14C-labelled purinyl-6-histamine is catabolized in vivo in the same way as in vitro. The main metabolites are 2,8-dihydroxy-purinyl-derivatives, carbon-dioxide and a product in which the imidazole ring of the purine ring system is opened. The speed of catabolism, the incorporation of produced ca...

A series of new 6-substituted purinyl-5′-nor-1′-homocarbanucleosides based on indanol were synthesized from (±)-cis-3-hydroxymethyl-1-indanol, an appropriately functionalized derivative of which was reacted with 6-chloropurine in the presence of NaH and 18-crown-6 ether to prepare a key inter...

Purinyl-6-histamine, which is selectively cytotoxic to tumour cells in tissue culture, does not inhibit the incorporation of precursors of macromolecular syntheses into acid insoluble material of ascites tumour cells in vitro, but it is bound to RNA within cells and to isolated RNA in vitro, as ...

The disposition of S-(6-purinyl)glutathione (6-PG) and its metabolites, including the antitumor agent 6-mercaptopurine (6-MP), was characterized in freshly isolated renal cortical cells from male F344 rats to assess the ability of the kidney to convert 6-PG to 6-MP. The intracellular transport a...

To address the issue of the cytotoxicity of glutamate antagonists, we administered representative agents to rats and used HSP72 immunocytochemistry as a measure of neuronal injury in the brain. The doses studied spanned the reported neuroprotective range for each compound. Some, but not all, glu...

Citrus canker provoked by Xanthomonas axonopodis pv. citri is a bacterial disease causing severe losses in all citrus-producing areas around the world. Xanthomonas infection is considered as an endemic disease in Northeast and Northwest Argentina, affecting as much as 10% of commercial citrus pl...

Over the last 20 years, natural peptides playing a key role in defense mechanisms and innate immunity have been isolated from unicellular organisms. Amphibian skin secretes dermaseptins, 24–34 amino acids in length that have a wide antimicrobial spectrum incorporating yeast, fungi, protozoa, ba...

Eight different strains of yeasts, Aspergillus niger, Aspergillus oryzae and White-rot fungus were tested for biotransformation of saponins to astragaloside IV in potato medium with Radix Astragali. Among these strains, immobilized cells of A. niger M85 exhibited the best performance on the biot...

Astragaloside IV (ASI) is the main active constituent of astragalosides in Radix Astragali. Its content in natural plants is relatively low. We selected the strain Absidia corymbifera AS2 to transform astragalosides to ASI. This strain enhanced ASI production approximately fourfold when cultures...

The performance of different tubular reactor designs for methanol synthesis was investigated by using computational fluid dynamics (CFD) simulations and experiments. The validated model was used to investigate the effect of various reactor geometries, coolant temperature, feed temperature, inlet...

Octane rating is an essential property for gasoline-type fuels because it is the major factor that determines the maximum compression ratio (CR) allowed in spark-ignition engines. In practice, a base gasoline, which is a mixture of various refinery streams, is dosed with octane-booster additives...

Enterovirus 71 (EV71) is a kind of RNA virus and one of the two causes of Hand, foot and mouth disease (HFMD). Inhibitors that target key components of Ras/Raf/MEK/ERK pathway in host cells could impair replication of EV71. A series of 3-benzyl-1,3-benzoxazine-2,4-diones were designed from a spe...

We report herein the design and optimization of a novel series of sulfamides and sulfamates derived from amino esters with anticonvulsant properties. The structures were designed based on the pharmacophoric pattern previously proposed, with the aim of improving the anticonvulsant action. The com...

Chitosan-N-2-hydroxypropyl trimethyl ammonium chloride (QTS) was prepared by reaction of chitosan (CS) and glycidyl trimethylammonium chloride. Later, O-acetyl-chitosan-N-2-hydroxypropyl trimethyl ammonium chloride (AQTS) was synthesized by reaction of QTS with acetic acid in the presence of SOC...

Aqueous two-phase system (ATPS) has been regarded as a potential method for removing heat-stable salts (HSS) in 1, 4-bis-(2-hydroxypropyl)-piperazine (HPP). In this work, the binodal and liquid-liquid equilibrium data of the HPP + Na2CO3 + H2O system have been determined by cloud point and phase...

We have synthesized N-2-hydroxypropyl dimethylethyl ammonium chloride chitosan (N-2-HFCC) with higher water solubility than chitosan. To evaluate its potential as delivery carrier, NDV encapsulated in N-2-HFCC/CMC nanoparticles (NDV/La Sota-N-2-HFCC/CMC-NPs) with a diameter of 252.2 ± 32.68 nm,...

The positionally substituted 2′-O-hydroxypropyl trimethyl ammonium chloride chitin (2′-O-HTACCT) with different substitution degree of quaternary ammonium salt were synthesized directly from β-chitin, after that these 2′-O-HTACCT were then deacetylated to obtain corresponding 2′-O-hydroxypr...

The study of the adsorption mechanism of 3-chloro-2-hydroxypropyl trimethylammonium chloride (CHPTA), which acts as an effective clay minerals hydration inhibitor, can provide an effective approach for the design of novel high-performance inhibitors with favorable molecular structures. Density f...

We have synthesized herein new glycopolymers derived from sugar (d-mannose) oligomers with itaconic moiety and 2-hydroxypropyl acrylate in different weight ratios (1:1, 1:2, 1:3 and 1:4), in bulk, using benzoyl peroxide as initiator. These glycopolymers were characterized using FTIR spectroscopy...

A novel surfactant N,N-Bis(2-hydroxypropyl)laurylamine (NHPA) was synthesized and utilized as a collector in the flotation of quartz. The properties of NHPA were explored. The adsorption behavior of NHPA on quartz surface was investigated by FT-IR spectra studies, zeta potential measurements and...