1.1. Single doses of paracetamol 400 (PAR 400) and 800 mg/kg (PAR 800), SUR 2647 combination (free paracetamol + paracetamol-N-acetyl-dl-methionate, paracetamol/methionine ratio 2:1) equivalent to PAR 400 (SURc 400) and PAR 800 (SURc 800) were given p.o. to male Bom:NMRI mice.2.2. The objective ...

The 33S-hyperfine tensor has been determined in a radical cation of N-acetyl DL-methionine produced by γ-irradiation at 77 K. The small s-character (3.2%) indicates that the unpaired orbital consists essentially of sulfur 3p orbitals. The intensity of the 33S satellites together with the p-char...

1.1. A single high peroral dose of N-acetyl-dl-methionine (859.5 mg/kg) was administered to Bom:NMRI male mice using methylcellulose as a drug vehicle.2.2. The administration of a single high peroral dose of N-acetyl-dl-methionine (859.5 mg/kg) to Bom:NMRI male mice caused an inhibition of the h...

A procedure for production of N-acetyl-l-methionine (N-Ac-l-Met) from its racemic mixture by enzymatic continuous hydrolysis of the l-enantiomer of N-acetyl-dl-methioninamide (N-Ac-dl-Met · NH2) is described. For this hydrolysis, whole cells of Erwinia carotovora immobilized by κ-carrageenan g...

Bulk size single crystal of N-acetyl DL-methionine (C7H13NO3S) (1) was grown using a home-made crystal growth setup (MKN setup). The identity of the grown crystal was confirmed by single crystal X-ray diffraction. The modes of vibrations of the functional groups present were assigned using the i...

N-Trifluoroacetyl-l-norvalyl-l-norvaline1 cyclohexyl ester has been synthesized in high yield and used as a stationary phase for the gas chromatographic enantiomeric separation of N-trifluoroacetyl-d,l-amino acid isopropyl esters. Separation factors and enthalpies of solution have shown a marked...

The effects of acylation on the enantiomeric separation of isopropyl esters of alanine, valine, allo-isoleucine, isoleucine, leucine and aspartic acid were investigated with a cross-linked polycyanoethyl vinyl siloxane-l-Val-tert-butylamide fused-silica capillary column. The gas chromatographic ...

The solubility of d-aspartic acid in co-solvent mixtures of dimethyl sulfoxide (DMSO) (1) + water (2), N,N-dimethylformamide (DMF) (1) + water (2), N-methyl-2-pyrrolidone (NMP) (1) + water (2) and 1,4-dioxane (1) + water (2) at the temperatures from (288.15/298.15 to 333.15) K was reported. Expe...

Redox data of the title compounds are given. In buffered aqueous medium the reduction gave aminomalonitrile and the corresponding N-methylamine. Based on the products obtained, mechanisms are proposed for the oxidation in acetonitrile medium of two products, p-chloro and m-chloro derivatives, ch...

The geometries of two trans- and two cis-2-vinylcycloprop-1-yl rotamers were optimized completely at the STO-3G level. The trans-(s-trans)2-vinylcycloprop-1-yl structure is predicted to be the most stable by both the STO-3G optimizations and by single-point 3-21G∗(5d)//STO-3G computations. The g...

The radiation-induced polymerization of 3-methyl-1,3-pentadiene (3MPD) as an inclusion complex in deoxycholic acid (DOCA) has produced in good yield the optically active polymer poly(3-methyl-1,4-pentadiene) (P3MPD) whose structure and properties were studied by FT-IR spectroscopy and thermal an...

To obtain information about the influence of hydrogen bonding on the monolayer behavior and molecular packing, amphiphiles with two hydroxyl groups attached to different positions in the alkyl chain are investigated at the air-water interface using π–A-isotherms, constant surface pressure rela...

The reduction of methyl-coenzyme M (CH3SCoM) to methane in methanogenic bacteria is dependent on component B (N-7-mercaptoheptanoyl-O-phospho-L-threonine, HSHTP). We report here that S-methyl-component B (N-7-(methylthio)heptanoyl-O-phospho-L-threonine, CH3SHTP) can substitute for neither CH3SCo...

The crystal and molecular structures of the potassium (I), ammonium (II) and diammonium (III) salts of O-phospho-l-threonine were determined by X-ray methods. The crystal structure of I contains two independent monoanions [denoted as (1) and (2)] and that of II four independent monoanions [denot...

The crystal and molecular structures of ThCl4(depa)3 (1) (depa = N,N-diethylpropionamide) and Th(NCS)4(dmpa)4 (2) (dmpa = N,N-dimethylpropionamide) have been determined from three-dimensional X-ray diffraction data. The compounds crystallize in space group P21/n (1) and P21/a (2), with a = 18.10...

A gas chromatographic–ion trap tandem mass spectrometric method was developed for the quantification of muramic acid, a marker of bacterial peptidoglycan, in environmental and clinical specimens. Samples (bacteria, house dust and urine) were heated in methanolic hydrochloric acid overnight and ...

The use of trimethylsilyl (TMS)-derivatisation for determining muramic acid in environmental and clinical samples by gas chromatography–mass spectrometry provides high detection sensitivity; however, questions have been raised as concerns the chemical structure of the entity giving the strong s...

BackgroundEndotoxin exposure has been shown to be associated with a decreased prevalence of atopic sensitization and symptoms. Yet endotoxin represents only a part of the indoor microbial exposure. Muramic acid, a constituent of peptidoglycan, is present in gram-negative and gram-positive bacter...

Characterizing functional and phylogenetic microbial community structure in soil is important for understanding the fate of microbially-derived compounds during the decomposition and turn-over of soil organic matter. This study was conducted to test whether amino sugars and muramic acid are suit...

The muramic acid assay is a powerful tool for detecting both intact bacteria and bacterial debris. Past use of aldononitrile acetate derivatization for determining muramic acid in complex samples by gas chromatography/mass spectrometry met detection needs in many instances; however, questions ha...