Product Name

  • Name

    sodium O-acetylsalicylate

  • EINECS
  • CAS No. 493-53-8
  • Article Data9
  • CAS DataBase
  • Density g/cm3
  • Solubility
  • Melting Point 218 °C
  • Formula C9H8 O4 . Na
  • Boiling Point 321.4°Cat760mmHg
  • Molecular Weight 202.142
  • Flash Point 131.2°C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by intraperitoneal and subcutaneous routes. Human systemic effects by intravenous route: unspecified changes in the blood. When heated to decomposition it emits toxic fumes of Na2O. See also ACETOL.
  • Risk Codes
  • Molecular Structure Molecular Structure of 493-53-8 (sodium O-acetylsalicylate)
  • Hazard Symbols
  • Synonyms Benzoicacid, 2-(acetyloxy)-, sodium salt (9CI); Salicylic acid acetate, sodium salt(8CI); Acetylsalicylate sodium; Acetylsalicylic acid, sodium salt; Aspirinsodium salt; Sodium acetylsalicylate; Sodium acetylsalicylic acid; Sodiumaspirin; Sodium o-acetoxybenzoate; Sodium o-acetyloxybenzoate; Sodiumsalicylate (NaO3C7H5), acetate
  • PSA 66.43000
  • LogP -0.02460

Synthetic route

aspirin
50-78-2

aspirin

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; isopropyl alcohol at 20℃; for 3h;88%
With sodium hydride In N,N-dimethyl-formamide for 0.5h;
With sodium carbonate
aspirin
50-78-2

aspirin

sodium bi carbonate

sodium bi carbonate

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

Conditions
ConditionsYield
With water
aspirin
50-78-2

aspirin

sodium carbonate

sodium carbonate

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

Conditions
ConditionsYield
With acetic acid ester
With methanol
With methanol
With acetic acid ester
acetylsalicylic acid sodium salt

acetylsalicylic acid sodium salt

CuCl2 dihydrate

CuCl2 dihydrate

aspirin
50-78-2

aspirin

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

Conditions
ConditionsYield
With sodium hydroxide In water
With sodium hydroxide In water
...Expand
Ti(4+)*2OH(1-)*SO4(2-)=Ti(OH)2SO4

Ti(4+)*2OH(1-)*SO4(2-)=Ti(OH)2SO4

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

(OH)2Ti(IV)(acetylsalicylate)2
294868-46-5

(OH)2Ti(IV)(acetylsalicylate)2

Conditions
ConditionsYield
92%
sodium acetate
127-09-3

sodium acetate

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

2-dipropylaminoethyl acetylsalicylate acetate

2-dipropylaminoethyl acetylsalicylate acetate

Conditions
ConditionsYield
Stage #1: 3-diethylamino-propyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform for 0.5h;
Stage #2: sodium acetate In chloroform for 2h; Product distribution / selectivity;		81.6%
sodium acetate
127-09-3

sodium acetate

2-dipropylaminoethyl bromide hydrobromide
22511-39-3

2-dipropylaminoethyl bromide hydrobromide

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

2-dipropylaminoethyl acetylsalicylate acetate

2-dipropylaminoethyl acetylsalicylate acetate

Conditions
ConditionsYield
Stage #1: 2-dipropylaminoethyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform at 20℃; for 5h;
Stage #2: sodium acetate In chloroform for 2h;		81.6%
Stage #1: 2-dipropylaminoethyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform at 20℃; for 5h;
Stage #2: sodium acetate In chloroform for 2h;		81.6%
Stage #1: 2-dipropylaminoethyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform at 20℃; for 5h;
Stage #2: sodium acetate In chloroform at 20℃; for 2h;
...Expand
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2
52462-29-0

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

[RuCl(κ2O-aspCO2)(η6-p-cymene)]

[RuCl(κ2O-aspCO2)(η6-p-cymene)]

