Product Name

  • Name

    Trimethyl phosphite

  • EINECS 204-471-5
  • CAS No. 121-45-9
  • Article Data66
  • CAS DataBase
  • Density 1.052g/mLat 25°C(lit.)
  • Solubility Hydrolyzes with water.
  • Melting Point -78 °C
  • Formula C3H9O3P
  • Boiling Point 110.2 °C at 760 mmHg
  • Molecular Weight 124.076
  • Flash Point 27.8 °C
  • Transport Information UN 2329 3/PG 3
  • Appearance clear colorless liquid
  • Safety 26
  • Risk Codes 10-22-36/37/38
  • Molecular Structure Molecular Structure of 121-45-9 (Trimethyl phosphite)
  • Hazard Symbols HarmfulXn
  • Synonyms Fosforyn trojmetylowy;Trimethoxyfosfin;Trimethyl phosphite;
  • PSA 41.28000
  • LogP 1.15250

Synthetic route

methanol
67-56-1

methanol

tris(4-dimethylaminopyridine)phosphorus(3+) bromide
139111-73-2

tris(4-dimethylaminopyridine)phosphorus(3+) bromide

A

(3-bromopyridin-4-yl)-dimethyl-amine
84539-35-5

(3-bromopyridin-4-yl)-dimethyl-amine

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
Inert atmosphere;A n/a
B 100%
methanol
67-56-1

methanol

4',4'-dimethyl-2λ5-spiro[benzo[1,3,2]dioxaphosphole-2,2'-[1,3,2]oxazaphospholidin]-5'-one
51145-42-7

4',4'-dimethyl-2λ5-spiro[benzo[1,3,2]dioxaphosphole-2,2'-[1,3,2]oxazaphospholidin]-5'-one

A

2-methoxy-1,3,2-benzodioxaphosphole
20570-25-6

2-methoxy-1,3,2-benzodioxaphosphole

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide for 0.5h; Ambient temperature;A 85%
B 5%
ammonium hexafluorophosphate

ammonium hexafluorophosphate

(cyclopentadienyl)(iodomethyl)rhodium(P(OMe3)I
97688-35-2

(cyclopentadienyl)(iodomethyl)rhodium(P(OMe3)I

1,2-bis(dimethylphosphanyl)ethane
23936-60-9

1,2-bis(dimethylphosphanyl)ethane

A

(cyclopentadienyl)(I)rhodium(dpme)(PF6)
84330-26-7

(cyclopentadienyl)(I)rhodium(dpme)(PF6)

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
In benzene dropwise addn. of phosphine to Rh-compound in benzene (N2, Schlenk tube technique), stirring for 1h at room temp., filtn., washing with ether, drying in vac., dissolving in methanol, addn. of NH4PF6, stirring for 10 min; addn. of ether, filtn., washing with ether, recrystn. (acetone/ether);A 83%
B n/a
methanol
67-56-1

methanol

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
With potassium phosphate; tetrahexylammonium chloride; phosphorus trichloride In dichloromethane at 20℃; for 3h;65%
With phosphorus trichloride Herstellung;
With pyridine; phosphorus trichloride
mer-chloro(dinitrogen)(PPh3)(trimethylphosphite)3rhenium*0.166C6H6

mer-chloro(dinitrogen)(PPh3)(trimethylphosphite)3rhenium*0.166C6H6

4-methylphenyl isocyanide
7175-47-5

4-methylphenyl isocyanide

A

chloro(p-tolueneisocyanide)3(P(OMe)3)2rhenium

chloro(p-tolueneisocyanide)3(P(OMe)3)2rhenium

B

triphenylphosphine
603-35-0

triphenylphosphine

C

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
In tetrahydrofuran byproducts: N2; addn. of the isocyanide to the Re compd. in THF and stirring for 2 h at room temp.; filtn., concn. (vac.), addn. of CH2Cl2 or THF, then Et2O, filtn., washing with Et2O and drying in vac.;A 50%
B n/a
C n/a
methanol
67-56-1

methanol

2-methoxy-2,3-dihydro-1,3,2-benzoxazaphosphole
7051-21-0

2-methoxy-2,3-dihydro-1,3,2-benzoxazaphosphole

A

2-amino-phenol
95-55-6

2-amino-phenol

B

2',3'-dihydro-3H-2λ5-[2,2']spirobi(benzo[1,3,2]oxazaphosphole)
67528-50-1, 16841-91-1

