Phosphatidylinositol 3-kinase (PI3K) is a pivotal regulator of intracellular signaling pathways and considered as a promising target in the development of a therapeutic treatment of cancer. Among the different PI3K subtypes, the PIK3CA gene encoding PI3K p110α is frequently mutated and overexpr...

A series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates contained sulfonamido were designed and synthesized, and their anticancer effects in vitro was evaluated to develop some new PI3Kα inhibitors. Most of desired compounds exhibited the better antiproliferative activities against four ca...

Neurofibrillary tangles (NFTs) composed of hyperphosphorylated and aggregated tau are common pathological characteristics in Alzheimer's disease (AD) and other tauopathies. Aberrant tau phosphorylation is an early and pivotal event in the pathogenesis of tauopathies, and since GSK-3 is a ke...

Some new azo dye derivatives having pyrazole and trichlorotriazine moieties were synthesized and were evaluated as reactive dyes for the exhaust dyeing of cotton fiber. The title dyes 5a–c were synthesized from reactions of diazonium salts of 3-substituted-1-phenyl-5-aminopyrazoles 2a–c with 6...

The development of small π-conjugated functional organic molecules capable of forming supramolecular columnar self-assembly, is a rapidly growing area of material research. In this context, the present work describes the design and synthesis of a new series of wedge-shaped rhodanine derivatives...

To develop colorless and soluble polyimide films, a novel dianhydride containing 1,4:3,6-dianhydro-D-mannitol unit, 2,5-bis(3,4-dicarboxyphenoxy)-1,4:3,6-dianhydromannitol dianhydride (IMDA) was synthesized. And two series of polyimides were prepared via a two-step thermal imidization, PI−(1–4)...

The metabolites 2-aminobenzothiazole (ABT) and 2-(methylamino)benzothiazole (MABT) have been reported to represent a major fraction of the soil-bound residue of the urea herbicide methabenzthiazuron, which is preferentially bound to the humic fraction of soil. To better understand the fate of th...

The separation of 32 alkyl-substituted phenoxyalkanoic acids from phenoxyacetic to 3-pentadecylphenoxylauric acid was studied using adsorption chromatography, three types of partition chromatography (water, formamide or liquid paraffin as stationary phases) and reversed-phase high-performance th...

Poly[(methyl methacrylate)-co-acrylamide] of various compositions were previously prepared by the radical copolymerization reaction of methyl methacrylate and the acrylamide monomer in a solvent. The copolymers were modified through a resonating salt by the addition reaction of a chlorotitanium-...

Dehydration of 4ξ , 5ξ -dihydroxy-5,6-diketo steroids was investigated. The possibility that the products of dehydration might complex with metals was examined and steroidal cupric and ferric chelates are described.

Based on density measurements, volumetric properties including excess molar volumes, partial molar volumes, partial molar excess volumes and their infinite dilution values, for binary and ternary solutions of allyl alcohol, 1,3-dichloro-2-propanol and 1-ethyl -3-methyl imidazolium ethyl sulfate ...

A selection of amino-substituted 1,1,2,2,9,9,10,10 octafluoro[2.2]paracyclophanes were tested for enantiodiscrimination by 1H and 19F NMR spectroscopy via their interaction with different lanthanide tris β-diketonate chiral shift reagents. The amino-, and the pseudo-ortho di-amino substituted o...

(1) In lymphoid cell lines established by Epstein-Barr virus transformation of B-lymphocytes from normal subjects there exist two lipases hydrolysing triolein (the first one with acid optimum pH and the other one with alkaline optimum pH) and one cholesterol esterase (with acidic optimum pH). Th...

1.1. The characteristics of acid lipase with 4-methylumbelliferyl oleate as substrate and acid cholesteryl esterase with cholesteryl [1-14C]oleate as substrate were investigated in homogenates of human leucocytes, fibroblasts and liver. The substrates were encapsulated in egg yolk lecithin vesic...

An acid lipase was purified from rabbit liver lysosomes by, in sequence, osmotic treatment of the lysosomal fraction, Sephadex LH-20, DEAE-Sephadex A-50, Bio-Gel A-5m, hydroxyapatite and, finally, Sephadex G-200 column chromatography. The substrate was 4-methylumbelliferyl oleate. The enzyme was...

IntroductionThis study aimed to compare the cytocompatibility and angiogenic potential of 2 antibiotics (clindamycin [CLIN] and minocycline [MINO]) at distinct concentrations on dental pulp stem cells (DPSCs) and human umbilical vein endothelial cells (HUVECs).

ABSTRACTObjectiveThe mortality rate for Staphylococcus aureus endocarditis remains as high as 20–30% despite improvements in medical and surgical treatment. This study evaluated the efficiency and tolerance of a combination of intravenous trimethoprim-sulfamethoxazole and clindamycin (T&C) +/- ...

BackgroundAntibiotics are recognized as first-line treatments for hidradenitis suppurativa (HS), but the data on their efficacy are limited.

Addition to Bacillus acidocaldarius of acids which can act as primers for fatty acid synthesis promote the synthesis of corresponding fatty acids competitively. The effective acids are n−C5 to -∉7 (not C4 or C8), iso- and anteiso-C, and −C, (not C4), and a range of cyclic acids from cyclobutylac...

The conversion efficiency of alkanoic, alkenoic, branched, alicyclic, aromatic, keto-substituted, and dioic carboxylic acids to their corresponding butyl esters was compared under different reaction conditions (time, temperature, catalyst). We show that boron trifluoride is generally a more effi...