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LIDE PHARMACEUTICALS LIMITED

We are the main manufacturer of Lansoprazole in China and export to 40 countries and areas regularly. Our manufactuing capacity is 2000kg/Month. The specification is complied with USP and can reach Injectable grade. At present, we are setting 10

Lansoprazole

Cas:103577-45-3

Min.Order:25 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Lansoprazole Manufacturer/High quality/Best price/In stock

Cas:103577-45-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance A white to off-white colour powder Complies Dentificatio A:IR/B

High quality lansoprazole 103577-45-3

Cas:103577-45-3

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1600.0

Type:Trading Company

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Kono Chem Co.,Ltd

a Test Item Analysis Specification Result Description White to off white crystalline powder Conforms

CAS :103577-45-3 Lansoprazole

Cas:103577-45-3

Min.Order:1 Kilogram

Negotiable

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to brownish-white powder Storage:2-8°C Package:1kg/foil

Manufacturer supply Lansoprazole CAS 103577-45-3 of EP standard

Cas:103577-45-3

Min.Order:1 Kilogram

FOB Price: $150.0 / 380.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Lansoprazole. enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environmental pro

Lansoprazole

Cas:103577-45-3

Min.Order:1 Metric Ton

FOB Price: $0.1

Type:Manufacturers

inquiry

Hefei TNJ chemical industry co.,ltd

White Crystalline Powder,with Melting point 178-182℃ and Boiling point 504.9°C at 760 mmHg. Used as a gastric proton pump inhibitor. Appearance:White Crystalline Powder Storage:25kgs/drum Package:25kgs/fiber drum Application:1)Used as a gastric

Lansoprazole

Cas:103577-45-3

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell Package:According to the demand of customer Application:Pharmaceutical intermediates Transportation:by air or by sea Port:shanghai

Lansoprazole

Cas:103577-45-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Lansoprazole

Cas:103577-45-3

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Lansoprazole 103577-45-3 ISO Producer

Cas:103577-45-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Lansoprazole

Cas:103577-45-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Lansoprazole

Cas:103577-45-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:lansoprazole CAS:103577-45-3 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

Lansoprazole Manufacturer/High quality/Best price/In stock

Cas:103577-45-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Lansoprazole Basic information Product Name: Lansoprazole Synonyms: 1h-benzimidazole,2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)su;2-(((3-methyl-4-(2,2,2-trifluoroethoxy)

103577-45-3

Cas:103577-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Lansoprazole

Cas:103577-45-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 103577-45-3 with best quality

Cas:103577-45-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name lansoprazole Molecular Formula C17H14F3N3O2 Molecular Weight 349.3072 CAS Registry Number 103577-45-3 Quality:BP/EP/USP Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:drum Application:

Lansoprazole

Cas:103577-45-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Lansoprazole Manufacturer For Digestive System Medication

Cas:103577-45-3

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Lansoprazole Structure: Formula: 103577-45-3 Molecular Weight : 369.36 Synonyms: LANSOPRAZOLE,RELATEDCOMPOUNDA2-[[[3-METHYL-4-(2,2,2-TRIFLOUROETHOXY)-2-PYR

Lansoprazole

Cas:103577-45-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Lansoprazole 103577-45-3

Cas:103577-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

API Raw Powder Lansoprazole High Purity Lansoprazole raw powder Lansoprazole price

Cas:103577-45-3

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Synonyms: LANSOPRAZOLE, RELATED COMPOUND A2-[[[3-METHYL-4-(2,2,2-TRIFLOUROETHOXY)-2-PYRIDYL]METHYL]SULFONYL]BENZIMIDAZOLE USP STANDARD;LANSOPRAZOLE, MM(CRM STANDARD);LANSOPRAZOLE USP(CRM STANDARD);2-[3-METHYL-4-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDIN-2-YL

Lansoprazole 103577-45-3

Cas:103577-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply lansoprazole CAS 103577-45-3 for Scientific Research use only

Cas:103577-45-3

Min.Order:1 Gram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Lansoprazole 99%