2',3'-dihydro-3H-2λ5-[2,2']spirobi(benzo[1,3,2]oxazaphosphole)

C

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
A 17%
B 24%
C 15%
methanol
67-56-1

methanol

N1-methyl-N1-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosylamido)-N2,N3-tetraethyldiamidophosphite
80948-53-4

N1-methyl-N1-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosylamido)-N2,N3-tetraethyldiamidophosphite

A

mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine
80948-50-1, 80948-51-2

mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
at 20℃; for 3h; Product distribution;
methanol
67-56-1

methanol

α-methyllyxo-D-furanoside 2,3,5-bicyclophosphite
90213-29-9

α-methyllyxo-D-furanoside 2,3,5-bicyclophosphite

A

methyl-α-D-lyxofuranoside
22416-73-5

methyl-α-D-lyxofuranoside

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

methanol
67-56-1

methanol

1-N-methyl-3,5,6-tri-O-methyl-α-D-glucofuranosylamine 1,2-N,O-cyclodiethylphosphoramidite

1-N-methyl-3,5,6-tri-O-methyl-α-D-glucofuranosylamine 1,2-N,O-cyclodiethylphosphoramidite

A

1-N-methyl-3,5,6-tri-O-methyl-α,β-D-glucofuranosylamine

1-N-methyl-3,5,6-tri-O-methyl-α,β-D-glucofuranosylamine

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

methanol
67-56-1

methanol

1-N-methyl-3,5,6-tri-O-methyl-α-D-glucofuranosylamine 1,2-N,O-cyclodiethylphosphoramidite

1-N-methyl-3,5,6-tri-O-methyl-α-D-glucofuranosylamine 1,2-N,O-cyclodiethylphosphoramidite

A

1-N-methyl-3,5,6-tri-O-methyl-α,β-D-glucofuranosylamine

1-N-methyl-3,5,6-tri-O-methyl-α,β-D-glucofuranosylamine

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

methanol
67-56-1

methanol

(1S,2R,3R,4R)-2,3-Bis-trifluoromethyl-2,3-diphospha-bicyclo[2.2.1]hept-5-ene

(1S,2R,3R,4R)-2,3-Bis-trifluoromethyl-2,3-diphospha-bicyclo[2.2.1]hept-5-ene

A

trifluoromethan
75-46-7

trifluoromethan

B

trifluoromethylphosphine
420-52-0

trifluoromethylphosphine

C

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
at 70℃; Product distribution;
dimethyl phenylphosphonite
18351-42-3

dimethyl phenylphosphonite

sodium methylate
124-41-4

sodium methylate

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
In dichloromethane at 25℃; Rate constant; reaction in CH3OH;
2-methoxy-1,3,2-benzodioxaphosphole
20570-25-6

2-methoxy-1,3,2-benzodioxaphosphole

sodium methylate
124-41-4

sodium methylate

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
In dichloromethane at 20℃; Rate constant; reaction in CH3OH;
perfluoro-2-phosphapropene
72344-34-4

perfluoro-2-phosphapropene

A

Difluoromethane
75-10-5

Difluoromethane

B

trifluoromethan
75-46-7

trifluoromethan

C

Difluormethyl-phosphonigsaeure-dimethylester
4669-85-6

Difluormethyl-phosphonigsaeure-dimethylester

D

Difluormethyl-trifluormethyl-phosphinigsaeure-methylester
1571-80-8

Difluormethyl-trifluormethyl-phosphinigsaeure-methylester

E

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
With methanol; sodium methylate Product distribution; further reagents: EtOH/NaOEt, MeOH/NaOEt (80:20), EtOH/NaOMe (70:30);
phosphorous acid trimethyl ester; protonated form
39097-02-4

