Enantiopure diethyl oxirane dicarboxylate 1 reacts with o-aminophenols 2 either to 1,4-benzoxazin-2-ones 5 or to the 1,5-benzoxazepin-2-one 4 while a condensed 1,4-oxazin-3-one 6 was obtained with 2-amino-3-hydroxypyridine. On the other hand optical active oxirane carboxylic acids 7 react with o...

Herein we present the use of group (IV) metal alkoxides as catalysts for the polymerisation of esters of β-alanine and its derivatives. The influence of different group (IV) metal alkoxides, different esters, temperature and solvents on the polymerisation are investigated. The order in which th...

The 2-pyridyl residue serves as a protecting group for various carboxylic acids. The protecting group is selectively cleaved under mild conditions via N-methylation of the pyridyl group. During the deprotection process, the various functional groups as well as the other ester moieties remain int...

The 6-O-sulphates of 2-acetamido-2-deoxy-α-D-galactose I-phosphate (N-acetylgalactosamine-αI-phoshate), O-(β-D-glucopyranosyluronic acid)-(I→3)-2-acetamido-2-deoxy-D-galactase (N-acetylchondrosine) and UDP-2-acetamido-2-deoxy-α-D-galactose (UDP-N-acetylgalactosamine) were synthesized using ...

Nonsulfated di- to octadeca-saccharides having 2-acetamido-2-deoxy-d-galactose at the reducing end were prepared, in 81% yield, by treatment of chondroitin 6-sulfate (pyridinium salt) with dimethyl sulfoxide containing 10% of water for 14 h at 90°. N-Acetylchondrosine and N-acetyldermosine were...

N-Acetylchondrosine was incubated at pH 4.0 with a rabbit-liver crude enzyme extract. Gel filtration of the reaction products on Sephadex G-15 revealed the presence of monosaccharide liberated from the disaccharide. The monosaccharide fraction was analyzed by gas-liquid chromatography, and ident...

Alkylation of the cobalt(II) complex of ethyl acetoacetate with 1-bromoadamantane affords ethyl 2-(1-adamantyl)acetoacetate, which was converted into rac-(1-adamantyl)glycine 1 and rac-2-(1-adamantyl)-2-aminoethanol 7. This was separated into enantiomers by means of vinyl acetate in the presence...

Raman spectra of 1,1-difluoro-1-silacyclohexane as a liquid, and as a solid at 78 K were recorded and depolarization data obtained. The infrared spectra of the vapour, liquid and amorphous and crystalline solids have been studied. In the low temperature IR and Raman spectra eight and three bands...

The conformational preference of the cyano group of the 1-cyano-1-silacyclohexane was studied experimentally by means of gas electron diffraction (GED) and dynamic nuclear magnetic resonance (DNMR) as well as by quantum chemical (QC) calculations applying high-level coupled cluster methods as we...

The synthesis and results of gas electron diffraction (GED), temperature-dependent Raman spectroscopy, along with detailed quantum chemical (QC) study of 1-methoxy-1-silacyclohexane 1 are reported. Within the series of the QC results, DFT(B3LYP, PBE0, M06, M062X), and MP2, the conformational pre...

The infrared spectra of 1-chloro-1-silacyclohexane have been studied as a vapour and liquid at ambient temperature and as amorphous and annealed crystalline solids at 78 K. Various infrared bands present in the vapour and liquid states vanished in the crystalline state upon cooling. Raman spectr...

A 1,1-disubstituted silacyclohexane, 1-chloro-1-methyl-1-silacyclohexane, C5H10SiClCH3, was synthesized and studied by infrared and Raman spectroscopy. The infrared spectra of the vapor and liquid were recorded at ambient temperature and the solid sample investigated at 78 K. Negligible spectral...

In this paper, 2-hydroxyethyl dibutyldithiocarbamate (HEBTC) containing thione and hydroxy groups was synthesized and introduced as a new flotation surfactant for recovering chalcopyrite. HEBTC’s chemical reactivity and dispersion performances were studied via DFT calculations and surface tensi...

Salicylamide is an important model compound for use in investigations concerning drug disposition. In this study the metabolic fate of salicylamide at high doses was evaluated in male mice using HPLC methodology. The concentrations of salicylamide and its metabolites were determined in urine and...

The review deals with the pharmaceutically important group of pyrimido[5,4-d]pyrimidines (PPs) and covers the relevant literature published from about 1986 through 2014. A synthetic section describes the formation of PPs from pyrimidines both by cyclization to give a second pyrimidine ring and b...

In this study, a 50-membered library of substituted 4-hydroxyquinolin-2(1H)-ones and two closely related analogues was designed, scored in-silico for drug likeness and subsequently synthesized. Thirteen derivatives, all sharing a common 3-phenyl substituent showed minimal inhibitory concentratio...

New 7-hydroxy-6-phenyl-3-(phenyldiazenyl)pyrazolo[1,5-a]pyrimidine-2,5(1H,4H)-dione derivatives were synthesized from the reaction of (chlorocarbonyl)phenyl ketene and 5-amino pyrazolones in high to excellent yields and short reaction times. Structures of the new compounds were fully characteriz...

Proton-substitution effects of 4-hydroxy-5-phenyl-6H-pyrido[3,2,1-jk]carbazol-6-one (HPPCO) on structural and photophysical properties were presented. HPPCO crystallized in the orthorhombic space group Pbca with an intermolecular hydrogen bonding between OH and oxygen atom of the carbonyl. The p...

Both experimental and calculated spectral and electronic properties of two isomers 1-methyl-3-nitropyrazole and 1-methyl-5-nitropyrazole have been demonstrated and discussed in details based on normal mode analysis. The fully anharmonic infrared spectra with calculated anharmonic intensities for...

Here, the Conductor-like Polarizable Continuum Model (CPCM) was used as a less demanding substitute of Periodic Boundary Conditions (PBC) method to attempt to reliably simulate infrared spectra and some structural parameters of solid compound - 5-amino-3-methyl-4-isoxazolecarbohydrazide (HIX). T...