Corynebacterium glutamicum was metabolically engineered for the production of glutaric acid, a C5 dicarboxylic acid that can be used as platform building block chemical for nylons and plasticizers. C. glutamicum gabT and gabD genes and Pseudomonas putida davT and davD genes encoding 5-aminovaler...

The influence of impurities on the solubility and metastable zone width (MSZW) of glutaric acid in acetic acid solution was studied. At T = (300.15–340.15) K, the presence of impurity succinic acid or adipic acid increases the solubility of glutaric acid in acetic acid solution, and the solubil...

Tyrosinase enzyme plays a crucial role in melanin biosynthesis and enzymatic browning process of vegetables and fruits. Hence, tyrosinase inhibitors are important in the fields of medicine, cosmetics and agriculture. In this study, novel N-(2-morpholinoethyl)cinnamamide derivatives bearing diffe...

In this study, several chiral diamine (35, 36, 37 and 39), triamine (24 and 25), diaminol (38, 42 and 43) and triaminol ligands (29 and 30) having chiral morpholine and pyrrolidine moieties conjugated constitutes, were prepared from commercially available (S)-2-amino-2-phenylacetic acid and (S)-...

This study involves the synthesis of novel N-heterocyclic carbene (NHC)PdX2(morpholine) complexes (1a–i). These Pd-based complexes are synthesized from pyridine enhanced precatalyst preparation stabilization and initiation (PEPPSI) complexes and morpholine. The new complexes were characterized ...

Strong international focus on measures aiming to mitigate the emission of carbon dioxide into the atmosphere call for efficient solutions feasible for a wide range of CO2 sources. Low-cost chemicals that are both environmentally friendly and potentially applicable for all stages of carbon dioxid...

Experimental and computational studies were performed in this work with the aim of evaluating and understanding the energetic effect inherent to the substitution of the hydrogen of the morpholine amino group by aminoalkyl substituents: N-(2-aminoethyl)morpholine and N-(3-aminopropyl)morpholine.T...

Replacement of the piperidine ring in the lead benzenesulfonamide Nav1.7 inhibitor 1 with a weakly basic morpholine core resulted in a significant reduction in Nav1.7 inhibitory activity, but the activity was restored by shortening the linkage from methyleneoxy to oxygen. These efforts led to a ...

Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a moiety of great significance. It forms an important intermediate in many industrial and organic syntheses. Morpholine containing drugs are of high therapeutic value. Its wide array of pharmacological activit...

A series of mono metallic and hetero-metallic morpholine complexes were synthesized and characterized by elemental analysis, spectral (IR, UV-VIS and ESR) studies, room-temperature magnetic susceptibility and thermal analysis techniques(TG, DTG, DTA, DSC). IR spectra showed, that morpholine beha...

Six previously undescribed piperidine alkaloids were isolated from the rhizomes of Alocasia macrorrhiza (L.) Schott. Their structures were elucidated based on 1D and 2D NMR, IR, HR-ESI-MS spectroscopic analysis and the application of a modified Mosher method. All isolated alkaloids were evaluate...

Highly efficient substrate and reagent controlled stereoselective synthesis of 2,6-trans-piperidine derivative (1) using an aza-Michael reaction is reported. This method was utilized to synthesize a variety of trans-piperidines on hundred-gram scales.

Diastereoselective synthesis of cis-2,6-disubstituted piperidines from 1,2-cyclic sulfamidates is described. Regioselective ring-opening reactions of 1,2-cyclic sulfamidates derived from L-phenylalanine, alanine, valine, norvaline with the ketal protected acetylide with a phenyl substituent proc...

Vapor phase dehydration of 5-amino-1-pentanol to produce piperidine was investigated over various oxide catalysts such as ZrO2, TiO2, Al2O3 and SiO2. Among the tested catalysts, SiO2 selectively produced piperidine at 300 °C. A high 5-amino-1-pentanol conversion of 99.9% with a piperidine selec...

The synthesis and characterization of meso-piperidine linked Bodipy starting from 4-(2-(piperidine-1-yl)ethoxy)benzaldehyde was described. Meso-piperidine linked Bodipy was subsequently used for the construction of distyryl-piperidine-Bodipy and distyryl-morpholine-Bodipy via Knoevenagel type re...

Piperidine is an important pharmacophore, a privileged scaffold and an excellent heterocyclic system in the field of drug discovery which provides numerous opportunities in studying/exploring this moiety as an anticancer agent by acting on various receptors of utmost importance. Cancer is an unc...

The influence of piperidine ring on chemical reactivity and stability of piperine (PPN) was elucidated using quantum chemistry calculations with Density Functional Theory at DFT/B3LYP/6-31G(d,p) level of theory. Conformational analysis and electronic properties for PPN were compared to piperic a...

Two undescribed piperidine racemates, (±)-caulophines A and B (1 and 2), a new N-containing xanthone derivative (3), together with six known piperidines, were isolated from the roots of Caulophyllum robustum Maxim. Their structures were determined by extensive spectroscopic techniques. Compound...

An approach to the synthesis of 3-substituted piperidines bearing partially fluorinated alkyl groups was proposed. The method was based on the DAST-mediated nucleophilic fluorination of easily available 2-bromopyridin-3-yl alcohols and ketones affording 2-bromo-3-(1-fluoroalkyl)pyridines and 2-b...

Rotationally-resolved spectra of the ν16 band of 1,3,5-trioxane, centered near 1177 cm-1, have been obtained via cavity ringdown spectroscopy using a continuous-wave external-cavity quantum cascade laser and a slit expansion nozzle. 219 transitions were identified and fitted to determine the ex...