tert-Butylamine supplier

Name
tert-Butylamine
EINECS 200-888-1
CAS No. 75-64-9
Article Data165
CAS DataBase
Density 0.744 g/cm³
Solubility miscible with water
Melting Point -67 °C
Formula C₄H₁₁N
Boiling Point 44.399 °C at 760 mmHg
Molecular Weight 73.138
Flash Point -9 °C
Transport Information UN 3286 3/PG 2
Appearance colourless liquid
Safety 16-26-36/37/39-45-28
Risk Codes 11-20/22-35-25
Molecular Structure
Hazard Symbols F,C,T
Synonyms tert-Butylamine(8CI);1,1-Dimethylethanamine;1,1-Dimethylethylamine;1-Amino-1,1-dimethylethane;2-Amino-2-methylpropane;2-Aminoisobutane;2-Methyl-2-aminopropane;2-Methyl-2-propanamine;2-Methyl-2-propylamine;Erbumine;N-tert-Butylamine;NSC 9571;Trimethylaminomethane;t-Butylamine;
PSA 26.02000
LogP 1.44390

Synthetic route

: 4262-38-8
1,3,5,7-Tetra-tert-butyl-2,4,6,8-tetrachloro-[1,3,5,7,2,4,6,8]tetrazatetraborocane

A: 11113-50-1
boric acid

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With water In further solvent(s) byproducts: HCl; solvent cyclohexanol, in tube 20.5 h at 160°C;	A n/a B 97%
With H2O In further solvent(s) byproducts: HCl; solvent cyclohexanol, in tube 20.5 h at 160°C;	A n/a B 97%
With water In xylene byproducts: HCl; in tube 20.5 h boiling;	A n/a B 62%
With H2O In xylene byproducts: HCl; in tube 20.5 h boiling;	A n/a B 62%

: 594-70-7
2-Methyl-2-nitropropane

: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With [Zn(BH4)2(py)] In tetrahydrofuran for 0.67h; Heating;	96%
Stage #1: 2-Methyl-2-nitropropane In water; acetonitrile at 20℃; for 0.0833333h; Stage #2: With sodium tetrahydroborate In water; acetonitrile at 20℃; for 0.5h;	90%
With palladium on activated charcoal; tetrabutylammomium bromide; water; sodium hydroxide; silicon at 100℃; for 6h;	86%

: 1118-12-3
1,1-dimethylethylurea

: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With calcium hydroxide at 240 - 270℃; for 1.5h; other hydroxides as reagent;;	96%
With sodium hydroxide In 2-ethoxy-ethanol; water at 100℃; Kinetics; Rate constant; other temperature; activaction energy;	93%
Hydrolysis;	83%
With sodium hydroxide; ethylene glycol
With 2-ethoxy-ethanol; sodium hydroxide

: 111-86-4
n-Octylamine

: 28227-42-1, 30834-74-3
1,4-di-tert-butyl-1,4-diazabutadiene

A: N,N'-di(n-octyl)ethylenediimine

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With formic acid In water; acetonitrile at 15℃; for 30h;	A 92% B n/a

...Expand

: 60399-04-4
N-(2-hydroxybenzyl)-tert-butylamine

A: C21H18O3

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
at 200 - 230℃; for 0.0833333h; Product distribution; pyrolysis without solvent, product isolated as hydrochloride;	A n/a B 86%

: 28227-42-1, 30834-74-3
1,4-di-tert-butyl-1,4-diazabutadiene

: 613-73-0
1,2-phenylenediacetonitrile

A: 3029-30-9
naphthalene-1,4-dicarbonitrile

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
In dimethyl sulfoxide at 120℃; for 1h;	A 82% B n/a

...Expand

: 507-19-7
t-butyl bromide

: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With 5-methyl-1,3,4-thiadiazol-2-amine; triethylamine In ethanol; water at 25℃; for 1h;	81%

: N‑(tert‑butyl)‑2‑phenylimidazo[1,2‑a]pyridin‑3‑amine

A: 4589-12-2
N-(pyrid-2-yl)benzamide

B: 5336-24-3
1,3-di-tert-butylurea

C: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A 80% B n/a C n/a

...Expand

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 156-87-6
propan-1-ol-3-amine

