Phosphoinositide 3-kinase gamma (PI3Kγ) is a lipid kinase that plays a crucial role in cell migration, chemotaxis, oxidative burst and myocardial contractility. It is activated downstream of G protein-coupled receptors (GPCRs) and small GTPases of Ras superfamily. PI3Kγ is a heterodimer compos...

Quox-1 is an homeogene isolated in the quail by using the Drosophila Antp cDNA as a probe. Quox-1 homeodomain sequence homology is 98% and 100% with Antp and mouse Hox1.1 homeodomains respectively. The region of the molecule 3′ to the homeodomain has no homology with any known protein sequence ...

The expression of vertebrate homeoproteins has been extensively studied in a variety of normal and cancerous tissues, but little is known on the role of vertebrate homeoproteins in the proliferation and differentiation of cells from these tissues. In the present study, we investigate the relatio...

leuCD operon encodes isopropylmalate isomerase (IPMI), an essential enzyme in leucine biosynthesis. Leucine biosynthesis is one of the essential metabolic pathways for Mycobacterium tuberculosis survival inside the macrophage. In this study, we identified an IclR like transcription regulator, Rv...

Knowledge of the profile of fatty acids, including the profile of long chain fatty acids, is an important parameter for many areas like human health, food sciences, and the study of gene expression in plant tissues, among others. Moreover, very long chain fatty acids occur at low concentrations ...

In this work we present bifacial cells with Ni/Ag co-plated contacts with average Voc values of 691±2 mV and efficiencies of 22.4±0.2 % (internal measurement using a lowly-reflective GridtouchTM contacting unit from Pasan). The Ni/Ag co-plating sequence used in this paper presents numerous adv...

ObjectiveFibromyalgia (FM) is a confounding factor for diagnosing and assessing rheumatic disease activity. This study sought to assess the extent of this syndrome in rheumatism patients at a French rheumatology department.

Aryl dialkyl phosphate, which is readily available from phenol, was a good substrate for the Pd(II) catalyzed aryl–aryl coupling reaction through ortho-C–H activation. Although a phosphate group is regarded as a poor coordinating group, highly regioselective ortho-arylation could be achieved b...

A mesoporous aluminosilicate (Al-MCM-41) was found to be an effective heterogeneous catalyst for the reaction of both carbonyl compounds and acetals with allylsilanes to afford the corresponding homoallyl silyl ethers and homoallyl alkyl ethers, respectively. Both the mesoporous structure and th...

An 8-oxopurine-6-carboxamide compound (1a) was previously identified as an inhibitor of non-small cell lung cancer (NSCLC). In this study, more than 30 purine-6-carboxamide derivatives with variations at the C2, N7, C8, and N9 positions were synthesized to investigate the structure−activity rela...

Novel purine-pyrazole hybrids combining thiazoles, thiazolidinones and rhodanines, were designed and tested as 15-LOX inhibitors, potential anticancer and antioxidant agents. All tested compounds were found to be potent 15-LOX inhibitors with IC50 ranging from 1.76 to 6.12 µM. The prepared comp...

A series of 1-(2,4-dinitrophenyl)-3,5-diphenyl-4-arylazopyrazoles and 1-carbamoyl-3,5-diphenyl-4-arylazopyrazoles have been synthesised by the condensation of the corresponding 1,3-diphenyl-2-arylhydrazono-1,2,3-propanetriones with 2,4-dinitrophenylhydrazine and semicarbazide hydrochloride, resp...

The bioluminescent squid, Watasenia scintillas has three visual pigments. The major pigment, based on retinal (λmax 484 nm), is distributed over the whole retina. Another pigment based on 3-dehydroretinal (λmax ≈ 500 nm) and the third pigment (λmax 470 nm) are localized in the specific area ...

The firefly squid, Watasenia scintillans, is the only animal known to possess a visual pigment in which the chromophore is 4-hydroxyretinal. This paper describes the absorbance spectrum and some properties of a synthetic “A4” visual pigment generated from bovine opsin and 4-hydroxyretinal. The...

A series of N-(2-(3,4,5-trimethoxybenzyl)-benzoxazole-5-yl)benzamide derivatives (3a–3n) was synthesized and evaluated for its in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50

An efficient and practical isatin-based oxidative domino protocol has been developed for the facile synthesis of 2-aminobenzamides and 2-aminobenzoates. The robust nature of this reaction system is reflected by accessible starting materials, room temperature and high-yield gram-scale synthesis.

N-(8-Isopropyl-nortropan-3-β-yl)-2-methoxy-4-amino-5-chlorobenzamide has been synthesized and its crystal and molecular structures determined by X-ray diffraction, IR, 1H NMR and 13C NMR methods. The pyrrolidine and piperidine rings adopt a flattened N-8 envelope and distorted chair conformatio...

N-(8-Isopropyl-nortropan-3-α-yl)-2-methoxy-4-amino-5-chlorobenzamide has been synthesized and its crystal and molecular structures determined by X-ray diffraction, IR, 1H-NMR and 13C-NMR methods. The pyrrolidine and piperidine rings adopt a flattened N-8 envelope and distorted chair conformatio...

Alterations in serotonin and norepinephrine neuronal functions have been observed in patients with major depression. Several antidepressants bind to both serotonin transporters and norepinephrine transporters (NET). The ability to image NET in the human brain would be a useful step toward unders...

Direct liquefaction of macroalgae Enteromorpha prolifera without predrying treatment was performed in a batch reactor. Effects of temperature, reaction time, biomass-to-water ratio and acid catalysts (sulfuric acid and acetic acid) on liquefaction products were investigated. Raw material and liq...