phosphorous acid trimethyl ester; protonated form

cyclohexylamine
108-91-8

cyclohexylamine

A

cyclohexyl-ammonium cation
29384-28-9

cyclohexyl-ammonium cation

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
under 1E-05 - 0.001 Torr; Thermodynamic data; Equilibrium constant; Ambient temperature; Δ G, Δ H;
methanol
67-56-1

methanol

2-ethoxy-2,3-dihydro-1,3,2-benzoxazaphosphole
7051-22-1

2-ethoxy-2,3-dihydro-1,3,2-benzoxazaphosphole

A

ethyl dimethyl phosphite
20502-40-3

ethyl dimethyl phosphite

B

2-amino-phenol
95-55-6

2-amino-phenol

C

2',3'-dihydro-3H-2λ5-[2,2']spirobi(benzo[1,3,2]oxazaphosphole)
67528-50-1, 16841-91-1

2',3'-dihydro-3H-2λ5-[2,2']spirobi(benzo[1,3,2]oxazaphosphole)

D

2-Ethoxy-2-methoxy-2,3-dihydro-2λ5-benzo[1,3,2]oxazaphosphole

2-Ethoxy-2-methoxy-2,3-dihydro-2λ5-benzo[1,3,2]oxazaphosphole

E

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
at -10℃; for 2h;
methanol
67-56-1

methanol

2-ethoxy-2,3-dihydro-1,3,2-benzoxazaphosphole
7051-22-1

2-ethoxy-2,3-dihydro-1,3,2-benzoxazaphosphole

A

ethyl dimethyl phosphite
20502-40-3

ethyl dimethyl phosphite

B

2-amino-phenol
95-55-6

2-amino-phenol

C

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
2 h at -10 deg C, then at room temp.;
N1-methyl-N1-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosylamido)-N2,N3-tetramethyldiamidophosphite
80948-52-3

N1-methyl-N1-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosylamido)-N2,N3-tetramethyldiamidophosphite

A

mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine
80948-50-1, 80948-51-2

mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
With methanol for 3h; Ambient temperature;
1-methyltrimethylene N-methyl-N-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosyl)amidophosphite
80948-54-5

1-methyltrimethylene N-methyl-N-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosyl)amidophosphite

A

mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine
80948-50-1, 80948-51-2

mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
With methanol for 3h; Ambient temperature;
N1-methyl-N1-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosylamido)-N2,N3-tetraethyldiamidophosphite
80948-53-4

N1-methyl-N1-(2,3:5,6-di-O-isopropylidene-α-D-mannofuranosylamido)-N2,N3-tetraethyldiamidophosphite

A

mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine
80948-50-1, 80948-51-2

mixture of α- and β-2,3:5,6-di-O-isopropylidene-N-methyl-D-mannofuranosylamine

B

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
With methanol for 3h; Ambient temperature;
methanol
67-56-1

methanol

dimethyl chlorophosphite
3743-07-5

dimethyl chlorophosphite

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

Conditions
ConditionsYield
With tetramethylammonium
benzil
134-81-6

benzil

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

2,2,2-trimethoxy-4,5-diphenyl-2,2-dihydro-1,3,2-dioxaphospholene
4850-55-9

2,2,2-trimethoxy-4,5-diphenyl-2,2-dihydro-1,3,2-dioxaphospholene

Conditions
ConditionsYield
100%
In benzene
1,3-diphenyl-propane-1,2,3-trione
643-75-4

1,3-diphenyl-propane-1,2,3-trione

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

2,2,2-trimethoxy-4-benzoyl-5-phenyl-2,2-dihydro-1,3,2-dioxaphosphole
2908-28-3

2,2,2-trimethoxy-4-benzoyl-5-phenyl-2,2-dihydro-1,3,2-dioxaphosphole

Conditions
ConditionsYield
In neat (no solvent)100%
In dichloromethane
4-phthalimidobutyryl chloride
10314-06-4

