Lansoprazole supplier | CasNO.103577-45-3

Name
Lansoprazole
EINECS 2017-001-1
CAS No. 103577-45-3
Article Data62
CAS DataBase
Density 1.5 g/cm³
Solubility
Melting Point 178-182 °C
Formula C₁₆H₁₄F₃N₃O₂S
Boiling Point 555.8 °C at 760 mmHg
Molecular Weight 369.367
Flash Point 289.9 °C
Transport Information
Appearance white crystalline powder
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Amarin;Promp;Monolitum;Lanz;Prevacid (TN);Ulpax;Lansoprazolum [INN-Latin];Takepron;Blason;2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole;Ilsatec;A 65006;Bamalite;Prevacid SoluTab;Lansopep;2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole;Limpidex;Pro Ulco;Zoton;Lanproton;Lansoprazol [INN-Spanish];Lansoprazole [USAN:BAN:INN];Ogastro;1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-;AG 1749;Dakar;1H-Benzimidazole,2-[[[3-methyl-4-(2,2,2- trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-;Agopton;2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzoimidazole;Prosogan;
PSA 87.08000
LogP 4.38090

Synthetic route

: 103577-40-8
lansoprazole sulfide

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With 2C5H8N2*VO2F; dihydrogen peroxide In ethanol at 10 - 15℃; for 2h; Temperature; Industrial scale;	100%
With dihydrogen peroxide; methyltrioxorhenium(VII) In 2,2,2-trifluoroethanol; water at 0℃; for 1h; Product distribution / selectivity;	98%
With magnesium monoperoxyphthalate hexahydrate In ethanol; water at -20 - -10℃; for 4h;	95%

: 3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride

: 134469-07-1
Benzimidazol-2-thiol

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
Stage #1: 3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride; Benzimidazol-2-thiol With carboxy chlorine; sodium carbonate In methanol at 64℃; for 3h; Stage #2: With titanium(IV) isopropylate In water; toluene at 28 - 55℃; for 1.83333h; Temperature; Solvent; Reagent/catalyst; Further stages;	98%

: lansoprazole hydrate acetonitrile solvate

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With ammonia In water; acetonitrile at 0 - 40℃; for 3.5h; Product distribution / selectivity;	95.2%
With ammonia In water; acetone at 30 - 35℃; Product distribution / selectivity;	79%
In water at 15 - 30℃; Product distribution / selectivity;

: lansoprazole sulphide hydrate

: 180330-54-5
water ethanol

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium thiosulfate In vanadium(V) oxide; dichloromethane; tert-butyl alcohol	93.2%
With dihydrogen peroxide; sodium thiosulfate In vanadium(V) oxide; dichloromethane; tert-butyl alcohol	93.2%
With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid In ethanol; chloroform

: 207790-96-3
iansoprazole ethanol hydrate

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
In water at 40℃; Product distribution / selectivity;	93%
With triethylamine In water; acetonitrile at 35℃; Product distribution / selectivity;	92%
In water; acetonitrile at 35℃; Product distribution / selectivity;	92%

: 2-({[3-methyl-4-(2,2,2-trifluoroethoxy)-1,4-dihydropyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In toluene at 0 - 10℃; for 9h; Solvent; Reagent/catalyst; Temperature;	93%

: 2-[(RS)-[(4-chloro-3-methylpyridin-2-yl)methyl]sulfinyl]-1H-benzimidazole

: 75-89-8
2,2,2-trifluoroethanol

: 420-87-1
sodium 2,2,2-trifluoroethanolate

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
In dimethyl sulfoxide at 90 - 100℃; Solvent; Large scale;	92.1%

...Expand

: lansoprazole sulphide hydrate

Vanadium(IV) acetylacetonate: Vanadium(IV) acetylacetonate

: 180330-54-5
water ethanol

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium thiosulfate In ethanol	91%
With dihydrogen peroxide; sodium thiosulfate In ethanol	91%