A: 5638-63-1
5,6-dihydro-4H-[1,3]oxazine

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With silver cyanide at 90℃; for 18h;	A 70% B n/a

...Expand

: 125454-66-2
N-(3-phenylprop-2-yn-1-ylidene)-t-butylamine

: 1192-72-9
4,5-Dimethyl-2(2H)-imidazolinethione

A: 2,3-dimethyl-7-phenyl-5H-imidazo[2,1-b][1,3]-thiazin-5-ol

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
Stage #1: N-(3-phenylprop-2-yn-1-ylidene)-t-butylamine; 4,5-Dimethyl-2(2H)-imidazolinethione In methanol at 60℃; for 0.5h; Stage #2: With water In methanol	A 70% B n/a

...Expand

: 22975-87-7
tert-butyl-(di-tert-butyl-diaziridin-3-ylidene)-amine

A: 683223-12-3
1,2,4-tri(tert-butyl)semicarbazide

B: 13952-69-7
1,2-di-tert-butylhydrazine

C: 75-64-9
tert-butylamine

D: 1609-86-5
Tert-butyl isocyanate

Conditions

Conditions	Yield
With water In 1,4-dioxane for 2h; Reflux;	A 69% B n/a C n/a D n/a

...Expand

: 125454-66-2
N-(3-phenylprop-2-yn-1-ylidene)-t-butylamine

: 2349-58-8
4,5-diphenyl-1H-imidazole-2-thiol

A: 2,3,7-triphenyl-5-imidazolo[2,1-b][1,3]thiazin-5-ol

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
Stage #1: N-(3-phenylprop-2-yn-1-ylidene)-t-butylamine; 4,5-diphenyl-1H-imidazole-2-thiol In methanol at 60℃; for 0.5h; Stage #2: With water In methanol	A 65% B n/a

...Expand

: 1118-17-8
3-tert-Butylamino-3-methyl-1-butyne

A: 2085-66-7
3-tert-Butylamino-tert-pentylamine

B: 40137-02-8
3-tert-Butylamino-3-methyl-1-butene

C: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With hydrogen; Lindlar's catalyst In various solvent(s) at -10℃; under 2585.74 Torr; Catalytic hydrogenation; Hydrogenolysis;	A n/a B 64% C n/a
With hydrogen; W-2 Raney nickel In ethanol Product distribution; Further Variations:; Catalysts; Solvents; Catalytic hydrogenation; Hydrogenolysis;

...Expand

: N-(tert-butyl)-2-(thiophen-3-yl)imidazo[1,2-a]pyridin-3-amine

A: 5336-24-3
1,3-di-tert-butylurea

B: 340258-79-9
N-(pyridin-2-yl)thiophene-3-carboxamide

C: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A n/a B 63% C n/a

...Expand

: 28227-42-1, 30834-74-3
1,4-di-tert-butyl-1,4-diazabutadiene

: 109-73-9
N-butylamine

A: 24764-88-3
butyl[2-(butylimino)ethylidene]amine

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With formic acid In water; acetonitrile at 15℃; for 2h;	A 62% B n/a

