-44-0
Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester

: 4447-60-3
Triisopropoxymethan

: 3-(carboethoxy)-1-isopropylpyrazolo[1,5-a]pyridin-1-ium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: tetrafluoroboric acid; Pyrazolo<1,5-a>pyridin-3-carbonsaeureethylester In water at 0 - 20℃; for 0.5h; Stage #2: Triisopropoxymethan Inert atmosphere;	95%

...Expand

: 4447-60-3
Triisopropoxymethan

: 1312757-32-6
(S)-2-(9-methoxy-3,3a,4,5,6,11-hexahydro-2H-pyrrolo[3',2':2,3]azepino[4,5-b]indol-3a-yl)aniline

: 1313018-40-4
(-)-trigonoliimine B

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane at 23℃; for 1h; Inert atmosphere;	94.3%

: 4447-60-3
Triisopropoxymethan

: 505-57-7
2-hexenal

: 1146221-07-9
C12H24O2

Conditions

Conditions	Yield
With cerium triflate In isopropyl alcohol; toluene at 20℃; for 4h;	94%

: 4447-60-3
Triisopropoxymethan

: 108-94-1
cyclohexanone

: 1132-95-2
1,1-diisopropoxycyclohexane

Conditions

Conditions	Yield
With cerium triflate In isopropyl alcohol; toluene at 20℃; for 0.0833333h;	94%

: 4447-60-3
Triisopropoxymethan

: 1312757-32-6
(S)-2-(9-methoxy-3,3a,4,5,6,11-hexahydro-2H-pyrrolo[3',2':2,3]azepino[4,5-b]indol-3a-yl)aniline

: (-)-trigonoliimine B

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In dichloromethane at 23℃; Inert atmosphere;	94%

: 4447-60-3
Triisopropoxymethan

: BF4(1-)*C4H5NS*H(1+)

: 3-isopropyl-5-methylthiazol-3-ium tetrafluoroborate

Conditions

Conditions	Yield
at 130℃; for 25h;	94%

: 4447-60-3
Triisopropoxymethan

: BF4(1-)*C4H5NS*H(1+)

: 3-isopropyl-4-methylthiazol-3-ium tetrafluoroborate

Conditions

Conditions	Yield
at 130℃; for 25h;	94%

: 3581-89-3
5-methylthiazole

: tetrafluoroboric acid

: 4447-60-3
Triisopropoxymethan

: 3-isopropyl-5-methylthiazol-3-ium tetrafluoroborate

Conditions

Conditions	Yield
In water at 0 - 130℃; for 24h;	94%

...Expand

: 55628-54-1
3,4,6-tri-O-benzyl-D-glucal

: 4447-60-3
Triisopropoxymethan

: C23H28O4

Conditions

Conditions	Yield
indium(III) chloride In acetonitrile at 20℃; for 1h;	93%

: 4447-60-3
Triisopropoxymethan

: C7H6NS(1+)*C2F6NO4S2(1-)

: 1227694-43-0
3-isopropylbenzo[d]thiazol-3-ium bis((trifluoromethyl)sulfonyl)imide

Conditions

Conditions	Yield
at 130℃; for 26h;	93%

: 95-16-9
1,3-Benzothiazole

: 4447-60-3
Triisopropoxymethan

: 82113-65-3
bis(trifluoromethanesulfonyl)amide

: 1227694-43-0
3-isopropylbenzo[d]thiazol-3-ium bis((trifluoromethyl)sulfonyl)imide

Conditions

Conditions	Yield
at 130℃; for 26h;	93%

...Expand

: tetrafluoroboric acid

: 4447-60-3
Triisopropoxymethan

: 8-methyl-3-phenyl-H-imidazo[1,2-a]pyridine

: 1-isopropyl-8-methyl-3-phenyl-imidazole[1,2-a]pyridin-1-ium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: tetrafluoroboric acid; 8-methyl-3-phenyl-H-imidazo[1,2-a]pyridine In water at 0 - 20℃; for 0.5h; Stage #2: Triisopropoxymethan Inert atmosphere;	93%

...Expand

: 4447-60-3
Triisopropoxymethan

: 169522-70-7
(S)-3-<(tert-butyldimethylsilyl)oxy>-4-(tosyloxy)butanal

: 169522-71-8
(S)-3-<(tert-Butyldimethylsilyl)oxy>-4-(tosyloxy)butanal diisopropyl acetal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In isopropyl alcohol for 2h; Ambient temperature;	92%

: 4447-60-3
Triisopropoxymethan

: C12H6Cl3F19O3Si

: C21H27F19O6Si

Conditions

Conditions	Yield
In isopropyl alcohol at 60℃; for 3h; Inert atmosphere;	92%

: 4447-60-3
Triisopropoxymethan

: 358642-61-2
p-bromo-[4-(trichlorosilyl)butyl]benzene

: 358642-63-4
p-bromo[4-(triisopropylsilyl)butyl]benzene

Conditions

Conditions	Yield
at 20℃; for 72h;	91.3%

: 4447-60-3
Triisopropoxymethan

: 57224-63-2
methyl (2S,3R)-2-(benzyloxycarbonylamino)-3-hydroxybutyrate

: methyl (2RS,4S,5R)-3-<(benzyloxy)carbonyl>-2-isopropoxy-5-methyloxazolidine-4-carboxylate