...Expand

: 75-89-8
2,2,2-trifluoroethanol

: 2-(((4-nitro-3-methyl-2-pyridyl)methyl)sulfinyl)benzimidazole

: 420-87-1
sodium 2,2,2-trifluoroethanolate

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
In dimethyl sulfoxide at 90 - 100℃; Solvent; Large scale;	90.8%

...Expand

: sodium vanadate

: lansoprazole sulphide hydrate

: 180330-54-5
water ethanol

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium thiosulfate In ethanol	90.5%
With dihydrogen peroxide; sodium thiosulfate In ethanol	90.5%

...Expand

: 788133-24-4
vanadium(V) oxide

: lansoprazole sulphide hydrate

: 180330-54-5
water ethanol

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium thiosulfate In ethanol	89.5%
With dihydrogen peroxide; sodium thiosulfate In ethanol	89.5%

...Expand

: 666727-70-4
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]thio]-1H-benzimidazole

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
Stage #1: 2-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]thio]-1H-benzimidazole With tert.-butylhydroperoxide; vanadium(III) 2,4-pentanedionate In ethanol at 5℃; for 6h; Stage #2: With ammonia; sodium sulfite In ethanol; water at 25℃; for 17h; pH=8 - 8.5;	85%

: 103577-40-8
lansoprazole sulfide

A: 103577-45-3
lansoprasole

B: Lansoprazole sulfone

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; vanadium acetyl acetonate In ethanol at 5℃; for 4h; Purification / work up;	A 79% B 0.3%
Stage #1: lansoprazole sulfide With tert.-butylhydroperoxide; vanadium acetyl acetonate In ethanol at 5℃; for 6h; Stage #2: With ammonium hydroxide In water at 25℃; for 17h; pH=8 - 8.5; Purification / work up; Alkaline aqueous solution;	A n/a B 0.15%

aqueous sodium metabisulphate: aqueous sodium metabisulphate

(acac)2: (acac)2

aqueous tert-butyl hydroperoxide (TBHP): aqueous tert-butyl hydroperoxide (TBHP)

: 103577-40-8
lansoprazole sulfide

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
In ethanol	79%

...Expand

: 163119-30-0
2-[[(3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl-1-oxide)methyl]sulfanyl]-1H-benzoimidazole

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
sodium(hydrogen ethylenediaminetetraacetato)ruthenium(III)Cl} In ethanol; water at 50℃; for 1h;	50%
{Ru[(EDTA)H]Cl}Na In ethanol; water at 50℃; for 1h;	50%

: 37699-43-7
2,3-dimethyl-4-nitropyridine N-oxide

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 94 percent / tert-BuOK / 42 h / 50 - 60 °C 2: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h 3: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h 4: 45 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling View Scheme

: 103577-66-8
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h 2: 45 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling View Scheme
Multi-step reaction with 3 steps 1: Triphenylphosphine oxide; bis(trichloromethyl) carbonate / toluene / 6 h / 20 - 60 °C 2: sodium hydroxide / ethanol / 2 h / Reflux 3: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / -5 - 20 °C View Scheme

: 103577-61-3
2,3-dimethyl-4-(2,2,2-trifluoroethoxy)-pyridine N-oxide

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 1) Ac2O, conc. H2SO4, 2) aq. NaOH / 1) 100-120 deg C, 5 h, 2) MeOH, rt, 3 h 2: 1) SOCl2, 2) MeONa / 1) CHCl3, reflux, 20 min, 2) MeOH, reflux, 1 h 3: 45 percent / m-chloroperbenzoic acid / CHCl3 / ice-cooling View Scheme

: 408332-88-7
Diethyl tartrate

: 103577-40-8
lansoprazole sulfide

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; ethyl acetate
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene

: lansoprazole sulphide hydrate

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With urea hydrogen peroxide adduct; vanadium(V) oxytrifluoride In 1-methyl-pyrrolidin-2-one at 0 - 20℃; Product distribution / selectivity;