4-phthalimidobutyryl chloride

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

dimethyl [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyryl]phosphonate
125040-04-2

dimethyl [4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyryl]phosphonate

Conditions
ConditionsYield
at 20℃; for 2h;100%
In benzene overnight;
In chloroform at 20℃; for 1h;
Adipic acid dichloride
111-50-2

Adipic acid dichloride

Dimethyl phosphite
868-85-9

Dimethyl phosphite

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[6-(Dimethoxy-phosphoryl)-1,6-bis-(dimethoxy-phosphoryloxy)-hexyl]-phosphonic acid dimethyl ester

[6-(Dimethoxy-phosphoryl)-1,6-bis-(dimethoxy-phosphoryloxy)-hexyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
at 130 - 135℃; for 6h;100%
suberoyl chloride
10027-07-3

suberoyl chloride

Dimethyl phosphite
868-85-9

Dimethyl phosphite

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[1,8,8-Tris-(dimethoxy-phosphoryl)-1,8-dihydroxy-octyl]-phosphonic acid dimethyl ester

[1,8,8-Tris-(dimethoxy-phosphoryl)-1,8-dihydroxy-octyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
at 60℃; for 8h;100%
suberoyl chloride
10027-07-3

suberoyl chloride

Dimethyl phosphite
868-85-9

Dimethyl phosphite

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[8-(Dimethoxy-phosphoryl)-1,8-bis-(dimethoxy-phosphoryloxy)-octyl]-phosphonic acid dimethyl ester

[8-(Dimethoxy-phosphoryl)-1,8-bis-(dimethoxy-phosphoryloxy)-octyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
at 130 - 135℃; for 6h;100%
benzalacetophenone
94-41-7

benzalacetophenone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

dimethyl (3-oxo-1,3-diphenylpropyl)phosphonate
56825-91-3

dimethyl (3-oxo-1,3-diphenylpropyl)phosphonate

Conditions
ConditionsYield
With acetic acid100%
pimeloyl chloride
142-79-0

pimeloyl chloride

Dimethyl phosphite
868-85-9

Dimethyl phosphite

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[1,7,7-Tris-(dimethoxy-phosphoryl)-1,7-dihydroxy-heptyl]-phosphonic acid dimethyl ester

[1,7,7-Tris-(dimethoxy-phosphoryl)-1,7-dihydroxy-heptyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
at 60℃; for 8h;100%
pimeloyl chloride
142-79-0

pimeloyl chloride

Dimethyl phosphite
868-85-9

Dimethyl phosphite

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[7-(Dimethoxy-phosphoryl)-1,7-bis-(dimethoxy-phosphoryloxy)-heptyl]-phosphonic acid dimethyl ester

[7-(Dimethoxy-phosphoryl)-1,7-bis-(dimethoxy-phosphoryloxy)-heptyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
at 130 - 135℃; for 6h;100%
azelaoyl chloride
123-98-8

azelaoyl chloride

Dimethyl phosphite
868-85-9

Dimethyl phosphite

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[9-(Dimethoxy-phosphoryl)-1,9-bis-(dimethoxy-phosphoryloxy)-nonyl]-phosphonic acid dimethyl ester

[9-(Dimethoxy-phosphoryl)-1,9-bis-(dimethoxy-phosphoryloxy)-nonyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
at 130 - 135℃; for 6h;100%
sebacoyl chloride
111-19-3

sebacoyl chloride

Dimethyl phosphite
868-85-9

Dimethyl phosphite

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[10-(Dimethoxy-phosphoryl)-1,10-bis-(dimethoxy-phosphoryloxy)-decyl]-phosphonic acid dimethyl ester

[10-(Dimethoxy-phosphoryl)-1,10-bis-(dimethoxy-phosphoryloxy)-decyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
at 130 - 135℃; for 6h;100%
methyl 2-methoxypyrrolidine-1-carboxylate
56475-88-8

methyl 2-methoxypyrrolidine-1-carboxylate

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

2-(Dimethoxy-phosphoryl)-pyrrolidine-1-carboxylic acid methyl ester
80402-79-5

2-(Dimethoxy-phosphoryl)-pyrrolidine-1-carboxylic acid methyl ester

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane for 3.5h; Ambient temperature;100%
4'-chlorochalcone
956-02-5

