A series of 1,3-bis(2-alkyltetrazol-5-yl)triazenes have been synthesized in high yields by treatment of sodium nitrite and hydrochloric acid with substituted-5-aminotetrazoles. All compounds were fully characterized using IR spectroscopy, 1H NMR and 13C NMR spectroscopy and high resolution mass ...

Two novel 1,3-bis[tris(hydroxymethyl)methylamino]propane (H6L) functionalized 3d-4f heterometallic arsenotungstates (ATs) [H2N(CH3)2]5Na2H4[Cu(H2L)]{[Ln0.5Na1.5Cu3(H2O)5](AsW9O33)2}·17H2O [Ln = HoIII (1), YbIII (2)] have been synthesized in conventional aqueous solution by using simple material...

New thiourea derivatives incorporating two benzo[d][1,3]dioxol-5-yl moieties have been synthesized through the reaction of two molecules of benzo[d][1,3]dioxol-5-yl isothiocyanate with one molecule of various diamino derivatives. The synthesized compounds were examined for their cytotoxic effect...

The syntheses, characterizations and structures of three novel dichloro(bis{2-[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl-κN3]pyridine-κN})metal(II), [M(L)2Cl2], complexes (metal = Mn, Co and Ni) are presented. In the solid state the molecules are arranged in infinite hydrogen-bonded 3D supramo...

A protonated third-order nonlinear optical crystal, (4-Methoxyphenyl) methanaminium chloride (4MPMAC) has been synthesized by the low-temperature solvent evaporation method. Single crystal X-ray diffraction (SCXRD) analysis reveals the monoclinic crystal system with centrosymmetric space group, ...

A readily accessible trans-chloro-(1-naphthyl)bis-[tris-(4-methoxyphenyl)phosphine]-nickel(II) [NiCl(MOTPP)2(1-naphthyl)] complex was prepared and applied successfully to the Suzuki-Miyaura coupling of aryl chlorides with phenylboronic acid. The pre-catalyst readily forms the catalytically activ...

Diethyl 1,1-cyclopropanedicarboxylate undergoes nucleophilic ring opening with Na2Fe(CO)4·32 dioxane under CO at room temperature to produce a variety of carbonylated products

The oxidation of diethyl ω-phenylalkenylmalonates by Mn(III) acetate in acetic acid and Fe(III) perchlorate nonahydrate in acetonitrile or acetonitrile/acetic anhydride is investigated. Diethyl cinnamylmalonates 1, 2 and 3 afford intramolecular addition products to the double bond (cyclopropane...

Several novel chalcone derivatives containing malonate and pyridine moieties were synthesized, and their structures were confirmed by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, 19F nuclear magnetic resonance, infrared, and elemental analyses. Antiviral bioassays revealed that...

The synthesis in 4 steps of new N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines issued from various symmetric primary diamines as linkers was reported. The key step of our strategy has been the sulphur/nitrogen displacement of (5Z)-5-arylidene-2-ethylsulfanyl-3,5-dihydro-4H-imi...

Two novel cross-linked polystyrene-supported N-sulfonylated β-aminoalcohol resins 13 and 14 have been prepared from radical co-polymerizations of styrene, divinylbenzene, and styrenes bearing a para-substituent of N-sulfonylated aminoalcohol. Resins 13 and 14 were obtained in high yields of 85....

Asymmetric synthesis of (S)-N-(1-arylethyl)-N-hydroxyureas, (S)-N-(6-methoxy)- and (S)-N-(6-benzyloxy-2,3-dihydrobenzofuran-3-yl)-N-hydroxyurea— lipoxygenase inhibitor, is described. Three approaches to the formation of the N-hydroxyurea moiety at the stereogenic center have been used. The firs...

A one-pot tandem direct reductive amination of aldehydes with primary amines resulting in N-Boc secondary amines using a (Boc)2O/sodium triacetoxyborohydride (STAB) system is reported. The tandem procedure is efficient, selective, and versatile, giving excellent yields of N-Boc protected seconda...

The present study demonstrates the identification of N-hydroxycinnamamide derivatives and their anticancer potential against human triple-negative breast cancer cell line MDA-MB‑231, MCF-7 and non-malignant origin cell line, HEK-293 (human embryonic kidney). MTT assay was studied with HEK-293 ce...

A dihydropyridone-mediated approach to the morphine skeleton was investigated. The hexahydroisoquinoline 2 was synthesized in nine steps using N-acylpyridinium chemistry and dihydropyridone functionalization methods. This new approach should be useful in the design of more efficient syntheses of...

We screened a series of 4-anilinoquinolines and 4-anilinoquinazolines and identified novel inhibitors of Mycobacterium tuberculosis (Mtb). The focused 4-anilinoquinoline/quinazoline scaffold arrays yielded compounds with high potency and the identification of 6,7-dimethoxy-N-(4-((4-methylbenzyl)...

Binary mixtures of Pluronics are studied as drug nanocarriers in this work. H2 and Zn 5,10,15,20-tetrakis[4-(benzyloxy) phenyl] porphyrin were encapsulated onto binary micelle mixture of Pluronic F127/P123. The fluorescence and singlet oxygen generating behaviour of the porphyrins were investiga...

Efficient cleavage of CO bonds in lignin and its models is of great importance for the production of value-added aromatic compounds. A simple TiO2 photochemical approach was applied for β-O-4 ketone hydrogenolysis by an electron transfer photocatalytic reaction. The conversion of the substrate ...

Reaction of phenylacetylenes 1a–e with manganese(III) triacetate in acetic acid/acetic anhydride at reflux gave the corresponding 5-acetoxy-5-phenyl-2(5H)-furanones 2a–e in good yield (40–86%). Furanones 2 were derived from further oxidation of the initially formed 5-phenyl-2(3H)-furanones 4 ...

The intermolecular arylation of malonate esters in acetic acid solution in the presence of manganese(III) triacetate is known to proceed via an Electron Transfer mechanism. Under sonication, this reaction undergoes only minor changes. In contrast, the intramolecular reaction of dimethyl α-(3-ph...