The detection of developmental neurotoxicity (DNT) of chemicals has high relevance for protection of human health. However, DNT of many pesticides is only little known. Furthermore, validated in vitro systems for assessment of DNT are not well established. Here we employed the rat phaeochromocyt...

BackgroundIschemic cerebrovascular disease (ICVD) is the third leading cause of death worldwide. Luteolin is a naturally flavonoid widely distributed in many plant leaves. This study aimed to explore the effects of luteolin on H2O2-induced ICVD cell oxidative injury model, as well as underlying ...

Cerebral ischemia is the second leading cause of death and disability worldwide. Despite the neuroprotective role of Tanshinone IIA has been widely reported, the molecular mechanisms involving miRNAs remains unclear. We aimed to figure out a novel regulatory mechanism of Tanshinone IIA associate...

PC-12 cells originate from neuroblastic cells, which have an ability to differentiate into neuronlike cells. In this work, the purpose was to estimate the influence of microenvironments on cell attachment and neuritogenesis capacity of PC-12 cells on parylene-N and parylene-C films with and with...

BackgroundDiabetic foot is a severe complication of diabetes mellitus, mainly caused by diabetic peripheral neuropathy. The objective of this study was to investigate the function of emodin (a neuroprotective agent reported previously) in diabetic peripheral neuropathy.

LncRNA H19 has been widely reported to be up-regulated upon hypoxia. We aimed to uncover the function and mechanism of lncRNA H19 in hypoxic PC-12 cells. Neural-like PC-12 cells were exposed to hypoxia to stimulating an in vitro model of hypoxic brain damage. The expression levels of lncRNA H19 ...

The limited therapeutic strategies and the unsatisfied prognosis for spinal cord injury (SCI) make the identification of innovative therapeutic targets for SCI become very urgent. Herein, we explored the role of long non-cording RNA taurine up-regulated gene 1 (lncRNA TUG1) in lipopolysaccharide...

Biomimetic scaffolds inspired by fields and forces of the natural environment of cells is essential in tissue engineering. This study reports on controlled growth of two model cell lines, NIH/3T3 (promiscuous, fibroblast) and PC-12 (electroresponsive, neural progenitor) cells, given electrical a...

1.1. THC, PCP, and MK-801 increased DOPAC in rat olfactory tubercle and prefrontal cortex without affecting DA levels, suggesting increased DA release.2.2. Effects on NE and MHPG were not evident.3.3. These two classes of drugs can effect dopaminergic systems independently of noradrenergic systems.

The effects of MK-801, a non-competitive NMDA receptor antagonist, and of antidepressant drugs were studied in the forced swimming test in rats. MK-801 reduced immobility time. Combined treatment with MK-801 + imipramine induced a stronger effect in Porsolt's test than administration of eit...

Antagonism of the NMDA receptor with MK-801 is considered to be an effective pharmacologic manipulation to prevent the development of sensitization effects to drugs such as cocaine. The present study investigated this issue by comparing the behavioral response of separate groups of rats to three...

Background and Objectives. Not only the facilitation of inhibitory synapses but also the suppression of excitatory synapses may be effective in treating convulsion induced by local anesthetics. The effects of MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist, on bupivacaine-induced convu...

ObjectiveEvaluate safety/tolerability/efficacy of MK-8242 in subjects with refractory/recurrent AML.

ObjectiveTo develop a highly effective HPLC method for standardization of silymarin and for characterization of minor components, which has not been reported previously.

ObjectiveTo characterize the cardiovascular effects of dexmedetomidine, with or without MK-467, following intravenous (IV) administration in cats.

We study electron spin resonance (ESR) of DPPH at mK temperatures. Here we employ a superconducting coplanar microwave resonator that allows convenient implementation in a dilution refrigerator as well as operation at multiple ESR frequencies, in this case 1.5 GHz, 3.0 GHz, and 4.5 GHz. We find ...

An enantioselective synthesis of MK 287 (L-680,573), a member of a family of trans-,5-diaryltetrahydrofurans, and its biological activity are described.

Following a general method of synthesis of optically active 2,5-disubstituted tetrahydrofurans, an enantioselective synthesis of the PAF antagonist, MK-287 is described.

Two highly similar, PtdIns(4,5)P2-selective, Gβγ-activated PI3Ks were purified from pig neutrophil cytosol. Both were heterodimers, were composed of a 101 kDa protein and either a 120 kDa or a 117 kDa catalytic subunit, and were activated greater than 100-fold by Gβγs. Peptide sequence–base...

Plasmodium vivax merozoite surface protein-9 (Pvmsp-9) is characterized here along with orthologues from the related simian malarias Plasmodium cynomolgi and Plasmodium knowlesi. We show that although the corresponding MSP-9 proteins do not have acidic–basic repeated amino acid (aa) motifs, the...