...Expand

: 1152035-05-6
2-(3-Bromophenyl)-N-(tert-butyl)imidazo[1,2-a]pyridin-3-amine

A: 5336-24-3
1,3-di-tert-butylurea

B: 75-64-9
tert-butylamine

C: 2-bromo-N-(pyridine-2-yl)benzamide

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A n/a B n/a C 62%

...Expand

: C18H21N3

A: 5336-24-3
1,3-di-tert-butylurea

B: 321943-80-0
3-methyl-N-(pyridin-2-yl)benzamide

C: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A n/a B 61% C n/a

...Expand

: 518015-60-6
N-tert-butyl-2-p-tolyl-1H-imidazo[1,2-a]pyridine-3-amine

A: 5336-24-3
1,3-di-tert-butylurea

B: 14547-80-9
4-methyl-N-(pyridine-2-yl)benzamide

C: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A n/a B 60% C n/a

...Expand

: 857671-17-1
N-tert-butyl-2-(3-methoxyphenyl)imidazo[1,2-a]pyridin-3-amine

A: 5336-24-3
1,3-di-tert-butylurea

B: 114570-45-5
2-methoxy-N-(pyridin-2-yl)benzamide

C: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A n/a B 59% C n/a

...Expand

: N-(tert-butyl)-2-(5-methylfuran-2-yl)imidazo[1,2-a]pyridin-3-amine

A: 99984-52-8
5-methyl-N-(pyridin-2-yl)furan-2-carboxamide

B: 5336-24-3
1,3-di-tert-butylurea

C: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A 59% B n/a C n/a

...Expand

: 853706-94-2
N-(tert-butyl)-2-(2-chlorophenyl)imidazo[1,2-a]pyridin-3-amine

A: 5336-24-3
1,3-di-tert-butylurea

B: 54979-78-1
2-chloro-N-(pyridine-2-yl)benzamide

C: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A n/a B 58% C n/a

...Expand

: C13H19N3

A: 13606-94-5
N-(pyridine-2-yl)propionamide

B: 5336-24-3
1,3-di-tert-butylurea

C: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A 57% B n/a C n/a

...Expand

: 1171753-50-6
N-tert-butyl-2-(3-nitrophenyl)imidazo[1,2-a]pyridin-3-amine

A: 5336-24-3
1,3-di-tert-butylurea

B: 75-64-9
tert-butylamine

C: 85367-01-7
3-nitro-N-(pyridin-2-yl)benzamide

Conditions

Conditions	Yield
With potassium tert-butylate; copper diacetate In m-xylene for 8h; Schlenk technique; Heating; chemoselective reaction;	A n/a B n/a C 56%

...Expand

: 125454-66-2
N-(3-phenylprop-2-yn-1-ylidene)-t-butylamine

: 6857-34-7
2-mercapto-4(5)-phenylimidazole

A: 2,7-diphenyl-5H-imidazolo[2,1-b][1,3]thiazin-5-ol

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
Stage #1: N-(3-phenylprop-2-yn-1-ylidene)-t-butylamine; 2-mercapto-4(5)-phenylimidazole In methanol at 60℃; for 0.5h; Stage #2: With water In methanol	A 50% B n/a

...Expand

: 105887-09-0
(E)-3-Phenyl-acrylic acid 1-tert-butylcarbamoyl-1-methyl-2-oxo-propyl ester

A: 105887-13-6
N-tert.butyl 2-acetyl 2-hydroxy propanamide

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride In tetrahydrofuran for 72h; Heating;	A 45% B n/a

: 115-11-7
isobutene

: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
With ammonia; zeolite BEA (Si/Al ratio of 12.5) at 250℃; under 22502.3 Torr; Product distribution / selectivity;	44.78%
With ammonia; MF114 zeolite at 274.9℃; under 30002.4 Torr;	8.9%
With ammonia; sodium at 250℃; under 661957 Torr;

: 3378-72-1
N-tert-butylbenzylamine

: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
Stage #1: N-tert-butylbenzylamine With rhodium(III) tetra(p-sulfonato-phenyl)porphyrin; oxygen; benzaldehyde In methanol; water at 100℃; under 750.075 Torr; for 6h; Stage #2: With hydrogenchloride In methanol; water at 80℃; Catalytic behavior;	24.5%

: 7515-80-2
N-isopropyl-N-tert-butylamine

: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
Stage #1: N-isopropyl-N-tert-butylamine With rhodium(III) tetra(p-sulfonato-phenyl)porphyrin; oxygen; benzaldehyde In methanol; water at 100℃; under 750.075 Torr; for 6h; Stage #2: With hydrogenchloride In methanol; water at 80℃; Catalytic behavior;	22%

: 10375-18-5
Bis-tert.-butylamino-phenylboran

A: 118331-74-1
(t-butylimino)phenylborane

B: 75-64-9
tert-butylamine

Conditions

Conditions	Yield
	A n/a B 12%
	A n/a B 12%

: 100-52-7
benzaldehyde

: 75-64-9
tert-butylamine

: 6852-58-0
N-benzylidene tert-butylamine

Conditions

Conditions	Yield
In dichloromethane for 18h; Molecular sieve;	100%
at 20℃; for 2h;	100%
In dichloromethane at 20℃; for 4h;	100%

