We demonstrate a novel strategy to produce (R)-3-hydroxybutyric acid [(R)-3-HB] using Pseudomonas sp. DS1001a or its extracellular poly (3-hydroxybutyrate) (PHB) depolymerase. While approximately 77.8% PHB was degraded by Pseudomonas sp. DS1001a after 12 h of cultivation, only 1.555 g/l of 3-HB ...

The aim of this work was to investigate the use of zinc oxide nanoparticles (nZnO) as nanocarriers for plant auxins indole-3-acetic acid (IAA) and indole-3-butyric acid (IBA) and determine the effects on rhizogenesis in micro cuttings of different Pyrus species. Auxin loaded nanoparticles (IAA-n...

(R)-3-amino-1-butanol is a key intermediate of Dolutegravir for the treatment of HIV/AIDS and its green and efficient biosynthesis has attracted a great deal of attention. Transaminases are currently used as promising biocatalyst for the synthesis of chiral amines. However, many transaminases ha...

Background and aimsPopulation-based studies often use plasma fatty acids (FAs) as objective indicators of FA intake, especially for n-3 FA and linoleic acid (LA). The relation between dietary and circulating FA in cardiometabolic patients is largely unknown. We examined whether dietary n-3 FA an...

The enantioselective transport of amino acids as their sodium and potassium salts has been investigated by optically active diaza crown ethers. The reversed enantioselectivity of chiral crown ether 1 was observed.

The asymmetric synthesis of 3-alkyl-3-hydroxyindolin-2-ones via direct aldol reaction of isatin with ketones catalyzed by natural amino acid salts is described, in which the phenylalanine lithium salt was found to be the best catalyst. This strategy was then applied to a variety of isatin and ke...

Four chiral lariat ethers 8–11 containing a (p-methoxyphenoxy) methyl side arm were used for chiral discrimination of amino acids in their zwitterionic form or as potassium and sodium salts in transport across a bulk chloroform membrane with satisfactory selectivity. The carriers that were empl...

The extraction equilibria of α-phenylglycine in alkaline solutions with tri-n-octylmethylammonium chloride (TOMAC) (10%, v/v) in 1-decanol as diluent have been studied. Hydroxide anion and water co-extraction were also investigated. Equilibrium constants for the extraction of phenylglycine and ...

The synthesis of α-substituted N-[((2S)-2-hydroxy-2-phenyl)-ethyl]-2-phenylglycine derivatives is reported. The key step of the sequence is the highly diastereoselective alkylation of (6R)-2,3,5,6-tetrahydro-3,6-diaryl-N-[(2′R)-(2′-methyl)phenylmethyl]-4H-1,4-oxazin-2-ones after deprotonation...

The adsorption of the potassium salt of N-phenylglycine (KNPG) on synthetic hydroxyapatite from aqueous and ethanol solutions was studied at 22°C. The adsorption isotherm of KNPG from aqueous solutions is Langmuirian in shape, and the analysis showed that one glycinate ion was adsorbed per abou...

Phenylglycine, the simplest aromatic amino acid is interesting because of its potential applications as medical agent involved in the alkali ions transport in the biological and medical systems. Rather scarce structural and spectroscopic data concerning this molecule encouraged us to study a cry...

Infrared spectra from complexes of 2-chloro-4-nitrobenzoic acid and some amines with proton affinities (PA) ranging from 205.9 to 229.4 kcal mol−1 are studied. A characteristic relationship between the center of gravity of the infrared protonic vibrational band and proton affinity is obtained. A...

Publisher SummaryThis chapter discusses the analytical profile of lobeline hydrochloride. Lobeline is one of the pyridine-piperidine alkaloids. Its chemical structure was proposed by Wieland and co-workers, and has been confirmed by the total synthesis of the alkaloid, which was first carried ou...

Treatment of aryl and heteroaryl halides with catalytic amounts of Pd/C in the presence of hydrazine hydrochloride in basic medium (sodium hydroxide or sodium t-butylate) at room temperature leads to the corresponding hydrodehalogenation products with high selectivity. Aryl iodides, bromides, ch...

N-(3-Pyridinyl)-substituted secondary and tertiary sulfonamides have been synthesized in good to excellent yields by the reaction of 3-bromopyridine with primary and secondary alkyl and aryl sulfonamides (MeSO2NH2, MeSO2NHMe, TolSO2NH2, TolSO2NHMe, 1,3-propanesultam, and 1,4-butanesultam), catal...

Aminodefluorination of 2-n-butylamino- and 2-diethylaminopentafluoro-1,4-naphthoquinone by alkylamines HNR1R2 (NR1R2 = NHEt, NHnBu and NEt2) occurs at the 6- or 8-position and further, accordingly, at the 8- or at one of the 5- and 6-sites. The isomer ratio changes significantly in favor of a β...

Four new n-butylamino and two sulfur-containing derivatives of polyfluoro-1,4-naphthoquinone were synthesized and their mutagenic and antioxidant properties in Salmonella cells, as well as the cytotoxicity in human myeloma (RPMI 8226), human mammary adenocarcinoma (MCF-7), mouse fibroblasts (LMT...

This chapter discusses the individual pyrolysis of a number of α-amino acids including alanine, arginine, asparagine, aspartic acid, cysteine, cysteine, glutamic acid, glutamine, glycine, histidine, hydroxylysine, hydroxyproline, isoleucine, leucine, lysine, methionine, phenylalanine, proline, ...

The drug action of ester type local anesthetic (LA) procaine hydrochloride (PRC HCl) is activated by blocking Na+ ion flow when it binds to the ion channel in the ligand gated sodium ion channel protein. Büchi's model, explains binding action of ester type LA drug with receptor in terms of...

Native collagen cannot be dissolved in neutral pH buffer, limiting its application in many fields. The traditional method to prepare water-soluble collagen is succinylation modification, which causes the decrease in the thermal stability. Therefore, poly(γ-glutamic acid)-N-hydroxysuccinimide (γ...