Cas:103577-45-3

Min.Order:1 Kilogram

FOB Price: $71.0 / 86.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Lansoprazole CAS: 103577-45-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia

Lansoprazole CAS: 103577-45-3

Cas:103577-45-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Chinese suppliers CAS 103577-45-3 Lansoprazole

Cas:103577-45-3

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Lansoprazole

Cas:103577-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Lansoprazole CAS103577-45-3

Cas:103577-45-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biological Technology Co., Ltd. is specialize in the production of chemical raw materials and reagents,located in Shijiazhuang, Hebei Province. In recent decades, under the efforts of all staff, in Shandong, Henan, Guangdong and many othe

Lansoprazole CAS 103577-45-3

Cas:103577-45-3

Min.Order:1 Kilogram

FOB Price: $20.0 / 40.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Lansoprazole

Cas:103577-45-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

lansoprazole sulfide
103577-40-8

lansoprazole sulfide

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With 2C5H8N2*VO2F; dihydrogen peroxide In ethanol at 10 - 15℃; for 2h; Temperature; Industrial scale;100%
With dihydrogen peroxide; methyltrioxorhenium(VII) In 2,2,2-trifluoroethanol; water at 0℃; for 1h; Product distribution / selectivity;98%
With magnesium monoperoxyphthalate hexahydrate In ethanol; water at -20 - -10℃; for 4h;95%
3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride

3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride

Benzimidazol-2-thiol
134469-07-1

Benzimidazol-2-thiol

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
Stage #1: 3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride; Benzimidazol-2-thiol With carboxy chlorine; sodium carbonate In methanol at 64℃; for 3h;
Stage #2: With titanium(IV) isopropylate In water; toluene at 28 - 55℃; for 1.83333h; Temperature; Solvent; Reagent/catalyst; Further stages;
98%
lansoprazole hydrate acetonitrile solvate

lansoprazole hydrate acetonitrile solvate

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With ammonia In water; acetonitrile at 0 - 40℃; for 3.5h; Product distribution / selectivity;95.2%
With ammonia In water; acetone at 30 - 35℃; Product distribution / selectivity;79%
In water at 15 - 30℃; Product distribution / selectivity;
lansoprazole sulphide hydrate

lansoprazole sulphide hydrate

water ethanol
180330-54-5

water ethanol

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With dihydrogen peroxide; sodium thiosulfate In vanadium(V) oxide; dichloromethane; tert-butyl alcohol93.2%
With dihydrogen peroxide; sodium thiosulfate In vanadium(V) oxide; dichloromethane; tert-butyl alcohol93.2%
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In ethanol; chloroform
iansoprazole ethanol hydrate
207790-96-3

iansoprazole ethanol hydrate

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
In water at 40℃; Product distribution / selectivity;93%
With triethylamine In water; acetonitrile at 35℃; Product distribution / selectivity;92%
In water; acetonitrile at 35℃; Product distribution / selectivity;92%
2-({[3-methyl-4-(2,2,2-trifluoroethoxy)-1,4-dihydropyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole

2-({[3-methyl-4-(2,2,2-trifluoroethoxy)-1,4-dihydropyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In toluene at 0 - 10℃; for 9h; Solvent; Reagent/catalyst; Temperature;93%
2-[(RS)-[(4-chloro-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

2-[(RS)-[(4-chloro-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

sodium 2,2,2-trifluoroethanolate
420-87-1

sodium 2,2,2-trifluoroethanolate

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
In dimethyl sulfoxide at 90 - 100℃; Solvent; Large scale;92.1%
lansoprazole sulphide hydrate

lansoprazole sulphide hydrate

Vanadium(IV) acetylacetonate

Vanadium(IV) acetylacetonate

water ethanol
180330-54-5

water ethanol

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With dihydrogen peroxide; sodium thiosulfate In ethanol91%
With dihydrogen peroxide; sodium thiosulfate In ethanol91%
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