: 1116-76-3
Tri-n-octylamine

: 408332-88-7
Diethyl tartrate

: 103577-40-8
lansoprazole sulfide

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene

...Expand

: 405897-14-5
dimethyl tartrate

: 103577-40-8
lansoprazole sulfide

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene

: 344268-32-2
dibutyl tartrate

: 103577-40-8
lansoprazole sulfide

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene

: 13811-71-7
diethyl (2S,3S)-tartrate

: 103577-40-8
lansoprazole sulfide

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; isopropylbenzene hydroperoxide; titanium(IV) isopropylate In water; toluene	0.63 g (29%)

: 75-89-8
2,2,2-trifluoroethanol

: (R)-2-(4-methanesulfonyl-3-methyl-pyridin-2-ylmethanesulfinyl)-1H-benzimidazole

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
Stage #1: 2,2,2-trifluoroethanol With potassium tert-butylate In N,N-dimethyl-formamide at 25 - 30℃; Stage #2: (R)-2-(4-methanesulfonyl-3-methyl-pyridin-2-ylmethanesulfinyl)-1H-benzimidazole In N,N-dimethyl-formamide at 25 - 30℃; for 24h; Stage #3: With acetic acid In water; N,N-dimethyl-formamide at 0 - 10℃; pH=7.0 - 7.5;

: C26H28F3N3O5S2

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
Stage #1: C26H28F3N3O5S2 With sodium hydroxide In methanol; water at 30℃; for 0.916667h; Stage #2: With acetic acid pH=7;

: (S)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (S)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethyl acetate at 5 - 10℃; for 0.5h;

: (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole (R)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethyl acetate at 5 - 10℃; for 0.5h;

: 128430-66-0
2-(chloromethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine

: 134469-07-1
Benzimidazol-2-thiol

: 103577-45-3
lansoprasole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide / water / Flow reactor 2: sodium hypochlorite; sodium hydroxide / water; acetonitrile / Flow reactor; Large scale View Scheme
Multi-step reaction with 2 steps 1: potassium hydroxide / 1,2-dimethoxyethane / 8 h / 50 °C 2: 3-chloro-benzenecarboperoxoic acid / chloroform / 0 °C View Scheme

: 69986-21-6
2-[p-(chlorosulfonyl)phenoxy]acetamide

: 103577-45-3
lansoprasole

: 259183-34-1
2-(4-{[2-({[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl}sulfinyl)benzimidazol-1-yl]sulfonyl}phenoxy)acetamide

Conditions

Conditions	Yield
Inert atmosphere; Basic conditions;	96%
With triethylamine In dichloromethane

: 67-48-1
choline chloride

: 103577-45-3
lansoprasole

: 2-[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-ylmethanesulfinyl]-1H-benzoimidazole choline salt

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 24h;	94%

: 651728-13-1
(4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester

: 103577-45-3
lansoprasole

: (4-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}phenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester

Conditions

Conditions	Yield
With sodium hydride; sodium hydrogencarbonate In dichloromethane at 20℃;	94%
Stage #1: lansoprasole With sodium hydride In dichloromethane at 20℃; Inert atmosphere; Stage #2: (4-chlorosulfonylphenoxy)acetic acid 2-(toluene-4-sulfonyl)ethyl ester With sodium hydrogencarbonate In dichloromethane Inert atmosphere;	94%

: 651728-35-7
6-[2-(4-chlorosulfonyl-phenoxy)-acetylamino]-n-hexanoic acid 2-(3-nitro-benzenesulfonyl)ethyl ester

: 103577-45-3
lansoprasole

: 6-[2-(4-{2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}-phenoxy)-acetylamino]-n-hexanoic acid 2-(3-nitro-benzenesulfonyl)ethyl ester

Conditions

Conditions	Yield
With sodium hydride In dichloromethane at 20℃; for 2h;	94%

: 259183-87-4
2-[p-(chlorosulfonyl)phenoxy]-N-(2-pyridyl)acetamide

: 103577-45-3
lansoprasole

: 259183-03-4
2-(4-{[2-({[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl}sulfinyl)benzimidazol-1-yl]sulfonyl}-phenoxy)-N-(2-pyridyl)acetamide

