Three new manganese(II) complexes of 2-hydroxymethylbenzimidazole [Mn(hmbzim)2(NCS)2] (1), [Mn2(hmbzim)4(μ1,1-N3)2](NO3)2 (2) and [Mn(hmbzim)2(dca)2]n (3) were synthesized and characterised. On the basis of structural data, the influence of pseudohalide ions on a final complex structure and rol...

Mn doped zirconia is utilized as an environmental-friendly and efficient catalyst for an ultrasound mediated four-component coupling reaction, containing dimethylacetylenedicarboxylate/ethyl acetoacetate, hydrazine hydrate, malononitrile, and aromatic aldehyde. These reactions were performed und...

Ethyl 6-amino-4-aryl-5-cyano-2,4-dihydropyrano[2,3-с]pyrazole-3-carboxylates were synthesized via a four-component reaction of the sodium salt of diethyloxaloacetate, an aromatic aldehyde, hydrazine hydrate, and malononitrile. The products were obtained in moderate to high yields.

We describe a one-pot four component synthesis of pyranopyroles from aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of catalytic amounts of an organocatalyst imidazole in water as medium. A plausible mechanism for the formation of imidazole catalyzed pyra...

Recently, the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) have been considered as promising targets for the treatment of cancer. Herein, we synthesized a series of N-(5-(quinolin-6-yl)pyridin-3-yl)benzenesulfonamides as novel PI3K/mTOR dual inhibitors for cancer the...

A series of indazol-2-yl(pyridin-4-yl)methanones, 4 were acquired from 2,6-bisbenzylidene cyclohexanones, 3 and anti-tubercular drug (isoniazid), and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate a...

A synthesis of 3-(pyridin-2-yl)dihydro-1,2,4-triazinone (1) is achieved utilizing the appropriate “in situ generated” nitrile imine 1,3-dipole. In solution, compound 1 rapidly reacts with dichlorobis(benzonitrile)palladium(II) to form dichloro[3-(pyridin-2-yl)dihydro-1,2,4-triazinone]palladium...

A series of novel 4-chloro-benzamides derivatives containing substituted five-membered heteroaryl ring were designed, synthesized and evaluated as RET kinase inhibitors for cancer therapy. Most of compounds exhibited moderate to high potency in ELISA-based kinase assay. In particular, compound I...

Four metal dithiocarbamate complexes (Zn, Ni, Hg and Sn) based on an amine containing pyridyl and nitrile groups, 3-((pyridin-2-yl)methylamino)propanenitrile, were prepared and characterized by their elemental analysis, spectroscopic data (such as IR, 1H and 13C NMR), TGA analysis and X-ray crys...

Self-assembly of transition metal salts with long bifunctional ligand affords three entangled coordination frameworks, namely, [Co(ppmba)2] (1), [Zn(ppmba)2]·0.5H2O (2) and [Cd(ppmba)2]·0.25H2O (3) (Hppmba = 4-((3-(pyridin-4-yl)-1H-pyrazol-1-yl)methyl)benzoic acid). Their structures were deter...

Nicotinamide phosphoribosyltransferase (NAMPT) has emerged as a promising target for the discovery of anticancer drugs. Based on NAMPT inhibitor FK866 that has been advanced into phase II trial, we identified a trans-3-(pyridin-3-yl)acrylamide compound 13 incorporating with a biarylsulfanilamide...

An attempt to use 1,5-diamino-4,8-dihydroxyanthraquinone (1) as a precursor to synthesize bisazo pigments, by an azotization-coupling reaction sequence, is reported. The tetrazotization of 1, by a slight excess of sodium nitrite, is effective both in concentrated hydrochloric acid and concentrat...

Three kinetic methods for the determination of manganese, two of them by photometric monitoring and another by fluorimetric monitoring, based on the oxidation of sodium 4,8-diamino-1,5-dihydroxyanthraquinone-2,6-disulphonate are described. A critical comparative evaluation of both monitoring tec...

Surface-enhanced Raman scattering studies on 1,5-dihydroxyanthraquinone (1,5-DHAQ) were undertaken to elucidate the molecular orientation on the silver particles and the enhancement mechanism. The 1,5-DHAQ molecule is adsorbed through its coordinating sites (CO groups) and it is found to have ...

1,5-Dihydroxyanthraquinone (1,5-DHAQ) and in the presence of β-cyclodextrin (β-CD) has been used to find Fe3 + ion in aqueous solution by UV–visible and fluorescence spectroscopy. The chromo-fluorogenic probe undergoes absorption and emission intensity enhancement upon binding to Fe3 + ion in...

Poly(1-amino-5-chloroanthraquinone) (PACA) nanofibrils were applied as new nano-adsorbents for heavy metal removal from aqueous solutions. Adsorption properties including adsorption capacity, selectivity, kinetics, mechanism, and isotherm of PACA nanofibrils were studied in detail. The competiti...

Using an isolated muscle bath technique, five different segments of the rabbit gastrointestinal tract (duodenum, jejunum, ileum, and ascending and descending colon) were used to record the effects of two doses of 1,5-dihydroxyanthraquinone. Transducer-recorded tracings were made of contractions ...

Complex formation between cyclodextrins and 1,8-dihy-droxyanthraquinone in buffer solution has been investigated using absorption, its second derivative (D2), and fluorescence spectroscopy. The results showed that whereas the self-association process was found for 1,8-dihydroxyanthraquinone alon...

The Raman spectra and excitation profiles of solid 1,8-dihydroxyanthraquinone at 8 K have been measured. Their analysis together with the absorption and fluorescence spectra allowed us to individuate the existence of four electronic transitions in the visible region. For the two highest energy t...

In this work, the synthesis of molecular materials formed from A2[TiO(C2O4)2] (A = K, PPh4) and 1,8 dihydroxyanthraquinone is reported. The synthesized materials were characterized by atomic force microscopy (AFM), infrared (IR) and ultraviolet-visible (UV–vis) spectroscopy. IR spectroscopy sho...