: 75-64-9
tert-butylamine

: 594-70-7
2-Methyl-2-nitropropane

Conditions

Conditions	Yield
With dihydrogen peroxide; Na12[WZn3(H2O)2(ZnW9O34)2] at 75℃; for 7h;	100%
With potassium permanganate In water 1.) 11 deg C -> room temperature, 8 h, 2.) 55 deg C, 18 h;	78%
With sodium permanganate In hexane at 69℃; for 24h;	76%

: 108-31-6
maleic anhydride

: 75-64-9
tert-butylamine

: 32350-46-2
(Z)-4-(tert-butylamino)-4-oxo-2-butenoic acid

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h;	100%
In toluene at 45 - 50℃; for 1h;	94%
In diethyl ether at 20℃;	89%

: 108-30-5
succinic acid anhydride

: 75-64-9
tert-butylamine

: 6622-06-6
4-(tert-butylamino)-4-oxobutanoic acid

Conditions

Conditions	Yield
Stage #1: succinic acid anhydride; tert-butylamine In N,N-dimethyl acetamide at 20℃; for 24h; Stage #2: In N,N-dimethyl acetamide; xylene at 140℃; for 48h;	100%
In dichloromethane at 20℃; for 1h;	52%
Stage #1: succinic acid anhydride; tert-butylamine In dichloromethane at 20℃; for 1h; Stage #2: With sodium hydroxide In water at 20℃; for 2h; Stage #3: With hydrogenchloride In water at 0℃;	52%

: 100-07-2
4-methoxy-benzoyl chloride

: 75-64-9
tert-butylamine

: 19486-73-8
N-tert-butyl-4-methoxybenzamide

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane	100%
With dmap; sodium hydroxide In dichloromethane at 0 - 20℃;	100%
In tetrahydrofuran at 0℃;	86%

: 4504-12-5
ethyl 5-oxo-2-phenyl-2,5-dihydroisoxazole-4-carboxaldehyde

: 75-64-9
tert-butylamine

: 31081-02-4
ethyl (N-t-butylcarbamoyl)(N-phenylcarbamoyl)acetate

Conditions

Conditions	Yield
In acetone at 25℃;	100%

: 75-64-9
tert-butylamine

: 98-09-9
benzenesulfonyl chloride

: 2512-24-5
N-tert-butylbenzenesulfonamide

Conditions

Conditions	Yield
In chloroform at 0℃;	100%
With hydrogenchloride In dichloromethane at 0 - 20℃; for 0.666667h;	97%
With triethylamine In dichloromethane at 20℃;	95%

: 122-60-1
Phenyl glycidyl ether

: 75-64-9
tert-butylamine

: 64980-40-1
1-(N-tert-butyl)amino-3-phenoxy-2-propanol

Conditions

Conditions	Yield
In 2,2,2-trifluoroethanol at 20℃; for 6h; regioselective reaction;	100%
With lithium perchlorate In diethyl ether at 20℃; for 0.5h;	96%
In water at 0 - 20℃;	96%

: 70-34-8
2,4-Dinitrofluorobenzene

: 75-64-9
tert-butylamine

: 13059-89-7
N-tert-butyl-2,4-dinitro-aniline

Conditions

Conditions	Yield
With 2-hydroxypyridin In benzene at 25℃; Rate constant; other catalysts, other solvents, var. conc. of catalysts;	100%

: 1122-91-4
4-bromo-benzaldehyde

: 75-64-9
tert-butylamine

: 62058-76-8
N-(4-bromobenzylidene)-2-methylpropan-2-amine

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 4h;	100%
With 4 A molecular sieve for 24h; Ambient temperature;	97%
With titanium tetrachloride In diethyl ether; toluene at 0℃; for 0.25h; Glovebox; Inert atmosphere; Schlenk technique;	86%
at 100℃; Schlenk technique;
In 1,2-dichloro-ethane at 70℃; for 4h; Glovebox;

