New pyrazole Schiff bases containing azo groups, 4-((E)-phenyldiazenyl)-3-(4-nitrobenzylidene)-1-phenyl-pyrazole-5-amine and its series, were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-1-phenyl-4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine in the molar ratio of ...

A series five coumarin azo disperse dyes with thiophene bridge are synthesized using diazotized aniline derivatives which are confirmed by FT-IR, 1H NMR, 13C NMR, and CHN analysis. The dyes are applied on polyester and nylon material. The multifunctional properties (lightfastness, washing fastne...

The preparation of some phenylazo substituted tetra-aza macrocycle complexes is reported. The electrochemical properties of these compounds have been examined using polarographic and voltammetric techniques. These studies revealed that both the ligand and metal are electrochemically active. The ...

IntroductionThe small molecule 2-(5-(dimethylamino)naphthalene-1-sulfonamido)-2-(fluoromethyl)butanoic acid (NST732) is a member of the ApoSense family of compounds, capable of selective targeting, binding and accumulation within cells undergoing apoptotic cell death. It has application in molec...

An α2 → 3 glycolipid galactosyl sialyltransferase (SAT3/4) has been partially purified from embryonic chicken skeletal muscle. It is preserved in 50 mM Hepes buffer (pH 6.8) containing 1% Triton CF-54 and 20% glycerol at −70°C for a period of 6 months without loss of activity. The SAT3/4 prep...

Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment associated with a variety of disorders including Alzheimer’s disease and schizophrenia. Alpha 7 nAChRs are expressed in brain regions associated with cogn...

A chemiluminescent method has been used recently for the determination of acetylcholine with limitations such as the presence of a cholinesterase inhibitor in the incubation medium, which is indispensable for the study of acetylcholine release by various agents. A modified procedure is presented...

N-ethyl-choline aziridinium (ECA) and N-ethyl-acetylcholine aziridinium (EAA) were shown to be inhibitors of high affinity choline uptake in vitro(IC50=0.4 ωMand 1.5 ωM, respectively), and intraventricular administration showed that EAA was more selective in its inhibition of hippocampal choli...

α7 nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal medicinal chemistry program we investigated a novel series of α7 nAChR agonists. Starting from molecular docking studies on two series of ...

1. A method has been developed for maintaining nervous tissues of the decapod crustacean, Palaemonetes varians (Leach), in organ culture.2. Radioactive tracers were used to measure choline uptake, acetylcholide synthesis and the distribution of radioactivity amongst the various choline metabolit...

Dioctanoylglycerol, a synthetic diacylglycerol, stimulated [14C]choline uptake in cultured human neuroblastoma (LA-N-2) cells. As this effect has not, to our knowledge, been reported before, it was of interest to characterize it in more detail. In the presence of 500 μM dioctanoylglycerol the l...

A study has been undertaken of the lithium and sodium metallation of N,N′-di(aryl)formamidines with alkyl groups at the 2- and 6-aryl position. 1H NMR and X-ray diffraction data indicate an increase in steric bulk from 2,6-dimethylphenyl to 2,6-diethylphenyl to 2,6-diisopropylphenyl incites inc...

The title compound, N,N′-di(2-methoxyphenyl)formamidine (DMPF) was synthesized and characterized byFT-IR, FT-Raman, 1H NMR, 13C NMR spectroscopy and X-ray single crystal diffraction. The results show that the compound crystallizes in anorthorhombic system, with space group of Pbca and eight mol...

Discrete Zn(II) and Cu(II) complexes have been synthesized by using N-hydroxy-N,N′-diarylformamidine ligands: N-hydroxy-N,N′-bis(2,6-diisopropylphenyl)formamidine (L1), N-hydroxy-N,N′-bis(2,6-dimethyl)formamidine (L2), N-hydroxy-N-(2-methoxyphenyl)-N′-(2,6-diisopropylphenyl)formamidine (L3),...

The reactions of N,N′-bis(2,6-dimethylphenyl)formamidine (L1) and N,N′-bis(2,6-diisopropylphenyl)formamidine (L2), with Zn(OAc)2·2H2O salt and auxiliary benzoate ligands produced the respective Zn(II) formamidine benzoate complexes 1–4. All the complexes were characterized by IR, NMR spectro...

Redox transmetallation/protolysis (RTP) reactions between free rare-earth metals (La, Nd, or Yb), Hg(C6F5)2, and FFormH (FFormH = N,N′-bis(2-fluorophenyl)formamidine) in thf afforded four rare-earth complexes: trivalent [La(FForm)3(thf)2]·thf, [Nd(FForm)3(thf)x], [Yb(FForm)3(thf)] (when a slig...

The pesticides, chlordimeform and amitraz, and their metabolites, demethylchlordimeform, N1-(2,4-dimethylphenyl)-N-methylformamidine, and 2,4-dimethylformanilide, are effective at concentrations as low as 3 μM in raising the firing rate of endogenously active neurosecretory fibres in the isolat...

l-Lysine monohydrochloride dihydrate (LLMHCl), a semiorganic potential nonlinear optically active crystal possessing large hyperpolarizability and which belongs to noncentrosymmetry class has been grown and studied. The XRD analysis shows that it belongs to the auspicious symmetric space group P...

Thin film composite membrane having chiral selective layer was prepared by the interfacial polymerization of trans-1,4-diaminocyclohexane, piperazine and trimesoyl chloride. The composition of chiral selective layer of composite membrane was elucidated by Fourier transfer infrared spectroscopy i...

l-Ornithine monohydrochloride (LOMHCl) single crystal is a potential material for non linear optical and opto-electronic applications. In the present study, good quality single crystals were grown by slow evaporation solution technique at room temperature. The bulk single crystals were subjected...