Conditions
ConditionsYield
In methanol at 20℃; for 2.5h; Schlenk technique; Inert atmosphere;79%
bis(cyclopentadienyl)titanium dichloride
1271-19-8

bis(cyclopentadienyl)titanium dichloride

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

(η(5)-cyclopentadienyl)2Ti(IV)(acetylsalicylate)2

(η(5)-cyclopentadienyl)2Ti(IV)(acetylsalicylate)2

Conditions
ConditionsYield
In benzene Na salt and Ti complex refluxed in benzene for 15 h; cooled to room temp., filtered, filtrate concd. in vac., petroleum ether added, placed in refrigerator overnight, filtered, dried in vac. desiccator over P4O10 for 30 h, elem. anal.;78%
In benzene a mixt. of (η-C5H5)2TiCl2 and Na salt of the substituted benzoic acid in anhydrous benzene stirred at 30°C for 4 h; orange soln. filtered, concd., crystn. (refrigerator), recrystd. (benzene);7%
In not given
dibutyltin chloride
683-18-1

dibutyltin chloride

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

nBu2Sn(acetylsalicylic acid(-H))2

nBu2Sn(acetylsalicylic acid(-H))2

Conditions
ConditionsYield
In ethanol Reflux;74%
zinc perchlorate

zinc perchlorate

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

tris(N-benzyl-benzimidazol-2-ylmethyl)amine

tris(N-benzyl-benzimidazol-2-ylmethyl)amine

[(N(CH2(C7H4N2(CH2C6H5)))3)ZnOCO(C6H4(OCOCH3))](1+)*ClO4(1-) = [(N(CH2(C7H4N2(CH2C6H5)))3)ZnOCO(C6H4(OCOCH3))](ClO4)
159665-24-4

[(N(CH2(C7H4N2(CH2C6H5)))3)ZnOCO(C6H4(OCOCH3))](1+)*ClO4(1-) = [(N(CH2(C7H4N2(CH2C6H5)))3)ZnOCO(C6H4(OCOCH3))](ClO4)

Conditions
ConditionsYield
In ethanol soln. of Na-salt and Zn(ClO4)2*6H2O added under stirring to a soln. of the amine; stirred for 4 days; concd. in vacuo, stored for 5 days at -25°C, ppt. washed (cold MeOH), dried in vacuo; elem. anal.;72%
...Expand
zinc perchlorate

zinc perchlorate

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

tris(N-methylbenzimidazol-2-ylmethyl)amine
82137-72-2

tris(N-methylbenzimidazol-2-ylmethyl)amine

[(N(CH2(C7H4N2(CH3)))3)ZnOCO(C6H4(OCOCH3))](1+)*ClO4(1-) = [(N(CH2(C7H4N2(CH3)))3)ZnOCO(C6H4(OCOCH3))](ClO4)
159694-94-7

[(N(CH2(C7H4N2(CH3)))3)ZnOCO(C6H4(OCOCH3))](1+)*ClO4(1-) = [(N(CH2(C7H4N2(CH3)))3)ZnOCO(C6H4(OCOCH3))](ClO4)

Conditions
ConditionsYield
In ethanol soln. of Na-salt and Zn(ClO4)2*6H2O added under stirring to a soln. of the amine; stirred for 4 days; concd. in vacuo, stored for 5 days at -25°C, ppt. washed (cold MeOH), dried in vacuo; elem. anal.;51%
...Expand
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

O2-(chloromethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate
340728-86-1, 960231-74-7

O2-(chloromethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate

C14H17N3O6

C14H17N3O6

Conditions
ConditionsYield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 25℃; for 24h;46%
O2-(chloromethyl)-1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate
858135-02-1