: 50-00-0
formaldehyd

: 60829-54-1
2,2,5,5-tetramethyl-4-nitromethyleneimidazolidine-1-oxyl

: 75-64-9
tert-butylamine

: C14H25N4O3

Conditions

Conditions	Yield
In methanol; water	100%

...Expand

: 19519-59-6
2-chloroacetylenephosphonic acid dimethyl ester

: 75-64-9
tert-butylamine

: 85829-45-4
dimethyl <2-(tert-butylimino)vinyl>phosphonate

Conditions

Conditions	Yield
	100%
In diethyl ether for 2h; Ambient temperature;	98%
In diethyl ether at -10 - 20℃;	98%
In diethyl ether at -5 - 20℃; for 2h;	98%

: 35673-10-0
bis(3-(trifluoromethyl)benzenesulfonyl) peroxide

: 75-64-9
tert-butylamine

A: 85462-15-3
N-t-Butyl-O-m-trifluoromethylbenzenesulfonylhydroxylamine

B: 3-Trifluoromethyl-benzenesulfonic acid; compound with tert-butylamine

Conditions

Conditions	Yield
In diethyl ether at -78℃; for 2h;	A 90% B 100%

...Expand

: 68654-16-0
6-methylhepto-5-enal

: 75-64-9
tert-butylamine

: 128266-08-0
6-methylhept-5-en-1-al tert-butylimine

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 1.5h;	100%

: 6209-72-9
4-nitrobenzenesulfonyl peroxide

: 75-64-9
tert-butylamine

A: 85462-14-2
C10H14N2O5S

B: 4-Nitro-benzenesulfonic acid; compound with tert-butylamine

Conditions

Conditions	Yield
In diethyl ether at -78℃; for 2h;	A 87% B 100%

...Expand

: 50777-76-9
(2-formylphenyl)(diphenyl)phosphine

: 75-64-9
tert-butylamine

: 100350-40-1
N-(tert-butyl)-2-[(diphenylphosphino)benzylidene]amine

Conditions

Conditions	Yield
In methanol; dichloromethane at 20℃; for 2h; Inert atmosphere;	100%
In toluene at 150 - 160℃; for 6h; Inert atmosphere;	96%
With molecular sieve for 2h; Heating;	93%
In toluene at 110℃; for 18h; Inert atmosphere; Molecular sieve; Sealed tube; Schlenk technique;	73%
Heating;

: 80360-20-9
1-(phenylsulfonyl)indole-3-carbaldehyde

: 75-64-9
tert-butylamine

: 136878-55-2
3-((tert-butylimino)methyl)-1-(phenylsulfonyl)indole

Conditions

Conditions	Yield
In benzene for 24h; Heating;	100%
In benzene 1.) RT, 1 h, 2.) reflux, 2 h;

: 111252-28-9
N-<2,4,6-tri(tert-butyl)phenyl>phosphenimidous acid 2,6-di-tert-butyl-4-methylphenyl ester

: 75-64-9
tert-butylamine

: O-(2,6-di-tert-butyl-4-methylphenyl)-N-tert-butyl-N'-<2,4,6-tri(tert-butyl)phenyl>amidophosphite

Conditions

Conditions	Yield
In benzene for 240h;	100%
In diethyl ether at 20℃;	100 % Spectr.

: 128346-30-5
(2-formylphenyl)butyl tellurium dibromide

: 75-64-9
tert-butylamine

: 130191-27-4
2-(tert-butyliminomethinyl)phenyltellurenyl bromide

Conditions

Conditions	Yield
With trifluoroacetic acid In benzene	100%

: 125556-28-7
(Z)-6,10-Dimethyl-5,9-undecadienal

: 75-64-9
tert-butylamine

: 125556-25-4
(Z)-6,10-Dimethyl-5,9-undecadienal tert-butylimine

Conditions

Conditions	Yield
In diethyl ether 1.) -10 deg C, 30 min, 2.) room temp., 1.5 h;	100%
In diethyl ether at 20℃; for 1.5h;