2-(((4-nitro-3-methyl-2-pyridyl)methyl)sulfinyl)benzimidazole

2-(((4-nitro-3-methyl-2-pyridyl)methyl)sulfinyl)benzimidazole

sodium 2,2,2-trifluoroethanolate
420-87-1

sodium 2,2,2-trifluoroethanolate

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
In dimethyl sulfoxide at 90 - 100℃; Solvent; Large scale;90.8%
sodium vanadate

sodium vanadate

lansoprazole sulphide hydrate

lansoprazole sulphide hydrate

water ethanol
180330-54-5

water ethanol

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With dihydrogen peroxide; sodium thiosulfate In ethanol90.5%
With dihydrogen peroxide; sodium thiosulfate In ethanol90.5%
vanadium(V) oxide
788133-24-4

vanadium(V) oxide

lansoprazole sulphide hydrate

lansoprazole sulphide hydrate

water ethanol
180330-54-5

water ethanol

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With dihydrogen peroxide; sodium thiosulfate In ethanol89.5%
With dihydrogen peroxide; sodium thiosulfate In ethanol89.5%
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]thio]-1H-benzimidazole
666727-70-4

2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]thio]-1H-benzimidazole

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
Stage #1: 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]thio]-1H-benzimidazole With tert.-butylhydroperoxide; vanadium(III) 2,4-pentanedionate In ethanol at 5℃; for 6h;
Stage #2: With ammonia; sodium sulfite In ethanol; water at 25℃; for 17h; pH=8 - 8.5;
85%
lansoprazole sulfide
103577-40-8

lansoprazole sulfide

A

lansoprasole
103577-45-3

lansoprasole

B

Lansoprazole sulfone

Lansoprazole sulfone

Conditions
ConditionsYield
With tert.-butylhydroperoxide; vanadium acetyl acetonate In ethanol at 5℃; for 4h; Purification / work up;A 79%
B 0.3%
Stage #1: lansoprazole sulfide With tert.-butylhydroperoxide; vanadium acetyl acetonate In ethanol at 5℃; for 6h;
Stage #2: With ammonium hydroxide In water at 25℃; for 17h; pH=8 - 8.5; Purification / work up; Alkaline aqueous solution;
A n/a
B 0.15%
aqueous sodium metabisulphate

aqueous sodium metabisulphate

(acac)2

(acac)2

aqueous tert-butyl hydroperoxide (TBHP)

aqueous tert-butyl hydroperoxide (TBHP)

lansoprazole sulfide
103577-40-8

lansoprazole sulfide

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
In ethanol79%
2-[[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole
163119-30-0

2-[[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
sodium(hydrogen ethylenediaminetetraacetato)ruthenium(III)Cl} In ethanol; water at 50℃; for 1h;50%
{Ru[(EDTA)H]Cl}Na In ethanol; water at 50℃; for 1h;50%
2,3-dimethyl-4-nitropyridine N-oxide
37699-43-7

2,3-dimethyl-4-nitropyridine N-oxide

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / tert-BuOK / 42 h / 50 - 60 °C
2: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h
3: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h
4: 45 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling
View Scheme
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine
103577-66-8

2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h
2: 45 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling
View Scheme
Multi-step reaction with 3 steps
1: Triphenylphosphine oxide; bis(trichloromethyl) carbonate / toluene / 6 h / 20 - 60 °C
2: sodium hydroxide / ethanol / 2 h / Reflux
3: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / -5 - 20 °C
View Scheme
2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide
103577-61-3

2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h
2: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h
3: 45 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling
View Scheme
Diethyl tartrate
408332-88-7

Diethyl tartrate

lansoprazole sulfide
103577-40-8

lansoprazole sulfide

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; ethyl acetate
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene
lansoprazole sulphide hydrate

lansoprazole sulphide hydrate

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With urea hydrogen peroxide adduct; vanadium(V) oxytrifluoride In 1-methyl-pyrrolidin-2-one at 0 - 20℃; Product distribution / selectivity;
Tri-n-octylamine
1116-76-3

