Parkinson’s disease (PD) is a chronic progressive neurological disorder with an increasing incidence in the aging population. Neuroprotective and/or neuroregenerative strategies remain critical in the treatment of this increasingly prevalent disease. Prosaposin is a neurotrophic factor whose ne...

Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of nigrostriatal dopaminergic neurons with an accompanying neuroinflammation leading to loss of dopamine in the basal ganglia. Caffeine, a well-known A2A receptor antagonist is reported to slow down the n...

The protective effects of 2-amino-6-trifluoromethoxy benzothiazole (riluzole), a Na+ channel blocker with antiglutamatergic activity were investigated in the model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depletion of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and hom...

The argyrins are a family of non-ribosomal peptides that exhibits different biological activities through only small structural changes. Ideally, a biologically active molecule can be tracked and observed in a variety of biological and clinical settings in a non-invasive manner. As a step toward...

Three C-terminal sequences (VSIPVV, VCKWT, and LTLLS) of rat heart-type fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase have been reported. To elucidate the mechanism of generating the heterogeneity of the enzyme, we carried out reverse transcriptase PCR using three pairs of specific p...

Vanadyl phosphate (VOP) was used as acid catalyst in the dehydration of fructose aqueous solutions to afford 5-hydroxymethyl-2-furaldehyde (HMF). Promising results, in terms of activity (turnover frequency (TOF) ≈ 200 mmol HMF/gcat h) and selectivity, have been achieved. New catalytic systems, ...

A fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase (F6P2K/F26BPase) gene was found to exhibit different transcript expression levels after 48 h of salt treatment between the salt-tolerant rice line, LPT123-TC171, and its original cultivar, LPT123, by differential RNA display and confirm...

We have reported the occurrence of eight splice variants of rat brain fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase (RB2K). In the present study, we quantified these splice variants in various tissues using a RNAse protection assay and found a tissue-specific pattern of alternative s...

Six thermophilic enzymes from Thermus thermophilus were used to construct an ‘artificial bio-synthetic pathway’ for the production of 2-deoxyribose 5-phosphate from fructose. By a simple operation using six recombinant Escherichia coli strains producing the thermophilic enzymes, respectively, ...

5-Hydroxymethyl-2-furfural (HMF) is considered an important platform chemical among other intermediates derived from biomass. In this study, we have used mesoporous zirconium phosphate as a catalyst for the conversion of sugars into HMF. The catalyst was synthesized using a hydrothermal method a...

To know the potential of growth, invasion and metastasis of endometrial cancer associated with neovascularization, the effects of sex steroids and O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) on basic fibroblast growth factor (FGF) expression and secretion and its mRNA expression we...

PurposeThe effect of 0-(chloroacetyl-carbamoyl) fumagillol (TNP-470) on tumor growth and metastasis is investigated.

(−)-Fumagillol (2), a hydrolysis product of fumagillin (1), has been synthesized in a highly stereoselective manner utilizing a glycolate Claisen rearrangement and an intramolecular ester enolate alkylation as key steps starting from carbohydrate-based precursor 5.

Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated. The cyclopentane-fumagillol derivatives were synthesized from (−)-2,3-O-isopropylidene-d-erythronolactone via stereoselective glycolate Claisen rearrangement...

A formal synthesis of fumagillol, a congener of fumagillin that possesses varied biological activity, is disclosed. Initial attempts at preparing an allylic sulfide via an α-chloro sulfide met with failure. The successful route involves a carbonyl-ene reaction, one-pot stannyl cupration, methyl...

In this paper synthesis, crystal structure and spectral properties of a new, N-(methylene-2-pyridine)-N,N,-di-(methylenephosphonic) acid (hereinafter IV) are reported. The X-ray structure analysis revealed that in crystal of the ammonium dihydrogen N-(methylene-2-pyridine)-N,N-di(methylenephosph...

An efficient one-pot synthesis of bis(2-fluoro/chloro-3-pyridyl) diselenide has been successfully achieved under dry-ice/acetone bath temperature that involves deprotonation of corresponding 2-fluoro/chloropyridine at C-3 with lithium di-isopropylamide, insertion of elemental selenium followed b...

A simple, sensitive, low-cost and rapid flow injection (FI) on-line sorption preconcentration/hydride generation system has been synchronously coupled to an electrothermal atomic absorption spectrometer (ETAAS) for the determination of trace amounts of Sb in aqueous environmental samples (river ...

The thermolysis of methylzinc bis(2-pyridylmethyl)amide (1) leads to the formation of gold-shining zinc bis[1,3-di(2-pyridyl)-2-azapropenide] (2) and colorless 1,2-di(2-pyridyl)ethane (3). The 1,3-di(2-pyridyl)-2-azapropenide ligand which forms from the bis(2-pyridylmethyl)amide anion by dehydro...

Two new ruthenium (II) complexes containing coupled di(2-pyridyl) and 1,3-dithiole units, cis-[Ru(Medpydt)2(NCS)2] (2, Medpydt = dimethyl 2-(di(2-pyridyl)methylene)-1,3-dithiole-4,5-dicarboxylate) and cis-[Ru(H2dpydt)2(NCS)2] (3, H2dpydt = 2-(di(2-pyridyl)methylene)-1,3-dithiole-4,5-dicarboxylat...