: C17H25N2O(1+)*BF4(1-)

: 75-64-9
tert-butylamine

: C19H29N3*BF4(1-)*H(1+)

Conditions

Conditions	Yield
	100%

: 133828-22-5
1,2,2,5,5,6,6-heptamethyl-3-methylene-4-piperidone

: 75-64-9
tert-butylamine

: 134614-31-6
1,2,2,3,3,6,6-heptamethyl-5-tert-butylaminomethyl-4-piperidone

Conditions

Conditions	Yield
In ethanol at 25℃; for 168h;	100%

: 73452-24-1
N-(bis-p-methoxyphenylphosphinoyl)-O-methylsulphonylhydroxylamine

: 75-64-9
tert-butylamine

: 73452-27-4
N',P-bis-p-methoxyphenyl-N-t-butylphosphonic diamide

Conditions

Conditions	Yield
	100%

: 75-64-9
tert-butylamine

: 824-94-2
p-methoxybenzyl chloride

: 22675-83-8
N-(p-methoxybenzyl)-N-tert-butylamine

Conditions

Conditions	Yield
	100%
With sodium carbonate; sodium iodide In N,N-dimethyl-formamide at 65℃; for 4h; Inert atmosphere;	56%
In N,N-dimethyl-formamide for 6h; Yield given;

: 75-64-9
tert-butylamine

: 3127-08-0
bis(hydroxymethyl)phenylphosphine

: 139604-87-8
1,5-Di(tert-butyl)-3,7-diphenyl-1,5-diaza-3,7-diphosphacyclooctane

Conditions

Conditions	Yield
In ethanol	100%

: 75-64-9
tert-butylamine

: 1620-98-0
3,5-di-t-butyl-4-hydroxybenzaldehyde

: 71530-29-5
4-<(N-tert-butylimino)methyl>-2,6-di-tert-butylphenyl

Conditions

Conditions	Yield
In ethanol for 3h; Heating;	100%

: 75-64-9
tert-butylamine

: 161868-74-2
1,1-dichloro-5-aza-2,8-dioxa-1-phosphaV-dibenzo<9,9',11,11'-tetra-tert-butyl>-bicyclo<3.3.0>octadiene

: 1,1-di-tert-butylamino-5-aza-2,8-dioxa-1-phosphaV-dibenzo<9,9',11,11'-tetra-tert-butyl>-bicyclo<3.3.0>octadiene

Conditions

Conditions	Yield
In benzene for 2h; Ambient temperature;	100%

: 5535-48-8
PVS

: 75-64-9
tert-butylamine

: 16191-98-3
2-methyl-N-[2-(phenylsulfonyl)ethyl]propan-2-amine

Conditions

Conditions	Yield
In dichloromethane at 20℃;	100%
In ethanol at 20℃; Cooling with ice;	81%

: 75-64-9
tert-butylamine

: 221636-53-9
N,N-dimethyl-5,7-bis(trifluoroacetyl)-8-quinolylamine

: 1-[8-tert-Butylamino-5-(2,2,2-trifluoro-acetyl)-quinolin-7-yl]-2,2,2-trifluoro-ethanone

Conditions

Conditions	Yield
In acetonitrile at 50℃; for 72h;	100%
In acetonitrile at 50℃; for 72h; Substitution;	100%

: 75-15-0
carbon disulfide

: 75-64-9
tert-butylamine

: 4041-95-6
N,N-di-tert-butylthiourea

Conditions

Conditions	Yield
aluminum oxide; zinc(II) oxide at 100℃; for 2h; Condensation;	100%
In water at 20℃; for 1h; Green chemistry;	93%
In water at 20℃; for 1h; Green chemistry;	93%
Stage #1: carbon disulfide; tert-butylamine In water at 35℃; for 1h; Large scale; Stage #2: With dihydrogen peroxide In vaseline at 65℃; for 2h; Temperature; Large scale;

tert-Butylamine Consensus Reports

Reported in EPA TSCA Inventory.