4'-chlorochalcone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[3-(4-chloro-phenyl)-3-oxo-1-phenyl-propyl]-phosphonic acid dimethyl ester

[3-(4-chloro-phenyl)-3-oxo-1-phenyl-propyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With acetic acid100%
3-phenyl-1-p-tolylprop-2-en-1-one
4224-96-8

3-phenyl-1-p-tolylprop-2-en-1-one

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

(3-Oxo-1-phenyl-3-p-tolyl-propyl)-phosphonic acid dimethyl ester

(3-Oxo-1-phenyl-3-p-tolyl-propyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With acetic acid100%
4-methyl-chalcone
4224-87-7

4-methyl-chalcone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

(3-Oxo-3-phenyl-1-p-tolyl-propyl)-phosphonic acid dimethyl ester

(3-Oxo-3-phenyl-1-p-tolyl-propyl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With acetic acid100%
3-(4-chlorophenyl)-1-phenylprop-2-en-1-one
956-04-7

3-(4-chlorophenyl)-1-phenylprop-2-en-1-one

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[1-(4-Chloro-phenyl)-3-oxo-3-phenyl-propyl]-phosphonic acid dimethyl ester

[1-(4-Chloro-phenyl)-3-oxo-3-phenyl-propyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With acetic acid100%
pimeloyl chloride
142-79-0

pimeloyl chloride

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[7-(Dimethoxy-phosphoryl)-7-oxo-heptanoyl]-phosphonic acid dimethyl ester

[7-(Dimethoxy-phosphoryl)-7-oxo-heptanoyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
for 2h; Ambient temperature;100%
2,2,3,3-tetrafluoropropionaldehyde
756-04-7

2,2,3,3-tetrafluoropropionaldehyde

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

2,2,2-Trimethoxy-3,5-bis-(1,1,2,2-tetrafluoro-ethyl)-2λ5-[1,4,2]dioxaphospholane

2,2,2-Trimethoxy-3,5-bis-(1,1,2,2-tetrafluoro-ethyl)-2λ5-[1,4,2]dioxaphospholane

Conditions
ConditionsYield
In diethyl ether 1) -70 deg C, 0.5 h, then 20 deg C, 1 h;100%
2,2,3,3,4,4,5,5-octafluorovaleraldehyde
2648-47-7

2,2,3,3,4,4,5,5-octafluorovaleraldehyde

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

2,2,2-Trimethoxy-3,5-bis-(1,1,2,2,3,3,4,4-octafluoro-butyl)-2λ5-[1,4,2]dioxaphospholane

2,2,2-Trimethoxy-3,5-bis-(1,1,2,2,3,3,4,4-octafluoro-butyl)-2λ5-[1,4,2]dioxaphospholane

Conditions
ConditionsYield
In diethyl ether 1) -70 deg C, 0.5 h, then 20 deg C, 1 h;100%
N-(carbomethoxy)-α-methoxydimethylamine
76469-93-7

N-(carbomethoxy)-α-methoxydimethylamine

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[(Methoxycarbonyl-methyl-amino)-methyl]-phosphonic acid dimethyl ester
53376-20-8

[(Methoxycarbonyl-methyl-amino)-methyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane for 5h; Ambient temperature;100%
phenyl (β-sec-butylethynyl)iodonium tosylate
92473-43-3

phenyl (β-sec-butylethynyl)iodonium tosylate

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

Dimethyl (sec-butylethynyl)phosphonate
125172-83-0

Dimethyl (sec-butylethynyl)phosphonate

B

methyl p-toluene sulfonate
80-48-8

methyl p-toluene sulfonate

Conditions
ConditionsYield
Ambient temperature;A 63%
B 100%
Bromo-acetic acid (2S,3S,4aR,6S,7R,8aS)-2-acetyl-6-[3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-7-(4-methoxy-benzyloxy)-8a-methyl-octahydro-pyrano[3,2-b]pyran-3-yl ester
131310-84-4, 131310-85-5