Conditions

Conditions	Yield
Inert atmosphere; Basic conditions;	94%
With triethylamine In dichloromethane

: 651728-20-0
2-(4-chlorosulfonylphenoxy)butyric acid 2-(toluene-4-sulfonyl)ethyl ester

: 103577-45-3
lansoprasole

: 2-(4-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethanesulfinyl]benzoimidazole-1-sulfonyl}phenoxy)butyric acid 2-(toluene-4-sulfonyl)ethyl ester

Conditions

Conditions	Yield
With sodium hydride In dichloromethane at 20℃; for 2h;	93%
Stage #1: lansoprasole With sodium hydride In dichloromethane at 20℃; Inert atmosphere; Stage #2: 2-(4-chlorosulfonylphenoxy)butyric acid 2-(toluene-4-sulfonyl)ethyl ester In dichloromethane at 20℃; Inert atmosphere;	93%

: neodymium(III) nitrate hexahydrate

: 103577-45-3
lansoprasole

: 66-22-8
uracil

: [Nd2([[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-yl]methyl]sulfinyl]-1H-benzimidazole)(uracil)·4H2O]NO4·nH2O

Conditions

Conditions	Yield
In ethanol; water at 80℃;	93%

...Expand

: 18531-94-7
(R)-1,1'-Bi-2-naphthol

: 103577-45-3
lansoprasole

: (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole R-(+)-2,2'-dihydroxy-1,1'-binaphthyl

Conditions

Conditions	Yield
In dichloromethane at 20 - 40℃; Resolution of racemate;	92.55%
In dichloromethane at 20 - 40℃;	92.55%
In dichloromethane at 20 - 40℃;	92.55%

: 103577-45-3
lansoprasole

: 7758-99-8
copper(II) sulfate

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

: C16H14F3N3O2S*Cu(2+)*2C5H5N5*(x)H2O*O4S(2-)

Conditions

Conditions	Yield
In ethanol; water Reflux;	89%

...Expand

: 651728-72-2
3-chlorosulfonylbenzoic acid 2-(toluene-4-sulfonyl)ethyl ester

: 103577-45-3
lansoprasole

: 2-[(4-methylphenyl)sulfonyl]ethyl 3-{[2-({[3-methyl-4-(2,2,2-trifluoroethoxy)(2-pyridyl)]methyl}sulfinyl)benzimidazolyl]sulfonyl}benzoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	87%

: chromium sulfate

: 103577-45-3
lansoprasole

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

: C16H14F3N3O2S*Cr(2+)*(x)H2O*O4S(2-)*2C5H5N5

Conditions

Conditions	Yield
In ethanol; water Reflux;	87%

...Expand

: cobalt(II) sulfate

: 103577-45-3
lansoprasole

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

: C16H14F3N3O2S*Co(2+)*(x)H2O*O4S(2-)*2C5H5N5

Conditions

Conditions	Yield
In ethanol; water Reflux;	83%

...Expand

: 259183-84-1
[2-(morpholin-4-yl)ethoxy]benzene-4-sulfonyl chloride

: 103577-45-3
lansoprasole

: 259183-38-5
1-[{2-(morpholin-4-yl)ethoxy}phenyl-4-sulfonyl]-2-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methylsulfinyl]-1H-benzimidazole

Conditions

Conditions	Yield
Inert atmosphere; Basic conditions;	82%
With sodium hydrogencarbonate; triethylamine; sodium chloride In dichloromethane

: manganese(II) sulfate

: 103577-45-3
lansoprasole

: 66224-66-6, 66224-67-7, 66224-68-8, 66224-69-9, 134434-48-3, 134434-49-4, 134454-76-5, 134461-75-9
adenine

: C16H14F3N3O2S*Mn(2+)*(x)H2O*O4S(2-)*2C5H5N5

Conditions

Conditions	Yield
In ethanol; water Reflux;	82%

...Expand

: 651728-08-4
3-chlorosulfonylbenzoic acid 2-(3-nitrobenzenesulfonyl)ethyl ester

: 103577-45-3
lansoprasole

: 3-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-ylmethanesulfinyl]benzimidazole-1-sulfon-yl}benzoic acid 2-(3-nitrobenzenesulfonyl)ethyl ester