O2-(chloromethyl)-1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

C12H15N3O6

C12H15N3O6

Conditions
ConditionsYield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 25℃; for 24h;40%
zinc perchlorate

zinc perchlorate

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

N,N',N''-tris(2-benzimidazolylmethyl)amine
64019-57-4

N,N',N''-tris(2-benzimidazolylmethyl)amine

[(N(CH2(C7H5N2))3)ZnOCO(C6H4(OCOCH3))](1+)*ClO4(1-) = [(N(CH2(C7H5N2))3)ZnOCO(C6H4(OCOCH3))](ClO4)
159665-20-0

[(N(CH2(C7H5N2))3)ZnOCO(C6H4(OCOCH3))](1+)*ClO4(1-) = [(N(CH2(C7H5N2))3)ZnOCO(C6H4(OCOCH3))](ClO4)

Conditions
ConditionsYield
In ethanol soln. of Na-salt and Zn(ClO4)2*6H2O added under stirring to a soln. of the amine; stirred for 4 days; concd. in vacuo, stored for 5 days at -25°C, ppt. washed (cold MeOH), dried in vacuo; elem. anal.;11%
...Expand
2-chloroacetyl-10-phenoxyacetyl-10H-phenothiazine
58754-72-6

2-chloroacetyl-10-phenoxyacetyl-10H-phenothiazine

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

2-acetoxy-benzoic acid 2-oxo-2-(10-phenoxyacetyl-10H-phenothiazin-2-yl)-ethyl ester
58754-58-8

2-acetoxy-benzoic acid 2-oxo-2-(10-phenoxyacetyl-10H-phenothiazin-2-yl)-ethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 1.5h;
10-chloroacetylphenothiazine
786-50-5

10-chloroacetylphenothiazine

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

2-acetoxy-benzoic acid 2-oxo-2-phenothiazin-10-yl-ethyl ester
58754-68-0

2-acetoxy-benzoic acid 2-oxo-2-phenothiazin-10-yl-ethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 130℃; for 3h;
2-chloroacetylphenothiazine
5325-15-5

2-chloroacetylphenothiazine

sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

2-acetoxy-benzoic acid 2-oxo-2-(10H-phenothiazin-2-yl)-ethyl ester
58754-59-9

2-acetoxy-benzoic acid 2-oxo-2-(10H-phenothiazin-2-yl)-ethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 1h;
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

ethyl bromoacetate
105-36-2

ethyl bromoacetate

Acetylsalicyloylglykolsaeureethylester
50785-24-5

Acetylsalicyloylglykolsaeureethylester

Conditions
ConditionsYield
In water; acetone at 30 - 40℃; Rate constant;
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

O-acetylsalicyloyl chloride
5538-51-2

O-acetylsalicyloyl chloride

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃; for 2.33333h;
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

salicylic acid-(2-nitro-anilide)
37183-26-9

salicylic acid-(2-nitro-anilide)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2 / 2.33 h / 0 - 20 °C
2: 84 percent / benzene / 16 h / Heating
View Scheme
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

N-(4-Chloro-2-nitro-phenyl)-2-hydroxy-benzamide
37399-40-9

N-(4-Chloro-2-nitro-phenyl)-2-hydroxy-benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2 / 2.33 h / 0 - 20 °C
2: 88 percent / benzene / 16 h / Heating
View Scheme
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

(1H-benzo[d][1,2,3]triazol-1-yl)(2-hydroxyphenyl)methanone
347370-91-6

(1H-benzo[d][1,2,3]triazol-1-yl)(2-hydroxyphenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: SOCl2 / 2.33 h / 0 - 20 °C
2: 84 percent / benzene / 16 h / Heating
3: 89 percent / H2 / Pd/C / acetic acid / 20 °C
4: 52 percent / aq. AcOH; NaNO2 / 2 h
View Scheme
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

(2-hydroxy-phenyl)-(5-methyl-benzotriazol-1-yl)-methanone

(2-hydroxy-phenyl)-(5-methyl-benzotriazol-1-yl)-methanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: SOCl2 / 2.33 h / 0 - 20 °C
2: 79 percent / benzene / 16 h / Heating
3: 96 percent / H2 / Pd/C / methanol / 20 °C
4: 96 percent / aq. AcOH; NaNO2 / 2 h
View Scheme
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