Bromo-acetic acid (2S,3S,4aR,6S,7R,8aS)-2-acetyl-6-[3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-7-(4-methoxy-benzyloxy)-8a-methyl-octahydro-pyrano[3,2-b]pyran-3-yl ester

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

(Dimethoxy-phosphoryl)-acetic acid (2S,3S,4aR,6S,7R,8aS)-2-acetyl-6-[3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-7-(4-methoxy-benzyloxy)-8a-methyl-octahydro-pyrano[3,2-b]pyran-3-yl ester
131310-86-6, 131310-87-7

(Dimethoxy-phosphoryl)-acetic acid (2S,3S,4aR,6S,7R,8aS)-2-acetyl-6-[3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-7-(4-methoxy-benzyloxy)-8a-methyl-octahydro-pyrano[3,2-b]pyran-3-yl ester

Conditions
ConditionsYield
at 70℃; for 3h;100%
methyl 2-[2-chloro-1-(chloromethyl)ethylidene]-1-hydrazinecarboxylate
87595-89-9

methyl 2-[2-chloro-1-(chloromethyl)ethylidene]-1-hydrazinecarboxylate

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[3-(Dimethoxy-phosphoryl)-2-(methoxycarbonyl-hydrazono)-propyl]-phosphonic acid dimethyl ester
103517-97-1

[3-(Dimethoxy-phosphoryl)-2-(methoxycarbonyl-hydrazono)-propyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
In toluene for 3h; Heating;100%
2-phenyl-3-(α-chlorobenzyl)quinoxaline
136603-87-7

2-phenyl-3-(α-chlorobenzyl)quinoxaline

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

2-phenyl-3-(O,O-dimethylphosphonobenzyl)quinoxaline
136603-88-8

2-phenyl-3-(O,O-dimethylphosphonobenzyl)quinoxaline

Conditions
ConditionsYield
for 50h; Heating;100%
2,2,3,3,4,4,5,5-octafluoro-5-chloropentanal
88332-86-9

2,2,3,3,4,4,5,5-octafluoro-5-chloropentanal

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

3,5-Bis-(4-chloro-1,1,2,2,3,3,4,4-octafluoro-butyl)-2,2,2-trimethoxy-2λ5-[1,4,2]dioxaphospholane

3,5-Bis-(4-chloro-1,1,2,2,3,3,4,4-octafluoro-butyl)-2,2,2-trimethoxy-2λ5-[1,4,2]dioxaphospholane

Conditions
ConditionsYield
In diethyl ether 1) -70 deg C, 0.5 h, then 20 deg C, 1 h;100%
((2E,6E)-(S)-8-Bromo-1-pentyl-octa-2,6-dien-4-ynyloxy)-tert-butyl-dimethyl-silane
111037-05-9

((2E,6E)-(S)-8-Bromo-1-pentyl-octa-2,6-dien-4-ynyloxy)-tert-butyl-dimethyl-silane

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

[(2E,6E)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-trideca-2,6-dien-4-ynyl]-phosphonic acid dimethyl ester
111037-06-0

[(2E,6E)-(S)-8-(tert-Butyl-dimethyl-silanyloxy)-trideca-2,6-dien-4-ynyl]-phosphonic acid dimethyl ester

Conditions
ConditionsYield
In acetonitrile at 60℃;100%
5,5'-dibromo-4,4'-bis(bromomethyl)-3,3'-bithiophene-2,2'-dicarbaldehyde
158362-56-2

5,5'-dibromo-4,4'-bis(bromomethyl)-3,3'-bithiophene-2,2'-dicarbaldehyde

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

tetramethyl 5,5'-dibromo-2,2'-diformyl-3,3'-bithiophene-4,4'-diylbis(methylphosphonate)
158362-57-3

tetramethyl 5,5'-dibromo-2,2'-diformyl-3,3'-bithiophene-4,4'-diylbis(methylphosphonate)

