The widespread occurrence of pesticide residues in different agricultural and food commodities has raised concern among the environmentalists and food chemists. In order to keep a proper track of these materials, studies on their decay profiles in the various segments of ecosystem under varying ...

Quinalphos is one of the widely used organophosphate pesticides and known for its persistence in water. The present study investigates the TiO2 mediated photocatalytic degradation of quinalphos. The rate constant for degradation of quinalphos were calculated to be 0.00567 min−1 and higher degrad...

This study outlines the toxic effects of Quinalphos (QP), an organophosphrous insecticide on the development of zebrafish (Danio rerio) embryos, with special emphasis on toxicomorphomics and toxicokinetics of target enzyme, AChE. A range of concentrations was used to elucidate the median lethal ...

Quinalphos is a synthetic organophosphate used as a broad spectrum insecticide and acaricide. The present study investigates the effect of three sub-lethal doses (0.52, 1.04, 2.6 mg/kg b.wt) of quinalphos for variable durations (15, 30 and 90 days) on oxidative stress and histopathological chang...

A simple and selective p-nitroaniline dithiocarbamate capped gold nanoparticles (p-NA-DTC-Au NPs)-based colorimetric sensor was developed for the detection of quinalphos in water and food samples. The method was based on the color change of p-NA-DTC-Au NPs from red to blue with the addition of q...

A pharmacokinetic in vitro and in vivo degradation study has been carried out in rat to evaluate the deleterious effects of exposure to quinalphos on a target population. Degradation of quinalphos in simulated gastric and intestinal phases has been investigated. The metabolic intermediates of qu...

Quinalphos (QP), an organophosphate pesticide is used worldwide in agricultural practices. Extensive use of pesticides creates toxicological and environmental nuisances on non-target organisms, where it severely affects cholinergic neurons in higher animals and also induces Parkinson, Alzheimer&...

A simple and rapid procedure for the determination of quinalphos in human whole blood using liquid-liquid extraction and high-performance thin-layer chromatography was developed and validated. Seven different organic solvents were tested for optimum extraction of quinalphos from spiked blood sam...

A series of 11 new 9H-bis-[1,2,4]triazolo[4,3-a:3′,4′-d] [1,5]benzodiazepine derivatives 8e–o was synthesized. Ten of these compounds (8e–m,o), along with four analogues (8a–d) (previously synthesized by us) were tested in vitro in order to evaluate their cytotoxic and anti-HIV-1 properties...

Herein, the design and synthesis of 10 novel N′-arylidene pyrazole-3-carbohydrazides are described. Compounds were pretended to act as dual agents against diabetes and oxidative stress, two correlated pathologies involved in metabolic syndrome development and progression. The antioxidant capaci...

A stepwise approach has been used in the syntheses of pentamannosyl tetraphosphate HO-[-6Man(α)-PO4-]4-6Man(α)-OMe and tetra(N-acetylglucosaminyl) triphosphate HO-[-3GlcNAc(α)-PO4]3-3GlcNAc(β)-OC6H4NO2, which are fragments of the yeast and bacteria extracellular phosphoglycans. Elongation of...

The radical telomerisation of vinylidene fluoride (VDF) with diethyl hydrogenphosphonate (DEHP) was investigated to synthesize fluorinated telomers bearing a phosphonate end-group, as H(VDF)nP(O)(OEt)2. Di-t-butyl peroxide was the most effective radical initiator A minute structural study of typ...

The hydrogenphosphonate approach has been used in syntheses of methyl α-d-mannopyranoside 2-, 3-, and 4-(α-d-mannopyranosyl phosphate), benzyl β-d-galactopyranoside 2-(α-d-mannopyranosyl phosphate), and methyl β-d-galactopyranoside 4-(α-d-mannopyranosyl phosphate). Condensation of 2,3,4,6-...

The effect of homo-azasteroidal esters of benzoic acid mustard isomers and the 4-methyl derivatives, which have steroidal lactams as a biological basis, on cytogenetic damage was studied. Twenty compounds were comparatively studied, on a molar basis, as regards their ability to induce sister-chr...

The synthetic sequence to make 4-[4′-bis(2″-chloroethyl)aminophenyl]-4,4-difluorobutanoic acid {4,4-difluorochlorambucil} was not taken beyond the intermediate stage involving methyl 4,4-difluoro-4-(4′-aminophenyl) butanoate, since this amine was hydrolytically unstable. Reaction of methyl 4-...

In the course of the development of N-phenyl-N′-(2-chloroethyl)ureas (CEUs) as potential antineoplastic agents, we investigated the effect of carbonylated substituting chains of the aromatic ring of CEU on their covalent binding to the colchicine-binding site (C-BS). In this study, we found tha...

The analysis of wastewater for the determination of human biomarkers of exposure (human metabolites) is a non-intrusive, economic and complementary alternative to the analysis of urine in the monitoring of human exposure to chemicals of concern. This study provides the first gas chromatography-b...

Tris(2-chloroethyl)phosphate (TCEP) is a widely used environmental organic pollutant. Studies have revealed the presence of both TCEP and its metabolites in environmental media. The neurotoxicity of TCEP has been investigated in vitro but rarely in mammals. This study aimed to determine the neur...

Organophosphate esters (OPEs) and phthalate esters (PAEs) are extensively used as additives in commercial and household products. However, knowledge on human exposure to OPEs and PAEs remains limited in China. This study aimed to investigate OPE and PAE metabolites in urine samples of primiparas...

Tris-2-chloroethyl phosphate (TCEP), an emerging contaminant of concern, is largely recalcitrant to removal due to its relatively high water solubility and non-degradability. Adsorption from wastewater is an option for separation, with a suitable adsorbent. In this study, equilibrium adsorption ...