Conditions

Conditions	Yield
With (CF3SO3)3 In benzene for 12h; Heating;	90%

: 4447-60-3
Triisopropoxymethan

: 120-92-3
cyclopentanone

: 1146221-00-2
cyclopentanone diisopropyl acetal

Conditions

Conditions	Yield
With cerium triflate In isopropyl alcohol; toluene at 0℃; for 6h;	90%

: 4447-60-3
Triisopropoxymethan

: 6630-33-7
ortho-bromobenzaldehyde

: 1258208-81-9
1-bromo-2-(diisopropoxymethyl)benzene

Conditions

Conditions	Yield
With methanesulfonic acid In isopropyl alcohol at 20℃; for 24h;	90%

: 7164-98-9
1-phenylimidazole

: ammonium tetrafluoroborate

: 4447-60-3
Triisopropoxymethan

: 1434057-48-3
1-isopropyl-3-phenyl-1H-imidazol-3-ium tetrafluoroborate

Conditions

Conditions	Yield
Schlenk technique; Reflux; Inert atmosphere;	90%

...Expand

: 4447-60-3
Triisopropoxymethan

: 2873-29-2
D-glucal triacetate

: 171228-22-1
isopropyl 4,6-di-O-acetyl-2,3-dideoxy-D-erythro-hex-2-enopyranoside

Conditions

Conditions	Yield
indium(III) chloride In acetonitrile at 20℃; for 1.4h;	89%

: 4447-60-3
Triisopropoxymethan

: 6-amino-3-methyl-5-(methylamino)pyrimidine-2,4(1H,3H)-dione

: 611-59-6
paraxanthine

Conditions

Conditions	Yield
With sulfonic acid monohydrate In toluene at 90 - 100℃; for 3h;	89%

: 4447-60-3
Triisopropoxymethan

: 33069-62-4
taxol

: 349655-04-5
1,1-diisopropyloxy-2,2-dimethyl-3-pentanone

Conditions

Conditions	Yield
With p-TsOH In isopropyl alcohol	88%
With p-TsOH In isopropyl alcohol	88%
With p-TsOH In isopropyl alcohol	88%

: 4447-60-3
Triisopropoxymethan

: 80040-79-5
3,4,6-tri-O-benzyl-D-galactal

: C23H28O4

Conditions

Conditions	Yield
indium(III) chloride In acetonitrile at 20℃; for 1.2h;	88%

Triisopropyl orthoformate Specification

The Triisopropyl orthoformate, with the cas registry number 4447-60-3, has the IUPAC name of 2-[di(propan-2-yloxy)methoxy]propane and the systematic name of 2-[bis(propan-2-yloxy)methoxy]propane. This is a kind of clear colourless liquid, and its product categories are including Orthoesters; Acetals/Ketals/Ortho Esters; Organic Building Blocks; Oxygen Compounds.

The characteristics of this chemical are as below: (1)ACD/LogP: 3.19; (2)ACD/LogD (pH 5.5): 3.19; (3)ACD/LogD (pH 7.4): 3.19; (4)ACD/BCF (pH 5.5): 155.82; (5)ACD/BCF (pH 7.4): 155.82; (6)ACD/KOC (pH 5.5): 1291.5; (7)ACD/KOC (pH 7.4): 1291.5; (8)#H bond acceptors: 3; (9)#H bond donors: 0; (10)#Freely Rotating Bonds: 6; (11)Polar Surface Area: 27.69; (12)Index of Refraction: 1.413; (13)Molar Refractivity: 53.44 cm³; (14)Molar Volume: 214.1 cm³; (15)Polarizability: 21.18 ×10^-24 cm³; (16)Surface Tension: 24.9 dyne/cm; (17)Density: 0.888 g/cm³; (18)Flash Point: 63.4 °C; (19)Enthalpy of Vaporization: 38.69 kJ/mol; (20)Boiling Point: 167 °C at 760 mmHg; (21)Vapour Pressure: 2.29 mmHg at 25°C; (22)Exact Mass: 190.156895; (23)MonoIsotopic Mass: 190.156895; (24)Topological Polar Surface Area: 27.7; (25)Heavy Atom Count: 13; (26)Formal Charge: 0; (27)Complexity: 97.6.

Use of Triisopropyl orthoformate: Triisopropyl orthoformate could react to produce diisopropoxymethinium; tetrafluoroborate, with the following condition: reagent: BF3-Et2O; solvent: CH₂C_l2; reaction temp.: 30 ℃.

When you are using this chemical, please be very cautious, and then take some measures to protect yourself. Being a kind of irritant chemical, it is irritating to eyes, respiratory system and skin and it may cause inflammation to the skin or other mucous. Therefore, you should take the following instructions. Wear suitable protective clothing, gloves and eye/face protection, and if in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice. While storing, keep away from sources of ignition - No smoking.

Additionally, you could convert the following datas into the molecular structure:
(1)Canonical SMILES: CC(C)OC(OC(C)C)OC(C)C
(2)InChI: InChI=1S/C10H22O3/c1-7(2)11-10(12-8(3)4)13-9(5)6/h7-10H,1-6H3
(3)InChIKey: FPIVAWNGRDHRSQ-UHFFFAOYSA-N

Product Name

Triisopropyl orthoformate

Synthetic route

Triisopropyl orthoformate Specification

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