Conditions
ConditionsYield
for 2h; Heating;100%
for 2h; Heating; Yield given;
phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

trimethyl phosphite
512-56-1

trimethyl phosphite

Conditions
ConditionsYield
With sulfur trioxide In dichloromethane at -95℃;100%
With dihydrogen peroxide In pyridine at -20℃; adding different FeIII compounds; determination of half-lives of reactions;
With naphthalene-1,4-dicarbonitrile; water In water; acetonitrile Irradiation;
phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

O,O,O-trimethylthiophosphate
152-18-1

O,O,O-trimethylthiophosphate

Conditions
ConditionsYield
With benzophenone; 1-thiopropane; hydrogen sulfide In benzene for 15h; Product distribution; Irradiation; variation of reagents and conditions;100%
With pyridine; sulfur 1.) 0 deg C, 1 h, 2.) room temperature, 1 h;70%
With sulfur at 0℃; for 24h;70%
3-chloro-3-phenylphthalide
18852-53-4

3-chloro-3-phenylphthalide

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

3-dimethoxyphosphinoyl-3-phenylphthalide

3-dimethoxyphosphinoyl-3-phenylphthalide

Conditions
ConditionsYield
In acetonitrile at 60℃; for 3h;100%

Trimethyl phosphite Specification

The Trimethyl phosphite, with its CAS registry number 121-45-9, is a kind of clear colorless liquid with a strong foul odor. This chemical is sensitive to air and moisture. It can also be named as fosforyntrojmetylowy;Methyl phosphite ((MeO)3P); P(OCH3)3; Phosphonousacidtrimethylester; Trimethoxyfosfin. As to its usage, it is widely applied in many ways. It could be used as the organic phosphorus pesticide intermediates, such as for the dichlorvos, phosphorous amines and monocrotophos; And it could also be used as flame retardants of plastic and wood, as well as catalyst of synthetic polymer and additive of painting.

Physical properties about Trimethyl phosphite are: (1)ACD/LogP: -0.797; (2)ACD/LogD (pH 5.5): -0.80; (3)ACD/LogD (pH 7.4): -0.80; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 8.78; (7)ACD/KOC (pH 7.4): 8.78; (8)#H bond acceptors:3; (9)#Freely Rotating Bonds: 3; (10)Flash Point: 27.778 °C; (11)Enthalpy of Vaporization: 33.446 kJ/mol; (12)Boiling Point: 110.229 °C at 760 mmHg; (13)Vapour Pressure: 28.1490001678467 mmHg at 25°C

Uses of Trimethyl phosphite: Trimethyl phosphite could react with chloro-triphenyl-methane to produce trityl-phosphonic acid dimethyl ester. This reaction could react in the temperature of 140 - 175 ℃.

When you are dealing with this chemical, you should be very careful. For being a kind of harmful chemical, it may cause damage to health. And it is irritating to eyes, respiratory system and skin and it will be very dangerous if swallowed. Therefore, if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: COP(OC)OC
(2)InChI: InChI=1S/C3H9O3P/c1-4-7(5-2)6-3/h1-3H3
(3)InChIKey: CYTQBVOFDCPGCX-UHFFFAOYSA-N 

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LC inhalation > 32700mg/m3/6 (32700mg/m3) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
National Technical Information Service. Vol. OTS0537047,
mouse LCLo inhalation 32700mg/m3/6H (32700mg/m3) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
National Technical Information Service. Vol. OTS0537047,
mouse LD50 intraperitoneal 4180mg/kg (4180mg/kg)   Environmental Research. Vol. 9, Pg. 1, 1975.
mouse LD50 oral 4280mg/kg (4280mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
National Technical Information Service. Vol. OTS0540442,
rabbit LD50 skin 2600mg/kg (2600mg/kg)   American Industrial Hygiene Association Journal. Vol. 34, Pg. 286, 1973.
rat LCLo inhalation 32700mg/m3/6H (32700mg/m3) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
National Technical Information Service. Vol. OTS0537047,
rat LD50 oral 1600mg/kg (1600mg/kg)   Albright & Wilson Inc. Vol. #OPB-3, Pg. 1984,

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