Tri-n-octylamine

Diethyl tartrate
408332-88-7

Diethyl tartrate

lansoprazole sulfide
103577-40-8

lansoprazole sulfide

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene
dimethyl tartrate
405897-14-5

dimethyl tartrate

lansoprazole sulfide
103577-40-8

lansoprazole sulfide

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene
dibutyl tartrate
344268-32-2

dibutyl tartrate

lansoprazole sulfide
103577-40-8

lansoprazole sulfide

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene
diethyl (2S,3S)-tartrate
13811-71-7

diethyl (2S,3S)-tartrate

lansoprazole sulfide
103577-40-8

lansoprazole sulfide

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene0.63 g (29%)
2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

(R)-2-(4-methanesulfonyl-3-methyl-pyridin-2-ylmethanesulfinyl)-1H-benzimidazole

(R)-2-(4-methanesulfonyl-3-methyl-pyridin-2-ylmethanesulfinyl)-1H-benzimidazole

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
Stage #1: 2,2,2-trifluoroethanol With potassium tert-butylate In N,N-dimethyl-formamide at 25 - 30℃;
Stage #2: (R)-2-(4-methanesulfonyl-3-methyl-pyridin-2-ylmethanesulfinyl)-1H-benzimidazole In N,N-dimethyl-formamide at 25 - 30℃; for 24h;
Stage #3: With acetic acid In water; N,N-dimethyl-formamide at 0 - 10℃; pH=7.0 - 7.5;
C26H28F3N3O5S2

C26H28F3N3O5S2

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
Stage #1: C26H28F3N3O5S2 With sodium hydroxide In methanol; water at 30℃; for 0.916667h;
Stage #2: With acetic acid pH=7;
(S)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

(S)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethyl acetate at 5 - 10℃; for 0.5h;
(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (R)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (R)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethyl acetate at 5 - 10℃; for 0.5h;
2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine
128430-66-0

2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

Benzimidazol-2-thiol
134469-07-1

Benzimidazol-2-thiol

lansoprasole
103577-45-3

lansoprasole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / Flow reactor
2: sodium hypochlorite; sodium hydroxide / water; acetonitrile / Flow reactor; Large scale
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / 1,2-dimethoxyethane / 8 h / 50 °C
2: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 °C
View Scheme
2-[p-(chlorosulfonyl)phenoxy]acetamide
69986-21-6

2-[p-(chlorosulfonyl)phenoxy]acetamide

lansoprasole
103577-45-3

lansoprasole

2-(4-{[2-({[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl}sulfinyl)benzimidazol-1-yl]sulfonyl}phenoxy)acetamide
259183-34-1

2-(4-{[2-({[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl}sulfinyl)benzimidazol-1-yl]sulfonyl}phenoxy)acetamide

Conditions
ConditionsYield
Inert atmosphere; Basic conditions;96%
With triethylamine In dichloromethane
choline chloride
67-48-1

choline chloride

lansoprasole
103577-45-3

lansoprasole

2-[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-ylmethanesulfinyl]-1H-benzoimidazole choline salt

2-[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-ylmethanesulfinyl]-1H-benzoimidazole choline salt

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 20℃; for 24h;94%
(4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester
651728-13-1

(4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester

lansoprasole
103577-45-3

lansoprasole

(4-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}phenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester

(4-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}phenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester

Conditions
ConditionsYield
With sodium hydride; sodium hydrogencarbonate In dichloromethane at 20℃;94%
Stage #1: lansoprasole With sodium hydride In dichloromethane at 20℃; Inert atmosphere;
Stage #2: (4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester With sodium hydrogencarbonate In dichloromethane Inert atmosphere;
94%
6-[2-(4-chlorosulfonyl-phenoxy)-acetylamino]-n-hexanoic acid 2-(3-nitro-benzenesulfonyl)ethyl ester
651728-35-7

6-[2-(4-chlorosulfonyl-phenoxy)-acetylamino]-n-hexanoic acid 2-(3-nitro-benzenesulfonyl)ethyl ester

lansoprasole
103577-45-3

lansoprasole

6-[2-(4-{2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}-phenoxy)-acetylamino]-n-hexanoic acid 2-(3-nitro-benzenesulfonyl)ethyl ester