N-(4-chloro-2-aminophenyl)salicylamine
403599-67-7

N-(4-chloro-2-aminophenyl)salicylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SOCl2 / 2.33 h / 0 - 20 °C
2: 88 percent / benzene / 16 h / Heating
3: 77 percent / H2 / Raney Ni / methanol / 20 °C
View Scheme
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

N-(4-methyl-2-aminophenyl)salicylamide
403599-66-6

N-(4-methyl-2-aminophenyl)salicylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SOCl2 / 2.33 h / 0 - 20 °C
2: 79 percent / benzene / 16 h / Heating
3: 96 percent / H2 / Pd/C / methanol / 20 °C
View Scheme
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

2-hydroxy-N-(4-methyl-2-nitro-phenyl)-benzamide
403599-64-4

2-hydroxy-N-(4-methyl-2-nitro-phenyl)-benzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: SOCl2 / 2.33 h / 0 - 20 °C
2: 79 percent / benzene / 16 h / Heating
View Scheme
sodium O-acetylsalicylate
493-53-8

sodium O-acetylsalicylate

(5-chloro-benzotriazol-1-yl)-(2-hydroxy-phenyl)-methanone

(5-chloro-benzotriazol-1-yl)-(2-hydroxy-phenyl)-methanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: SOCl2 / 2.33 h / 0 - 20 °C
2: 88 percent / benzene / 16 h / Heating
3: 77 percent / H2 / Raney Ni / methanol / 20 °C
4: 92 percent / aq. AcOH; NaNO2 / 2 h
View Scheme

o-ACETYLSALICYLIC ACID, SODIUM SALT Chemical Properties

O-acetylsalicylic acid, sodium salt has some synonyms like sodium O-acetylsalicylate;2-(Acetyloxy)benzoic acid sodium salt;2-Acetyloxybenzoic acid sodium salt,etc.

Molecular Formula: C9H7NaO4
Molecular Weight: 202.13925
EINECS: 207-777-7

o-ACETYLSALICYLIC ACID, SODIUM SALT Toxicity Data With Reference

1.   

ivn-hmn TDLo:306 µg/kg:BLD

   GWXXBX    German Offenlegungsschrift Patent Document. (U.S. Patent Office, Science Library, 2021 Jefferson Davis Highway, Arlington, VA 22202) #2810425 .
2.   

ipr-rat LD50:1450 mg/kg

   NYKZAU    Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. 79 (1982),357.
3.   

scu-mus LDLo:700 mg/kg

   HDTU**    Pharmakologische Prufung von Analgetika, Gunter Herrlen Dissertation. (Pharmakologischen Institut der Universitat Tubingen, Germany, 1933)1933.
4.   

ipr-mus LDLo:500 mg/kg

   JACSAT    Journal of the American Chemical Society. 63 (1941),1437.
5.   

scu-frg LDLo:909 mg/kg

   HBAMAK    Abdernalden’s Handbuch der Biologischen Arbeitsmethoden. 4 (1935),1290.

o-ACETYLSALICYLIC ACID, SODIUM SALT Safety Profile

O-acetylsalicylic acid, sodium salt  was moderately toxic by intraperitoneal and subcutaneous routes. Human systemic effects by intravenous route: unspecified changes in the blood. When heated to decomposition it emits toxic fumes of Na2O. See also ACETOL.

o-ACETYLSALICYLIC ACID, SODIUM SALT Specification

Storage and transport characteristics:storage house needs to be ventilated ,at low-temperature and dry;O-acetylsalicylic acid, sodium salt  are kept separately with oxidants, acids, food chemical additives.

Extinguishing agent:
Water mist, foam, carbon dioxide, sand

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