A simple synthetic strategy is described for the hitherto unreported 3-arylazo-8H-imidazo[1,2-b]pyrazolo[4,3-d]pyridazines 7 is described based on the reaction of 3-acetyl-4-cyano-1,5-diphenylpyrazole hydrazone 3 with the hydrazonoyl halides 1a–l. The structures of such dyes were confirmed by s...

2,3-Butanediol (BDO) is an important chemical with broad industrial applications and can be naturally produced by many bacteria at high levels. However, the pathogenicity of these native producers is a major obstacle for large scale production. Here we report the engineering of an industrially f...

Using synthetic probes cDNA clones were isolated correponding to the precursor forms of cecropins A and D. The sequences obtained were compared to earlier data for preprocecropin B. A processing scheme in three or four steps is discussed.

Acyl glucuronides are key metabolites for many carboxylic acid-containing drugs, notably those of the non-steroidal anti-inflammatory class. In the processes of drug safety assessment and new drug development, it is essential that acyl glucuronides, if formed in vivo, should be made conveniently...

A synthesis of the (3aS-cis)-(−)- and (3aR-cis)-(+)-enantiomers of debromoflustramine B 1 is reported. The synthesis involves the chromatographic separation of the corresponding (−)- and (+)-N-phenylethyl lactams 10 and 11, obtained by the reaction of racemic lactone 6 with (S)-(−)-1-phenylethyl...

Metallothioneins (MTs) are low-molecular weight proteins with high Cys content and a high affinity for metals. Plant MTs are classified into four types based on the arrangement of Cys in their amino acid sequences. In the present study, the gene encoding OsMTI-3a, a type 3 MT found in rice, was ...

The C1-symmetrical cis-bis(Hdpa)Ru(II) complex, cis-[RuCl(Hdpa)2(dmso-S)]X (1·X; X = Cl or OTf, Hdpa = di-2-pyridylamine, dmso = dimethyl sulfoxide, OTf− = CF3SO3−), was synthesized and spectroscopically and crystallographically characterized. The crystal structures of 1·Cl and 1·(OTf) reveal...

Background & AimsSofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections, and resistance-associated substitutions in the polymerase are rare. However, HCV genotype 3 responds slightly less well to sofosbuvir-b...

Objectives and AimIn this study, we aimed to compare the potency of different G-CSF agents including original filgrastim (Neupogen®), biosimilar filgrastim (Leucostim®) and Lenograstim (Granocyte®) on CD34+ cell mobilization in patients that underwent allogeneic hematopoietic stem cell transplan...

Biosimilar filgrastim (Leucostim®) was shown to be similar in terms of efficacy and safety in hematopoietic progenitor cell mobilization (HPCM) compared to originator filgrastim (Neupogen®) and lenograstim (Granocyte®) in healthy donors and chemomobilization settings. Here we report our retrospe...

The aim of this study was to show a lower incidence of febrile episodes in multiple myeloma patients receiving lenograstim vs. filgrastim after high-dose cyclophosphamide for stem cell mobilization.Patients treated with cyclophosphamide were randomly assigned to receive filgrastim or lenograstim...

The substitution of 6-fluoroquinolines was modified in ring positions 2 and 4. The new compounds were tested in vitro for their activities against a sensitive and a multidrug resistant strain of Plasmodium falciparum. Some physicochemical parametres were calculated (log P, log D, ligand efficien...

9-((6-Phenylpyridin-3-yl)methyl)-9H-carbazole and 9-((6-(4-fluorophenyl)pyridin-3-yl)methyl)-9H-carbazole were synthesized as ligands by attaching a carbazolyl group to the pyridine in 2-phenylpyridine and 2-(4-fluorophenyl)pyridine, respectively. Four different Ir(III) complexes were prepared u...

In an endeavour to develop potent anti-tumor agents from diosgenin, a series of C-6 derived 1,2,3-triazolyl derivatives were designed and synthesized by employing Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition reaction of novel azides - (22R,25R)-6β-azidospirostan-3β,5α-diol and 6β-azido-...

The regioselectivity of the coupling reactions of the internal acetylenic derivative Ph2P–CC–SiMe3 (2) and the benzyne complex [Cp2Zr(η2-C6H4)] (1) resulted preferentially in the formation of the zirconaindene metallacycle with the metal α-carbanions stabilized by the trimethylsilyl group....

A novel composite adsorbent, [email protected](Cr), was prepared using MIL-101(Cr) functionalized with different amount of phenol via an impregnation technique. These new composite adsorbents were characterized by X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, Fouri...

Four new A2CdSn2S6 (A = Cs(1), Rb(2), K(3-β) and K(3-α)) compounds have been synthesized and characterized by X-ray diffraction and spectroscopic methods. The isostructural cesium(1) and rubidium(2) compounds have noncentrosymmetric three-dimensional tetrahedral [CdSn2S6]2- framework structure...

This study was undertaken to investigate the effects induced by the systemic administration of RB 101 [N-{(R,S)-2-benzyl-3[(S)(2-amino-4-methylthio)butyl dithio]-1-oxoprpyl}-l-phenylalanine benzyl ester], a mixed inhibitor of the enkephalin catabolism able to cross the blood–brain barrier, in a...

Accumulating evidence demonstrated that abnormal expression of long non-coding RNAs (lncRNAs) was closely associated with cancer development including retinoblastoma (RB). LncRNA X inactive specific transcript (XIST) has been found to function as an oncogene or a tumor suppressor in several canc...

ObjectiveWe aimed to explore the effect of Sappanone A on neurologic damage induced by hypoxia.