6-[2-(4-{2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}-phenoxy)-acetylamino]-n-hexanoic acid 2-(3-nitro-benzenesulfonyl)ethyl ester

Conditions
ConditionsYield
With sodium hydride In dichloromethane at 20℃; for 2h;94%
2-[p-(chlorosulfonyl)phenoxy]-N-(2-pyridyl)acetamide
259183-87-4

2-[p-(chlorosulfonyl)phenoxy]-N-(2-pyridyl)acetamide

lansoprasole
103577-45-3

lansoprasole

2-(4-{[2-({[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl}sulfinyl)benzimidazol-1-yl]sulfonyl}-phenoxy)-N-(2-pyridyl)acetamide
259183-03-4

2-(4-{[2-({[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl}sulfinyl)benzimidazol-1-yl]sulfonyl}-phenoxy)-N-(2-pyridyl)acetamide

Conditions
ConditionsYield
Inert atmosphere; Basic conditions;94%
With triethylamine In dichloromethane
2-(4-chlorosulfonylphenoxy)butyric acid 2-(toluene-4-sulfonyl)ethyl ester
651728-20-0

2-(4-chlorosulfonylphenoxy)butyric acid 2-(toluene-4-sulfonyl)ethyl ester

lansoprasole
103577-45-3

lansoprasole

2-(4-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethanesulfinyl]benzoimidazole-1-sulfonyl}phenoxy)butyric acid 2-(toluene-4-sulfonyl)ethyl ester

2-(4-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethanesulfinyl]benzoimidazole-1-sulfonyl}phenoxy)butyric acid 2-(toluene-4-sulfonyl)ethyl ester

Conditions
ConditionsYield
With sodium hydride In dichloromethane at 20℃; for 2h;93%
Stage #1: lansoprasole With sodium hydride In dichloromethane at 20℃; Inert atmosphere;
Stage #2: 2-(4-chlorosulfonylphenoxy)butyric acid 2-(toluene-4-sulfonyl)ethyl ester In dichloromethane at 20℃; Inert atmosphere;
93%
neodymium(III) nitrate hexahydrate

neodymium(III) nitrate hexahydrate

lansoprasole
103577-45-3

lansoprasole

uracil
66-22-8

uracil

[Nd2([[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-yl]methyl]sulfinyl]-1H-benzimidazole)(uracil)·4H2O]NO4·nH2O

[Nd2([[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-yl]methyl]sulfinyl]-1H-benzimidazole)(uracil)·4H2O]NO4·nH2O

Conditions
ConditionsYield
In ethanol; water at 80℃;93%
(R)-1,1'-Bi-2-naphthol
18531-94-7

(R)-1,1'-Bi-2-naphthol

lansoprasole
103577-45-3

lansoprasole

(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole R-(+)-2,2'-dihydroxy-1,1'-binaphthyl

(R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole R-(+)-2,2'-dihydroxy-1,1'-binaphthyl

Conditions
ConditionsYield
In dichloromethane at 20 - 40℃; Resolution of racemate;92.55%
In dichloromethane at 20 - 40℃;92.55%
In dichloromethane at 20 - 40℃;92.55%
lansoprasole
103577-45-3

lansoprasole

copper(II) sulfate
7758-99-8

copper(II) sulfate

C16H14F3N3O2S*Cu(2+)*2C5H5N5*(x)H2O*O4S(2-)

C16H14F3N3O2S*Cu(2+)*2C5H5N5*(x)H2O*O4S(2-)

Conditions
ConditionsYield
In ethanol; water Reflux;89%
3-chlorosulfonylbenzoic acid 2-(toluene-4-sulfonyl)ethyl ester
651728-72-2

3-chlorosulfonylbenzoic acid 2-(toluene-4-sulfonyl)ethyl ester

lansoprasole
103577-45-3

lansoprasole

2-[(4-methylphenyl)sulfonyl]ethyl 3-{[2-({[3-methyl-4-(2,2,2-trifluoroethoxy)(2-pyridyl)]methyl}sulfinyl)benzimidazolyl]sulfonyl}benzoate