Conditions

Conditions	Yield
With sodium hydride In dichloromethane at 20℃; for 2h;	80%
Stage #1: lansoprasole With sodium hydride In dichloromethane at 20℃; Inert atmosphere; Stage #2: 3-chlorosulfonylbenzoic acid 2-(3-nitrobenzenesulfonyl)ethyl ester In dichloromethane at 20℃; for 2h; Inert atmosphere;	80%

: 651728-46-0
4-(4-chlorosulfonyl-3-isopropylphenoxyactamido)butyric acid 2-(3-nitrobenzenesulfonyl)ethyl ester

: 103577-45-3
lansoprasole

: 4-[2-(3-isopropyl-4-{-2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}phenoxy)acetylamino]butyric acid 2-(3-nitrobenzenesulfonyl)ethyl ester

Conditions

Conditions	Yield
With sodium hydride In dichloromethane at 20℃; for 2h;	80%

: 3-methyl-4-(2,2,2-trifluoroethoxy)-2-chloromethylpyridine hydrochloride

: 103577-45-3
lansoprasole

: 1083100-26-8
1-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole

Conditions

Conditions	Yield
With sodium hydroxide In water Heating;	80%

Lansoprazole Specification

The Lansoprazole with CAS registry number of 103577-45-3 is also known as 1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-. The IUPAC name is 2-[[3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole. It belongs to product categories of Active Pharmaceutical Ingredients; Intermediates & Fine Chemicals; Pharmaceuticals; Sulfur & Selenium Compounds; Ion Pump Inhibitors; Monovalent Ion Channels; Voltage-gated Ion Channels; ATPase; Pharmaceutical Intermediates. In addition, the formula is C₁₆H₁₄F₃N₃O₂S and the molecular weight is 369.36. This chemical is a white crystalline powder and should be sealed in cool place without light. What's more, it can be used for the treatment of duodenal ulcer embolism and it is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.

Physical properties about Lansoprazole are: (1)ACD/LogP: 2.76; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.75; (4)ACD/LogD (pH 7.4): 2.76; (5)ACD/BCF (pH 5.5): 72.3; (6)ACD/BCF (pH 7.4): 72.89; (7)ACD/KOC (pH 5.5): 740.79; (8)ACD/KOC (pH 7.4): 746.86; (9)#H bond acceptors: 5; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 5; (12)Index of Refraction: 1.635; (13)Molar Refractivity: 88.03 cm³; (14)Molar Volume: 245.8 cm³; (15)Surface Tension: 68.9 dyne/cm; (16)Density: 1.5 g/cm³; (17)Flash Point: 289.9 °C; (18)Enthalpy of Vaporization: 83.72 kJ/mol; (19)Boiling Point: 555.8 °C at 760 mmHg; (20)Vapour Pressure: 2.16E-12 mmHg at 25 °C.

Preparation of Lansoprazole: it is prepared by reaction of 2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethylsulfanyl]-1H-benzoimidazole. The reaction needs reagent m-chloroperbenzoic acid and solvent CHCl₃ with other condition of ice-cooling. The yield is about 45%.

Lansoprazole is prepared by reaction of 2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethylsulfanyl]-1H-benzoimidazole.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. During using it, wear suitable protective clothing. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
2. InChI: InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,
18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
3. InChIKey: MJIHNNLFOKEZEW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD	oral	> 2gm/kg (2000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 387, 1993.
mouse	LD50	intraperitoneal	> 5gm/kg (5000mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE WEAKNESS KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
mouse	LD50	oral	> 5gm/kg (5000mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
mouse	LDLo	intravenous	75mg/kg (75mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24, Pg. 905, 1996.
rat	LD50	intraperitoneal	5gm/kg (5000mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 18(Suppl,
rat	LDLo	intravenous	58mg/kg (58mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24, Pg. 905, 1996.

Product Name

Lansoprazole

Synthetic route

Lansoprazole Specification

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