tert-Butylamine Standards and Recommendations

DFG MAK: 5 ppm (15 mg/m³)
DOT Classification: 8; Label: Corrosive, Flammable Liquid (UN 2734); DOT Class: 3; Label: Flammable Liquid, Corrosive (UN 2733)

tert-Butylamine Specification

The tert-Butylamine, with the CAS registry number 75-64-9, is also known as 2-Amino-2-methylpropane. Its EINECS registry number is 200-888-1. This chemical's molecular formula is C₄H₁₁N and molecular weight is 73.14. What's more, both its IUPAC name and systematic name are the same which is called 2-Methylpropan-2-amine. Its classification code is Human Data. The production is an organic chemical compound (specifically, an amine) and occurs as a colorless liquid. It is one of the four isomeric amines of butane, the others being n-Butylamine, sec-Butylamine and Isobutylamine. In addition, it should be kept in a cool and ventilated place.

Physical properties about tert-Butylamine are: (1)ACD/LogP: 0.80; (2)# of Rule of 5 Violations: 0; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 1; (6)ACD/KOC (pH 7.4): 1; (7)#H bond acceptors: 1; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 1; (10)Polar Surface Area: 26.02 Å²; (11)Index of Refraction: 1.405; (12)Molar Refractivity: 24.081 cm³; (13)Molar Volume: 98.288 cm³; (14)Surface Tension: 23.076 dyne/cm; (15) Density: 0.744 g/cm³; (16)Enthalpy of Vaporization: 28.27 kJ/mol; (17)Boiling Point: 44.399 °C at 760 mmHg; (18)Vapour Pressure: 362.95 mmHg at 25 °C.

Preparation of tert-Butylamine: this chemical can be prepared by tert-Butyl-ure. This reaction needs reagent ethylene glycol and solvents H₂SO₄, HCN.

(CH₃)₂C=CH₂ + HCN + H₂SO₄ + 2H₂O → (CH₃)₃CNH₂ · H₂SO₄ + HCOOH

(CH₃)₃CNH₂ · H₂SO₄ + NH₃ → (CH₃)₃CNH₂ + NH₄HSO₄

Uses of tert-Butylamine: (1) it is used as an intermediate in the preparation of rubber accelerators, pesticides, pharmaceuticals, dyes and other organic compounds; (2) it is used to produce other chemicals. For example, it is used to produce N-tert-Butyl-acetamide. The reaction occurs with solvent tetrahydrofuran and other condition of heating for 25 hours. The yield is 97 %.

tert-Butylamine is used to produce N-tert-Butyl-acetamide.

When you are dealing with this chemical, you should be very careful. This chemical may destroy living tissue on contacting. In addition, this chemical is highly flammable and it is harmful by inhalation. What's more, it is toxic if swallowed. Therefore, you should wear suitable protective clothing, gloves and eye/face protection. And in case of contacting with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1) SMILES: CC(C)(C)N
(2) InChI: InChI=1S/C4H11N/c1-4(2,3)5/h5H2,1-3H3
(3) InChIKey: YBRBMKDOPFTVDT-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TCLo	inhalation	40mg/m³/8H-I (40mg/m³)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE	British Journal of Industrial Medicine. Vol. 48, Pg. 26, 1991.
mouse	LD50	unreported	378mg/kg (378mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(12), Pg. 70, 1985.
rabbit	LD50	unreported	375mg/kg (375mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(12), Pg. 70, 1985.
rabbit	LDLo	skin	2gm/kg (2000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: OTHER CHANGES	National Technical Information Service. Vol. OTS0570521,
rat	LC50	inhalation	3800mg/m³/4H (3800mg/m³)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: HEMORRHAGE	National Technical Information Service. Vol. OTS0570798,
rat	LD50	oral	44mg/kg (44mg/kg)	BEHAVIORAL: FOOD INTAKE (ANIMAL) LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI LIVER: OTHER CHANGES	National Technical Information Service. Vol. OTS0534846,
rat	LD50	unreported	450mg/kg (450mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 50(12), Pg. 70, 1985.

Product Name

tert-Butylamine

Synthetic route

tert-Butylamine Consensus Reports

tert-Butylamine Standards and Recommendations

tert-Butylamine Specification

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