2-[(4-methylphenyl)sulfonyl]ethyl 3-{[2-({[3-methyl-4-(2,2,2-trifluoroethoxy)(2-pyridyl)]methyl}sulfinyl)benzimidazolyl]sulfonyl}benzoate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 1h;87%
chromium sulfate

chromium sulfate

lansoprasole
103577-45-3

lansoprasole

C16H14F3N3O2S*Cr(2+)*(x)H2O*O4S(2-)*2C5H5N5

C16H14F3N3O2S*Cr(2+)*(x)H2O*O4S(2-)*2C5H5N5

Conditions
ConditionsYield
In ethanol; water Reflux;87%
cobalt(II) sulfate

cobalt(II) sulfate

lansoprasole
103577-45-3

lansoprasole

C16H14F3N3O2S*Co(2+)*(x)H2O*O4S(2-)*2C5H5N5

C16H14F3N3O2S*Co(2+)*(x)H2O*O4S(2-)*2C5H5N5

Conditions
ConditionsYield
In ethanol; water Reflux;83%
[2-(morpholin-4-yl)ethoxy]benzene-4-sulfonyl chloride
259183-84-1

[2-(morpholin-4-yl)ethoxy]benzene-4-sulfonyl chloride

lansoprasole
103577-45-3

lansoprasole

1-[{2-(morpholin-4-yl)ethoxy}phenyl-4-sulfonyl]-2-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methylsulfinyl]-1H-benzimidazole
259183-38-5

1-[{2-(morpholin-4-yl)ethoxy}phenyl-4-sulfonyl]-2-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methylsulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
Inert atmosphere; Basic conditions;82%
With sodium hydrogencarbonate; triethylamine; sodium chloride In dichloromethane
manganese(II) sulfate

manganese(II) sulfate

lansoprasole
103577-45-3

lansoprasole

C16H14F3N3O2S*Mn(2+)*(x)H2O*O4S(2-)*2C5H5N5

C16H14F3N3O2S*Mn(2+)*(x)H2O*O4S(2-)*2C5H5N5

Conditions
ConditionsYield
In ethanol; water Reflux;82%
3-chlorosulfonylbenzoic acid 2-(3-nitrobenzenesulfonyl)ethyl ester
651728-08-4

3-chlorosulfonylbenzoic acid 2-(3-nitrobenzenesulfonyl)ethyl ester

lansoprasole
103577-45-3

lansoprasole

3-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethanesulfinyl]benzimidazole-1-sulfon-yl}benzoic acid 2-(3-nitrobenzenesulfonyl)ethyl ester

3-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethanesulfinyl]benzimidazole-1-sulfon-yl}benzoic acid 2-(3-nitrobenzenesulfonyl)ethyl ester

Conditions
ConditionsYield
With sodium hydride In dichloromethane at 20℃; for 2h;80%
Stage #1: lansoprasole With sodium hydride In dichloromethane at 20℃; Inert atmosphere;
Stage #2: 3-chlorosulfonylbenzoic acid 2-(3-nitrobenzenesulfonyl)ethyl ester In dichloromethane at 20℃; for 2h; Inert atmosphere;
80%
4-(4-chlorosulfonyl-3-isopropylphenoxyactamido)butyric acid 2-(3-nitrobenzenesulfonyl)ethyl ester
651728-46-0

4-(4-chlorosulfonyl-3-isopropylphenoxyactamido)butyric acid 2-(3-nitrobenzenesulfonyl)ethyl ester

lansoprasole
103577-45-3

lansoprasole

4-[2-(3-isopropyl-4-{-2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}phenoxy)acetylamino]butyric acid 2-(3-nitrobenzenesulfonyl)ethyl ester

4-[2-(3-isopropyl-4-{-2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}phenoxy)acetylamino]butyric acid 2-(3-nitrobenzenesulfonyl)ethyl ester

Conditions
ConditionsYield
With sodium hydride In dichloromethane at 20℃; for 2h;80%
3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride

3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride

lansoprasole
103577-45-3

lansoprasole

1-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
1083100-26-8

1-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole

Conditions
ConditionsYield
With sodium hydroxide In water Heating;80%

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